Iodides-buliding-blocks

Synthetic Route of 116632-41-8, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 116632-41-8 name is 2-Chloro-5-iodotoluene, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

General procedure: In a Schlenk tube are added 6-azaindole (0.846 mmol), potassium phosphate (1.78 mmol) and CuI(0.042 mmol). The tube is twice evacuated and back-filled with Ar. Toluene (1 ml), 2-chloro-5-iodotoluene (0.846 mmol) and (trans)-N,N’-dimethyl-1,2-cyclohexanediamine (0.085 mmol) are added. The tube is sealed and the reaction mixture is stirred for 22 h at 110 C. The reaction mixture is diluted with dichloromethane and dry loaded on silica gel to be purified by flash chromatography (hexane/EtOAc 10% to 30%) to give 1-(4-chloro-3-methylphenyl)-1H-pyrrolo[2,3-c]pyridine as a white solid (184 mg).

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 2-Chloro-5-iodotoluene, and friends who are interested can also refer to it.

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 460-37-7, name is 1,1,1-Trifluoro-3-iodopropane belongs to iodides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. Computed Properties of C3H4F3I

To a solution of 500 mg (1.79 mmol) of the compound from Ex. 35A in 22 ml of DMF were added 620 mg (4.49 mmol) of potassium carbonate, and the mixture was stirred at RT for 15 min. Then 1.24 g (5.39 mmol) of 1,1,1-trifluoro-3-iodopropane were added, and the mixture was stirred at 50 C. for 15 h. The DMF was very substantially distilled off and the residue obtained was partitioned between semisaturated sodium chloride solution (100 ml) and ethyl acetate (50 ml). The water phase was extracted with ethyl acetate. The combined organic phases were dried over sodium sulfate, filtered and concentrated. The residue obtained was chromatographed using a silica gel cartridge (Biotage, 100 g of silica gel, eluent: hexane/ethyl acetate 94:6?50:50). In this way, 600 mg (88% of theory) of the title compound were obtained. 1H-NMR (400 MHz, DMSO-d6, delta/ppm): 10.09 (s, 1H), 4.15 (br. d, 2H), 2.85-2.71 (m, 5H), 2.42 (dd, 1H), 1.17 (s, 3H), 1.06 (dd, 1H), 0.87 (s, 3H), 0.73 (dd, 1H). LC/MS (Method 4, ESIpos): Rt=1.32 min, m/z=375 [M+H]+.

The synthetic route of 460-37-7 has been constantly updated, and we look forward to future research findings.

Electric Literature of 35453-19-1, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 35453-19-1 name is 5-Amino-2,4,6-triiodoisophthalic acid, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

Example 1 Preparation of R iopamidol [R-5-(alpha-hydroxypropionylamino)-2,4,6-triiodoisophthalic add di-(1,3 dihydroxyisopropylamide)]. 400g (0.72 Mole) 5-amino-2,4,6-triiodoisophthalic acid should be added to 200 ml thionyl chloride, the mixture boiled and stirred for six hours, and the resulting solution then evaporated. The residue should then be dissolved in anhydrous ethyl acetate, and the solution should again be evaporated to dryness. The solid material should then be dissolved in 4000 ml ethyl acetate, and the solution stirred into an ice-cold solution of 500 g sodium chloride and 200 g sodium bicarbonate in 2.5 liters water. The organic phase should be separated from the aqueous solution, washed with aqueous sodium chloride solution, dried by contact with anhydrous calcium chloride, and evaporated to dryness. The resulting 5-amino-2,4,6-triiodoisophthalyl chloride has a melting point of about 300C when recrystallized from toluene.

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 5-Amino-2,4,6-triiodoisophthalic acid, and friends who are interested can also refer to it.

Some common heterocyclic compound, 76801-93-9, name is 5-Amino-N1,N3-bis(2,3-dihydroxypropyl)-2,4,6-triiodoisophthalamide, molecular formula is C14H18I3N3O6, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. HPLC of Formula: C14H18I3N3O6

In a three-necked flask equipped with a stirrer and a reflux condenser,5-amino-N, N’-bis- (2,3-dihydroxypropyl) -2,4,6-triiodo-1,3-benzenedicarboxamide (84.6 g, 0.12 mol)N, N-dimethylacetamide 172ml, stirred, heated to 50 C dissolved, cooled to 10 C, chloroacetyl chloride 62ml (88.09g, 0.78mol) dropwise over about 30min was completed, heated to 50 C and stirred for 3h, Cooled to 0 ~ 10 , at 10 ,156ml of 10mol / L sodium hydroxide solution was added dropwise and stirred at room temperature for 1h.100 ml of water was added and 59 ml of 1N hydrochloric acid was added dropwise. After standing overnight, the mixture was filtered and the filter cake was washed with water and dried to give 83.2 g. The yield was 90.0%.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 76801-93-9, its application will become more common.

Related Products of 32337-97-6, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 32337-97-6 name is 1-Chloro-2-iodo-3-nitrobenzene, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

To a stirred solution of l-chloro-2-iodo-3-nitrobenzene (143-2; 1.4 g, 0.00490 mol) in ethanol (20 mL) was added stannous chloride dihydrate (5.5 g, 0.0245 mol) portion wise at 0 C. Reaction mixture was allowed to stir at 70 C for 30 min. The reaction mixture was concentrated and diluted with ice cold water (150 mL) and PH was made slightly basic by addition of saturated aqueous sodium carbonate solution before being extracted with ethyl acetate (4 x 100 mL). The combined organic layer was washed with saturated aqueous sodium chloride solution, dried over sodium sulphate and concentrated under vacuum to obtain the title compound. 1H NMR (400 MHz, CDCI3) delta 7.048-7.008 (t, J = 8 Hz, 1 H), 6.713-6.693 (dd, J= 8, 8.8 Hz, 1 H), 6.655-6.632 (dd, J= 8.4, 9.2 Hz, 1 H), 5.5 (bs, 2 H).

