Iodides-buliding-blocks

Kusche, Brian R. published the artcileNonactin biosynthesis: Setting limits on what can be achieved with precursor-directed biosynthesis, Product Details of C5H9IO2, the publication is Bioorganic & Medicinal Chemistry Letters (2009), 19(4), 1233-1235, database is CAplus and MEDLINE.

Nonactin, produced by Streptomyces griseus ETH A7796, is a macrotetrolide assembled from nonactic acid. It is an effective inhibitor of drug efflux in multidrug resistant erythroleukemia K562 cells at sub-toxic concentrations and has been shown to possess both antibacterial and antitumor activity. As total synthesis is impractical for the generation of nonactin analogs the authors have studied precursor-directed biosynthesis as an alternative as it is known that nonactic acid can serve as a nonactin precursor in vivo. To determine the scope of the approach the authors prepared and evaluated a furan-based nonactic acid derivative, (I). Although no new nonactin analogs were detected when (I) was administered to S. griseus fermentative cultures, a significant inhibition of nonactin biosynthesis was noted (IC₅₀ âˆ?100 μM). Cell mass, nonactic acid production and the generation of other secondary metabolites in the culture were unaffected by (I) demonstrating that (I) selectively inhibited the assembly of nonactin from nonactic acid. While the authors were unable to generate new nonactin analogs the authors have discovered, however, a useful inhibitor that can be used to probe the mechanism of nonactin assembly with the ultimate goal of developing more successful precursor-directed biosynthesis transformations.

Bioorganic & Medicinal Chemistry Letters published new progress about 31253-08-4. 31253-08-4 belongs to iodides-buliding-blocks, auxiliary class Iodide,Ester, name is Ethyl 2-Iodopropionate, and the molecular formula is C5H9IO2, Product Details of C5H9IO2.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Popov, Alexander I. published the artcileStudies on the chemistry of halogens and polyhalides. X. The reactions of iodine monochloride with pyridine and 2,2′-bipyridine, Application of Pyridine Iodochloride complex, the publication is Journal of the American Chemical Society (1957), 570-2, database is CAplus.

cf. C.A. 51, 4191i. The preparation and isolation of addition compounds of pyridine and of 2,2′-bipyridine (bp) and ICl and with HICl₂ is described. Absorption spectra of these compounds in acetonitrile solutions were determined Complexes of both 2,2′-bipyridine and the pyridine with ICl dissociate according to bpI.2ICl â‡?bpI⁺ + ICl₂^– and 2pyICl â‡?py₂I⁺ + ICl₂^–. 15 references.

Journal of the American Chemical Society published new progress about 6443-90-9. 6443-90-9 belongs to iodides-buliding-blocks, auxiliary class Pyridines, name is Pyridine Iodochloride complex, and the molecular formula is C5H5ClIN, Application of Pyridine Iodochloride complex.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Stahl, Egon published the artcileThin layer chromatography. XII. Separation and specific detection of organic iodine compounds such as x-ray contrast materials and tyrosine derivatives, Category: iodides-buliding-blocks, the publication is Fresenius’ Zeitschrift fuer Analytische Chemie (1964), 200(5), 377-85, database is CAplus.

cf. CA 58, 12369f. Mixtures of I-containing x-ray contrast compounds are separated by thin layer chromatography on silica gel-starch using either acidic or basic eluents. The spots are detected via I release by short wavelength ultraviolet light and appearance of the blue starch-I complex. As little as 0.1 γ I can be detected.

Fresenius’ Zeitschrift fuer Analytische Chemie published new progress about 101-29-1. 101-29-1 belongs to iodides-buliding-blocks, auxiliary class Pyridine,Iodide,Carboxylic acid,Ketone, name is 2-(3,5-Diiodo-4-oxopyridin-1(4H)-yl)acetic acid, and the molecular formula is C7H8BNO4, Category: iodides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Milovanovic, Vesna M. published the artcileGreen synthesis of benzamide-dioxoisoindoline derivatives and assessment of their radical scavenging activity – Experimental and theoretical approach, Application of 4-Iodobenzohydrazide, the publication is Tetrahedron (2020), 76(38), 131456, database is CAplus.

