Category: iodides-buliding-blocks

Zhou, Fang published the artcileCatalytic Asymmetric Hydroalkylation of α,β-Unsaturated Amides Enabled by Regio-Reversed and Enantiodifferentiating syn-Hydronickellation, Formula: C6H13I, the publication is ACS Catalysis (2021), 11(14), 8766-8773, database is CAplus.

Here, an enantioselective nickel-hydride catalyzed hydroalkylation of readily accessible β-alkyl-α,β-unsaturated amides to form structurally diverse β-chiral amides e.g., I was reported. This process was proposed to proceed through an enantiodifferentiating syn-hydrometalation of nickel hydride, forming chiral alkylnickel at β-position in which regioselectivity is different than that with copper hydride. This regio-reversed hydronickellation process provided a complementary approach to access enantioenriched β-functionalization amides with a stereocenter at β-position.

ACS Catalysis published new progress about 638-45-9. 638-45-9 belongs to iodides-buliding-blocks, auxiliary class Iodide,Aliphatic hydrocarbon chain, name is 1-Iodohexane, and the molecular formula is C5H5F3O2, Formula: C6H13I.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Rajasekaran, Deepa published the artcileTargeting distinct tautomerase sites of D-DT and MIF with a single molecule for inhibition of neutrophil lung recruitment, Application of 4-Iodo-6-phenylpyrimidine, the publication is FASEB Journal (2014), 28(11), 4961-4971, database is CAplus and MEDLINE.

We report a new inflammatory activity for extracellular D-dopachrome tautomerase (D-DT), the recruitment of neutrophils to the lung on D-DT intratracheal installation of C57BL/6J mice with an EC₅₀ of 5.6 μg. We also find that D-DT and macrophage migration inhibitory factor (MIF) have additive effects in neutrophil recruitment. Although the tautomerase site of D-DT and its homolog MIF are biophys. very different, 4-iodo-6-phenylpyrimidine (4-IPP) forms a covalent bond with Pro-1 of both proteins, resulting in a 6-phenylpyrimidine (6-PP) adduct. Recruitment of neutrophils to the lung for the 6-PP adducts of D-DT and MIF are reduced by ∼50% relative to the apo proteins, demonstrating that an unmodified Pro-1 is important for this activity, but there is no cooperativity in inhibition of the proteins together. The differences in the binding mode of the 6-PP adduct for D-DT was determined by crystallog. studies at 1.13 Å resolution and compared to the structure of the MIF-6-PP complex. There are major differences in the location of the 6-PP adduct to the D-DT and MIF active sites that provide insight into the lack of cooperativity by 4-IPP and into tuning the properties of the covalent inhibitors of D-DT and MIF that are necessary for the development of therapeutic small mols. against neutrophil damage from lung infections such as Pseudomonas aeruginosa in cystic fibrosis and immunocompromised patients.

FASEB Journal published new progress about 41270-96-6. 41270-96-6 belongs to iodides-buliding-blocks, auxiliary class Pyrimidine,Iodide,Benzene,Immunology/Inflammation,MIF, name is 4-Iodo-6-phenylpyrimidine, and the molecular formula is C10H7IN2, Application of 4-Iodo-6-phenylpyrimidine.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Zhang, Yadong published the artcilePolymers with Carbazole-Oxadiazole Side Chains as Ambipolar Hosts for Phosphorescent Light-Emitting Diodes, Quality Control of 39115-95-2, the publication is Chemistry of Materials (2011), 23(17), 4002-4015, database is CAplus.

Polymethacrylates, polystyrenes, and polynorbornenes bearing 2-(3-(carbazol-9-yl)phenyl)-5-phenyl-1,3,4-oxadiazole, 2-(4-(carbazol-9-yl)phenyl)-5-phenyl-1,3,4-oxadiazole, 2-((3,5-di(carbazol-9-yl)phenyl)-5-phenyl-1,3,4-oxadiazole) groups linked to the polymer backbone through the 3-position of their terminal Ph groups have been synthesized for use as solution-processable ambipolar hosts for phosphorescent light-emitting diodes. The polymers exhibit good thermal stabilities, with no weight loss below 350 °C, and have glass-transition temperatures in the range 118-209°. Spectroscopic, electrochem., and quantum-chem. data for small-mol. model compounds suggest that the side chain groups are suitable hosts for a range of phosphors, including the green-emitter fac-tris(2-phenylpyridinato-N,C²‘)iridium (Ir(ppy)₃). Light-emitting diodes were fabricated, each with a solution-processed photo-cross-linked hole-transport layer, a solution-processed emissive layer composed of a carbazole-oxadiazole-functionalized polymethacrylate doped with Ir(ppy)₃, and an evaporated electron-transport layer. The polymer with 2-(3,5-(dicarbazol-9-yl)phenyl)-5-phenyl-1,3,4-oxadiazole units in the side chain exhibited the lowest turn-on voltage (6.0 V), and the highest efficiency (external quantum efficiency of 10.0%, current efficiency of 34.1 cd/A).

