Iodides-buliding-blocks

Reference of 615-43-0, The chemical industry reduces the impact on the environment during synthesis 615-43-0, name is 2-Iodoaniline, I believe this compound will play a more active role in future production and life.

Acetyl chloride (6 mmol) was added dropwise to the mixture of 2-iodoaniline (5 mmol) and sodium hydroxide (13 mmol) in THF/H2O (1/1, 4 mL). Stirred the mixture at 0 C. for 2 h, and then at room temperature for overnight. The mixture was diluted with 10 mL water and extracted with diethyl ether 3 times. The combined organic layer was washed with water 3 times and brine. Dried over sodium sulfate, filtered, and removed solvent. The residue was then purified by column chromatography afforded white solid of 2-iodoacetanilide 68% yield. NMR

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-Iodoaniline, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; University of Massachusetts; US7473786; (2009); B1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 1252046-13-1, name is 2-Bromo-5-iodobenzonitrile, This compound has unique chemical properties. The synthetic route is as follows., Recommanded Product: 2-Bromo-5-iodobenzonitrile

Under an argon atmosphere, to a 500 ml, three-neck flask, 5.00 g of (6-bromopyridin-3-yl)boronic acid, 7.63 g of 2-bromo-5-iodobenzonitrile, 0.28 g of Pd(OAc)2, 1.02 g of SPhos, and 10.52 g of K3PO4 were dissolved in 120 ml of a deaerated mixture solvent of toluene/ethanol/water (10:1:2), followed by stirring at about 80 C. for about 12 hours. After finishing the reaction, water was added, and extraction with CH2Cl2 was conducted. An organic layer was separated and dried with MgSO4, and solvents were removed by distillation under a reduced pressure. The crude product thus obtained was separated by silica gel column chromatography to obtain 6.20 g (yield 74%) of Intermediate O. The molecular weight of Intermediate O measured by FAB-MS was 338.

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 1252046-13-1.

Reference:
Patent; Samsung Display Co., Ltd.; SAKAMOTO, Naoya; (128 pag.)US2019/296247; (2019); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 249647-25-4, name is 3-Bromo-4-iodobenzoic acid, A new synthetic method of this compound is introduced below., name: 3-Bromo-4-iodobenzoic acid

STEP 1 : 3-BROMO-4-IODO-N-(METHYLSULFONYL)BENZAMIDE (INTERMEDIATE D)[00338] A suspension of l-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride (0.586 g, 3.06 mmol), 4-(dimethylamino) pyridine (0.561 g, 4.59 mmol), methanesulfonamide (0.128 ml, 1.835 mmol) and 3-bromo-4-iodobenzoic acid (0.5 g, 1.529 mmol, HDH Pharma) was shaken at ambient temperature for 16 h. The reaction mixture was purified by reverse phase HPLC using water and acetonitrile and TFA as modifier to obtain Intermediate D (0.268 g, 0.663 mmol, 43.4 % yield) as a white sticky, solid. MS (ESI, positive ion) m/z 405.0.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; AMGEN INC.; BREGMAN, Howard; CHAKKA, Nagasree; DIMAURO, Erin F.; GAO, Hua; GUNAYDIN, Hakan; HUANG, Hongbing; OLIVIERI, Philip; SCHENKEL, Laurie; WEISS, Matthew; WO2015/51043; (2015); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Related Products of 133232-56-1, These common heterocyclic compound, 133232-56-1, name is 3-Iodo-2-methylbenzoic acid, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

[0469] To a solution of 3-iodo-2-methylbenzoic acid (2.0 g, 3.82 mmol) in dry MeOH (10 mL) at 0 C was added thionyl chloride (681mg, 5.72 mmol). Then the reaction was heated to 80 C for 16 hrs. TLC showed the starting material was consumed and one main spot was present. The reaction was cooled to rt and the solvent was removed. The residue was diluted with water (20 mL) and extracted with EA (40 mL) twice. The combined organic layers were washed with saturated sodium bicarbonate aqueous (30 mL), brine, dried over sodium sulfate, filtered and concentrated providing crude product, which was purified by column chromatography on silica-gel elution with petroleum ether:EA (from 0% to 8%) providing methyl 3-iodo-2-methylbenzoate (1.7 g, 80.4% yield) as a colorless oil. MS (ESI) m/z 277.0 [M+H]+. 1H NMR (400 MHz, CDCl3) delta 7.97 (dd, J = 1.2, 8.0 Hz, 1 H), 7.73 (dd, J = 0.8, 8.0 Hz, 1 H), 6.92 (t, J = 8.0 Hz, 1 H), 3.89 (s, 3 H), 2.66 (s, 3 H).