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 1-Chloro-2-iodo-3-nitrobenzene, and friends who are interested can also refer to it.

6136-66-9, name is (4-Iodophenyl)(phenyl)methanone, belongs to iodides-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Computed Properties of C13H9IO

Compound 23: 25-mL reaction flask was charged with 4-iodobenzophenone (0.5 mmol), 1-(p-toluenesulfonyl)indole-3-boronic acid (0.75 mmol), sodium carbonate (1.0 mmol), cesium hydroxide monohydrate. (2.5 mmol), sodium iodide (0.25 mmol), pivalic acid (0.75 mmol), chloroform (1.5 mmol) and ethylene glycol (2.0 g), reacted at 120 C for 24 h. Cool to room temperature, extract, the solvent was evaporated under reduced pressure and then purified by column chromatography to yield 84%.

The synthetic route of 6136-66-9 has been constantly updated, and we look forward to future research findings.

Synthetic Route of 175278-30-5, A common heterocyclic compound, 175278-30-5, name is 4-Bromo-2-ethyl-1-iodobenzene, molecular formula is C8H8BrI, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Compound (T-1) (10.0 g), 4-bromo-2-ethyl-1-iodobenzene (13.6 g), Tetrakis (triphenylphosphine) palladium(2.1 g), potassium carbonate (10.1 g), tetrabutylammonium bromide (1.18 g) and toluene (300 ml), IPA (80 ml) and pure water (20 ml) were charged into a reactor And the mixture was stirred at 90 ° C. for 5 hours. The reaction mixture was poured into water and the aqueous layer was extracted with toluene. The combined organic layers were washed with brine and dried over anhydrous magnesium sulfate. The solution was concentrated under reduced pressure, and the residue was purified by silica gel chromatography (volume ratio, heptane: toluene = 4: 1). (T-2) (12.6 g; 80percent) was obtained by further recrystallization from a mixed solvent of heptane and toluene (volume ratio, 4: 1).

The synthetic route of 175278-30-5 has been constantly updated, and we look forward to future research findings.

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 13421-13-1 as follows. Recommanded Product: 4-Chloro-2-iodobenzoic acid

General procedure: To a solution of imidazole carbaldehyde (1a-d) (100 mg, 1 equiv) in methanol (3 mL) were added successively Na2SO4 (0.2 g), amine 2a-d (1.2 equiv), alkynoic acid 3a-c (1.2 equiv) and isonitrile 4a-c (1.2 equiv) in a screw capped vial equipped with a magnetic stir bar. The reaction mixture was stirred at room temperature for 24-48 h in closed vial. After completion of the reaction, the mixture was diluted with dichloromethane (100 mL) and was extracted with water (50 mL). Organic layer was washed with brine (50 mL), dried over magnesium sulfate and evaporated under reduced pressure to obtained residue which was subjected to silica gel column chromatography (1-5 % methanol in dichloromethane) to afford the desired product 5a-r as solid.

According to the analysis of related databases, 13421-13-1, the application of this compound in the production field has become more and more popular.

Related Products of 31827-94-8, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 31827-94-8 as follows.

General procedure: A sealed tube (35 mL) equipped with a stirring bar was loaded with 2-bromoethanones (1.0 mmol), then sodium benzenesulfinate (1.2 mmol) in DMF (20 mL) or phosphite (1.0 mmol) in toluene (20 mL) was added to the tube and the mixtures were stirred at room temperature till the 2-bromoethanones was totally consumed as indicated by TLC analysis (ca. 12 h for 1 and 24 h for 3). Then, the mixture was diluted with water (20 mL) and extracted with CH2Cl2 (30 mL x 3). Next, the organic phase was combined and dried over anhydrous Na2SO4. The solvent was removed by rotary evaporation and the oily mixture was purified with flash chromatograph column (elute: mixture of ethyl acetate and n-hexane), giving the desired products. And the 1H NMR spectra of the purified substrates were in accordance with the known literatures.

According to the analysis of related databases, 31827-94-8, the application of this compound in the production field has become more and more popular.

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 628-77-3, name is 1,5-Diiodopentane, This compound has unique chemical properties. The synthetic route is as follows., Safety of 1,5-Diiodopentane

Example 19. (1 laS, 1 ia?S)-8,8-(pentane- 1 ,5-diylbis(oxy))bis(7-methoxy-2-methylene-23-dihydro- 1H-benzo[e]pyrrolo[ 1 ,2-aj [1 ,4jdiazepin-5( 11 aH)-one) (97) To a stirred suspended solution of Cs2CO3 (0.761 g, 2.33 mmol) in butanone (8 ml) were added (S)-8-hydroxy-7-methoxy-2-methyiene-2,3-dihydro- 1 H-benzo[e]pyrroio[ 1,2- aj[1,4jdiazepin-5(1 laH)-one (401 mg, 1.55 mmol) and 1,5-diiodopentane (240 mg, 0.740mmol). The mixture was stirred at RT overnight, concentrated, and purified on Si02 chromatography eluted with EtOAc/CH2C12 (1:10) to afford 337 rng (78% yield) of the title producL ElMS mlz 607.2 ([Mj+Na).

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 628-77-3.