Category: iodides-buliding-blocks

Geng, Hui-Qing published the artcileCopper-Catalyzed Alkoxycarbonylation of Alkyl Iodides for the Synthesis of Aliphatic Esters: Hydrogen Makes the Difference, Name: 1-Iodohexane, the publication is Organic Letters (2021), 23(20), 8062-8066, database is CAplus and MEDLINE.

A copper-catalyzed alkoxycarbonylation transformation of unactivated alkyl iodides was developed. Various alkyl iodides were converted into the corresponding tert-Bu esters in good yields. NaOt-Bu acts as both a nucleophile and a base. Moreover, other types of aliphatic esters was also be obtained in moderated yields if extra alcs. are added. Both primary and secondary alkyl alcs. can react successfully.

Organic Letters published new progress about 638-45-9. 638-45-9 belongs to iodides-buliding-blocks, auxiliary class Iodide,Aliphatic hydrocarbon chain, name is 1-Iodohexane, and the molecular formula is C6H13I, Name: 1-Iodohexane.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Wu, Fu-Peng published the artcileCopper-Catalyzed Borylative Methylation of Alkyl Iodides with CO as the C1 Source: Advantaged by Faster Reaction of CuH over CuBpin, Application In Synthesis of 638-45-9, the publication is Angewandte Chemie, International Edition (2021), 60(21), 11730-11734, database is CAplus and MEDLINE.

CuH and CuBpin are versatile catalysts and intermediates in organic chem. However, studies that involve both CuH and CuBpin in the same reaction is still rarely reported due to their high reactivity. Now, a study on CuH- and CuBpin-catalyzed borylative methylation of alkyl iodides with CO as the C1 source is reported. Various one carbon prolongated alkyl boranes (RCH₂Bpin and RCH(Bpin)₂) were produced in moderate to good yields from the corresponding alkyl iodides (RI). In this cooperative system, CuH reacts with alkyl iodide faster than CuBpin.

Angewandte Chemie, International Edition published new progress about 638-45-9. 638-45-9 belongs to iodides-buliding-blocks, auxiliary class Iodide,Aliphatic hydrocarbon chain, name is 1-Iodohexane, and the molecular formula is C7H5Cl2NO, Application In Synthesis of 638-45-9.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Han, Jie published the artcileSynthesis, liquid crystalline and photoluminescent properties of 1,3,4-oxadiazole derivatives: From calamitic monomers, H-Shaped dimers to calix[4]arene-based tetramers, Quality Control of 39115-95-2, the publication is Dyes and Pigments (2018), 234-241, database is CAplus.

A new class of calamitic 1,3,4-oxadiazole monomers H-shaped dimers , and calix [4]arene-based tetramer have been synthesized and characterized fully by means of ¹H NMR (proton NMR), ¹³C-NMR, high resolution mass spectroscopy (HRMS) and elemental anal., and the thermal properties and photoluminescent behaviors have been investigated systemically. All of the monomers display stable liquid crystalline properties with smectic and/or nematic mesophases determined by the electronic and steric nature of the terminal groups. In contrast, both the H-shaped dimers and the calix [4]arene based tetramer are not mesogenic, while they show specific recognition for Cu²⁺ through the fluorescent emission intensity quenching. The relationship between the mol. structures and properties has been discussed according to the mol. shapes.

Dyes and Pigments published new progress about 39115-95-2. 39115-95-2 belongs to iodides-buliding-blocks, auxiliary class Iodide,Hydrazine,Amine,Benzene,Hydrazide,Amide, name is 4-Iodobenzohydrazide, and the molecular formula is C7H7IN2O, Quality Control of 39115-95-2.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Huang, Zhuo-Bin published the artcileSelective C-H dithiocarbamation of arenes and antifungal activity evaluation, Application of 4-Iodo-1-methyl-1H-pyrazol-5-amine, the publication is Organic & Biomolecular Chemistry (2020), 18(7), 1369-1376, database is CAplus and MEDLINE.

This paper discloses a transition metal-free selective C-H dithiocarbamation of drug skeletons using disulfiram (DSF) in the presence of KI/K₂S₂O₈ in DMF/H₂O. Drug skeletons, including 5-aminopyrazoles, indoles, pyrroloquinoline, and Julolidine, underwent C-H dithiocarbamation smoothly to afford a variety of drug-like mols. in moderate to good yields. It was found that the in situ formed 5-aminopyrazole iodide is the key intermediate for the dithiocarbamation. Bioassay results show that some of these N-heterocyclic dithiocarbamate derivatives exhibit good antifungal activity against Colletotrichum gloeosprioides and Fusarium oxysporum, F. proliferatum, Fusarium solani, Geotrichum candidum, Penicillium digitatum, Penicillium italicum, Pyricularia grisea.