The synthetic route of 133232-56-1 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; BIOTHERYX, INC.; CHAN, Kyle, W.H.; FUNG, Leah; SULLIVAN, Robert; ERDMAN, Paul, E.; MERCURIO, Frank; (225 pag.)WO2017/201069; (2017); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Adding a certain compound to certain chemical reactions, such as: 459424-72-7, name is 1,2,3-Trifluoro-4-iodobenzene, belongs to iodides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 459424-72-7, category: iodides-buliding-blocks

To a solution of diisopropylamine (4.3 g, 42.6 mmol) in THF (50 ml) was added n-butyl lithium (21.3 ml, 2 N in hexane) dropwise at -10 0C, and the solution was stirred for 30 minutes at -10 0C. The reaction mixture was cooled to -78 0C and to this was added l,2,3-trifluoro-4- iodobenzene (5 g, 19.38 mmol) in THF (50 ml), stirred at -78 0C under a nitrogen atmosphere. After stirring for 5 hours at this temperature, DMF (7 ml, 89 mmol) was added dropwise such that the temperature was maintained below -60 0C. The reaction mixture was slowly allowed to warm to room temperature and stirred overnight. The reaction mixture was treated with saturated aqueous NH4Cl solution and the aqueous layer extracted with ethyl acetate (2 X 100 ml). The organic phases were combined, dried over anhydrous sodium sulfate, and concentrated. The residue was purified over silica gel flash column using a gradient of ethyl acetate in petroleum ether to give the title product as a yellow solid. Yield: 2.4 g (45%).MS (MH+): 287.2 for C7H2F3IO1H NMR (300MHz, CDCl3) delta: 8.1 (m, IH), 10.2 (s, IH).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1,2,3-Trifluoro-4-iodobenzene, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; ASTRAZENECA AB; ASTRAZENECA UK LIMITED; WO2009/4382; (2009); A2;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Adding a certain compound to certain chemical reactions, such as: 447464-03-1, name is 2-Fluoro-3-iodobenzoic acid, belongs to iodides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 447464-03-1, Computed Properties of C7H4FIO2

Trimethyl borate (1.92 mL, 17.2 mmol) was added dropwise to a stirred solution of 2-fluoro-3-iodobenzoic acid (preparation 22b, 4.39 g, 16.5 mmol) in tetrahydrofuran (25 mL) at 0 C and the mixture was stirred for a further 15 minutes at this temperature. Then borane-methyl sulfide complex (10 M, 4.4 mL, 44 mmol) in tetrahydrofuran (3 mL) was added dropwise to the mixture at 0 C and the mixture was then allowed to warm to room temperature. After 1 hour, the mixture was carefully quenched by dropwise addition of methanol (10 mL). After stirring overnight, the mixture was concentrated in vacuo and ethyl acetate was added to the residue. The organic layer was washed with saturated aqueous potassium carbonate solution, brine, dried (MgSO4) and evaporated to give the title compound (4.03 g, 97%) as an oil. 1H-NMR delta (CDCl3): 1.85 (t, J=6.0 Hz, 1H), 4.78 (d, J=6.0 Hz, 2H), 6.93 (t, J=9.0 Hz, 1H), 7.39-7.44 (m, 1H), 7.66-7.71 (m, 1H).

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 2-Fluoro-3-iodobenzoic acid, and friends who are interested can also refer to it.

Reference:
Patent; Laboratorios Almirall, S.A.; EP2113503; (2009); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Electric Literature of 172681-47-9, The chemical industry reduces the impact on the environment during synthesis 172681-47-9, name is 2-Amino-6-iodotoluene, I believe this compound will play a more active role in future production and life.

