Iodides-buliding-blocks

Khaliullin, F. A. published the artcileSynthesis and Antidepressant Activity of 4-Alkyl-5-Bromo-2,4-Dihydro-2-(Thietan-3-yl)-1,2,4-Triazol-3-Ones, Quality Control of 638-45-9, the publication is Pharmaceutical Chemistry Journal (2021), 55(2), 123-129, database is CAplus.

A series of 4-alkyl-5-bromo-2,4-dihydro-2-(thietan-3-yl)-1,2,4-triazol-3-ones I (R = Me, Bn, Et, etc.) were synthesized by reacting 5-bromo-2,4-dihydro-2-(thietan-3-yl)-1,2,4-triazol-3-one (II) with alkyl halides RX (X = I, Br) and di-Me sulfate. The antidepressant activity of the synthesized compounds I in non-inbred male mice was investigated using tail-suspension and forced-swim tests. Compounds II and I (R = Me, n-Pr, Bn, 2-bromoethyl) after a single i.p. injection produced antidepressant effects in screening tests and did not cause sedative and/or psychostimulatory effects in the open-field test. Compound II produced an antidepressant effect comparable to that of fluoxetine, had low toxicity (class IV toxicity), and was superior to fluoxetine in therapeutic index and strength of the antidepressant effect after a course of administration. The calculated physicochem. properties and toxic risks showed that all synthesized compounds I complied fully with Lipinski’s rule of five. The calculated drug score and absence of predicted toxic risks for the most active compound II suggested that it was promising for creating a new pharmaceutical substance with antidepressant activity.

Pharmaceutical Chemistry Journal published new progress about 638-45-9. 638-45-9 belongs to iodides-buliding-blocks, auxiliary class Iodide,Aliphatic hydrocarbon chain, name is 1-Iodohexane, and the molecular formula is C6H13I, Quality Control of 638-45-9.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Li, Yan published the artcileCobalt-catalysed enantioselective C(sp³)-C(sp³) coupling, Application In Synthesis of 638-45-9, the publication is Nature Catalysis (2021), 4(10), 901-911, database is CAplus.

Enantioselective C(sp³)-C(sp³) coupling substantially impacts organic synthesis but remains challenging. Cobalt has played an important role in the development of homogeneous organometallic catalysis, but there are few examples of its use in asym. cross-coupling. Here, a cobalt-catalyzed enantioselective C(sp³)-C(sp³) coupling reaction, namely, alkene hydroalkylation, to access chiral fluoroalkanes was reported. This reaction represents a catalyst-controlled enantioselective coupling mode in which a tailor-made auxiliary is unnecessary; via this reaction, an aliphatic C-F stereogenic center can be introduced at the desired position in an alkyl chain.

Nature Catalysis published new progress about 638-45-9. 638-45-9 belongs to iodides-buliding-blocks, auxiliary class Iodide,Aliphatic hydrocarbon chain, name is 1-Iodohexane, and the molecular formula is C6H13I, Application In Synthesis of 638-45-9.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Li, Yan published the artcileCobalt-catalysed enantioselective C(sp³)-C(sp³) coupling, Synthetic Route of 161370-66-7, the publication is Nature Catalysis (2021), 4(10), 901-911, database is CAplus.

Enantioselective C(sp³)-C(sp³) coupling substantially impacts organic synthesis but remains challenging. Cobalt has played an important role in the development of homogeneous organometallic catalysis, but there are few examples of its use in asym. cross-coupling. Here, a cobalt-catalyzed enantioselective C(sp³)-C(sp³) coupling reaction, namely, alkene hydroalkylation, to access chiral fluoroalkanes was reported. This reaction represents a catalyst-controlled enantioselective coupling mode in which a tailor-made auxiliary is unnecessary; via this reaction, an aliphatic C-F stereogenic center can be introduced at the desired position in an alkyl chain.

Nature Catalysis published new progress about 161370-66-7. 161370-66-7 belongs to iodides-buliding-blocks, auxiliary class Chiral,Iodide,Amine,Aliphatic hydrocarbon chain,Ester,Amide, name is (S)-tert-Butyl 2-((tert-butoxycarbonyl)amino)-4-iodobutanoate, and the molecular formula is C13H24INO4, Synthetic Route of 161370-66-7.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Jones, Andrew C. published the artcileA Ball Milling-Enabled Cross-Electrophile Coupling, Quality Control of 638-45-9, the publication is Organic Letters (2021), 23(16), 6337-6341, database is CAplus and MEDLINE.

