Iodides-buliding-blocks

A bright two-photon fluorescent probe for real-time monitoring autophagy in living cells was written by Jiang, Chuankun;Li, Longchun;Jiang, Jiacheng;Hou, Lilin;Fang, Gemin;Haizhu, Yu;Meng, Xiangming. And the article was included in Chinese Chemical Letters in 2020.Synthetic Route of C7H5IO2 This article mentions the following:

A novel donor-acceptor (D-A) type of two-photon (TP) fluorescent probe, i.e. Lyso-OSC, based on the lysosome-targeting morpholine group was developed. The polarity sensing coumarin group was functionalized as the acceptor and the 1-vinyl-4-methoxybenzene group was engineered as the donor. The fluorescence intensity and emission maximum wavelength of Lyso-OSC are highly sensitive to the polarity changes of solvent. The two-photon absorption cross-section and tissue penetration depth are up to 254 GM and 150μm, resp. The strong fluorescence, high sensitivity to polarity, low cytotoxicity, and accurate lysosome-targeting ability entail Lyso-OSC the excellent performance in detecting the polarity changes of cellular environment. To this end, a bright, real-time imaging autophagy of living cells has been achieved. In the experiment, the researchers used many compounds, for example, 4-Hydroxy-2-iodobenzaldehyde (cas: 90151-01-2Synthetic Route of C7H5IO2).

4-Hydroxy-2-iodobenzaldehyde (cas: 90151-01-2) belongs to iodide derivatives. Organic iodides can be alkyl, alkenyl, or alkynyl, and all of them are very reactive toward with many kinds of nucleophiles. The C–I bond is the weakest of the carbon–halogen bonds. These bond strengths correlate with the electronegativity of the halogen, decreasing in the order F > Cl > Br > I.Synthetic Route of C7H5IO2

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Palladium-catalyzed alkoxycarbonylation of unactivated secondary alkyl bromides at low pressure was written by Sargent, Brendon T.;Alexanian, Erik J.. And the article was included in Journal of the American Chemical Society in 2016.Product Details of 77350-52-8 This article mentions the following:

Catalytic carbonylations of organohalides are important C-C bond formations in chem. synthesis. Carbonylations of unactivated alkyl halides remain a challenge and currently require the use of alkyl iodides under harsh conditions and high pressures of CO. Herein we report a palladium-catalyzed alkoxycarbonylation of secondary alkyl bromides that proceeds at low pressure (2 atm CO) under mild conditions. Preliminary mechanistic studies are consistent with a hybrid organometallic-radical process. These reactions efficiently deliver esters from unactivated alkyl bromides across a diverse range of substrates and represent the first catalytic carbonylations of alkyl bromides with carbon monoxide. In the experiment, the researchers used many compounds, for example, N,N-Diethyl-4-iodobenzamide (cas: 77350-52-8Product Details of 77350-52-8).

N,N-Diethyl-4-iodobenzamide (cas: 77350-52-8) belongs to iodide derivatives. Iodide-containing intermediates are common in organic synthesis, because of the easy formation and cleavage of the C–I bond. The C–I bond is the weakest of the carbon–halogen bonds. These bond strengths correlate with the electronegativity of the halogen, decreasing in the order F > Cl > Br > I. This periodic order also follows the atomic radius of halogens and the length of the carbon-halogen bond.Product Details of 77350-52-8

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

A formal synthesis of crinipellin B based on the arene-alkane meta-photocycloaddition reaction was written by Wender, Paul A.;Dore, Timothy M.. And the article was included in Tetrahedron Letters in 1998.SDS of cas: 133232-56-1 This article mentions the following:

Starting from tri-Et phosphonopropionate and 3-nitro-2-methylbenzoic acid, a formal synthesis of crinipellin B was achieved. The strategy draws on the use of a novel version of the arene-alkene meta-photocycloaddition reaction that proceeds with the generation of 4 rings and 4 quaternary stereocenters in one synthetic operation. In the experiment, the researchers used many compounds, for example, 3-Iodo-2-methylbenzoic acid (cas: 133232-56-1SDS of cas: 133232-56-1).