Organic & Biomolecular Chemistry published new progress about 1443278-79-2. 1443278-79-2 belongs to iodides-buliding-blocks, auxiliary class Pyrazole,Iodide,Amine, name is 4-Iodo-1-methyl-1H-pyrazol-5-amine, and the molecular formula is C4H6IN3, Application of 4-Iodo-1-methyl-1H-pyrazol-5-amine.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Dai, Lei published the artcileVisible-Light-Driven N-Heterocyclic Carbene Catalyzed γ- and ε-Alkylation with Alkyl Radicals, COA of Formula: C5H9IO2, the publication is Angewandte Chemie, International Edition (2019), 58(50), 18124-18130, database is CAplus and MEDLINE.

The merging of photoredox catalysis and N-heterocyclic carbene (NHC) catalysis for γ- and ε-alkylation of enals with alkyl radicals was developed. The alkylation reaction of γ-oxidized enals with alkyl halides worked well for the synthesis γ-multisubstituted-α,β-unsaturated esters, including those with challenging vicinal all-carbon quaternary centers. The synthesis of ε-multisubstituted-α,β-γ,δ-diunsatd. esters by an unprecedented NHC-catalyzed ε-functionalization was also established.

Angewandte Chemie, International Edition published new progress about 31253-08-4. 31253-08-4 belongs to iodides-buliding-blocks, auxiliary class Iodide,Ester, name is Ethyl 2-Iodopropionate, and the molecular formula is C5H9IO2, COA of Formula: C5H9IO2.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Cheng, Chaozhihui published the artcileNickel-Catalyzed Arylcarbamoylation of Alkenes of N-(o-Iodoaryl)acrylamides with Nitroarenes via Reductive Aminocarbonylation: Facile Synthesis of Carbamoyl-Substituted Oxindoles, Name: 1-Iodohexane, the publication is Organic Letters (2021), 23(24), 9543-9547, database is CAplus and MEDLINE.

Nickel-catalyzed arylcarbamoylation reactions of alkenes of N-(o-haloaryl)acrylamides with CO and nitroarenes via reductive aminocarbonylation to produce carbamoyl-substituted oxindoles with an all-carbon quaternary stereogenic center are presented. Starting with N-(o-haloaryl)acrylamides, simple CO, and inexpensive nitroarenes and using a Ni catalyst, a dinitrogen-based ligand, a Zn reductant, a TMSCl additive, and a base system, this protocol enables the synthesis of various carbamoyl-substituted oxindoles and allows the efficient late-stage derivatization of valuable mols.

Organic Letters published new progress about 638-45-9. 638-45-9 belongs to iodides-buliding-blocks, auxiliary class Iodide,Aliphatic hydrocarbon chain, name is 1-Iodohexane, and the molecular formula is C6H13I, Name: 1-Iodohexane.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Lu, Xi published the artcilePractical carbon-carbon bond formation from olefins through nickel-catalyzed reductive olefin hydrocarbonation, HPLC of Formula: 161370-66-7, the publication is Nature Communications (2016), 11129pp., database is CAplus and MEDLINE.

A general process for the intermol. reductive coupling of unactivated olefins with alkyl or aryl electrophiles under the promotion of a simple nickel catalyst system was reported. This new reaction presented a conceptually unique and practical strategy for the construction of C(sp²)-C(sp³) and C(sp³)-C(sp³) bonds without using any organometallic reagent. The reductive olefin hydrocarbonation also exhibited excellent compatibility with varieties of synthetically important functional groups and therefore, provided a straightforward approach for modification of complex organic mols. containing olefin groups.

Nature Communications published new progress about 161370-66-7. 161370-66-7 belongs to iodides-buliding-blocks, auxiliary class Chiral,Iodide,Amine,Aliphatic hydrocarbon chain,Ester,Amide, name is (S)-tert-Butyl 2-((tert-butoxycarbonyl)amino)-4-iodobutanoate, and the molecular formula is C13H24INO4, HPLC of Formula: 161370-66-7.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Gu, Yu-lei published the artcileGene knockout or inhibition of macrophage migration inhibitory factor alleviates lipopolysaccharide-induced liver injury via inhibiting inflammatory response, Application of 4-Iodo-6-phenylpyrimidine, the publication is Hepatobiliary & Pancreatic Diseases International (2021), 20(5), 469-477, database is CAplus and MEDLINE.

