Iodides-buliding-blocks

Rhodium-Catalyzed Intermolecular C-H Silylation of Arenes with High Steric Regiocontrol was written by Cheng, Chen;Hartwig, John F.. And the article was included in Science (Washington, DC, United States) in 2014.Safety of 4-Iodo-1,2-dimethoxybenzene This article mentions the following:

Regioselective C-H functionalization of arenes has widespread applications in synthetic chem. The regioselectivity of these reactions is often controlled by directing groups or steric hindrance ortho to a potential reaction site. Here, authors report a catalytic intermol. C-H silylation of unactivated arenes that manifests very high regioselectivity through steric effects of substituents meta to a potential site of reactivity. The silyl moiety can be further functionalized under mild conditions but is also inert toward many common organic transformations, rendering the silylarene products useful building blocks. The remote steric effect that we observe results from the steric properties of both the rhodium catalyst and the silane. In the experiment, the researchers used many compounds, for example, 4-Iodo-1,2-dimethoxybenzene (cas: 5460-32-2Safety of 4-Iodo-1,2-dimethoxybenzene).

4-Iodo-1,2-dimethoxybenzene (cas: 5460-32-2) belongs to iodide derivatives. Organic iodides are organic compounds containing a carbon-iodine (C-I) bond. The carbon-iodine bond is weaker than other carbon-halogen bonds due to the poor electronegative nature of the iodine atom. Alkyl iodides react at a faster rate than alkyl fluorides due to the weak C-I bond.Safety of 4-Iodo-1,2-dimethoxybenzene

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

[Ni(NHC)]-Catalyzed Cycloaddition of Diynes and Tropone: Apparent Enone Cycloaddition Involving an 8π Insertion was written by Kumar, Puneet;Thakur, Ashish;Hong, Xin;Houk, K. N.;Louie, Janis. And the article was included in Journal of the American Chemical Society in 2014.Recommanded Product: 5460-32-2 This article mentions the following:

A Ni/N-heterocyclic carbene catalyst couples diynes to the C(α)-C(β) double bond of tropone, a type of reaction that is unprecedented for metal-catalyzed cycloadditions with aromatic tropone. Many different diynes were efficiently coupled to afford [5-6-7] fused tricyclic products, e.g., I, while [5-7-6] fused tricyclic compounds, e.g., II, were obtained as minor byproducts in a few cases. The reaction has broad substrate scope and tolerates a wide range of functional groups, and excellent regioselectivity is found with unsym. diynes. Theor. calculations show that the apparent enone cycloaddition occurs through a distinctive 8π insertion of tropone. The initial intramol. oxidative cyclization of diyne produces the nickelacyclopentadiene intermediate. This intermediate undergoes an 8π insertion of tropone, and subsequent reductive elimination generates the [5-6-7] fused tricyclic product. This initial product undergoes two competing isomerizations, leading to the observed [5-6-7] and [5-7-6] fused tricyclic products. In the experiment, the researchers used many compounds, for example, 4-Iodo-1,2-dimethoxybenzene (cas: 5460-32-2Recommanded Product: 5460-32-2).

4-Iodo-1,2-dimethoxybenzene (cas: 5460-32-2) belongs to iodide derivatives. Generally organic iodides can be divided into two classes of alkyl iodides and aryl iodides. Typical reactions of alkyl iodides include nucleophilic substitution, elimination, reduction, and the formation of organometallics. Organoiodine lubricants can be used with titanium, stainless steels, and other metals which tend to seize up with conventional lubricants: organoiodine lubricants can be used in turbines and spacecraft, and as a cutting oil in machining.Recommanded Product: 5460-32-2

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Hard acid and soft nucleophile systems. 8. Reductive dehalogenation of o- and p-halophenols and their derivatives was written by Node, Manabu;Kawabata, Takeo;Ohta, Keiichiro;Fujimoto, Mayumi;Fujita, Eiichi;Fuji, Kaoru. And the article was included in Journal of Organic Chemistry in 1984.Reference of 2314-37-6 This article mentions the following:

Treatment of o– or p-halophenols and their derivatives with the AlCl₃-EtSH system provides a dehalogenated product in 85-98% yield. In an example, 2-BrC₆H₄OMe at room temperature in CH₂Cl₂ containing 2.5 mol equiv AlCl₃ and EtSH gave 95% PhOH in 1.5 h. Cl and F cannot be removed by this system. Electron-withdrawing groups retard the reaction rate. The method was used for dehalogenation of halonaphthols and polyhalophenols. In the experiment, the researchers used many compounds, for example, 3-Iodo-4-methoxybenzaldehyde (cas: 2314-37-6Reference of 2314-37-6).