Chemistry of Materials published new progress about 39115-95-2. 39115-95-2 belongs to iodides-buliding-blocks, auxiliary class Iodide,Hydrazine,Amine,Benzene,Hydrazide,Amide, name is 4-Iodobenzohydrazide, and the molecular formula is C15H21BO3, Quality Control of 39115-95-2.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Schindler, Lisa published the artcileMacrophage migration inhibitory factor inhibits neutrophil apoptosis by inducing cytokine release from mononuclear cells, Category: iodides-buliding-blocks, the publication is Journal of Leukocyte Biology (2021), 110(5), 893-905, database is CAplus and MEDLINE.

The chemokine-like inflammatory cytokine macrophage migration inhibitory factor (MIF) is a pivotal driver of acute and chronic inflammatory conditions, cardiovascular disease, autoimmunity, and cancer. MIF modulates the early inflammatory response through various mechanisms, including regulation of neutrophil recruitment and fate, but the mechanisms and the role of the more recently described MIF homolog MIF-2 (D-dopachrome tautomerase; D-DT) are incompletely understood. Here, we show that both MIF and MIF-2/D-DT inhibit neutrophil apoptosis. This is not a direct effect, but involves the activation of mononuclear cells, which secrete CXCL8 and other prosurvival mediators to promote neutrophil survival. Individually, CXCL8 and MIF (or MIF-2) did not significantly inhibit neutrophil apoptosis, but in combination they elicited a synergistic response, promoting neutrophil survival even in the absence of mononuclear cells. The use of receptor-specific inhibitors provided evidence for a causal role of the noncognate MIF receptor CXCR2 expressed on both monocytes and neutrophils in MIF-mediated neutrophil survival. We suggest that the ability to inhibit neutrophil apoptosis contributes to the proinflammatory role ascribed to MIF, and propose that blocking the interaction between MIF and CXCR2 could be an important anti-inflammatory strategy in the early inflammatory response.

Journal of Leukocyte Biology published new progress about 41270-96-6. 41270-96-6 belongs to iodides-buliding-blocks, auxiliary class Pyrimidine,Iodide,Benzene,Immunology/Inflammation,MIF, name is 4-Iodo-6-phenylpyrimidine, and the molecular formula is C10H7IN2, Category: iodides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Abd El-Aal, Reda Mahmoud published the artcileThe synthesis of some bridgehead heterocyclic monomethine cyanine dyes, Application In Synthesis of 606-55-3, the publication is Dyes and Pigments (1998), 39(4), 267-280, database is CAplus.

α-Chloroacetic acid and phenacyl bromide were used as reagents reacting with 8-hydroxyquinoline to form bridgehead heterocycles. Reaction of these heterocycles with equi- or dimolar ratios of ethiodides of α- or -γ-picoline or quinaldine afforded a series of monomethine and bismonomethine cyanine dyes. The electronic spectra of the monomethine cyanine dyes in various solvents are discussed.

Dyes and Pigments published new progress about 606-55-3. 606-55-3 belongs to iodides-buliding-blocks, auxiliary class Quinoline,Salt, name is 1-Ethyl-2-methylquinolin-1-ium iodide, and the molecular formula is C12H14IN, Application In Synthesis of 606-55-3.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Abd El-Aal, Reda Mahmoud published the artcileSynthesis and characterization of new photosensitizer bridgehead cyanine dyes, Synthetic Route of 606-55-3, the publication is Proceedings – Indian Academy of Sciences, Chemical Sciences (1999), 111(2), 343-352, database is CAplus.

Oxazolo[1,2-a]quinoline derivatives were used to synthesize novel bridgehead cyanine dyes such as azamethine, monomethine, and trimethine cyanines. The electronic absorption spectra of these cationic dyes in ethanol and several organic solvents are discussed.

Proceedings – Indian Academy of Sciences, Chemical Sciences published new progress about 606-55-3. 606-55-3 belongs to iodides-buliding-blocks, auxiliary class Quinoline,Salt, name is 1-Ethyl-2-methylquinolin-1-ium iodide, and the molecular formula is C12H14IN, Synthetic Route of 606-55-3.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Abu El-Hamd, R. M. published the artcileSome new fused heterocyclic cyanine dyes with ring junction, Quality Control of 606-55-3, the publication is Chemical Papers (1997), 51(2), 117-127, database is CAplus.

New asym. pyrazolo[4′,5′:4,5]imidazo[3,2-a]/pyrrolo[1,2-a]pyridinium/quinolinium bromide iodide 1[4(1)]monomethine cyanines (I; R = H, Ph; A = 2 H, C₄H₄; X = CH₂, NH; Z = 2 H, C₄H₄), 1[2(4)]trimethine cyanines (II; A = 2 H, C₄H₄; X = CH₂, NH; Z = 2 H, C₄H₄) and/or 1-styryl cyanines (III; A = 2 H, C₄H₄; X = CH₂, NH; Y = H, p-OMe, p-NO₂) were synthesized to study their spectral behavior, solvatochromism, and acid-base properties. These dyes were characterized by elemental anal., IR, ¹H NMR, and electronic absorption spectra.

