Iodides-buliding-blocks

Adding a certain compound to certain chemical reactions, such as: 622-50-4, name is N-(4-Iodophenyl)acetamide, belongs to iodides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 622-50-4, Quality Control of N-(4-Iodophenyl)acetamide

General procedure: Under nitrogen atmosphere, Cu2O (10 mol %), DABCO (25 mol %), and a stirring bar were added into a 10 mL oven-dried sealed glass tube (as shown in Figure S1). Then NMP (0.5 mL), aryl iodides (0.125 mmol, 1.0 equiv.) and PhSiH3 (0.75 mmol, 6 equiv.) were injected by syringe. The tube was then sealed and CO2 (0.67 mmol, 5.4 equiv., 15 mL) as well as NH3 (0.67 mmol, 5.4 equiv., 15 mL) were injected by syringe after N2 was removed under vacuum. Finally, the mixture was stirred for 24 hr in a pre-heated-to-130 C alloyed block. After the reaction was finished, the tube was cooled to room temperature and the pressure was carefully released. The yield of were measured by GC analysis using dodecane as the internal standard or by flash chromatography on silica gel (petroleumether/ethyl acetate).

At the same time, in my other blogs, there are other synthetic methods of this type of compound, N-(4-Iodophenyl)acetamide, and friends who are interested can also refer to it.

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 444-29-1, name is 1-Iodo-2-(trifluoromethyl)benzene belongs to iodides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. Computed Properties of C7H4F3I

General procedure: General procedure: A 25 mL two-necked, round bottomed flask equipped with a water condenser, nitrogen gas inlet, Teflon coated magnetic stir bar, and a rubber septum port was charged with Pd(PPh3)4 (0.48 g, 3?5 molpercent), Cu(I)I (0.87 g, 4.6 mmol), and 10 mL of dry DMF. Next, 3-iodobenzotrifluorine (2.28 g, 8.30 mmol) was added to the solution via syringe. Then, 2 (3.93 g, 9.22 mmol) was slowly added to this solution by syringe. The reaction mixture was stirred 12 h at room temperature. To remove the ISnBu3-n, the reaction mixture was stirred with Cu(OAc)2 (3.36 g, 18.4 mmol) and 5 mL of extra DMF for 2 h. Alternately, dry KF (0.58 g, 9.9 mmol) was added to the reaction flask and the mixture was stirred overnight. The reaction mixture was then poured over water (25 mL) in a separatory funnel and extracted with ether (3× 25 mL). The combined ether layers were washed with water (2× 25 mL). The organic layer was dried over MgSO4, filtered, and the solvent was removed by rotary evaporation. The crude product was purified by silica gel column chromatography using hexanes as eluent to give 4 (2.90 g, 82percent isolated yield, Rf (hexanes) = 0.36, purity by GLPC analysis = 98percent): 19F NMR (CDCl3) ?63.4 ppm (s, 3F), ?143.3 ppm (dt, 1F, 3JFF = 122.6 Hz, 3JFH = 23.9 Hz), ?159.8 ppm (dt, 1F, 3JFF = 123.7 Hz, 4JFH = 4.6 Hz); 19F{H} NMR (CDCl3): ?63.4 ppm (s, 3F), ?143.3 ppm (d, 1F, 3JFF = 122.9 Hz), ?159.8 ppm (d, 1F, 3JFF = 123.4); 1H NMR (CDCl3): 7.9 ppm (s, 1H), 7.8 ppm (d, 1H, 3JHH = 7.9 Hz), 7.6 ppm (dd, 1H, 3JHH = 9.0 Hz, 3JHH = 7.8 Hz), 7.5 ppm (d, 1H, 3JHH = 7.7 Hz), 5.9 ppm (ddt, 1H, 3JHH = 17.0 Hz, 3JHH = 10.2 Hz, 3JHH = 6.4 Hz), 5.3 ppm (dm, 1H, 3JHH = 17.1 Hz), 5.2 ppm (dd, 1H, 3JHH = 10.1 Hz, 2JHH = 1.3 Hz), 3.3 ppm (ddddd, 2H, 3JHF = 23.3 Hz, 3JHH = 6.5 Hz, 4JHH = 5.3 Hz, 4JHH = 1.4 Hz, 4JHH = 1.3 Hz); 13C NMR (CDCl3): 151.51 ppm (dd, 1JCF = 251.6 Hz, 2JCF = 55.9 Hz), 146.00 ppm (dd, 1JCF = 225.2 Hz, 2JCF = 43.3 Hz), 131.11 ppm (qd, 2JCF = 32.0 Hz, 4JCF = 2.7 Hz), 130.96 ppm (dd, 3JCF = 1.9 Hz, 4JCF = 1.8 Hz), 130.64 ppm (dd, 2JCF = 25.8 Hz, 3JCF = 6.6 Hz), 129.03 ppm (d, 4JCF = 2.0 Hz), 128.35 ppm (ddm, 3JCF = 8.5 Hz, 4JCF = 1.4 Hz), 125.16 ppm (m), 124.04 ppm (q, 1JCF = 272.3 Hz), 122.11 ppm (m), 118.43 ppm (s), 32.13 ppm (d, 2JCF = 22.8 Hz); GC?MS, m/z (relative intensity): 248 (M+, 100.00), 213 (62.76), 201 (62.15), 179 (85.05), 177 (57.02) 164 (92.70), 159 (70.96), 151 (98.55); HRMS: C12H9F5 (calculated: 248.0624, observed: 248.0620).

