Iodides-buliding-blocks

Stereo-retentive Intramolecular Glycosyl Cross-Coupling: Development, Scope, and Kinetic Isotope Effect Study was written by Yi, Duk;Zhu, Feng;Walczak, Maciej A.. And the article was included in Organic Letters in 2018.HPLC of Formula: 13420-63-8 This article mentions the following:

A series of cyclic C-glycosides were synthesized using the palladium-catalyzed stereo-retentive intramol. glycosylation of aryl iodides by employing a bulky phosphine ligand. A variety of functional groups are tolerated in the reaction, and enantio-enriched anomeric nucleophiles could be coupled without erosion of optical purity. This study offers a unified method to access both cis- and trans-fused rings by capitalizing on the stereo-retentive nature of the Stille reaction. In addition, competition experiments for intermol. and intramol. cross-couplings revealed secondary KIEs of 1.43 and 0.81, resp., suggesting a profoundly different steric congestion at the transition state. In the experiment, the researchers used many compounds, for example, 2-Chloro-6-iodobenzoic acid (cas: 13420-63-8HPLC of Formula: 13420-63-8).

2-Chloro-6-iodobenzoic acid (cas: 13420-63-8) belongs to iodide derivatives. Generally organic iodides can be divided into two classes of alkyl iodides and aryl iodides. Typical reactions of alkyl iodides include nucleophilic substitution, elimination, reduction, and the formation of organometallics. Polyiodoorganic compounds are sometimes employed as X-ray contrast agents, in fluoroscopy, a type of medical imaging. This application exploits the X-ray absorbing ability of the heavy iodine nucleus.HPLC of Formula: 13420-63-8

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Copper-catalyzed trifluoromethylation of aryl iodides with potassium (trifluoromethyl)trimethoxyborate was written by Knauber, Thomas;Arikan, Fatih;Roeschenthaler, Gerd-Volker;Goossen, Lukas J.. And the article was included in Chemistry – A European Journal in 2011.HPLC of Formula: 77350-52-8 This article mentions the following:

Potassium (trifluoromethyl)trimethoxyborate is introduced as a new source of CF₃ nucleophiles in copper-catalyzed trifluoromethylation reactions. The crystalline salt is stable on storage, easy to handle, and can be obtained in near-quant. yields simply by mixing B(OMe)₃, CF₃SiMe₃, and KF. The trifluoromethylation reagent allows the conversion of various aryl iodides into the corresponding benzotrifluorides in high yields under mild, base-free conditions in the presence of catalytic quantities of a Cu^I/1,10-phenanthroline complex. In the experiment, the researchers used many compounds, for example, N,N-Diethyl-4-iodobenzamide (cas: 77350-52-8HPLC of Formula: 77350-52-8).

N,N-Diethyl-4-iodobenzamide (cas: 77350-52-8) belongs to iodide derivatives. Typical reactions of alkyl iodides include nucleophilic substitution, elimination, reduction, and the formation of organometallics. A typical method for synthesis of aromatic iodides is diazotization of primary aromatic amines followed by treatment of potassium iodide. Aliphatic alcohols are converted to alkyl iodides by treating with hydrogen iodide.HPLC of Formula: 77350-52-8

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Synthesis and Antimicrobial Activity of δ-Viniferin Analogues and Isosteres was written by Mattio, Luce Micaela;Pinna, Cecilia;Catinella, Giorgia;Musso, Loana;Pedersen, Kasandra Juliet;Krogfelt, Karen Angeliki;Dallavalle, Sabrina;Pinto, Andrea. And the article was included in Molecules in 2021.Application of 207115-22-8 This article mentions the following:

The construction of stilbenoid-derived 2,3-diaryl-5-substituted benzofurans, which allowed to prepare a focused collection of dehydro-δ-viniferin analogs. was reported. The antimicrobial activity of the synthesized compounds was evaluated against S. aureus ATCC29213. The simplified analog 5,5′-(2-(4-hydroxyphenyl)benzofuran-3,5-diyl)bis(benzene-1,3-diol), obtained in three steps from 4-bromo-2-iodophenol (63% overall yield), emerged as a promising candidate for further investigation (MIC = 4μg/mL). In the experiment, the researchers used many compounds, for example, 4-Bromo-2-iodophenol (cas: 207115-22-8Application of 207115-22-8).

