Iodides-buliding-blocks

Triarylboron-based fluorescent conjugated microporous polymers was written by Liu, Xiaoming;Zhang, Yuwei;Li, He;A, Sigen;Xia, Hong;Mu, Ying. And the article was included in RSC Advances in 2013.Safety of 1,4-Diiodo-2,3,5,6-tetramethylbenzene This article mentions the following:

Novel triarylboron-based conjugated microporous polymers (BCMPs) were successfully synthesized and characterized, which are insoluble in common organic solvents and water, and can keep stable up to 310 °C under a nitrogen atm. According to the nitrogen physisorption isotherms, the Brunauer-Emmett-Teller sp. surface area values for these porous materials vary between 815 and 911 m² g^-1. Two polymer frameworks display good carbon dioxide uptake capacity at 273 K and 1 bar. These materials might find applications in organic electronics and sensing technologies. In the experiment, the researchers used many compounds, for example, 1,4-Diiodo-2,3,5,6-tetramethylbenzene (cas: 3268-21-1Safety of 1,4-Diiodo-2,3,5,6-tetramethylbenzene).

1,4-Diiodo-2,3,5,6-tetramethylbenzene (cas: 3268-21-1) belongs to iodide derivatives. In general, organic iodides are light-sensitive and turn yellow during storage, owing to the formation of iodine. A typical method for synthesis of aromatic iodides is diazotization of primary aromatic amines followed by treatment of potassium iodide. Aliphatic alcohols are converted to alkyl iodides by treating with hydrogen iodide.Safety of 1,4-Diiodo-2,3,5,6-tetramethylbenzene

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Discovery of Small-Molecule Inhibitors Selectively Targeting the DNA-Binding Domain of the Human Androgen Receptor was written by Li, Huifang;Ban, Fuqiang;Dalal, Kush;Leblanc, Eric;Frewin, Kate;Ma, Dennis;Adomat, Hans;Rennie, Paul S.;Cherkasov, Artem. And the article was included in Journal of Medicinal Chemistry in 2014.Quality Control of 4,5-Diiodo-1H-imidazole This article mentions the following:

The human androgen receptor (AR) is considered as a master regulator in the development and progression of prostate cancer (PCa). As resistance to clin. used anti-AR drugs remains a major challenge for the treatment of advanced PCa, there is a pressing need for new anti-AR therapeutic avenues. In this study, we identified a binding site on the DNA binding domain (DBD) of the receptor and utilized virtual screening to discover a set of micromolar hits for the target. Through further exploration of the most potent hit (1), a structural analog (6) was identified demonstrating 10-fold improved anti-AR potency. Further optimization resulted in a more potent synthetic analog (25) with anti-AR potency comparable to a newly FDA-approved drug Enzalutamide. Site-directed mutagenesis demonstrated that the developed inhibitors do interact with the intended target site. Importantly, the AR DBD inhibitors could effectively inhibit the growth of Enzalutamide-resistant cells as well as block the transcriptional activity of constitutively active AR splice variants, such as V7. In the experiment, the researchers used many compounds, for example, 4,5-Diiodo-1H-imidazole (cas: 15813-09-9Quality Control of 4,5-Diiodo-1H-imidazole).

4,5-Diiodo-1H-imidazole (cas: 15813-09-9) belongs to iodide derivatives. Organic iodides are widely used in organic synthesis. Halogenation of aromatic hydrocarbons is a very important reaction via an electrophilic aromatic substitution. Organoiodine lubricants can be used with titanium, stainless steels, and other metals which tend to seize up with conventional lubricants: organoiodine lubricants can be used in turbines and spacecraft, and as a cutting oil in machining.Quality Control of 4,5-Diiodo-1H-imidazole

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Biological activity of various halogenated derivatives of Ioxynil was written by Cooke, A. R.;Hart, R. D.;Achuff, N. E.. And the article was included in Proceedings of the Northeastern Weed Control Conference in 1965.Application of 2314-37-6 This article mentions the following:

Ioxynil (I) is effective for the control of broadleaf weeds and grasses in small grains. The 3,5-dibromo- and 3-bromo- acetates of I and 3,5-dibromo-4-hydroxybenzonitrile acetate are almost as effective. Less active are the 3,5-dichloro, 3-iodo-, 3-bromo-, 3-chloro-, 3,5-dinitro-, and 3-nitro-derivatives of I, p-hydroxybenzonitrile, 3,5-diiodo-4-hydroxybenzamide, 3,5-diiodo-4-hydroxybenzoic acid, 3,5-diiodo-4-hydroxybenzene-sulfonamide, 3,5-diiodo-4-hydroxybenzamide, 3,5-diiodo-4-hydroxybenzaldehyde and its oxime, 3-iodo-p-anisaldehyde, 3,5-dichloro-4-hydroxybenzaldehyde, 3,5-diiodo-4-hydroxyhydrocinnamic acid, p-cyanophenoxyacetic acid, 2,6-dibromo-4-cyanophenoxyacetic acid, 2-chloro-4-cyanophenoxyacetic acid, and 3,-4-diiodosalicylonitrile. In the experiment, the researchers used many compounds, for example, 3-Iodo-4-methoxybenzaldehyde (cas: 2314-37-6Application of 2314-37-6).

3-Iodo-4-methoxybenzaldehyde (cas: 2314-37-6) belongs to iodide derivatives. Iodide-containing intermediates are common in organic synthesis, because of the easy formation and cleavage of the C–I bond. Polyiodoorganic compounds are sometimes employed as X-ray contrast agents, in fluoroscopy, a type of medical imaging. This application exploits the X-ray absorbing ability of the heavy iodine nucleus.Application of 2314-37-6

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Product class 1: organometallic complexes of zinc was written by Knochel, P.. And the article was included in Science of Synthesis in 2004.Application of 10297-05-9 This article mentions the following:

Preparation of zinc organometallic complexes are reviewed including sections on aryl, hetaryl, allenyl, allyl, alkynyl, alkenyl, alkyl and carbenoid complexes and triorganozincates. Applications of the complexes for organic syntheses are briefly given. In the experiment, the researchers used many compounds, for example, 1-Chloro-4-iodobutane (cas: 10297-05-9Application of 10297-05-9).

1-Chloro-4-iodobutane (cas: 10297-05-9) belongs to iodide derivatives. Typical reactions of alkyl iodides include nucleophilic substitution, elimination, reduction, and the formation of organometallics. Organoiodine lubricants can be used with titanium, stainless steels, and other metals which tend to seize up with conventional lubricants: organoiodine lubricants can be used in turbines and spacecraft, and as a cutting oil in machining.Application of 10297-05-9

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Selective and effective iodination of alkyl-substituted benzenes with elemental iodine activated by selectfluor F-TEDA-BF₄ was written by Stavber, Stojan;Kralj, Petra;Zupan, Marko. And the article was included in Synlett in 2002.Reference of 3268-21-1 This article mentions the following:

Selective direct introduction of an I atom into alkyl-substituted benzene derivatives was effectively achieved by reaction of target mols. with elemental I₂ in the presence of 1-chloromethyl-4-fluoro-1,4-diazoniabicyclo[2.2.2]octane bis(tetrafluoroborate) (Selectfluor F-TEDA-BF₄). The number of I atoms introduced could be modulated by the molar ratio between substrate, I₂ and F-TEDA-BF₄. In the experiment, the researchers used many compounds, for example, 1,4-Diiodo-2,3,5,6-tetramethylbenzene (cas: 3268-21-1Reference of 3268-21-1).

1,4-Diiodo-2,3,5,6-tetramethylbenzene (cas: 3268-21-1) belongs to iodide derivatives. Typical reactions of alkyl iodides include nucleophilic substitution, elimination, reduction, and the formation of organometallics. Organoiodine lubricants can be used with titanium, stainless steels, and other metals which tend to seize up with conventional lubricants: organoiodine lubricants can be used in turbines and spacecraft, and as a cutting oil in machining.Reference of 3268-21-1