Background: Liver injury is one of the most common complications during sepsis. Macrophage migration inhibitory factor (MIF) is an important proinflammatory cytokine. This study explored the role of MIF in the lipopolysaccharide (LPS)-induced liver injury through genetically manipulated mouse strains. Methods: The model of LPS-induced liver injury was established in wild-type and Mif-knockout C57/BL6 mice. Serum levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST), and total bilirubin (TBil) were detected, and the expressions of MIF, tumor necrosis factor-α (TNF-α) and interleukin-1β (IL-1β) were measured. Liver histopathol. was conducted to assess liver injury. Moreover, the inhibitions of MIF with (S, R)-3-(4-hydroxyphenyl)-4, 5-dihydro-5-isoxazole acetic acid Me ester (ISO-1) and 4-iodo-6-phenylpyrimidine (4-IPP) were used to evaluate their therapeutic potential of liver injury. Results: Compared with wild-type mice, the liver function indexes and inflammation factors presented no significant difference in the Mif^-/- mice. After 72 h of the LPS-induced liver injury, serum levels of ALT, AST, and TBil as well as TNF-α and IL-1β were significantly increased, but the knockout of Mif attenuated liver injury and inflammatory response. In liver tissue, m RNA levels of TNF-α, IL-1β and NF-κB p65 were remarkably elevated in LPS-induced liver injury, while the knockout of Mif reduced these levels. Moreover, in LPS-induced liver injury, the inhibitions of MIF with ISO-1 and 4-IPP alleviated liver injury and slightly attenuated inflammatory response. Importantly, compared to mice with LPS-induced liver injury, Mif knockout or MIF inhibitions significantly prolonged the survival of the mice. Conclusions: In LPS-induced liver injury, the knockout of Mif or MIF inhibitions alleviated liver injury and slightly attenuated inflammatory response, thereby prolonged the survival of the mice. Targeting MIF may be an important strategy to protect the liver from injury during sepsis.

Hepatobiliary & Pancreatic Diseases International published new progress about 41270-96-6. 41270-96-6 belongs to iodides-buliding-blocks, auxiliary class Pyrimidine,Iodide,Benzene,Immunology/Inflammation,MIF, name is 4-Iodo-6-phenylpyrimidine, and the molecular formula is C10H7IN2, Application of 4-Iodo-6-phenylpyrimidine.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Kuai, Chang-Sheng published the artcilePalladium-Catalyzed Regio- and Stereoselective Hydroaminocarbonylation of Unsymmetrical Internal Alkynes toward α,β-Unsaturated Amides, COA of Formula: C6H13I, the publication is Organic Letters (2022), 24(24), 4464-4469, database is CAplus and MEDLINE.

α,β-Unsaturated amides play a vital role in natural products, pharmaceuticals, organic synthesis, and functional materials. Herein, authors disclosed a regio- and stereoselective hydroaminocarbonylation of unsym. internal alkynes via palladium catalysis to synthesize α,β-unsaturated amides. This protocol features excellent regio- and exclusive (E)-stereoselectivity, high atom and step-economy, broad substrate scope, and functional group tolerance.

Organic Letters published new progress about 638-45-9. 638-45-9 belongs to iodides-buliding-blocks, auxiliary class Iodide,Aliphatic hydrocarbon chain, name is 1-Iodohexane, and the molecular formula is C6H13I, COA of Formula: C6H13I.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Shinohara, Mai published the artcilePhoto-control of Cellular Uptake by the Selective Adsorption of Spiropyran Derivatives on Albumin, HPLC of Formula: 638-45-9, the publication is Chemistry Letters (2022), 51(6), 594-597, database is CAplus.

A photochromic spiropyran derivative (SP6) as a drug tag was prepared SP6 was selectively taken up into cells by photo-controlling the adsorption on albumin, which has attracted attention as a carrier for delivering drugs to tumor cells. The desorption of SP6 from albumin was achieved via the isomerization and hydrolysis of SP6.

Chemistry Letters published new progress about 638-45-9. 638-45-9 belongs to iodides-buliding-blocks, auxiliary class Iodide,Aliphatic hydrocarbon chain, name is 1-Iodohexane, and the molecular formula is C3H6BrNaO3S, HPLC of Formula: 638-45-9.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com