4-Bromo-2-iodophenol (cas: 207115-22-8) belongs to iodide derivatives. Organic iodides can be alkyl, alkenyl, or alkynyl, and all of them are very reactive toward with many kinds of nucleophiles. Organoiodine lubricants can be used with titanium, stainless steels, and other metals which tend to seize up with conventional lubricants: organoiodine lubricants can be used in turbines and spacecraft, and as a cutting oil in machining.Application of 207115-22-8

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Nickel-Catalyzed Asymmetric Reductive 1,2-Carboamination of Unactivated Alkenes was written by He, Jun;Xue, Yuhang;Han, Bo;Zhang, Chunzhu;Wang, You;Zhu, Shaolin. And the article was included in Angewandte Chemie, International Edition in 2020.Recommanded Product: 4-Bromo-2-iodophenol This article mentions the following:

Starting from diverse alkene-tethered aryl iodides and O-benzoyl-hydroxylamines, the enantioselective reductive cross-electrophilic 1,2-carboamination of unactivated alkenes was achieved using a chiral pyrox/nickel complex as the catalyst. This mild, modular, and practical protocol provides rapid access to a variety of β-chiral amines with an enantioenriched aryl-substituted quaternary carbon center in good yields and with excellent enantioselectivities. This process reveals a complementary regioselectivity when compared to Pd and Cu catalysis. In the experiment, the researchers used many compounds, for example, 4-Bromo-2-iodophenol (cas: 207115-22-8Recommanded Product: 4-Bromo-2-iodophenol).

4-Bromo-2-iodophenol (cas: 207115-22-8) belongs to iodide derivatives. Organic iodides can be alkyl, alkenyl, or alkynyl, and all of them are very reactive toward with many kinds of nucleophiles. Iodo alkanes participate in a variety of organic synthesis reactions, which include the Simmons–Smith reaction (cyclopropanation using iodomethane), Williamson ether synthesis, Wittig reaction, Grignard reaction, alkyl coupling reactions, and Wurtz reaction.Recommanded Product: 4-Bromo-2-iodophenol

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Synthesis, crystal structure and antibacterial activity of new highly functionalized ionic compounds based on the imidazole nucleus was written by Bahnous, Mebarek;Bouraiou, Abdelmalek;Chelghoum, Meryem;Bouacida, Sofiane;Roisnel, Thierry;Smati, Farida;Bentchouala, Chafia;Gros, Philippe C.;Belfaitah, Ali. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2013.Product Details of 15813-09-9 This article mentions the following:

Several new highly functionalized imidazolium derivatives were synthesized, via appropriate synthetic routes, using imidazole, 1-methylimidazole, and 2-phenyl-1-methylimidazole as key intermediates. The antibacterial activity of the prepared compounds was evaluated against: Escherichia coli, Staphylococcus aureus, Pseudomonas aeruginosa, and Salmonella thipymurium using disk-diffusion and MIC methods. Crystal X-ray structures are reported for six compounds In the experiment, the researchers used many compounds, for example, 4,5-Diiodo-1H-imidazole (cas: 15813-09-9Product Details of 15813-09-9).

4,5-Diiodo-1H-imidazole (cas: 15813-09-9) belongs to iodide derivatives. Organic iodides are organic compounds containing a carbon-iodine (C-I) bond. The carbon-iodine bond is weaker than other carbon-halogen bonds due to the poor electronegative nature of the iodine atom. Iodo alkanes participate in a variety of organic synthesis reactions, which include the Simmons–Smith reaction (cyclopropanation using iodomethane), Williamson ether synthesis, Wittig reaction, Grignard reaction, alkyl coupling reactions, and Wurtz reaction.Product Details of 15813-09-9

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Copper-Catalyzed direct thioetherification of Alkyl Halides with S-Alkyl Butanethioate as Thiol transfer reagent was written by Tian, Qingqiang;Wang, Lili;Li, Yahui. And the article was included in Journal of Sulfur Chemistry in 2022.COA of Formula: C8H8BrI This article mentions the following:

A new and convenient copper-catalyzed synthesis of alkyl sulfides were accomplished using S-alkyl butanethioate as a thiol source. This catalytic protocol displayed a good functional groups tolerance and high efficiency. Both secondary and primary alkyl iodides were used in this procedure. In addition, this method featured operational simplicity and a wide substrate range, providing a complementary method for alkyl sulfide synthesis without requiring toxic thiols and noble metals. In the experiment, the researchers used many compounds, for example, 1-Bromo-4-(2-iodoethyl)benzene (cas: 85356-68-9COA of Formula: C8H8BrI).