A series of benzamide-dioxoisoindoline derivatives I (Ar = Ph, 4-HOC₆H₄, 4-IC₆H₄, etc.) was obtained, starting from phthalic anhydride and different benzoyl hydrazides, by ultrasound irradiation in water as solvent and without any catalyst. Five obtained compounds have been reported in this study for the first time and crystal structure of compound I (3,4,5-MeOC₆H₂) was determined All compounds were subjected to exptl. determination of their antioxidative potential. DPPH test revealed that newly synthesized phenolic compounds I (Ar = 2,3-HOC₆H₃, 3,4-HOC₆H₃, 3,4,5-HOC₆H₂) are the best antioxidants. Addnl., probable radical scavenging pathway was analyzed for reactions of the most active compounds and some radicals that can be found in living cells.

Tetrahedron published new progress about 39115-95-2. 39115-95-2 belongs to iodides-buliding-blocks, auxiliary class Iodide,Hydrazine,Amine,Benzene,Hydrazide,Amide, name is 4-Iodobenzohydrazide, and the molecular formula is C7H7IN2O, Application of 4-Iodobenzohydrazide.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Milovanovic, Vesna published the artcileStructural characterization of benzoyl-1H-pyrazole derivatives obtained in lemon juice medium: Experimental and theoretical approach, HPLC of Formula: 39115-95-2, the publication is Journal of Molecular Structure (2019), 85-94, database is CAplus.

Simple, one-pot and low-cost reactions of acetylacetone with a variety of substituted benzoyl hydrazides in lemon juice, as eco-friendly medium, were performed. In reactions of benzoyl hydrazides with electron-donating groups on Ph ring, the 1-benzoyl-1H-pyrazole derivatives were obtained in short reaction time and in good to high yields. On the other hand, benzoyl hydrazides with electron-withdrawing groups reacted slower, yielding the mixture of 1-benzoyl-5-hydroxy-4,5-dihydro-1H-pyrazole and benzoyl-1H-pyrazole derivatives It is worth pointing out that two products, (2-chlorophenyl)(4,5-dihydro-5-hydroxy-3,5-dimethylpyrazol-1-yl)methanone and (4-iodophenyl)(3,5-dimethyl-1H-pyrazol-1-yl)methanone were reported for the first time. All obtained compounds were characterized using IR, UV-Vis and NMR, exptl. and theor., as well as with m.ps. Good agreement between exptl. and simulated IR, UV-Vis, ¹H and ¹³C NMR spectra was achieved. In addition, crystal structures and Hirshfeld surfaces anal. of (4,5-dihydro-5-hydroxy-3,5-dimethylpyrazol-1-yl)(4-iodophenyl)methanone were reported.

Journal of Molecular Structure published new progress about 39115-95-2. 39115-95-2 belongs to iodides-buliding-blocks, auxiliary class Iodide,Hydrazine,Amine,Benzene,Hydrazide,Amide, name is 4-Iodobenzohydrazide, and the molecular formula is C7H7IN2O, HPLC of Formula: 39115-95-2.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Yarwood, J. published the artcileFar-infrared intensity studies of complexes of some pyridine bases with iodine monochloride, Safety of Pyridine Iodochloride complex, the publication is Journal of the American Chemical Society (1968), 90(15), 3930-9, database is CAplus.

Studies are reported of the far-ir spectra of complexes of ICl with pyridine, 3-picoline, and 2,6-lutidine. The frequencies and the intensities are given for both the I-Cl stretching vibration (�90 cm.-1) and the N-I stretching vibration (115-140 cm.-1) measured for complexes dissolved in benzene. The measurements were made with a Beckman IR-11 far-ir spectrometer, with polyethylene cells. Exptl. techniques for intensity measurements in this region of the spectrum are discussed. Attempts to obtain normal coordinates are described. Some interpretation is given of these results in terms of the theory presented by Friedrich and Person. 27 references.