3-Iodo-2-methylbenzoic acid (cas: 133232-56-1) belongs to iodide derivatives. Iodide-containing intermediates are common in organic synthesis, because of the easy formation and cleavage of the C–I bond. The C–I bond is the weakest of the carbon–halogen bonds. These bond strengths correlate with the electronegativity of the halogen, decreasing in the order F > Cl > Br > I. This periodic order also follows the atomic radius of halogens and the length of the carbon-halogen bond.SDS of cas: 133232-56-1

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Steroidal Wheel-and-Axle Host Type Molecules: Insights from Awkward Shape, Conformation, Z’ > 1 and Packing was written by Ramirez-Montes, Pedro I.;Ochoa, Maria E.;Santillan, Rosa;Ramirez, Daniel J.;Farfan, Norberto. And the article was included in Crystal Growth & Design in 2014.Safety of 1,2-Difluoro-3-iodobenzene This article mentions the following:

The synthesis and crystal structure of three new mol. rotors I,II,III , derived from levonorgestrel and norethisterone are reported. The conformation, close contacts, and shape characteristics of these mols. exhibiting Z’ = 2 and the inclusion of solvent mols. were analyzed together with the crystal structures of parent mols. retrieved from the Cambridge Structural Database. For the set of estranes studied, we confirmed that whenever an alternative conformer cannot satisfy the crystallog. symmetry, a second mol. is incorporated in the asym. unit resulting in conformational isomorphism (Z’ > 1). The shape of these mols. could make them interesting as potential hosts. In the experiment, the researchers used many compounds, for example, 1,2-Difluoro-3-iodobenzene (cas: 64248-57-3Safety of 1,2-Difluoro-3-iodobenzene).

1,2-Difluoro-3-iodobenzene (cas: 64248-57-3) belongs to iodide derivatives. Organic iodides are widely used in organic synthesis. Halogenation of aromatic hydrocarbons is a very important reaction via an electrophilic aromatic substitution. Alkyl iodides react at a faster rate than alkyl fluorides due to the weak C-I bond.Safety of 1,2-Difluoro-3-iodobenzene

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Substituent Effect on the Optoelectronic Properties of Alternating Fluorene-Cyclopentadithiophene Copolymers was written by Pal, Bikash;Yen, Wei-Che;Yang, Jye-Shane;Chao, Chi-Yang;Hung, Ying-Chieh;Lin, Shiang-Tai;Chuang, Chia-Hao;Chen, Chun-Wei;Su, Wei-Fang. And the article was included in Macromolecules (Washington, DC, United States) in 2008.COA of Formula: C9H4I2OS2 This article mentions the following:

A novel series of soluble alternating conjugated copolymers, comprised of 9,9-dihexylfluorene and cyclopentadithiophenes (P1-P5), were synthesized via Pd-catalyzed Suzuki coupling reaction in good yields. The UV-vis absorption spectra, fluorescence spectra, fluorescence quantum yields, and cyclic voltammograms of P1-P5 are also reported. The P2 and P3 with electron-donating non-π-substituents (ethylenedioxy and propylenedioxy bridges the 3,3-positions of the thiophene groups) display high fluorescence quantum yields and red-shifted absorption as compared with nonsubstituted P1. However, the P4 and P5 are weakly fluorescent and exhibit blue-shifted absorption which are due to the presence of electron-withdrawing π-substituents (carbonyl and dicyanoethenyl). The behavior of P4 and P5 can be attributed to the significant electronic coupling between the π-substituents and the conjugated polymer backbone that leads to a less allowed optical transition between the ground and the lowest excited state, resembling the meta conjugation effect in phenylene-derived conjugated π-systems. This argument is supported by MO distribution calculations In the experiment, the researchers used many compounds, for example, Bis(2-iodothiophen-3-yl)methanone (cas: 474416-61-0COA of Formula: C9H4I2OS2).