The synthetic route of 444-29-1 has been constantly updated, and we look forward to future research findings.

Electric Literature of 64248-58-4, These common heterocyclic compound, 64248-58-4, name is 1,2-Difluoro-4-iodobenzene, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

In a 50- mL RB-flask was added [3- (4-HYDROXYPHENYL)] propionic acid (1.66 g, [10.] 0 mmol), 3,4-difluoroiodobenzene (2.40 g, 10.0 mmol), copper (I) bromide (0.100 g), potassium carbonate (2.76 g, 20.0 [MMOL),] and [N-METHYL-2-PYRROLIDONE] (20 [ML)] as solvent. The mixture was stirred for 5 min at room temperature and then heated to [140 C] (oil bath). After being stirred for 12 hours at [140 C,] the reaction mixture was cooled to room temperature and diluted with [ETOAC] (100 mL). The diluted mixture was washed with citric acid (aq, 30 mL), water (3 x 50 mL, brine and dried over [MGS04. THE] removal of solvent in vacuo afforded crude which was purified by chromatography (0.901 g, [32%)] : [1H] NMR (400 MHz, CDCl3) 8 11.44-11. 06 (br, 1H), 7.24-7. 14 (m, 2H), 7.14-7. 00 (m, [1H),] 7.00-6. 86 (m, 2H), 6.86-6. 75 (m, 1H), 6.75-6. 61 (m, 1H), 2.94 (t, 2H, J = 7.6 Hz), 2.68 (t, 2H, [J = 7.] 6 Hz); ESMS [M/E] : 277.2 (M-H+).

Statistics shows that 1,2-Difluoro-4-iodobenzene is playing an increasingly important role. we look forward to future research findings about 64248-58-4.

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 51628-12-7, name is 2-(4-Iodophenyl)acetonitrile, This compound has unique chemical properties. The synthetic route is as follows., COA of Formula: C8H6IN

General procedure: A stirred mixture of 4-iodophenylacetonitrile (35), arylboronic acid (36-45) (1.1 equiv), Pd(PPh3)4 (0.03 equiv), KBr (1.1 equiv), and K3PO4 (2.5 equiv) in dioxane (5 mL/mmol) was purged with N2 for10 min at room temperature and then stirred overnight at 85 C under N2. The mixture was diluted with water and extracted with AcOEt. The organic phase was washed three times with water, dried (Na2SO4), and evaporated under vacuum. The residue was chromatographedon silica gel.

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 51628-12-7.

Reference of 461-17-6,Some common heterocyclic compound, 461-17-6, name is 1,1,1-Trifluoro-4-iodobutane, molecular formula is C4H6F3I, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

l-(2,4-Dichlorophenyl)-5-(4-hydroxyphenyl)-4-methyl-lH-pyrazole-3-carboxylic acid piperidin-l-yl amide from 1, Step F (250 mg, 0.56 mmol) was dissolved in acetone (10 ml) and potassium carbonate (77 mg, 0.56 mmol) was added followed by l-iodo-4,4,4- trifluorobutane (140 mg, 0.56 mmol). The reaction mixture was boiled under reflux overnight, concentrated and purified by flash chromatography (hexane : EtOAc 70 : 30 – 60 : 40) afforded 130 mg (42%) of a white solid that was triturated with hexane : EtOAc 95 : 5 and filtered.1H NMR(CDCl3): 5 7.63 (IH, broad s), 7.43 (IH, m), 7.30 (2H, m), 7.10-7.00 (2H, m), 6.85-6.78 (2H, m), 4.05 (2H, t), 2.90 (4H, m), 2.40-2.19 (5H, s and m), 2.15-1.97 (2H, m), 1.78 (4H, m), 1.45 (2 H, m). MS m/z 577 (M+Na). HPLC: 98.4%

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 1,1,1-Trifluoro-4-iodobutane, its application will become more common.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 626-62-0, name is Iodocyclohexane, A new synthetic method of this compound is introduced below., Product Details of 626-62-0