Journal of the American Chemical Society published new progress about 6443-90-9. 6443-90-9 belongs to iodides-buliding-blocks, auxiliary class Pyridines, name is Pyridine Iodochloride complex, and the molecular formula is C28H29NO4, Safety of Pyridine Iodochloride complex.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Galan, Elena published the artcileSynthesis of 1,2-biphenylethane based single-molecule diodes, COA of Formula: C7H3BrF3I, the publication is Organic & Biomolecular Chemistry (2016), 14(8), 2439-2443, database is CAplus and MEDLINE.

We have described the synthesis of novel biphenylethane-based wires for mol. electronics. Exceptional single-mol. diode behavior was predicted for unsym. substituted biphenylethane derivatives, synthesized here using the so far unexplored unsym. substituted 1,2-bis(4-bromophenyl)ethanes as key intermediates, which were obtained from the corresponding tolane precursor by selective hydrogenation.

Organic & Biomolecular Chemistry published new progress about 364-12-5. 364-12-5 belongs to iodides-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Bromide,Iodide,Benzene, name is 5-Bromo-2-iodobenzotrifluoride, and the molecular formula is C7H3BrF3I, COA of Formula: C7H3BrF3I.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Chen, Xiuli published the artcileNovel mitochondria-targeted and fluorescent DNA alkylation agents with highly selective activity against cancer cells, Quality Control of 606-55-3, the publication is Dyes and Pigments (2019), 107610, database is CAplus.

A series of novel nitrogen mustard-based fluorescent compounds were reported with good mitochondrial targeting ability and DNA alkylation activity. The results indicated that these compounds can be used directly as reporting and imaging agents for gel electrophoresis and flow cytometry without the necessity of addnl. fluorescent tagging agents. Notably, the compound CXL92 displayed highly selective activity against lung cancer cell line A549 with an IC₅₀ value of 0.32 μM compared to normal cell (LO2).

Dyes and Pigments published new progress about 606-55-3. 606-55-3 belongs to iodides-buliding-blocks, auxiliary class Quinoline,Salt, name is 1-Ethyl-2-methylquinolin-1-ium iodide, and the molecular formula is C12H14IN, Quality Control of 606-55-3.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Wang, Bingbing published the artcileElectrochemical Borylation of Alkyl Halides: Fast, Scalable Access to Alkyl Boronic Esters, Formula: C6H13I, the publication is Journal of the American Chemical Society (2021), 143(33), 12985-12991, database is CAplus and MEDLINE.

Herein, a fast, scalable, and transition-metal-free borylation of alkyl halides (X = I, Br, Cl) enabled by electroreduction is reported. This process provides an efficient and practical access to primary, secondary, and tertiary boronic esters at a high current. More than 70 examples, including the late-stage borylation of natural products and drug derivatives, are furnished at room temperature, thereby demonstrating the broad utility and functional-group tolerance of this protocol. Mechanistic studies disclosed that B₂cat₂ serves as both a reagent and a cathodic mediator, enabling electroreduction of difficult-to-reduce alkyl bromides or chlorides at a low potential.

Journal of the American Chemical Society published new progress about 638-45-9. 638-45-9 belongs to iodides-buliding-blocks, auxiliary class Iodide,Aliphatic hydrocarbon chain, name is 1-Iodohexane, and the molecular formula is C12H10O4S, Formula: C6H13I.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Locke, David M. published the artcileAtisine. The synthesis of 1-methyl-6-ethyl-3-azaphenanthrene, HPLC of Formula: 31253-08-4, the publication is Journal of the American Chemical Society (1959), 2246-50, database is CAplus.

