Iodides-buliding-blocks

Adding a certain compound to certain chemical reactions, such as: 886762-71-6, name is 1-Fluoro-3-iodo-2-nitrobenzene, belongs to iodides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 886762-71-6, Safety of 1-Fluoro-3-iodo-2-nitrobenzene

To a solution of 1-fluoro-3-iodo-2-nitrobenzene (228 mg, 0.854 mmol) in toluene (3 mL) was added potassium carbonate (177 mg, 1.28 mmol) and morpholine (1 mL). The mixture was heated at 85 C for 3 h. The cooled reaction mixture was evaporated and the residue partitioned between EtOAc and water. The aq. phase was extracted with more EtOAc, and the combined organic extracts were washed with water, then brine, dried (Na2SO4) and concentrated in vacuo to leave a residue. FCC (20-50% EtOAc in isohexane) gave the title compound as a light yellow solid (168 mg, 59%). M/z 335 (M+H).

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 1-Fluoro-3-iodo-2-nitrobenzene, and friends who are interested can also refer to it.

Reference of 10297-05-9,Some common heterocyclic compound, 10297-05-9, name is 1-Chloro-4-iodobutane, molecular formula is C4H8ClI, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

4-Chloro-1-(3-pyridyloxy)butane Under a nitrogen atmosphere, a solution of 3-hydroxypyridine (3.50 g, 36.8 mmol) in N, N-dimethylformamide (DMF) (10 mL) was added drop-wise over 5 min to a cold (0-5° C.), stirring slurry of sodium hydride (1.16 g of an 80percent dispersion in mineral oil, 38.6 mmol) in DMF (40 mL). The mixture was allowed to stir and warm to ambient temperature over 1 h. The mixture was then cooled to 0-5° C., and 1-chloro-4-iodobutane (9.67 g, 44.2 mmol) was added drop-wise over 5 min. The resulting dark-brown mixture was stirred at ambient temperature for 2 h. Water (25 mL) was added, followed by saturated NaCl solution (25 mL), and the mixture was extracted with ether (4*50 mL). The combined ether extracts were dried (Na2SO4), filtered, and concentrated by rotary evaporation to a residue that was dried briefly under high vacuum to give 6.89 g (quantitative yield) of an oil.

The synthetic route of 10297-05-9 has been constantly updated, and we look forward to future research findings.

3718-88-5, name is 3-Iodobenzylamine hydrochloride, belongs to iodides-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Recommanded Product: 3718-88-5

Example 2 Preparation of 2-Chloro-N6 -(3-Iodobenzyl)-9-Methyladenine (6) A solution of 2,6-dichloropurine (4, 2 g, 10.6 mmol), 3-iodobenzylamine hydrochloride (3.14 g, 11.6 mmol), and triethylamine (4.42 mL, 31.7 mmol) in ethanol (20 mL) was stirred for 5 days at room temperature. The resulting solid was filtered, washed with small amount of ethanol, and dried to give compound 5 (2.32 g, 57.0%). 1H NMR (DMSO-d6) delta 4.59 (br d, J=3.5 Hz, 2 H, CH2), 7.13 (pseudo t, J=8.2 and 7.5 Hz, 1 H, H-16), 7.36 (d, J=7.5 Hz, 1 H, H-17), 7.61 (d, J=7.5 Hz, 1 H, H-15), 7.74 (s, 1 H, H-13), 8.14 (s, 1 H, H-8), 8.75 (br s, 1 H, exchangeable with D2O, NH), 13.14 (br s, 1 H, exchangeable with D2O, N9 H). MS (CI NH3) m/z 386 (M+ +1).

The synthetic route of 3718-88-5 has been constantly updated, and we look forward to future research findings.