1-Bromo-4-(2-iodoethyl)benzene (cas: 85356-68-9) belongs to iodide derivatives. Organic iodides can be alkyl, alkenyl, or alkynyl, and all of them are very reactive toward with many kinds of nucleophiles. A typical method for synthesis of aromatic iodides is diazotization of primary aromatic amines followed by treatment of potassium iodide. Aliphatic alcohols are converted to alkyl iodides by treating with hydrogen iodide.COA of Formula: C8H8BrI

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Epiquinamide: A Poison That Wasn’t from a Frog That Was was written by Fitch, Richard W.;Sturgeon, Gordon D.;Patel, Shaun R.;Spande, Thomas F.;Garraffo, H. Martin;Daly, John W.;Blaauw, Richard H.. And the article was included in Journal of Natural Products in 2009.Name: 1-Chloro-4-iodobutane This article mentions the following:

In 2003, we reported the isolation, structure elucidation, and pharmacol. of epiquinamide (1), a novel alkaloid isolated from an Ecuadoran poison frog, Epipedobates tricolor. Since then, several groups, including ours, have undertaken synthetic efforts to produce this compound, which appeared initially to be a novel, β2-selective nicotinic acetylcholine receptor agonist. Based on prior chiral GC anal. of synthetic and natural samples, the absolute structure of this alkaloid was established as (1S,9aS)-1-acetamidoquinolizidine. We have synthesized the (1R*,9aS*)-isomer (epi-epiquinamide) using an iminium ion nitroaldol reaction as the key step. We have also synthesized ent-1 semisynthetically from (-)-lupinine. Synthetic epiquinamide is inactive at nicotinic receptors, in accord with recently published reports. We have determined that the activity initially reported is due to cross-contamination from co-occurring epibatidine in the isolated material. In the experiment, the researchers used many compounds, for example, 1-Chloro-4-iodobutane (cas: 10297-05-9Name: 1-Chloro-4-iodobutane).

1-Chloro-4-iodobutane (cas: 10297-05-9) belongs to iodide derivatives. Organic iodides are organic compounds containing a carbon-iodine (C-I) bond. The carbon-iodine bond is weaker than other carbon-halogen bonds due to the poor electronegative nature of the iodine atom. The C–I bond is the weakest of the carbon–halogen bonds. These bond strengths correlate with the electronegativity of the halogen, decreasing in the order F > Cl > Br > I. This periodic order also follows the atomic radius of halogens and the length of the carbon-halogen bond.Name: 1-Chloro-4-iodobutane

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Palladium-catalyzed difluoromethylthiolation of heteroaryl bromides, iodides, triflates and aryl iodides was written by Wu, Jiang;Liu, Yafei;Lu, Changhui;Shen, Qilong. And the article was included in Chemical Science in 2016.Formula: C6H2ClF3IN This article mentions the following:

Palladium-catalyzed difluoromethylthiolation of heteroaryl halides and triflates under mild conditions was described. A vast range of heteroaryl halides such as pyridyl, quinolinyl, benzothiazolyl, thiophenyl, carbazolyl and pyrazolyl halides could be difluoromethylthiolated efficiently, thus providing medicinal chemists with new tools for their search of new led compounds for drug discovery. Likewise, aryl iodides were difluoromethylthiolated in high yields under a modified reaction condition. In the experiment, the researchers used many compounds, for example, 2-Chloro-5-(trifluoromethyl)-4-iodopyridine (cas: 505084-55-9Formula: C6H2ClF3IN).