General procedure: A mixture of alkyl/aryl halide, 1 (1.2 mmol), ammonium hydroxide (1 mmol) and nanosulfur powder (3 mmol, 96 mg) was stirred in 5mL of solvent (ethanol/water (2:1)) at 60 C. Under this stirring condition indium oxide nanoparticles (3 mol-%) were added to it and the reaction was stirred for a period of 10 min to 1 h at 60 C. After completion of the reaction as indicated by thin layer chromatography (TLC), the reaction mixture was cooled to room temperature and a 2:1 mixture of ethyl acetate/water (15 mL) was added and indium oxide was removed by centrifuge. The combined organic extracts were dried with anhydrous sodium sulfate and concentrated to give desired product in high purity.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

1878-69-9, name is 2-(3-Iodophenyl)acetic acid, belongs to iodides-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Computed Properties of C8H7IO2

To a solution of 3-iodorhohenylacetic acid (24.8 g, 94.6 mmol) in CH2Cl2 (200 mL) was added oxalyl chloride (189 mmol, 2 equiv), followed by a drop of DMF. The mixture was stirred at room temperature for Ih and then concentrated. Addition of ethanol and purification by flash chromatography (EtOAc/Hex) gave yellow oil as product. 1H NMR (600 MHz, CDCl3): delta = 7.63 (s, 1 H), 7.59 (d, 1 H), 7.25 (d, 1 H), 7.04 (t, 1 H), 4.16 (q, 2 H), 3.53 (s, 2 H), 1.25 (t, 3 H); LRMS: m+1 (291.0, 4.228 min.).

The synthetic route of 1878-69-9 has been constantly updated, and we look forward to future research findings.

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 51628-12-7, name is 2-(4-Iodophenyl)acetonitrile, This compound has unique chemical properties. The synthetic route is as follows., Computed Properties of C8H6IN

1L pressure kettle,121.5 g (0.5 mol) of p-iodophenylacetonitrile,800 g (2 mol) of 10% sodium hydroxide,10.9 g (0.075 mol) of 8-hydroxyquinoline,12.8g (0.075mol) after adding copper chloride, the kettle heated to 50 ~ 55 , to maintain The pressure of the reactor is 0MPaG, the temperature of the reaction system is kept between 50 and 55 DEG C, and the reaction is carried out for 7 hours. The reaction solution is finished and the reaction vessel is cooled. The pH of the reaction solution is adjusted to between 7 and 8 with 36% hydrochloric acid. The mother liquor was adjusted to pH with 30% NaOH13 ~ 14, get dark red transparent liquid, sodium p-hydroxyphenylacetate solution, weighing 755g, the detection of p-hydroxyphenylacetic acid content of 9.79%, the yield was 97.3%.

According to the analysis of related databases, 51628-12-7, the application of this compound in the production field has become more and more popular.

Application of 260355-20-2,Some common heterocyclic compound, 260355-20-2, name is 1-Chloro-4-iodo-2-(trifluoromethyl)benzene, molecular formula is C7H3ClF3I, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

The 1-chloro-4-iodo-2-trifluoromethylbenzene (10 mmol) obtained in the reaction 1.2 was dissolved in 20 ml of toluene, and the system was sequentially added with isoxazol-4-amine (12 mmol), palladium acetate ( 0.5 mmol), 2,2′-bis(diphenylphosphino)-1,1′-binaphthyl (12 mmol), 3 ml of triethylamine. After stirring for 10 minutes, add 10 ml of cesium carbonate (10 mmol). The aqueous solution is heated to 50 C for 4 hours. After the reaction is completed, 20 ml of water is added to the system, stirred for 20 minutes, and the organic phase is dried over anhydrous sodium sulfate, concentrated, and then purified by flash column chromatography.2.2 g of yellow N-(4-chloro-3-trifluoromethylphenyl)-isoxazole-4-amine powder was obtained in a yield of 84%.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 1-Chloro-4-iodo-2-(trifluoromethyl)benzene, its application will become more common.

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 2043-57-4 as follows. Recommanded Product: 1,1,1,2,2,3,3,4,4,5,5,6,6-Tridecafluoro-8-iodooctane

In the first step, a fluorinated phosphonium salt was synthesized by reacting TPP and 2-perfluorohexyl ethyl iodide accordinto literature procedures [38,39]. Briefly, the fluorinated phosphonium salt was prepared by reacting TPP and fluoroalkyl iodide at 95 C in the absence of solvent. The reaction was continued for 24 h until all of the mixture was solidified. After cooling the resulting solid was washed several times with toluene and ether respectively. Then the white solid was dried at 50 C under vacuum.

According to the analysis of related databases, 2043-57-4, the application of this compound in the production field has become more and more popular.