Iodides-buliding-blocks

Synthetic Route of 13329-40-3,Some common heterocyclic compound, 13329-40-3, name is 1-(4-Iodophenyl)ethanone, molecular formula is C8H7IO, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Dissolving 20 g (81 mmol) of 4′-iodo acetophenone into 200 milliliter of acetic acid, and adding 12.8 g (81 mmol) of bromine while cooling with ice, stirred at the temperature of 15 C for 3 hours. After the color of bromine disappeared, adding water and separating the precipitated solids by filtration, thereby obtained 27 g of crude 2-bromo-4′-iodo acetophenone.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 1-(4-Iodophenyl)ethanone, its application will become more common.

Reference:
Patent; IDEMITSU KOSAN CO., LTD.; EP1582516; (2005); A1;,
Iodide – Wikipedia,
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In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 16355-92-3, name is 1,10-Diiododecane belongs to iodides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. COA of Formula: C10H20I2

1 molar parts taken honokiol and 2 moles of sodium carbonate were mixed in dry acetonitrile was added, the volume of acetonitrile and honokiol molar ratio of 150: 1 (L / mol), was added X (CH2)nY16 molar parts, at 85 for 5h was honokiol derivatives.However, the present embodiment of X (CH2)nThe Y, X, Y are I, n = 10.In other embodiments, X, Y independently is Br, O, S, F or Cl, n is an integer of ? 30 for 1,2,3,4, etc.

The synthetic route of 16355-92-3 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Guangzhou card licensing Biological Technology Co., Ltd; Yuan, Xiao; Zhou, Dongbin; Fan, Jianjun; Zhang, Wei; (27 pag.)CN105622603; (2016); A;,
Iodide – Wikipedia,
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Synthetic Route of 2468-56-6, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 2468-56-6 as follows.

3) Synthesis of 6-trifluoroacetamido-1-hexyne To a solution of sodium hydride (60% oil, 2.55 g, 63.6 mol) in DMF (50 ml), trifluoroacetamide (8.99 g, 79.6 mmol) was added portionwise as about 10 portions with ice cooling. Subsequently, a solution of 6-iodo-1-hexyne (3.31 g, 15.9 mmol) in DMF (15 ml) was added to the reaction mixture. The reaction mixture was stirred at room temperature for four hours. The reaction mixture was added with saturated aqueous ammonium chloride (100 ml) and ether (100 ml) for extraction. The ether layer was dried over magnesium sulfate, and concentrated under reduced pressure, and the resulting residue was purified by silica gel column chromatography (eluent; hexane-ethyl acetate mixed solvent) to afford 2.0 g of 6-trifluoroacetamido-1-hexyne (yield; 65.4%). Melting point: 41.0-42.5 C. 1H-NMR (270 MHz, CDCl3) delta ppm: 1.53-1.80 (m, 4H, -CH2(CH2)2-), 1.98 (t, 1H, J=2.7 Hz, H-CC-), 2.26 (dt, 2H, J=2.5, 6.7 Hz, CC-CH2-), 3.41 (q, 2H, J=6.8 Hz, CH2-N), 6.48 (brs, 1H, NHTfa)

According to the analysis of related databases, 2468-56-6, the application of this compound in the production field has become more and more popular.

Reference:
Patent; The Institute of Physical and Chemical Research; US6265569; (2001); B1;,
Iodide – Wikipedia,
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Related Products of 52548-63-7, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 52548-63-7, name is 5-Fluoro-2-iodobenzoic acid belongs to iodides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

Step B: The product of Step A (9.0 g, 34 mmol) was dissolved in tetrahydrofuran (50 mL) and cooled in an ice bath under nitrogen. A 2.0 M solution of borane-methyl-sulfide complex (42 mL, 8.5 mmol) in tetrahydrofuran was added dropwise and the mixture was stirred for 30 minutes. The ice bath was removed and the reaction mixture was refluxed for 2 hours at 70 C. The solvent was concentrated in vacuo and the residue was dissolved in saturated ammonium chloride and extracted twice with methylene chloride. The organic extract was washed with brine, dried over sodium sulfate, filtered, and concentrated in vacuo to afford the desired product (6.2 g, 73%) as an off-white solid: 1H NMR (500 MHz, CDCl3) delta 7.78-7.69 (m, 1H), 7.31-7.22 (m, 1H), 6.83-6.75 (m, 1H), 4.64 (s, 2H), 2.04 (s, 1H).

The synthetic route of 5-Fluoro-2-iodobenzoic acid has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Molino, Bruce F.; Liu, Shuang; Guzzo, Peter R.; Beck, James P.; US2006/52378; (2006); A1;,
Iodide – Wikipedia,
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Related Products of 2043-57-4, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 2043-57-4 as follows.