Application of 2974-94-9, These common heterocyclic compound, 2974-94-9, name is 1-Iodo-4-phenoxybenzene, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Example 2A 3-(4-phenoxyphenoxy)quinuclidine 3-Hydroxy quinuclidine (Aldrich, 254 mg, 2 mmol) was treated with 1-iodo-4-phenoxy-benzene (Aldrich, 296 mg, 1 mmol), Cul (Strem Chemicals, 19 mg, 0.1 mmol), 1,10-phenanthroline (Aldrich, 36 mg, 0.2 mmol), and Cs2CO3 (660 mg, 2.0 mmol) in toluene (anhydrous, Aldrich, 10 mL) and heated at 110 C. for two days. After cooling to room temperature, the reaction mixture was diluted with ethyl acetate (50 mL) and washed with water (2*10 mL). The organic phase was concentrated and the title compound was purified by chromatography (SiO2, CH2Cl2:MeOH:NH3H2O, 90:10:1, Rf. 0.20) as oil (220 mg, yield, 75%). 1H NMR (MeOH-d4, 300 MHz) delta 1.45-1.58 (m, 1H), 1.64-1.85 (m, 2H), 2.00-2.15 (m, 1H), 2.20-2.30 (m, 1H), 2.70-3.10 (m, 5H), 3.34-3.40 (m, 1H), 4.52 (m, 1H), 6.83-6.98 (m, 6H), 7.03 (tt, J=7.5, 1.0 Hz, 1H), 7.20-7.41 (m, 2H) ppm. MS (DCl/NH3) m/z 296 (M+H)+.

Statistics shows that 1-Iodo-4-phenoxybenzene is playing an increasingly important role. we look forward to future research findings about 2974-94-9.

Synthetic Route of 1271523-34-2, A common heterocyclic compound, 1271523-34-2, name is 1,5-Dichloro-2-iodo-3-methoxybenzene, molecular formula is C7H5Cl2IO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

To a solution of 11a (21.0g, 69.3mmol) in THF (250ml) was sequentially added Cul (1.32g, 6.9mmol) and NaH (60% dispersion in mineral oil, 4.2g, 104mmol), followed by a slow addition of pinacolborane (15.1ml, 104mmol). The resulting suspension was stirred at room temperature for 16 h under a N2 atmosphere, and then quenched with saturated NH4CI (250 ml). After 20 min, the mixture was extracted with EtOAc (x3), dried and then filtered over Celite. Concentrated and purification by column chromatography (Si02; EtOAc:PE 0: 1?3:7) to afford the title boronate as a white solid; (15. lg, 72%)NMR (CDC13) 6.87 (IH, d, J 1.6), 6.63 (IH, d, J 1.6), 3.37 (3H, s), 1.32 (12H, s);MS (m/e) No MI observed, Rt 1.17min (QC Method 2)

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Adding a certain compound to certain chemical reactions, such as: 16355-92-3, name is 1,10-Diiododecane, belongs to iodides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 16355-92-3, Formula: C10H20I2

2,15-hexadecanedione as an aliphatic diketone was synthesized. In a 2 L four-necked flask equipped with a thermometer, mixer and a reflux condenser, 260.3 g (2.0 mol) of ethyl acetoacetate and 500 ml of acetone were fed, stirred and mixed, 61.9 g (1.5 mol) of 97% sodium hydroxide was added and reacted for 15 minutes. Then 197.0 g (0.5 mol) of 1,10-diiododecane was added and the reaction was carried out under reflux for 6 hours. After completion of the reaction, acetone was distilled off by distillation under reduced pressure, neutralized by adding 2N hydrochloric acid, and separation was carried out. The upper layer organic layer was separated and 800 g (2.0 mol) of 10% sodium hydroxide aqueous solution was added and stirred at room temperature for 8 hours to carry out a saponification reaction, 205.8 g (1.1 mol) of 50% sulfuric acid was added, and the mixture was fully refluxed for 3 hours for decarboxylation reaction. After the decarboxylation reaction was completed, the upper organic layer was separated by phase separation and cooled to room temperature to obtain 130.8 g of a pale yellow crystal. A small amount of a part of the obtained crystal product was taken for gas chromatograph measurement. As a result of analyzing the composition of the separated crystals by gas chromatography, the conversion of 1,10-diiododecane was 100%, the purity of 2,15-hexadecanedione was 92%.The yield of 2,15-hexadecanedione based on 1,10-diiododecane was 95%

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 1,10-Diiododecane, and friends who are interested can also refer to it.