3-Iodo-4-methoxybenzaldehyde (cas: 2314-37-6) belongs to iodide derivatives. Iodide-containing intermediates are common in organic synthesis, because of the easy formation and cleavage of the C–I bond. In the chemical industry, alkyl iodides serve as excellent alkylating agents and, specifically, methyl iodide is used as a methylating agent in the synthesis of various pharmaceutical drugs.Reference of 2314-37-6

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Pd-Catalyzed Regio- and Stereoselective sp³ C-H Arylation of Primary Aliphatic Amines: Mechanistic Studies and Synthetic Applications was written by Ha, Hyeonbin;Choi, Ho Jeong;Park, Hahyoun;Gwon, Yunyeong;Lee, Jiin;Kwak, Jaesung;Kim, Min;Jung, Byunghyuck. And the article was included in European Journal of Organic Chemistry in 2021.Name: 4-Iodo-1,2-dimethoxybenzene This article mentions the following:

The Pd-catalyzed γ-position sp³-C-H arylation of primary amines bearing an aliphatic chain or cycloalkyl substituent and related mechanistic studies are disclosed. 3-Bromo-2-hydroxybenzaldehyde plays a key role in γ-position sp³-C-H arylation as a transient directing group (TDG) to assist the regio- and stereoselective C-H activation of a Pd catalyst, and the development of a tandem reaction to transform 1°-amines into γ-aryl-substituted ketones demonstrates synthetic utility. D. functional theory (DFT)-based calculations revealed the detailed reaction mechanism and the origins of the high selectivity (γ-position and cis-only). The X-ray crystal structure of the isolated endo-palladacycle intermediate supported the DFT results, and a kinetic isotope experiment confirmed the results of DFT calculations indicating that the C-H activation step via simultaneous palladation and deprotonation is rate-determining In the experiment, the researchers used many compounds, for example, 4-Iodo-1,2-dimethoxybenzene (cas: 5460-32-2Name: 4-Iodo-1,2-dimethoxybenzene).

4-Iodo-1,2-dimethoxybenzene (cas: 5460-32-2) belongs to iodide derivatives. Iodide-containing intermediates are common in organic synthesis, because of the easy formation and cleavage of the C–I bond. A typical method for synthesis of aromatic iodides is diazotization of primary aromatic amines followed by treatment of potassium iodide. Aliphatic alcohols are converted to alkyl iodides by treating with hydrogen iodide.Name: 4-Iodo-1,2-dimethoxybenzene

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

A general synthetic route towards bastadins. Part 1: synthesis of the eastern part of bastadins 4-16 was written by Couladouros, Elias A.;Moutsos, Vassilios I.. And the article was included in Tetrahedron Letters in 1999.Formula: C8H7IO2 This article mentions the following:

A general synthetic route for the construction of the eastern part of the macrocyclic bastadins 4-16 is presented. The brominated biaryl ethers are synthesized using the iodonium salt method. The synthesis is accomplished within 18 steps in 15.5% overall yield. In the experiment, the researchers used many compounds, for example, 3-Iodo-4-methoxybenzaldehyde (cas: 2314-37-6Formula: C8H7IO2).

3-Iodo-4-methoxybenzaldehyde (cas: 2314-37-6) belongs to iodide derivatives. In general, organic iodides are light-sensitive and turn yellow during storage, owing to the formation of iodine. The C–I bond is the weakest of the carbon–halogen bonds. These bond strengths correlate with the electronegativity of the halogen, decreasing in the order F > Cl > Br > I.Formula: C8H7IO2

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

New polyhydroxylated flavon-3-ols and 3-hydroxy-2-styrylchromones: synthesis and ROS/RNS scavenging activities was written by Sousa, Joana L. C.;Proenca, Carina;Freitas, Marisa;Fernandes, Eduarda;Silva, Artur M. S.. And the article was included in European Journal of Medicinal Chemistry in 2016.COA of Formula: C8H9IO2 This article mentions the following:

New polyhydroxylated flavon-3-ols I (R = OH, OMe; R¹ = OH, OMe) and 3-hydroxy-2-styrylchromones II were prepared and assessed as reactive oxygen species (ROS) and reactive nitrogen species (RNS) scavengers. The synthetic strategy involved the preparation of 2′-hydroxychalcones (E)-XC(O)CH:CHY [X = 2-HO-3,4-(C₆H₅CH₂O)₂C₆H₂, 2-HO-3,4-(H₃CO)₂C₆H₂; Y = 3,4-(C₆H₅CH₂O)₂C₆H₃, 3,4-(H₃CO)₂C₆H₃] and 2′-hydroxycinnamylidenoacetophenones (E),(E)-XC(O)CH:CHCH:CHY from base-catalyzed aldol reaction of appropriate 2′-hydroxyacetophenones such as 3′,4′-bis(benzyloxy)-2′-hydroxyacetophenone, 2′-hydroxy-3′,4′-dimethoxyacetophenone and benzaldehydes such as 3,4-dimethoxybenzaldehyde, 3,4-bis(benzyloxy)benzaldehyde/cinnamaldehydes such as (E)-3,4-dimethoxycinnamaldehyde, (E)-3,4-bis(benzyloxy)cinnamaldehyde, followed by an Algar-Flynn-Oyamada (AFO) reaction to give the polyalkoxy(flavon-3-ols I and 3-hydroxy-2-styrylchromones II). The last step of this synthetic route consisted of the cleavage of the protecting groups affording the expected polyhydroxylated derivatives I and II. The present work consisted of the study of the in vitro scavenging activities of the synthesized compounds against the most physiol. relevant ROS [superoxide radical (O₂·^–), hydrogen peroxide (H₂O₂), hypochlorous acid (HOCl), singlet oxygen (¹O₂) and peroxyl radical (ROO·)] and RNS [nitric oxide (·NO) and peroxynitrite anion (ONOO^–)]. Generally, all the tested new polyhydroxylated flavon-3-ols I and 3-hydroxy-2-styrylchromones II exhibited scavenging effects dependent on the concentration, and with IC₅₀ values found within the micromolar range. This work allowed the establishment of new structure-activity relationships and brought out the knowledge about the selective choice of a structure depending on the targeted reactive species. In the experiment, the researchers used many compounds, for example, 4-Iodo-1,2-dimethoxybenzene (cas: 5460-32-2COA of Formula: C8H9IO2).

4-Iodo-1,2-dimethoxybenzene (cas: 5460-32-2) belongs to iodide derivatives. Organic iodides are organic compounds containing a carbon-iodine (C-I) bond. The carbon-iodine bond is weaker than other carbon-halogen bonds due to the poor electronegative nature of the iodine atom. A typical method for synthesis of aromatic iodides is diazotization of primary aromatic amines followed by treatment of potassium iodide. Aliphatic alcohols are converted to alkyl iodides by treating with hydrogen iodide.COA of Formula: C8H9IO2

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

A facile synthesis of 2-(2-hydroxyethyl)allylsilanes was written by Bardot, Valerie;Remuson, Roland;Gelas-Mialhe, Yvonne;Gramain, Jean-Claude. And the article was included in Synlett in 1996.Application In Synthesis of 3-Iodo-4-methoxybenzaldehyde This article mentions the following:

Indium-mediated allylsilylation of carbonyl compounds provides a facile and efficient route to 2-(2-hydroxyethyl)allylsilanes. For example, 3-iodo-2-(trimethylsilylmethyl)-1-propene reacts with 2,6-dichlorobenzaldehyde in the presence of In powder in DMF to give 90% 2,6-Cl₂C₆H₃CH(OH)CH₂C(:CH₂)CH₂SiMe₃. In the experiment, the researchers used many compounds, for example, 3-Iodo-4-methoxybenzaldehyde (cas: 2314-37-6Application In Synthesis of 3-Iodo-4-methoxybenzaldehyde).

3-Iodo-4-methoxybenzaldehyde (cas: 2314-37-6) belongs to iodide derivatives. Iodide-containing intermediates are common in organic synthesis, because of the easy formation and cleavage of the C–I bond. Polyiodoorganic compounds are sometimes employed as X-ray contrast agents, in fluoroscopy, a type of medical imaging. This application exploits the X-ray absorbing ability of the heavy iodine nucleus.Application In Synthesis of 3-Iodo-4-methoxybenzaldehyde

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Iodine(III)-Mediated, Controlled Di- or Monoiodination of Phenols was written by Satkar, Yuvraj;Yera-Ledesma, Luisa F.;Mali, Narendra;Patil, Dipak;Navarro-Santos, Pedro;Segura-Quezada, Luis A.;Ramirez-Morales, Perla I.;Solorio-Alvarado, Cesar R.. And the article was included in Journal of Organic Chemistry in 2019.Safety of 4-Iodo-1,2-dimethoxybenzene This article mentions the following:

An oxidative procedure for the electrophilic iodination of phenols was developed by using iodosylbenzene as a nontoxic iodine(III)-based oxidant and ammonium iodide as a cheap iodine atom source. A totally controlled monoiodination was achieved by buffering the reaction medium with K₃PO₄. This protocol proceeds with short reaction times, at mild temperatures, in an open flask, and generally with high yields. Gram-scale reactions, as well as the scope of this protocol, were explored with electron-rich and electron-poor phenols as well as heterocycles. Quantum chem. calculations revealed PhII(OH)·NH₃ to be the most plausible iodinating active species as a reactive “I⁺” synthon. In light of the relevance of the iodoarene moiety, we present herein a practical, efficient, and simple procedure with a broad functional group scope that allows access to the iodoarene core unit. In the experiment, the researchers used many compounds, for example, 4-Iodo-1,2-dimethoxybenzene (cas: 5460-32-2Safety of 4-Iodo-1,2-dimethoxybenzene).