Chemical Papers published new progress about 606-55-3. 606-55-3 belongs to iodides-buliding-blocks, auxiliary class Quinoline,Salt, name is 1-Ethyl-2-methylquinolin-1-ium iodide, and the molecular formula is C12H14IN, Quality Control of 606-55-3.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Abu El-Hamd, Ragab M. published the artcileStudies on absorption spectra of newly synthesized cyanine dyes, Computed Properties of 606-55-3, the publication is Indian Journal of Heterocyclic Chemistry (1996), 5(4), 297-304, database is CAplus.

New asym. monomethine cyanines (I; R = H, Ph; X = NH, CH₂; A = H, C₄H₄; Z = H, C₄H₄), trimethine cyanines (II; X = NH, CH₂; A = H, C₄H₄; Z = H, C₄H₄), and styryl cyanines (III; R = H, OMe, NO₂; X = NH, CH₂; A = H, C₄H₄) were synthesized to study their spectral behavior, solvatochromism, mixed solvents and acid-base properties. These dyes are characterized by elemental anal., IR, ¹H NMR, and electronic absorption spectra.

Indian Journal of Heterocyclic Chemistry published new progress about 606-55-3. 606-55-3 belongs to iodides-buliding-blocks, auxiliary class Quinoline,Salt, name is 1-Ethyl-2-methylquinolin-1-ium iodide, and the molecular formula is C12H14IN, Computed Properties of 606-55-3.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Al-Zahrani, Fatimah A. M. published the artcileSynthesis, Dynamics of Solvatochromism and pH-sensory of Novel Push-π-pull Phenothiazine-quinoline Fluorophore Toward Turn-on Fluorescent and Colorimetric Test Strips, Safety of 1-Ethyl-2-methylquinolin-1-ium iodide, the publication is Fibers and Polymers (2022), 23(5), 1182-1189, database is CAplus.

Novel donor-central-π-bridge-acceptor (E)-1-ethyl-2-((10-hexyl-10H-phenothiazin-3-yl)methylene)-2,4a-dihydroquinolin-1-ium (PTZ-Q) fluorophore with remarkable solvatochromism, high fluorescence and pH-sensory properties was designed and synthesized in good yield. PTZ-Q sensor was fully characterized utilizing various spectroscopic techniques, including IR (FTIR), ¹H/¹³C NMR, and mass spectroscopic methods. UV-Vis absorption spectra of the prepared donor-acceptor PTZ-Q were explored in different solvents of varying polarities to show pos. solvatochromism related to intramol. charge transfer. Addnl., the fluorescence spectra of PTZ-Q displayed strongly solvent-dependent wavelength and band intensity. Stokes′ shifts were found to increase upon increasing the polarities of solvents up to 3984 cm^-1 for the highest polar solvents. Linear energy-solvation correlation was employed to examine solvent-dependent Stokes′ shift. Quantum yields () of PTZ-Q were determined The pH-dependent absorption and emission spectra in DMF were also explored. The UV-Vis absorption intensity was monitored at 522 nm, while the emission intensity was detected at 603 nm in DMF. The pH sensing mechanism was found to depend on proton abstraction to the PTZ-Q fluorophore to result in colorimetric and fluorescent spectral changes associated with a colorimetric shift from yellow to pink, red and purple. The synthesized PTZ-Q probe was utilized to fabricate colorimetric and fluorescent test strips with the ability to detect pH changes in aqueous media, which was verified with CIE Lab color coordinates.

Fibers and Polymers published new progress about 606-55-3. 606-55-3 belongs to iodides-buliding-blocks, auxiliary class Quinoline,Salt, name is 1-Ethyl-2-methylquinolin-1-ium iodide, and the molecular formula is C12H14IN, Safety of 1-Ethyl-2-methylquinolin-1-ium iodide.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Bagrov, F. V. published the artcileReaction of ethyl ethoxymethyleneacetoacetate with hydrazine monoderivatives, Application of 4-Iodobenzohydrazide, the publication is Russian Journal of Organic Chemistry (Translation of Zhurnal Organicheskoi Khimii) (2000), 36(2), 191-194, database is CAplus.

The reaction of Et α-ethoxymethyleneacetoacetate with acylhydrazines affords the corresponding acylhydrazones of α-formylacetoacetic ester. The ¹H NMR and IR spectra revealed that the compounds obtained existed in ketoenamine (ketoenhydrazine) form. The condensation of 4-chlorophenyl-, 4-nitrophenyl-, 6-chloropyridazinyl- and 4-phenylphthalazinylhydrazines with the Et ethoxymethyleneacetoacetate is accompanied by cyclization into the corresponding 5-methyl-4-ethoxycarbonylpyrazoles.

Russian Journal of Organic Chemistry (Translation of Zhurnal Organicheskoi Khimii) published new progress about 39115-95-2. 39115-95-2 belongs to iodides-buliding-blocks, auxiliary class Iodide,Hydrazine,Amine,Benzene,Hydrazide,Amide, name is 4-Iodobenzohydrazide, and the molecular formula is C7H7IN2O, Application of 4-Iodobenzohydrazide.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com