Category: iodides-buliding-blocks

Wang, Xiao-Xu published the artcileNiH-catalyzed reductive hydrocarbonation of enol esters and ethers, Recommanded Product: 1-Iodohexane, the publication is CCS Chemistry (2022), 4(2), 605-615, database is CAplus.

Chiral dialkyl carbinols and their derivatives are significant synthetic building blocks in organic chem. and related fields. The development of convenient and efficient methods to access these compounds has long been an important endeavor. Herein, authors report a NiH-catalyzed reductive hydroalkylation and hydroarylation of enol esters and ethers. α-Oxoalkyl organonickel species were generated in situ in a catalytic mode and then participated in cross-coupling with alkyl or aryl halides. This approach enabled C(sp3)-C(sp3) and C(sp3)-C(sp2) bond formation under mild reductive conditions with simple operations, thereby boosting a broad substrate scope and good functional compatibility. Esters of enantioenriched dialkyl carbinols were accessed in a catalytic asym. version. Mechanistic studies demonstrated that this reaction proceeded through a syn-addition of Ni-H intermediate to an enol ester with high regio- and enantioselectivity.

CCS Chemistry published new progress about 638-45-9. 638-45-9 belongs to iodides-buliding-blocks, auxiliary class Iodide,Aliphatic hydrocarbon chain, name is 1-Iodohexane, and the molecular formula is C10H12F6N4O6PdS2, Recommanded Product: 1-Iodohexane.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Sun, Li-Wen published the artcileTransition-metal-free hydroamination/defluorination/cyclization of perfluoroalkyl alkynes with amidines, Related Products of iodides-buliding-blocks, the publication is Organic Chemistry Frontiers (2022), 9(1), 109-116, database is CAplus.

An efficient defluorinative net-[3 + 3]-cyclization strategy for the construction of perfluoroalkyl-substituted pyrimidine derivatives by using a series of perfluoroalkyl alkynes and amidines as starting materials was developed. The present reaction proceeded successfully under transition-metal-free conditions to form two new C-N bonds and a new heterocyclic ring through a sequence of hydroamination, defluorination, and annulation. The desired pyrimidines could be obtained with good functional group tolerance and moderate to good yields. Moreover, the distinctive fluorine effects of perfluoroalkyl substituents are vital for tuning the reactivity of alkynes for the anticipated defluorinative annulation. The pendant π system would lower associated bond dissociation energy significantly compared to that of a nonactivated C(sp3)-F bond.

Organic Chemistry Frontiers published new progress about 134322-01-3. 134322-01-3 belongs to iodides-buliding-blocks, auxiliary class Salt,Iodide,Amine,Amidine,Benzene, name is 4-Iodobenzimidamide hydrochloride, and the molecular formula is C10H14O, Related Products of iodides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Long, Lingliang published the artcileConstruction of a fluorescent probe for selectively detecting singlet oxygen with a high sensitivity and large concentration range based on a two-step cascade sensing reaction, Application of 1-Ethyl-2-methylquinolin-1-ium iodide, the publication is Chemical Communications (Cambridge, United Kingdom) (2019), 55(58), 8462-8465, database is CAplus and MEDLINE.

A novel fluorescent probe XQ-1 for selectively detecting ¹O₂ on the basis of a two-step cascade reaction has been rationally constructed. The probe responded to ¹O₂ not only showing a high sensitivity, but also displaying a large concentration range, which means that the probe can be used as a powerful tool to monitor the efficacy of PDT toward cancer and concurrently track the adverse effects on healthy cells.

Chemical Communications (Cambridge, United Kingdom) published new progress about 606-55-3. 606-55-3 belongs to iodides-buliding-blocks, auxiliary class Quinoline,Salt, name is 1-Ethyl-2-methylquinolin-1-ium iodide, and the molecular formula is C12H14IN, Application of 1-Ethyl-2-methylquinolin-1-ium iodide.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Ai, Han-Jun published the artcileRuthenium pincer complex-catalyzed heterocycle compatible alkoxycarbonylation of alkyl iodides: substrate keeps the catalyst active, Name: 1-Iodohexane, the publication is Chemical Science (2022), 13(8), 2481-2486, database is CAplus and MEDLINE.