Synthetic Route of 443-85-6, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 443-85-6 name is 1-Fluoro-3-iodo-2-methylbenzene, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

To a flame dried RBF was added a solution of n-butyllithium (2.5M in hexanes; 3.01 ml, 7.51 mmol) and diethyl ether (15 ml). The solution was cooled to -78 C, and 2- fluoro-6-iodotoluene (0.981 ml, 7.51 mmol) was added dropwise and the reaction was stirred at -78 C for 10 minutes. A -78 C premixed solution of 4-(difluoromethyl)-2-oxa- 3-azabicyclo[3.1.0]hex-3-ene (1.00 g, 7.51 mmol) and boron trifluoride diethyl etherate (0.927 ml, 7.51 mmol) in toluene (10 ml) was added to the reaction via syringe. The reaction was stirred at -78 C for 10 minutes, quenched with saturated ammonium chloride and warmed to RT. The reaction was diluted with water and EtOAc. The organic layer was separated and concentrated under reduced pressure. The crude residue was purified via silica gel flash chromatography eluting with 0-20% ethyl acetate in hexanes to afford 4-(difluoromethyl)-4-(3-fluoro-2-methylphenyl)-2-oxa-3- azabicyclo[3.1.0]hexane (0.81 g, 3.33 mmol, 44.3 % yield). LC/MS (ESI+) m/z = 244.1 (M+H)

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 1-Fluoro-3-iodo-2-methylbenzene, and friends who are interested can also refer to it.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 628-21-7, name is 1,4-Diiodobutane, A new synthetic method of this compound is introduced below., COA of Formula: C4H8I2

A12 (50.0 mg, 244.82 mumol), 1,4-diiodobutane (48 muL, 367.23 mumol), potassium carbonate (50.8 mg, 367.23 mumol), and anhydrous N, N-dimethylformamide (3 mL) It was added to a 10 mL eggplan60t-shaped flask and stirred at 60 C for 4 hours. After the reaction was detected by TLC, it was filtered and the filtrate was concentrated. After recrystallization (petroleum ether / ethyl acetate, volume ratio of 1: 1), 60.0 mg of white solid was obtained with a yield of 95%. mp: 100-102 C;

The synthetic route of 628-21-7 has been constantly updated, and we look forward to future research findings.

Adding a certain compound to certain chemical reactions, such as: 25309-64-2, name is 1-Ethyl-4-iodobenzene, belongs to iodides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 25309-64-2, name: 1-Ethyl-4-iodobenzene

General procedure: A 100 mL Schlenk flask was charged with 2-bromopyridine (1.1 mmol), phenylacetylene (0.92 mmol), Cs2CO3 (1.84 mmol), 1-Pd (0.003 mmol based on Pd), DMF (6 mL) and the reaction mixture was stirred at 100 C under air atmosphere for 12 h. The mixture was cooled to the room temperature; the solid was removed by filtration and washed twice with DMF (3 mL). The filtrate was collected, dried and the residue was extracted with ethyl acetate (3 x 3 mL) followed by purification with silica gel chromatography (petroleum ether) to give a corresponding product.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1-Ethyl-4-iodobenzene, other downstream synthetic routes, hurry up and to see.

Electric Literature of 444-29-1, The chemical industry reduces the impact on the environment during synthesis 444-29-1, name is 1-Iodo-2-(trifluoromethyl)benzene, I believe this compound will play a more active role in future production and life.

General procedure: A 10 mL flask equipped with a Teflon valve was charged with a magnetic stir bar, CuI (2 mg, 1molpercent), Heteroarylamine (1.5 mmol), KOtBu (224 mg, 2.0 mmol), solid aryl halides (1.0 mmol). The tube was evacuated and backfilled with argon. Under a counter flow of argon, dioxane (1.5mL), aryl halides (1.0 mmol, if liquid) were added by syringe. The tube was sealed. The reaction mixture was allowed to stir at 110 °C (X=I) or 130 °C (X= Br) for 24 h. Then the mixture was cooled to room temperature and added 5.0 mL brine. Subsequently, the mixture was extracted with ethyl acetate. The organic layers were collected, dried over Na2SO4, filtered and the solvent was removed under vacuum. The residue was purified by column chromatography on silica gel.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1-Iodo-2-(trifluoromethyl)benzene, other downstream synthetic routes, hurry up and to see.