Specifically, first, 2-(perfluorohexyl)ethyl iodide 21.70g (45.8mmol), 4-mercaptophenol 5.72 g (45.3 mmol), potassium carbonate 7.24 g (52.8 mmol), and put the acetone 50mL in 200mL eggplant flask, 2 days at 65 C, was reflux. After completion of the reaction was transferred to stand by separatory funnel to room temperature. There was separated ethyl acetate and brine after addition of the appropriate amount of water and 1N hydrochloric acid 30mL further added to the aqueous phase and an organic phase. Then, after standing for 30 minutes over anhydrous magnesium sulfate the organic phase, subjected to pleat folding filtered to obtain a filtrate was concentrated with an evaporator solid. The obtained solid was purified by silica gel column chromatography with chloroform to give Compound (A) 18.23g (38.6mmol). The obtained compound (A) is a colorless powder, whose melting point is 65 to 68 C, the yield was 85.2%. Further, an infrared spectrophotometer (manufactured by Shimadzu Corp., trade name “IRPrestige-21”. Similarly below. ), And nuclear magnetic resonance apparatus (Nippon Denshi Co. Ltd., trade name “JMN-LA500”. Similarly below. ) Was thus identified compound (A). The results are shown in the following.

According to the analysis of related databases, 2043-57-4, the application of this compound in the production field has become more and more popular.

Reference:
Patent; YAMAGUCHI UNIVERSITY; OKAMOTO, HIROAKI; MORITA, YUKI; (32 pag.)JP2016/64990; (2016); A;,
Iodide – Wikipedia,
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Electric Literature of 1829-28-3,Some common heterocyclic compound, 1829-28-3, name is Ethyl 2-iodobenzoate, molecular formula is C9H9IO2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General Procedures for Synthesis of 5-Aryl-2-Furaldehydes (5). 5-Aryl-2-furaldehyde 5 was synthesized from Suzuki coupling of 5-formyl-2-furanboronic acid and corresponding aryl halides 4 in 72-75percent yields following a literature procedure (Scheme 3) (Hosoya, et al. (2003) Bioorg. Med. Chem. 11:663). The crude solid products were purified by column chromatography using dichloromethane as eluent. wherein R2 is 2-NO2, 3,4-diMe (4a, 5a); H (4b, 5b); 4-NO2 (4c, 5c); 2-COOEt (4d, 5d).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route Ethyl 2-iodobenzoate, its application will become more common.

Reference:
Patent; Marmorstein, Ronen; Liu, Xin; Cole, Philip A.; Wang, Ling; Bowers, Erin M.; Meyers, David J.; Mukherjee, Chandrani; US2010/216853; (2010); A1;,
Iodide – Wikipedia,
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Adding a certain compound to certain chemical reactions, such as: 364-77-2, name is 2-Iodo-5-fluoronitrobenzene, belongs to iodides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 364-77-2, SDS of cas: 364-77-2

General procedure: The appropriate 4-substituted-1-iodo-2-nitrobenzene 10 (1mmol), appropriate 1,3-disubstituted-5-aminopyrazole 11 (1.3mmol), and anhydrous potassium carbonate (248mg, 1.8mmol) were heated in the presence of rac-BINAP (23mg, 0.036mmol, 3.7mol%), Pd2dba3 (23mg, 0.024mmol, 2.5mol%), and 18-crown-6 (10mg, 0.038mmol) in toluene (8mL, purged with argon) at 100C. The reaction was carried out under argon for 24h. After cooling the reaction mixture was filtered and purified using column chromatography on aluminium oxide with toluene, or a toluene-ethyl acetate mixture (10:1) as an eluent. The product was recrystallized from toluene.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-Iodo-5-fluoronitrobenzene, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Danel, Andrzej; Wojtasik, Katarzyna; Szlachcic, Pawe?; Gryl, Marlena; Stadnicka, Katarzyna; Tetrahedron; vol. 73; 34; (2017); p. 5072 – 5081;,
Iodide – Wikipedia,
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Some common heterocyclic compound, 103962-05-6, name is 1-Iodo-4-(trifluoromethoxy)benzene, molecular formula is C7H4F3IO, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Safety of 1-Iodo-4-(trifluoromethoxy)benzene

General procedure: Under argon, imidazo[2,1-c][1,2,4]triazine 1 (100mg, 0.44mmol), (hetero)aryl iodide (0.46mmol) and cesium carbonate (216mg, 0.66mmol) were solubilized in 2mL of toluene. The mixture was evacuated and back-filled with dry argon twice and Xantphos (26mg, 0.044mmol), Palladium acetate (5mg, 0.022mmol) were added and the mixture was submitted to reflux with stirring for 8h. Then cooled to room temperature and the mixture was filtered through celite and the organic phase was extracted three times with ethyl acetate, dried over magnesium sulfate and then concentrated under reduced pressure. The residue was purified by flash chromatography on silica (EtOAc/EP 2:8 to 3:7) to provide the desired product.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 103962-05-6, its application will become more common.

