Iodides-buliding-blocks

Electric Literature of 1012882-90-4, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 1012882-90-4, name is Ethyl 5-chloro-2-iodobenzoate, This compound has unique chemical properties. The synthetic route is as follows.

A degassed mixture of ethyl 5-chloro-2-iodobenzoate (0.621 g, 2.00 mmol), Pd(PPh3)4 (0.116 mg, 0.1 mmol), quinolin-6-ylboronic acid (0.381 g, 2.2 mmol), K2C03 (0.553 g, 4.0 mmol), dimethoxyethane (20 mL), and water (5 mL) was heated under reflux overnight. Solvents were removed under reduced pressure. The residue was diluted with sat’d NH4CI (15 mL) and extracted with EtOAc (3 x 30 mL). The combined organic layers were dried (MgSC^), concentrated in vacuo and purified by chromatography to afford ethyl 5-chloro-2-(quinolin-6-yl)benzoate (0.244 g, 39% yield) as a colorless oil. MS (ESI) m/z: 312.0 (M+H+).

The chemical industry reduces the impact on the environment during synthesis Ethyl 5-chloro-2-iodobenzoate. I believe this compound will play a more active role in future production and life.

Reference:
Patent; DECIPHERA PHARMACEUTICALS, LLC; FLYNN, Daniel L.; PETILLO, Peter A.; KAUFMAN, Michael D.; WO2013/36232; (2013); A2;,
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132554-73-5, name is 2-Fluoro-1-iodo-4-(trifluoromethyl)benzene, belongs to iodides-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. SDS of cas: 132554-73-5

To a mixture of the 2-fluoro-1-iodo-4-(trifluoromethyl)benzene(580 mg, 2.0 mmol), tetrakis(triphenylphosphine)palladium(231 mg, 0.2 mmol), and CuI (381 mg, 2.0 mmol) in triethylamine at0 C was added tert-butyldimethyl(2-propynyloxy)silane (341 mg,2.0 mmol). The reaction mixturewas heated to 60 C for 30 min andthen filtrated through a short pad of silica gel. The residue waswashed with dichloromethane and the filtrate concentrated. Thecrude product was then purified by silica gel column chromatography(eluent, petroleum ether) to afford 17 as a brown oil. 1H NMR(400 MHz, CDCl3) delta 7.54 (t, J 7.4 Hz, 1H), 7.35 (dd, J 11.3, 8.9 Hz,2H), 4.58 (s, 2H), 0.92 (d, J 9.8 Hz, 9H), 0.17 (s, 6H).

The synthetic route of 132554-73-5 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Wei, Hanwen; Mao, Fei; Ni, Shuaishuai; Chen, Feifei; Li, Baoli; Qiu, Xiaoxia; Hu, Linghao; Wang, Manjiong; Zheng, Xinyu; Zhu, Jin; Lan, Lefu; Li, Jian; European Journal of Medicinal Chemistry; vol. 145; (2018); p. 235 – 251;,
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Synthetic Route of 116632-14-5, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 116632-14-5 as follows.

8-(3-aminonaphthalen-2-ylthio)-9H-purin-6-amine (S13-4).; A mixture of 8- mercaptoadenine (20.7 mg, 0.124 mmol), neocuproine hydrate (3.9 mg, 0.0185 mmol), Cul (3.5 mg, 0.0185 mmol), sodium tert-butoxide (23.7 mg, 0.24 mmol), S13-3 (100 mg, 0.37 . mmol) and DMF (2 mL) were heated at 115C for 20 h. The solvent was removed under reduced pressure and the residue was purified by preparatory TLC (CH2Cl2:MeOH-NH3 (7N), 10:1) to give 14 mg (37%) of S13-4 as a solid. 1H NMR (500 MHz, CDC^/MeOH-cU) delta 8.18 (s, 1H), 8.12 (s, 1H), 7.71 (d, J= 8.3 Hz, 1H), 7.62 (d, J= 8.1 Hz, 1H), 7.40-7.46 (m, 1H), 7.24-7.30 (m, 1H), 7.20 (s, 1H); MS (ESI) m/z 308.95 [M+H]+.

According to the analysis of related databases, 116632-14-5, the application of this compound in the production field has become more and more popular.