In this work, a pincer ruthenium pincer complex-catalyzed heterocycle compatible alkoxycarbonylation of alkyl iodides using alcs. and carbon monoxide to afford esters I [R = iPr, tBu, Ph, etc.; R¹ = tBu, cyclopentyl, (CH₂)₃Ph, etc.] was reported. Benefitting from the pincer ligand, a variety of heterocycles, such as thiophenes, morpholine, unprotected indoles, pyrrole, pyridine, pyrimidine, furan, thiazole, pyrazole, benzothiadiazole, and triazole, were compatible in this protocol.

Chemical Science published new progress about 638-45-9. 638-45-9 belongs to iodides-buliding-blocks, auxiliary class Iodide,Aliphatic hydrocarbon chain, name is 1-Iodohexane, and the molecular formula is C6H13I, Name: 1-Iodohexane.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Yokoyama, Takuya published the artcileIdentification of candidate molecular targets of the novel antineoplastic antimitotic NP-10, SDS of cas: 39115-95-2, the publication is Scientific Reports (2019), 9(1), 1-13, database is CAplus and MEDLINE.

We previously reported the identification of a novel antimitotic agent with carbazole and benzohydrazide structures: N’-[(9-ethyl-9H-carbazol-3-yl)methylene]-2-iodobenzohydrazide (code number NP-10). However, the mechanism(s) underlying the cancer cell-selective inhibition of mitotic progression by NP-10 remains unclear. Here, we identified NP-10-interacting proteins by affinity purification from HeLa cell lysates using NP-10-immobilized beads followed by mass spectrometry. The results showed that several mitosis-associated factors specifically bind to active NP-10, but not to an inactive NP-10 derivative Among them, NUP155 and importin β may be involved in NP-10-mediated mitotic arrest. Because NP-10 did not show antitumor activity in vivo in a previous study, we synthesized 19 NP-10 derivatives to identify more effective NP-10-related compounds HMI83-2, an NP-10-related compound with a Cl moiety, inhibited HCT116 cell tumor formation in nude mice without significant loss of body weight, suggesting that HMI83-2 is a promising lead compound for the development of novel antimitotic agents.

Scientific Reports published new progress about 39115-95-2. 39115-95-2 belongs to iodides-buliding-blocks, auxiliary class Iodide,Hydrazine,Amine,Benzene,Hydrazide,Amide, name is 4-Iodobenzohydrazide, and the molecular formula is C4H6O3, SDS of cas: 39115-95-2.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Siebum, Arjan H. G. published the artcileAccess to any site-directed isotopomer of methionine, selenomethionine, cysteine, and selenocysteine – use of simple, efficient modular synthetic reaction schemes for isotope incorporation, Quality Control of 161370-66-7, the publication is European Journal of Organic Chemistry (2004), 2905-2913, database is CAplus.

Simple modular reaction schemes that allow access to any isotopomer of protected serine and homoserine have been worked out. These systems could be simply converted into cysteine, selenocysteine, homocysteine, homoselenocysteine, the essential amino acid methionine, and selenomethionine by Mitsunobu chem. These sulfur- and selenium-containing amino acids fulfil many essential roles in the living organism. In addition, homoserine could be converted in a few steps into optically active L-vinylglycine. As well as the stable isotopes ¹³C, ¹⁵N, ¹⁷O, and ¹⁸O, the radioactive isotopes of sulfur, selenium and carbon can also be easily introduced in a site-directed fashion. In view of the wide scope of the Mitsunobu reaction, we feel that many more important systems with the carbon skeleton of serine and homoserine should be preparable through this basic chem. in any site-directed isotopically labeled form.

European Journal of Organic Chemistry published new progress about 161370-66-7. 161370-66-7 belongs to iodides-buliding-blocks, auxiliary class Chiral,Iodide,Amine,Aliphatic hydrocarbon chain,Ester,Amide, name is (S)-tert-Butyl 2-((tert-butoxycarbonyl)amino)-4-iodobutanoate, and the molecular formula is C8H9NOS, Quality Control of 161370-66-7.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Ginn, S. G. W. published the artcileIntermolecular vibrations of charge-transfer complexes, Computed Properties of 6443-90-9, the publication is Transactions of the Faraday Society (1966), 62(4), 777-87, database is CAplus.

The intermol. vibration band was identified in the far-ir spectra of the pyridine-IBr and pyridine-ICl charge-transfer complexes. All the reported observations on these and similar complexes can be accounted for by a simple 3-center mol. orbital treatment.