4-Iodo-1,2-dimethoxybenzene (cas: 5460-32-2) belongs to iodide derivatives. Typical reactions of alkyl iodides include nucleophilic substitution, elimination, reduction, and the formation of organometallics. A typical method for synthesis of aromatic iodides is diazotization of primary aromatic amines followed by treatment of potassium iodide. Aliphatic alcohols are converted to alkyl iodides by treating with hydrogen iodide.Safety of 4-Iodo-1,2-dimethoxybenzene

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Inhibition of bacteria by 5-fluoronicotinic acid and other analogs of nicotinic acid was written by Streigbtoff, Frank. And the article was included in Journal of Bacteriology in 1963.HPLC of Formula: 15366-65-1 This article mentions the following:

Several compounds related to 5-fluoronicotinic acid (I) have been demonstrated to inhibit Streptococcus spp. (Viridans group), Staphylococcus aureus, Escherichia coli, and Lactobacillus plan- tarum. The most active compounds were I and 5-fluoronicotin- amide (II). The growth of Streptococcus spp. was inhibited more than 5% by 0.05 γ/ml. of I or 0.5 of II. The inhibition of Streptococcus from 1 part of I or II was reversed by 4 and 2 parts of nicotinic acid, resp. The inhibition of E. coli from 100 parts of I or II was reversed by I part of nicotinic acid. Inhibitions by most other active compounds could be reversed by nicotinic acid. In experiments with mice, 8 compounds related to I had activity against Streptococcus pyogenes; I, II, and 5-fluoro-N-dimethyl- aminomethylnicotinamide protected all mice at 83 mg./kg. The action of 200 mg./kg. I was reversed by 20 mg./kg. of nicotinic acid. The activity of I was not increased by modifica- tions at the number 3 or 5 positions on the pyridine ring or by any other structural changes. In the experiment, the researchers used many compounds, for example, 5-Iodonicotinic acid (cas: 15366-65-1HPLC of Formula: 15366-65-1).

5-Iodonicotinic acid (cas: 15366-65-1) belongs to iodide derivatives. In general, organic iodides are light-sensitive and turn yellow during storage, owing to the formation of iodine. Iodo alkanes participate in a variety of organic synthesis reactions, which include the Simmons–Smith reaction (cyclopropanation using iodomethane), Williamson ether synthesis, Wittig reaction, Grignard reaction, alkyl coupling reactions, and Wurtz reaction.HPLC of Formula: 15366-65-1

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

From an Eight-Component Self-Sorting Algorithm to a Trisheterometallic Scalene Triangle was written by Mahata, Kingsuk;Saha, Manik Lal;Schmittel, Michael. And the article was included in Journal of the American Chemical Society in 2010.Related Products of 3268-21-1 This article mentions the following:

Using motifs from 3-fold completive self-sorting in an eight-component library, the authors report on the design and fabrication of a fully dynamic trisheterometallic scalene triangle, a demanding supramol. structure that complements the so far known triangular structures. The trisheterometallic scalene triangle complexes have the compositions [CuZn(7)(8)(9)](OTf)₂(PF₆) and [CuHg(7)(8)(9)](ClO₄)₂(PF₆) (7 = (5-(4-(2,9-bis(2,6-dimethoxyphenyl)-1,10-phenanthrolin-3-ylethynyl)phenyl)-10,15,20-trimesitylporphyrinato)zinc, 8 = 4′-(4-(1,10-phenanthrolin-3-ylethynyl)phenyl)-2,2′:6′,2”-terpyridine, 9 = 2-(4-bromo-2,3,5,6-tetramethylphenyl)-9-mesityl-3-((4-(pyridin-4-ylethynyl)-2,3,5,6-tetramethylphenyl)ethynyl)-1,10-phenanthroline). In the experiment, the researchers used many compounds, for example, 1,4-Diiodo-2,3,5,6-tetramethylbenzene (cas: 3268-21-1Related Products of 3268-21-1).

1,4-Diiodo-2,3,5,6-tetramethylbenzene (cas: 3268-21-1) belongs to iodide derivatives. Organic iodides can be alkyl, alkenyl, or alkynyl, and all of them are very reactive toward with many kinds of nucleophiles. Polyiodoorganic compounds are sometimes employed as X-ray contrast agents, in fluoroscopy, a type of medical imaging. This application exploits the X-ray absorbing ability of the heavy iodine nucleus.Related Products of 3268-21-1

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com