Reference:
Patent; SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH; CHIOSIS, Gabriela; TALDONE, Tony; SUN, Weilin; WO2011/44394; (2011); A1;,
Iodide – Wikipedia,
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Synthetic Route of 42048-11-3, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 42048-11-3, name is 2-Chloro-6-iodotoluene belongs to iodides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

Palladium acetate palladium (44.9 mg, 0.2 mmol) was added to a 25 mL eggplant bottle.Triphenylphosphine (52.4 mg, 0.2 mmol),Sodium formate (276 mg, 4 mmol),Norbornene (188 mg, 2 mmol),Potassium phosphate (2.544 g, 12 mmol),Potassium acetate (392 mg, 4 mmol),2-chloro-6-sulfonic acid toluene (504 mg, 2 mmol),Ethyl bromobutyrate (1.56 g, 8 mmol) and dimethylformamide (10 ml).High-purity nitrogen was replaced three times, after reacting at 50oC for 16 hours,Extracting the mixture with dichloromethane and water, combining the organic phases, enriching the organic solvent, and further purifying the product by column chromatography. 2-Deutero-3-(ethyl butyrate)-6-chlorotoluene was obtained in a yield of 78%.

The synthetic route of 2-Chloro-6-iodotoluene has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Anhui Xiulang New Materials Technology Co., Ltd.; Zhang Honghai; Guo Lei; Shui Xinfeng; (15 pag.)CN110054541; (2019); A;,
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Synthetic Route of 1000802-34-5, A common heterocyclic compound, 1000802-34-5, name is 6-Iodobenzo[d][1,3]dioxol-5-amine, molecular formula is C7H6INO2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

To a solution of 6-iodobenzo[d][1,3]dioxol-5-amine (1 g, 3.8 mmol) and paraformaldehyde (1.14 g, 38 mmol) in methanol (10 mL) was added NaBH3CN (2.39 g, 38 mmol) slowly with stirring. The mixture was heated to 50 C. for 4 h. Water (100 mL) was added and extracted with methylene chloride (100 mL). The organic layer was washed with brine (100 mL), dried (MgSO4) and evaporated under vacuum to give crude title compound 0107-111 (1.16 g) as a brown oil which was used directly to the next step without further purification. LCMS: 292 [M+1]+; 1H NMR (DMSO-d6) delta 2.56 (s, 6H), 6.02 (s, 2H), 6.96 (s, 1H), 7.32 (s, 1H).

The synthetic route of 1000802-34-5 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Cai, Xiong; Qian, Changgeng; Zhai, Haixiao; US2008/234314; (2008); A1;,
Iodide – Wikipedia,
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Related Products of 1097871-23-2,Some common heterocyclic compound, 1097871-23-2, name is 1-Chloro-2,5-difluoro-4-iodobenzene, molecular formula is C6H2ClF2I, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Step 2: Preparation of (S)-N-(-(4-chloro-2,5-difluorophenyl)(oxetan-3-yl)methyl)-2-methylpropane-2-sulfinamide To an oven-dried 500 mL round bottom flask under a nitrogen atmosphere was added 1-chloro-2,5-difluoro-4-iodobenzene (9.93 g, 36.18 mmol) in 175 mL anhydrous THF. The resulting solution was cooled to -100 C. with a diethyl ether/liquid nitrogen bath, and then n-BuLi solution (1.6M in THF, 22.6 mL, 36.2 mmol) was added dropwise so that the internal temperature remained between -90 and -100 C. The resulting yellow colored mixture was stirred between -90 and -100 C for 30 min and then (S,E)-2-methyl-N-(oxetan-3-ylmethylene)propane-2-sulfinamide (7.53 g, 39.80 mmol) in 15 mL THF was added dropwise via syringe so that the internal temperature remained between -90 and -100 C. The resulting mixture was stirred between -90 and -100 C. for 30 min and then quenched at the same temperature by dropwise addition of saturated NH4Cl solution followed by warming to room temperature. The mixture was diluted with 150 mL water and 150 mL EtOAc. The layers were shaken and separated and the organic phase was washed with saturated NaCl solution, dried over Na2SO4, and concentrated to a viscous nearly colorless oil which was purified by MPLC using silica gel (0-100% ethyl acetate/hexanes) to provide the desired single diastereomer (6.88 g, 20.38 mmol) as a white foam. LCMS-APCI (POS.) m/z: 338.1 (M+H)+

The synthetic route of 1097871-23-2 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; AMGEN INC.; CYTOKINETICS, INC.; Ashcraft, Luke; Boezio, Alessandro; Butler, John; Chandra, Aroop; Chuang, Chihyuan; Collibee, Scott E.; Debenedetto, Mikkel; DiMassa, Vincent; Graceffa, Russell; Malinowski, Justin; Moebius, David; Morgan, Bradley P.; Payette, Joshua; Romero, Antonio; St. Jean, JR., David; Vargas, Richard; Yeoman, John; Zhang, Hanmo; (146 pag.)US2019/77793; (2019); A1;,
Iodide – Wikipedia,
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Application of 404337-42-4, A common heterocyclic compound, 404337-42-4, name is 5-Chloro-2-iodo-m-xylene, molecular formula is C8H8ClI, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