Transactions of the Faraday Society published new progress about 6443-90-9. 6443-90-9 belongs to iodides-buliding-blocks, auxiliary class Pyridines, name is Pyridine Iodochloride complex, and the molecular formula is C5H5ClIN, Computed Properties of 6443-90-9.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Haque, Inamul published the artcileInfrared spectra of pyridine-halogen complexes, Synthetic Route of 6443-90-9, the publication is Spectrochimica Acta, Part A: Molecular and Biomolecular Spectroscopy (1967), 23(1), 959-67, database is CAplus.

The IR spectra of the complexes C5H5N.I2, C5H5N.IBr, C5H5N.ICl, and C5H5N.ICN have been examined, in a range of environments. In polar solvents the ionization 2C5H5N.IX ⇌ (C5H5N)2.I+ + IX2- takes place. The vibrations of the complexes are assigned and discussed on the basis of a M.O. treatment.

Spectrochimica Acta, Part A: Molecular and Biomolecular Spectroscopy published new progress about 6443-90-9. 6443-90-9 belongs to iodides-buliding-blocks, auxiliary class Pyridines, name is Pyridine Iodochloride complex, and the molecular formula is C5H5ClIN, Synthetic Route of 6443-90-9.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Guo, Yongxian published the artcileForce-Induced Molecular Isomerization for the Construction of Multicolor Luminescent Segmented Molecular Crystals, Related Products of iodides-buliding-blocks, the publication is Advanced Optical Materials (2022), 10(2), 2101794, database is CAplus.

Multicolor luminescent segmented materials have attracted tremendous research interest due to their potential applications as barcoding materials in information security and anti-counterfeiting. Although much effort has been devoted to the preparation of photonic barcodes based on different light-emitting materials, the rational design of barcoding materials with well-controlled emission color and length at desired position remains a challenge. Here, a novel strategy to fabricate multicolor luminescent segmented 1D mol. crystals is reported by manipulating the mol. conformation and intermol. interactions of the mechanochromic crystals, which are assembled from a rationally designed twisting conjugated mol. The emission color of these mechanochromic crystals changes from green to orange with the mechanism of synergy effect of force-induced mol. isomerization from trans to cis state and mol. packing changes from cross to parallel, which is revealed by single crystal X-ray diffraction. Multicolor luminescent segmented 1D microribbons are fabricated by applying precisely controlled forces by tapping mode at. force microscope, which shows the encoding capability. These findings provide a new method that allows the controllable fabrication of segmented materials with tunable emission color and length at desired position toward barcoding applications.

Advanced Optical Materials published new progress about 638-45-9. 638-45-9 belongs to iodides-buliding-blocks, auxiliary class Iodide,Aliphatic hydrocarbon chain, name is 1-Iodohexane, and the molecular formula is C6H13I, Related Products of iodides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Yu, Tao published the artcileDiscovery of dimethyl pent-4-ynoic acid derivatives, as potent and orally bioavailable DGAT1 inhibitors that suppress body weight in diet-induced mouse obesity model, Category: iodides-buliding-blocks, the publication is Bioorganic & Medicinal Chemistry Letters (2018), 28(10), 1686-1692, database is CAplus and MEDLINE.

Diacylglycerol acetyltransferase (DGAT) is expressed abundantly in intestine, liver, and adipose tissues. DGAT1 is the crucial and rate-limiting enzyme that mediates the final step in triacylglycerol (TAG) resynthesis during dietary fat absorption. However, too much triacylglycerol (TAG) reserve will lead to genetic obesity (Hubert et al., 2000). DGAT1 knockout mice could survive and displayed a reduction in the postprandial rise of plasma TG, and increased sensitivity of insulin and leptin. Here the authors report the discovery and characterization of a novel selective DGAT1 inhibitor 29 (5-(4-(4-amino-5-oxo-7,8-dihydropyrimido[5,4f][1,4] oxazepin-6(5H)-yl)-2,6-dimethylphenyl)-3,3-dimethylpent-4-ynoic acid) to potentially treat obesity. Compound 29 showed lipid lowering effect in mouse lipid tolerance test (LTT) and also reduced body weight in DIO mice without observable liver damage.

Bioorganic & Medicinal Chemistry Letters published new progress about 364-12-5. 364-12-5 belongs to iodides-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Bromide,Iodide,Benzene, name is 5-Bromo-2-iodobenzotrifluoride, and the molecular formula is C3H6O2, Category: iodides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com