The nickel-catalyzed cross-electrophile coupling of aryl halides and alkyl halides enabled by ball-milling is herein described. Under a mechanochem. manifold, the reductive C-C bond formation was achieved in the absence of bulk solvent and air/moisture sensitive set-ups, in reaction times of 2 h. The mech. action provided by ball milling permits the use of a range of zinc sources to turnover the nickel catalytic cycle, enabling the synthesis of 28 cross-electrophile coupled products.

Organic Letters published new progress about 638-45-9. 638-45-9 belongs to iodides-buliding-blocks, auxiliary class Iodide,Aliphatic hydrocarbon chain, name is 1-Iodohexane, and the molecular formula is C6H13I, Quality Control of 638-45-9.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Lesniak, Robert K. published the artcileDiscovery of G2019S-Selective Leucine Rich Repeat Protein Kinase 2 inhibitors with in vivo efficacy, Safety of 4-Iodo-3-nitrobenzonitrile, the publication is European Journal of Medicinal Chemistry (2022), 114080, database is CAplus and MEDLINE.

The discovery and development of compound I, an indazole-based, G2019S-selective (>2000-fold vs. WT) LRRK2 inhibitor capable of entering rodent brain (K_p = 0.5) and selectively inhibiting G2019S-LRRK2 was reported. The compounds disclosed herein present a starting point for further development of brain penetrant G2019S selective inhibitors that hopefully reduce lung phenotype side-effects and pave the way to providing a precision medicine for people with PD who carry the G2019S mutation.

European Journal of Medicinal Chemistry published new progress about 101420-79-5. 101420-79-5 belongs to iodides-buliding-blocks, auxiliary class Nitrile,Nitro Compound,Iodide,Benzene,Benzene Compounds, name is 4-Iodo-3-nitrobenzonitrile, and the molecular formula is C7H3IN2O2, Safety of 4-Iodo-3-nitrobenzonitrile.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Scott, Robert W. published the artcileDevelopment of a scalable synthesis to VEGFR Inhibitor AG-28262, Application In Synthesis of 602303-26-4, the publication is Organic Process Research & Development (2006), 10(2), 296-303, database is CAplus.

The synthesis of N,2-dimethyl-6-(2-(1-methyl-1H-imidazol-2-yl)thieno[3,2-b]pyridin-7-yloxy)benzo[b]thiophene-3-carboxamide (I, AG-28262) on kilogram scale is described. Initial syntheses of key components 6-hydroxy-N-2-dimethylbenzo[b]thiophene-3-carboxamide (II) and 7-chloro-2-(1-methyl-1H-imidazol-2-yl)thieno[3,2b]pyridine (III) worked well on laboratory scale but had significant drawbacks for larger-scale manufacture Therefore, new routes to these two key fragments were developed and demonstrated to synthesize kilogram quantities. Key steps involve a two-step thiophenol alkylation/cyclization protocol to synthesize II in a convergent manner. A difficult Pd-mediated coupling to produce III was replaced with a more scalable stepwise imidazole synthesis. Key rationale for the new routes are discussed.

Organic Process Research & Development published new progress about 602303-26-4. 602303-26-4 belongs to iodides-buliding-blocks, auxiliary class Other Aromatic Heterocyclic,Chloride,Iodide, name is 7-Chloro-2-iodothieno[3,2-b]pyridine, and the molecular formula is C7H13NO2, Application In Synthesis of 602303-26-4.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Hudson, Christine M. published the artcileSynthesis and mesomorphic properties of some disubstituted unsymmetrical phenyl-1,2,4,5-tetrazines, Quality Control of 134322-01-3, the publication is Liquid Crystals (1995), 19(6), 871-81, database is CAplus.

The synthesis of unsym. phenyl-1,2,4,5-tetrazines containing a cyano group either on the Ph ring (1a) or the tetrazine ring (11a, 11b) was accomplished by the introduction of the cyano group after formation of the tetrazine ring. The mesomorphic, solubility and absorption properties of these tetrazines and alkoxy tetrazines (12a–d) were studied. The compounds containing the cyano group on the tetrazine ring showed smectic A phases while nematic phases were observed in some of the alkoxy tetrazines.