cf. C.A. 52, 20143g. Pyrrolidine (33.4 ml.) in 400 ml. PhMe was refluxed 2 hrs. (Bidwell-Sterling moisture collector), 34.8 g. 7-ethyl derivative of tetralone with 100 mg. p-MeC₆H₄SO₃H added, refluxed 48 hrs. and the toluene distilled off. Ethyl α-iodopropionate (I) was prepared from 39.8 g. ethyl α-bromopropionate, 33 g. NaI, and 300 ml. dry Me₂CO. The mixture was filtered, and the Me₂CO removed by azeotropic distillation with 250 ml. C₆H₆. I was added to the pyrrolidine enamine mixture with 300 ml. dioxane, refluxed 8.5 hrs., concentrated in vacuo, saponified with methanolic KOH, concentrated, and extracted with C₆H₆. The C₆H₆ extract was concentrated in vacuo, taken up in a large volume of ether, filtered, and refrigerated to give 10.64 g. 7-ethyl-1-oxo-1,2,3,4-tetrahydro-α-methyl-2-naphthaleneacetic acid (II), m. 112-20° (Et₂O). II (7.31 g.) was reduced according to Martin (C.A. 30, 6726¹) and the precipitated crystals washed with ligroine to give 308 mg. 7-ethyl-1,2,3,4-tetrahydro-α-methyl-2-naphthaleneacetic acid (III), m. 195-99° (ligroine). 7-Ethyl-α-methyl-2-naphthaleneacetic acid (IV) was prepared as follows: the noncrystalline residue from the preparation of III treated with CH₂N₂ in Me₂CO, the solution evaporated to dryness with C₆H₆, the residue mixed with 10% Pd-C, heated 5 hrs. at 265-70°, cooled, dissolved in C₆H₆, filtered, evaporated to dryness in vacuo, saponified, concentrated in vacuo, diluted with H₂O, and extracted with C₆H₆ gave IV, m. 109-10°. IV (1.42 g.) heated with 1 ml. SOCl₂ for 1 hr., evaporated in vacuo, the residue taken up in benzene, anhydrous NH₃ bubbled through 1 hr., extracted with CHCl₃, and chromatographed over alumina gave crystals (precipitated from EtOAc) of 7-ethyl-α-methyl-2-naphthaleneacetamide (V), m. 105-7°. V (1.1 g.) in 100 ml. anhydrous Et₂O added to 1.8 g. LiAlH₄ was refluxed 4 hrs., cooled, and then EtOAc was added until reflux ceased. Salts which were precipitated by Et₂O and H₂O were filtered off, washed (Et₂O), dissolved in C₆H₆, extracted with HCl, basified and extracted with benzene. Anhydrous HCl was passed through the solution which was evaporated to dryness in vacuo. Recrystallization of the residue from C₆H₆ gave 780 mg. of the hydrochloride of 7-ethyl-α-methyl-2-naphthaleneëthylamine (VI), m. 208-9° (Et₂O-EtOH); picrate m. 215-18° (Me₂CO-Et₂O). VI (445 mg.) heated 2.5 hrs. (steam bath) with 100 ml. 2N HCl and 2 ml. 40% formalin, kept overnight at room temperature, evaporated to dryness in vacuo with C₆H₆, the residue dissolved in EtOH, and diluted with Et₂O gave 367 mg. of 1-methyl-6-ethyl-1,2,3,4-tetrahydro-3-azaphenanthrene (VII), m. 217-21° (from ethanol-ether). VII (262 mg.) was treated with 100 mg. 10% Pd-C at 225-35° for 45 min. The mixture was cooled, dissolved in hot ligroine, filtered, and concentrated to give 121 mg. of 1-methyl-6-ethyl-3-azaphenanthrene, m. 83.5-85.0°. Infrared and ultraviolet spectra were identical with an authentic sample; picrate m. 220-21°; trinitrobenzene adduct m. 122.5-123.5°.

Journal of the American Chemical Society published new progress about 31253-08-4. 31253-08-4 belongs to iodides-buliding-blocks, auxiliary class Iodide,Ester, name is Ethyl 2-Iodopropionate, and the molecular formula is C5H9IO2, HPLC of Formula: 31253-08-4.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com