2-Chloro-5-(trifluoromethyl)-4-iodopyridine (cas: 505084-55-9) belongs to iodide derivatives. Organoiodine compounds occur widely in organic chemistry, but are relatively rare in nature. Alkyl iodides react at a faster rate than alkyl fluorides due to the weak C-I bond.Formula: C6H2ClF3IN

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Difluorocarbene-Based Cyanation of Aryl Iodides was written by Zhang, Yin-Xiang;Xiao, Xuan;Fu, Zhi-Hong;Lin, Jin-Hong;Guo, Yu;Yao, Xu;Cao, Yu-Cai;Du, Ruo-Bing;Zheng, Xing;Xiao, Ji-Chang. And the article was included in Synlett in 2020.Quality Control of 3-Iodobenzo[b]thiophene This article mentions the following:

Herein, a difluorocarbene-based cyanation of aryl iodides promoted by a cheap copper source, Cu(NO₃)₂·2.5H₂O, under an air atm is reported. Difluoromethylene phosphobetaine (Ph₃P⁺CF₂CO₂^–), an easily available and shelf-stable difluorocarbene reagent, and NaNH₂ are used as the carbon source and the nitrogen source for the nitrile group, resp. The cyanation protocol is attractive because no toxic reagent is used and performing the reactions under an air atm. is operationally convenient. In the experiment, the researchers used many compounds, for example, 3-Iodobenzo[b]thiophene (cas: 36748-88-6Quality Control of 3-Iodobenzo[b]thiophene).

3-Iodobenzo[b]thiophene (cas: 36748-88-6) belongs to iodide derivatives. In general, organic iodides are light-sensitive and turn yellow during storage, owing to the formation of iodine. In the chemical industry, alkyl iodides serve as excellent alkylating agents and, specifically, methyl iodide is used as a methylating agent in the synthesis of various pharmaceutical drugs.Quality Control of 3-Iodobenzo[b]thiophene

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Neurotropic and psychotropic agents. LXVII. 9-Chloro-10-(4-methylpiperazino)-10,11-dihydrodibenzo[b,f]thiepin and some related synthetic experiments was written by Sindelar, K.;Kakac, B.;Svatek, E.;Holubek, J.;Rajsner, M.;Metysova, J.;Protiva, M.. And the article was included in Collection of Czechoslovak Chemical Communications in 1974.SDS of cas: 13420-63-8 This article mentions the following:

The title compound (I) was prepared in 9 steps from 1-chloro-4-nitrothioxanthone. The decisive step of the synthesis was the oxidation of 1-chloro-9-methylenethioxanthene (II) with Tl(NO3)3 in MeOH; the principal product was the enol-ether III which was hydrolyzed to 9-chlorodibenzo[b,f]thiepin-10(11H)-one (IV). The by-products of the oxidation reaction were 1-chlorodibenzo-[b,f]thiepin-10(11H)-one, bi[1-chloro-11-methoxy-10,11-dihydrodibenzo[b,f]thiepin-10-yl], bi[1-chlorodibenzo[b,f]thiepin-10-yl], and Me 1-chlorothioxanthene-9-carboxylate. IV was transformed to I via 9-chloro-10-hydroxy-10,11-dihydrodibenzo[b,f]-thiepin and 9,10-dichloro-10,11-dihydrodibenzo[b,f]thiepin. An attempt at cyclization of 2-(2-acetamido-5-chlorophenylthio)-phenylacetic acid with H3PO4 acid in the presence of PhMe gave 2-chloro-5H-dibenzo[b,g]-1,4-thiazocin-6(7H)-one (V) and two other products resulting from interaction of the amide group with PhMe, and assumed to be 2-chloro-6-(4-tolyl)-7H-dibenzo-[b,g]-1,4-thiazocine and 6-[1-(4-tolyl)-1-ethylideneamino]-9-chlorodibenzo[b,f]thiepin-10(11H)-one. In the experiment, the researchers used many compounds, for example, 2-Chloro-6-iodobenzoic acid (cas: 13420-63-8SDS of cas: 13420-63-8).

2-Chloro-6-iodobenzoic acid (cas: 13420-63-8) belongs to iodide derivatives. Organoiodine compounds occur widely in organic chemistry, but are relatively rare in nature. Polyiodoorganic compounds are sometimes employed as X-ray contrast agents, in fluoroscopy, a type of medical imaging. This application exploits the X-ray absorbing ability of the heavy iodine nucleus.SDS of cas: 13420-63-8

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com