Reference:
Article; Loubidi, Mohammed; Jouha, Jabrane; Tber, Zahira; Khouili, Mostafa; Suzenet, Franck; Akssira, Mohamed; Erdogan, Muemin Alper; Koese, Fadime Ayd?n; Dagc?, Taner; Armagan, Gueliz; Saso, Luciano; Guillaumet, Gerald; European Journal of Medicinal Chemistry; vol. 145; (2018); p. 113 – 123;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Related Products of 629-09-4, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 629-09-4, name is 1,6-Diiodohexane belongs to iodides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

Sodium methoxide (25 wt. %, 5.5 mL, 24.1 mmol) was added bysyringe to 20 (4.0 mL, 24.3 mmol) in DMF (10 mL) over 20 min. Thereaction solution was heated at 63 C for 17 h. After cooling to 0 C,the reaction solution was treated with 3:1 cold 0.5 M HCl/6 M NaCl(200 mL) and was extracted with EtOAc (2 150 mL, 50 mL). Theorganic extracts were washed with 1% NaHSO3 (150 mL), H2O(2 150 mL) and 6 M NaCl (100 mL), and solvent was removedby rotary evaporation. Flash column chromatography using 4%then 6% EtOAc/petroleum ether furnished 1.61 g of 2174 (28%) asa liquid: 1H NMR d 3.37 (t, J = 6.4 Hz, 2H), 3.33 (s, 3H), 3.19 (t,J = 7.0 Hz, 2H), 1.83 (quintet, J = 7.1 Hz, 2H), 1.54-1.62 (m, 2H),1.33-1.46 (m, 4H). 13C NMR d 72.78, 58.72, 33.58, 30.46, 29.57,25.26, 7.25. HRMS m/z calcd for C7H19INO, 260.0506 (M+NH4);found, 260.0515. Anal. Calcd for C7H15IO: C, 34.73; H, 6.25.Found: C, 34.44; H, 6.19.

The synthetic route of 1,6-Diiodohexane has been constantly updated, and we look forward to future research findings.

Reference:
Article; Bergeron, Raymond J.; Bharti, Neelam; McManis, James S.; Wiegand, Jan; Bioorganic and Medicinal Chemistry; vol. 23; 17; (2015); p. 5954 – 5971;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Application of 34270-90-1,Some common heterocyclic compound, 34270-90-1, name is 1-Iodo-2-(2-iodoethoxy)ethane, molecular formula is C4H8I2O, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Sodium bis(trimethylsilyl)amide solution in THF (1M, 19.5 mL, 19.5 mmol) was added dropwise to a solution of 2-(4-bromo-2-methylphenyl)acetonitrile (3.75 g, 17.85 mmol) in THF (90 mL) at 0C. After stirring for 0.5 h, the cooling bath was removed and the reaction mixture was stirred at 20C for 0.5 h. l-Iodo-2-(2-iodoethoxy)ethane (2.8 mL, 19.67 mmol) was added dropwise. The reaction mixture was stirred for 0.5 h at 20C. Sodium bis(trimethylsilyl)amide solution in THF (1M, 19.5 mL, 19.5 mmol) was added dropwise. The reaction mixture was stirred for 18 h at 20C, then quenched with saturated aqueous ammonium chloride solution (25 mL) and diluted with water (25 mL). The aqueous layer was extracted with EtOAc (3 x 50 mL). The combined organic extracts were washed with brine (50 mL) and dried over sodium sulfate, then filtered and concentrated in vacuo. The resulting brown oil was separated by flash column chromatography on silica, using a gradient of fc/7-butyl methyl ether in heptane (0-25%), to afford the title compound (2.3 g, 45%) as a yellow solid. 6n (250 MHz, CDCb) 7.47- 7.36 (m, 2H), 7.16 (d, 8.4 Hz, 1H), 4.16-4.06 (m, 2H), 4.06-3.91 (m, 2H), 2.65 (s, 3H), 2.33-2.21 (m, 2H), 2.17-1.99 (m, 2H). HPLC-MS (method 9): [M+water]+ m/z 297 and 299, RT 1.80 minutes.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 1-Iodo-2-(2-iodoethoxy)ethane, its application will become more common.

Reference:
Patent; UCB BIOPHARMA SRL; BRACE, Gareth Neil; BROOKINGS, Daniel Christopher; FOULKES, Gregory; LECOMTE, Fabien Claude; (0 pag.)WO2020/11731; (2020); A1;,
Iodide – Wikipedia,
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