4-Chloro-2,6-dimethyliodobenzene (9.6 g, 36 mmol) is dissolved in pyrene (60 mL). To this solution, a hot solution of KMnO4 (28 g, 0.18 mol) is poured and the mixture is stirred at 115 C. for 8 hours. After additional heating for 5 hours, a 1M HCl solution is added. The precipitate is filtered off and washed with THF. The resultant filtrate is washed with THF and dried over Na2SO4. After the evaporation, the dicarboxylic acid derivative is obtained as a solid. Yield 9.1 g (78%). FD-MS (8 kV): m/z=326.7. 1H NMR (250 MHz, DMSO-d6) delta ppm 7.24 (s, Ar): 13C NMR (62.5 MHz, CD3OD-d4): delta ppm 126.7, 128.1, 134.5, 150.1, 174.6.

The synthetic route of 404337-42-4 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; BASF SE; Kawano, Shin-Ichiro; Baumgarten, Martin; Muellen, Klaus; Murer, Peter; Schaefer, Thomas; Saleh, Moussa; US2014/357898; (2014); A1;,
Iodide – Wikipedia,
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In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 914636-93-4 as follows. Computed Properties of C7H4FIO

Step 5. (R,E)-N-(3-fluoro-5-iodobenzylidene)-2-methylpropane-2-sulfinamide To a solution of 3-fluoro-5-iodobenzaldehyde (8.75 g, 35 mmol) and (R)-(+)-t-Butylsulfinamide (4.67 g, 38.5 mmol) in DCE (117 mL) was added copper(II) sulfate (anhydrous) (16.76 g, 105 mmol) and the resulting suspension was heated at 60° C. overnight. LCMS indicated desired product formation. Reaction mixture was filtered through Celite and the filtrate concentrate in vacuo and then taken to the next step as such. LCMS (m/z): 354.1 (MH+), 1.08 min.

According to the analysis of related databases, 914636-93-4, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Novartis AG; Bagdanoff, Jeffrey T.; Ding, Yu; Han, Wooseok; Huang, Zilin; Jiang, Qun; Jin, Jeff Xianming; Kou, Xiang; Lee, Patrick; Lindvall, Mika; Min, Zhongcheng; Pan, Yue; Pecchi, Sabina; Pfister, Keith Bruce; Poon, Daniel; Rauniyar, Vivek; Wang, Xiaojing Michael; Zhang, Qiong; Zhou, Jianguang; Zhu, Shejin; (366 pag.)US9242996; (2016); B2;,
Iodide – Wikipedia,
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Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 13101-40-1, name is 1-Bromo-3-chloro-5-iodobenzene, A new synthetic method of this compound is introduced below., Recommanded Product: 1-Bromo-3-chloro-5-iodobenzene

In a 250mL three-necked flask, nitrogen is introduced.Add 0.02molRaw material I, 150ml DMF, 0.022mol raw material II,0.0002 mol of palladium acetate, stirred,Then add 3mL of 0.01mol/mL K3PO4 aqueous solution,The reaction was heated under reflux at 150 C for 12 hours.Sampling the plate and the reaction is complete.Cool naturally, add 100mL water,The mixture was filtered and the filter cake was dried in a vacuum oven.The residue obtained was purified by silica gel column to giveRaw material A-1;

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; Jiangsu March Optoelectric Technology Co., Ltd.; Lu Ying; Wang Fang; Xie Dandan; Wu Xiuqin; Zhang Zhaochao; (39 pag.)CN109928911; (2019); A;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Related Products of 1032231-24-5, A common heterocyclic compound, 1032231-24-5, name is 2-Bromo-5-iodobenzaldehyde, molecular formula is C7H4BrIO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

According to the method described in a journal, European Journal of Organic Chemistry, 2008, No. 10, pp. 1797-1801, a compound represented by the formula (I-9-3) was produced. In a nitrogen atmosphere, 2.0 g of the compound represented by the formula (I-9-2), 3.0 g of the compound represented by the formula (I-9-3), 2.0 g of potassium carbonate, 20 mL of tetrahydrofuran, 20 mL of water, and 0.1 g of tetrakis(triphenylphosphine)palladium(0) were put in a reactor and heated with stirring. After ordinary post-treatment, this was purified through column chromatography to give 2.3 g of a compound represented by the formula (I-9-4).

The synthetic route of 1032231-24-5 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; DIC Corporation; Horiguchi, Masahiro; Kadomoto, Yutaka; (139 pag.)US2018/22716; (2018); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com