N-Acetyl-3-Iodo-2-Methyl Aniline Charge a 5 L, 3 neck flask equipped with a mantle, stirrer, condenser, with 708 grams (5M) 3-Iodo-2-Methyl Aniline, followed by 700 ml glacial acetic acid. Add in a stream of 520 grams (5.1M) acetic anhydride and allow the solution to come to a gentle reflux for an hour. The solution is allowed to cool and poured in a stream in a large container of 8 L ice water. The product will crystallize immediately and is filtered and squeezed under vacuum and air-dried. Yield was 900 grams (Theoretical yield=918 g).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-Amino-6-iodotoluene, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Latham, Keith R.; (67 pag.)US2018/117164; (2018); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Reference of 116632-14-5, These common heterocyclic compound, 116632-14-5, name is 3-Iodonaphthalen-2-amine, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

(1) 1.0748 g (4 mmol) of 2-amino-3-iodophthalene (a) was dissolved in a nitrogen atmosphere.140.0 mg (0.2 mmol)Bistriphenylphosphine palladium dichloride [(Ph3P)2PdCl2], 75.9 mg (0.4 mmol) 40 ml of cuprous iodide (CuI)Slowly add 784.5mg (8mmol) to triethylamine (Et3N) solutionTrimethylsilylacetylene.Stir the reaction at room temperature,After TLC monitors the starting material a completely,Stop stirring,The reaction was quenched by adding 50 ml of saturated ammonium chloride to the reaction system.Extraction of organic phase with dichloromethane(3x100ml),The combined organic layers were washed with 50 ml of water, 50 ml of brine and dried over anhydrous magnesium sulfate.The crude product is passed through silica gelSpectroscopic purification (ethyl acetate: petroleum ether = 1:20),Light yellow solid b (783.6 mg, yield 82%)

The synthetic route of 116632-14-5 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Tsinghua University; Zhao Liang; Wu Han; (14 pag.)CN108997384; (2018); A;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Reference of 1031929-20-0, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 1031929-20-0 as follows.

Step A: 2-lodo-4-fluorobenzonitrile (2.54 g, 10.3 mmol) and 2- tributylstannane pyrimidine (3.69 g, 10.0 mmol) were dissolved indomethoxyethane (18 ml_) and treated with tetrakistriphenylphosphine) palladium (0) (578 mg, 0.5 mmol) and copper (I) iodide (95 mg, 0.5 mmol). The reaction was then heated to 160 C for 90 minutes in the microwave. The reaction was cooled, concenctrated under reduced pressure. Chromatography (20-100% EA in hexanes gave the desired product. 1H NMR (400 MHz, CDCI3): 8.93 (d, J = 4.9 Hz, 2H), 8.14 (dd, J = 9.6, 2.7 Hz, 1 H), 7.86 (dd, J = 8.6, 5.3 Hz, 1 H), 7.36 (t, J = 4.9 Hz, 1 H), 7.32 – 7.23 (m, 1 H).

According to the analysis of related databases, 1031929-20-0, the application of this compound in the production field has become more and more popular.

Reference:
Patent; JANSSEN PHARMACEUTICA NV; BRANSTETTER, Bryan, James; LETAVIC, Michael, A.; LY, Kiev, S.; RUDOLPH, Dale, A.; SAVALL, Brad, M.; SHAH, Chandravadan, R.; SHIREMAN, Brock, T.; WO2011/50202; (2011); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

These common heterocyclic compound, 41070-12-6, name is 3-(3-Iodophenyl)acrylic acid, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Application In Synthesis of 3-(3-Iodophenyl)acrylic acid

EXAMPLE 5(a) 3-Iodo-N-ethylcinnamamide Trans m-iodocinnamoyl chloride was prepared from trans m-iodocinnamic acid according to the standard procedure exemplified in Example 1. The acid chloride (6.6g) in dry toluene (200ml) was added with stirring to a solution of ethylamine (3.0g) in dry ether (300ml) at room temperature. The reaction mixture was heated at reflux for 1 hour and then worked up according to Example 2 to yield trans m-iodo-N-ethylcinnamamide (6.4g, 93% of theoretical), m.p. 116-117 C. as a white, crystalline material. NMR, IR and elemental analysis were consistent with this structure.

The synthetic route of 3-(3-Iodophenyl)acrylic acid has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Burroughs Wellcome Co.; US4041071; (1977); A;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com