Liquid Crystals published new progress about 134322-01-3. 134322-01-3 belongs to iodides-buliding-blocks, auxiliary class Salt,Iodide,Amine,Amidine,Benzene, name is 4-Iodobenzimidamide hydrochloride, and the molecular formula is C7H8ClIN2, Quality Control of 134322-01-3.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Suryawanshi, S. N. published the artcileFacile ω-bromination(iodination) of longifolene with bromine-pyridine(iodine) monochloride-pyridine complex, Related Products of iodides-buliding-blocks, the publication is Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry (1979), 17B(3), 304-5, database is CAplus.

Bromination of longifolene (I, R = H) with pyridine perbromide at 0-5° gave 98% pure I (R = Br), whereas iodination of longifolene with ICl-pyridine complex in AcOH gave 90% I (R = I). However, halogenation of camphene with Br₂ or ICl or their complexes with pyridine was non-specific and gave a mixture of products.

Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry published new progress about 6443-90-9. 6443-90-9 belongs to iodides-buliding-blocks, auxiliary class Pyridines, name is Pyridine Iodochloride complex, and the molecular formula is C4H10Br2CoO2, Related Products of iodides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

de Souza, Carlos A. published the artcileScope and mechanism of the electrochemical Reformatskii reaction of α-haloesters on a graphite powder cathode in aqueous anolyte, Quality Control of 31253-08-4, the publication is Electrochimica Acta (2014), 118-126, database is CAplus.

Six α-haloesters and eighteen carbonyl compounds were submitted to electrochem. coupling on a graphite powder cathode using aqueous anolyte free of organic solvents. Preparative yields of coupling products could be obtained with Et 2-bromoisobutyrate and aromatic aldehydes. Et 2-bromopropionate was much less efficient. Extensive variation of applied potential, electrolyte composition, stoichiometry, catalyst, leaving halogen and activating substituents on the carbonyl compound indicated that the reaction mechanism in most cases proceeds via a radical intermediate generated from the halide reduction Et chloroacetate produced only trace amounts of coupling product, most probably by a carbanionic mechanism.

Electrochimica Acta published new progress about 31253-08-4. 31253-08-4 belongs to iodides-buliding-blocks, auxiliary class Iodide,Ester, name is Ethyl 2-Iodopropionate, and the molecular formula is C5H9IO2, Quality Control of 31253-08-4.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Clausen, Rasmus P. published the artcileThe Glutamate Receptor GluR5 Agonist (S)-2-Amino-3-(3-hydroxy-7,8-dihydro-6H-cyclohepta[d]isoxazol-4-yl)propionic Acid and the 8-Methyl Analogue: Synthesis, Molecular Pharmacology, and Biostructural Characterization, HPLC of Formula: 161370-66-7, the publication is Journal of Medicinal Chemistry (2009), 52(15), 4911-4922, database is CAplus and MEDLINE.

The design, synthesis, and pharmacol. characterization of a highly potent and selective glutamate GluR5 agonist is reported. (S)-2-Amino-3-((RS)-3-hydroxy-8-methyl-7,8-dihydro-6H-cyclohepta[d]isoxazol-4-yl)propionic acid (I) is the 8-Me analog of (S)-2-amino-3-(3-hydroxy-7,8-dihydro-6H-cyclohepta[d]isoxazol-4-yl)propionic acid (II). I displays an improved selectivity profile compared to II. A versatile stereoselective synthetic route for this class of compounds is presented along with the characterization of the binding affinity of I to ionotropic glutamate receptors (iGluRs). Functional characterization of I at cloned iGluRs using a calcium imaging assay and voltage-clamp recordings show a different activation of GluR5 compared to (S)-glutamic acid, kainic acid, and (S)-2-amino-3-(3-hydroxy-5-tert-butyl-4-isoxazolyl)propionic acid as previously demonstrated for II. An X-ray crystallog. anal. of II and computational analyses of II and I bound to the GluR5 agonist binding domain (ABD) are presented, including a watermap anal., which suggests that water mols. in the agonist binding site are important selectivity determinants.

Journal of Medicinal Chemistry published new progress about 161370-66-7. 161370-66-7 belongs to iodides-buliding-blocks, auxiliary class Chiral,Iodide,Amine,Aliphatic hydrocarbon chain,Ester,Amide, name is (S)-tert-Butyl 2-((tert-butoxycarbonyl)amino)-4-iodobutanoate, and the molecular formula is C13H24INO4, HPLC of Formula: 161370-66-7.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com