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Gold(I)/Chiral Bronsted Acid Catalyzed Enantioselective Hydroamination-Hydroarylation of Alkynes: The Effect of a Remote Hydroxyl Group on the Reactivity and Enantioselectivity was written by Shinde, Valmik S.;Mane, Manoj V.;Vanka, Kumar;Mallick, Arijit;Patil, Nitin T.. And the article was included in Chemistry – A European Journal in 2015.Computed Properties of C6H3ClINO2 This article mentions the following:

The catalytic enantioselective hydroamination-hydroarylation of alkynes under the catalysis of (R₃P)AuMe/(S)-3,3′-bis(2,4,6-triisopropylphenyl)-1,1′-binaphthyl-2,2′-diyl hydrogenphosphate ((S)-TRIP) is reported. The alkyne was reacted with a range of pyrrole-based aromatic amines to give pyrrole-embedded aza-heterocyclic scaffolds bearing a quaternary carbon center. The presence of a hydroxyl group in the alkyne tether turned out to be very crucial for obtaining products in high yields and enantioselectivities. The mechanism of enantioinduction was established by carefully performing exptl. and computational studies. In the experiment, the researchers used many compounds, for example, 4-Chloro-2-iodo-1-nitrobenzene (cas: 160938-18-1Computed Properties of C6H3ClINO2).

4-Chloro-2-iodo-1-nitrobenzene (cas: 160938-18-1) belongs to iodide derivatives. Organic iodides can be alkyl, alkenyl, or alkynyl, and all of them are very reactive toward with many kinds of nucleophiles. The C–I bond is the weakest of the carbon–halogen bonds. These bond strengths correlate with the electronegativity of the halogen, decreasing in the order F > Cl > Br > I. This periodic order also follows the atomic radius of halogens and the length of the carbon-halogen bond.Computed Properties of C6H3ClINO2

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Photocatalytic Oxidative Iodination of Electron-Rich Arenes was written by Narobe, Rok;Duesel, Simon J. S.;Iskra, Jernej;Koenig, Burkhard. And the article was included in Advanced Synthesis & Catalysis in 2019.Category: iodides-buliding-blocks This article mentions the following:

A visible-light-mediated oxidative iodination of electron-rich arenes was developed. 2.5 mol% of unsubstituted anthraquinone as photocatalyst were used in combination with elementary iodine, trifluoroacetic acid and oxygen as the terminal oxidant. The iodination proceeded upon irradiation in non- or weakly-electron donating solvents (DCM, DCE and benzene) wherein a spectral window in strongly colored iodine solutions was observed at around 400 nm. The method provided good to excellent yields (up to 98%) and showed excellent regioselectivity and good functional group tolerance (triple bonds, ketone, ester, amide). Moreover, the photo-iodination was also upscaled to a 5 mmol scale (1.1 g). Mechanistic investigations by intermediate trapping and competition experiments indicate a photocatalytic arene oxidation and the subsequent reaction with iodine as a likely mechanistic pathway. In the experiment, the researchers used many compounds, for example, 4-Iodo-1,2-dimethoxybenzene (cas: 5460-32-2Category: iodides-buliding-blocks).

4-Iodo-1,2-dimethoxybenzene (cas: 5460-32-2) belongs to iodide derivatives. Generally organic iodides can be divided into two classes of alkyl iodides and aryl iodides. Typical reactions of alkyl iodides include nucleophilic substitution, elimination, reduction, and the formation of organometallics. The C–I bond is the weakest of the carbon–halogen bonds. These bond strengths correlate with the electronegativity of the halogen, decreasing in the order F > Cl > Br > I. This periodic order also follows the atomic radius of halogens and the length of the carbon-halogen bond.Category: iodides-buliding-blocks

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Base- and Additive-Free Ir-Catalyzed ortho-Iodination of Benzoic Acids: Scope and Mechanistic Investigations was written by Erbing, Elis;Sanz-Marco, Amparo;Vazquez-Romero, Ana;Malmberg, Jesper;Johansson, Magnus J.;Gomez-Bengoa, Enrique;Martin-Matute, Belen. And the article was included in ACS Catalysis in 2018.Recommanded Product: 13420-63-8 This article mentions the following:

A protocol for the C-H activation/iodination of benzoic acids catalyzed by a simple iridium complex has been developed. The method described in this paper allows the ortho-selective iodination of a variety of benzoic acids under extraordinarily mild conditions in the absence of any additive or base in 1,1,1,3,3,3-hexafluoroisopropanol as the solvent. The iridium catalyst used tolerates air and moisture, and selectively gives ortho-iodobenzoic acids with high conversions. Mechanistic investigations revealed that an Ir(III)/Ir(V) catalytic cycle operates, and that the unique properties of HFIP enables the C-H iodination using the carboxylic moiety as a directing group. In the experiment, the researchers used many compounds, for example, 2-Chloro-6-iodobenzoic acid (cas: 13420-63-8Recommanded Product: 13420-63-8).

2-Chloro-6-iodobenzoic acid (cas: 13420-63-8) belongs to iodide derivatives. Typical reactions of alkyl iodides include nucleophilic substitution, elimination, reduction, and the formation of organometallics. Alkyl iodides react at a faster rate than alkyl fluorides due to the weak C-I bond.Recommanded Product: 13420-63-8

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Isopropanol and potassium tert-butoxide promoted intramolecular direct sp² C-H functionalization: an expedient synthesis of 1,2,3-triazole annulated chromens and quinolones was written by Mondal, Biplab;Roy, Brindaban. And the article was included in Tetrahedron Letters in 2015.Electric Literature of C6H4BrIO This article mentions the following:

A series of 1,2,3-triazole annulated chromen I (R¹ = H, 8-Me, 8-t-Bu, 8-Br, 6,8-di-Cl, 8-Cl, 8-CO₂Et; R² = Bn, 2-NO₂Bn, 1-octyl, 1-heptyl), and quinolone derivatives II (R³ = Me, Et, n-Bu) have been synthesized by means of direct sp² C-H functionalization in the presence of iso-propanol and potassium tert-butoxide. The reaction proceeds through homolytic aromatic substitution (HAS). This efficient as well as simple C-H functionalization methodol. offers a straightforward route to 1,2,3-triazole annulated oxygen and nitrogen heterocycles. In the experiment, the researchers used many compounds, for example, 4-Bromo-2-iodophenol (cas: 207115-22-8Electric Literature of C6H4BrIO).

4-Bromo-2-iodophenol (cas: 207115-22-8) belongs to iodide derivatives. Organic iodides are widely used in organic synthesis. Halogenation of aromatic hydrocarbons is a very important reaction via an electrophilic aromatic substitution. The C–I bond is the weakest of the carbon–halogen bonds. These bond strengths correlate with the electronegativity of the halogen, decreasing in the order F > Cl > Br > I.Electric Literature of C6H4BrIO

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Catalytic, asymmetric difluorination of alkenes to generate difluoromethylated stereocenters was written by Banik, Steven M.;Medley, Jonathan William;Jacobsen, Eric N.. And the article was included in Science (Washington, DC, United States) in 2016.Synthetic Route of C8H7IO4 This article mentions the following:

Difluoromethyl groups possess specific steric and electronic properties that invite their use as chem. inert surrogates of alcs., thiols, and other polar functional groups important in a wide assortment of mol. recognition processes. We report here a method for the catalytic, asym., migratory geminal difluorination of β-substituted styrenes to access a variety of products bearing difluoromethylated tertiary or quaternary stereocenters. The reaction uses com. available reagents (m-chloroperbenzoic acid and hydrogen fluoride pyridine) and a simple chiral aryl iodide catalyst and is carried out readily on a gram scale. Substituent effects and temperature-dependent variations in enantioselectivity suggest that cation-π interactions play an important role in stereodifferentiation by the catalyst. In the experiment, the researchers used many compounds, for example, Methyl 3,5-dihydroxy-4-iodobenzoate (cas: 338454-02-7Synthetic Route of C8H7IO4).

Methyl 3,5-dihydroxy-4-iodobenzoate (cas: 338454-02-7) belongs to iodide derivatives. In general, organic iodides are light-sensitive and turn yellow during storage, owing to the formation of iodine. Alkyl iodides react at a faster rate than alkyl fluorides due to the weak C-I bond.Synthetic Route of C8H7IO4

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com