Bis(2-iodothiophen-3-yl)methanone (cas: 474416-61-0) belongs to iodide derivatives. Iodide-containing intermediates are common in organic synthesis, because of the easy formation and cleavage of the C–I bond. Polyiodoorganic compounds are sometimes employed as X-ray contrast agents, in fluoroscopy, a type of medical imaging. This application exploits the X-ray absorbing ability of the heavy iodine nucleus.COA of Formula: C9H4I2OS2

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Synthesis of benzimidazoles by CuI-catalyzed three-component reaction of 2-haloaniline, ammonia and aldehyde in water was written by Ke, Fang;Zhang, Peng;Lin, Chen;Lin, Xiaoyan;Xu, Jianhua;Zhou, Xiangge. And the article was included in Organic & Biomolecular Chemistry in 2018.Application of 220185-63-7 This article mentions the following:

An efficient copper-catalyzed three-component reaction of 2-haloaniline, ammonia and aldehyde for the synthesis of benzimidazoles I [R¹ = H, 5-Me, 5-Cl, 5-NO₂, 5,6-di-Cl, 5-Br; R² = i-Pr, Ph, 2-pyridyl, etc.] with 1,10-phenanthroline as the ligand was developed. In this copper catalytic system, a new reaction mechanism was developed and neat water was used as the solvent. A variety of substituted benzimidazole derivatives were obtained in yields up to 95% with diverse functional group tolerance. In the experiment, the researchers used many compounds, for example, 4,5-Dichloro-2-iodoaniline (cas: 220185-63-7Application of 220185-63-7).

4,5-Dichloro-2-iodoaniline (cas: 220185-63-7) belongs to iodide derivatives. Organic iodides are organic compounds containing a carbon-iodine (C-I) bond. The carbon-iodine bond is weaker than other carbon-halogen bonds due to the poor electronegative nature of the iodine atom. The C–I bond is the weakest of the carbon–halogen bonds. These bond strengths correlate with the electronegativity of the halogen, decreasing in the order F > Cl > Br > I. This periodic order also follows the atomic radius of halogens and the length of the carbon-halogen bond.Application of 220185-63-7

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

New Reagent for Highly Efficient Synthesis of Trifluoromethyl-Substituted Arenes and Heteroarenes was written by Zhang, Xiaomin;Wang, Jian;Wan, Zehong. And the article was included in Organic Letters in 2015.Recommanded Product: 4-Iodo-1,2-dimethoxybenzene This article mentions the following:

A new reagent trimethylsilyl chlorodifluoroacetate (TCDA) is reported for the introduction of a -CF₃ group to arenes and heteroarenes. Compared with current known reagents, TCDA shows very broad scope with respect to electron-deficient, -neutral, and -rich aryl/heteroaryl iodides as well as excellent functional group tolerance, including ester, amide, aldehyde, hydroxyl, and carboxylic acid. In the experiment, the researchers used many compounds, for example, 4-Iodo-1,2-dimethoxybenzene (cas: 5460-32-2Recommanded Product: 4-Iodo-1,2-dimethoxybenzene).

4-Iodo-1,2-dimethoxybenzene (cas: 5460-32-2) belongs to iodide derivatives. In general, organic iodides are light-sensitive and turn yellow during storage, owing to the formation of iodine. Iodo alkanes participate in a variety of organic synthesis reactions, which include the Simmons–Smith reaction (cyclopropanation using iodomethane), Williamson ether synthesis, Wittig reaction, Grignard reaction, alkyl coupling reactions, and Wurtz reaction.Recommanded Product: 4-Iodo-1,2-dimethoxybenzene

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Mechanochemically Generated Calcium-Based Heavy Grignard Reagents and Their Application to Carbon-Carbon Bond-Forming Reactions was written by Gao, Pan;Jiang, Julong;Maeda, Satoshi;Kubota, Koji;Ito, Hajime. And the article was included in Angewandte Chemie, International Edition in 2022.Computed Properties of C4H8ClI This article mentions the following:

Here, a mechanochem. technique using ball milling allows the generation of calcium-based heavy Grignard reagents from aryl halides and com. available calcium metal without complicated pre-activation processes was showed. Notably, all exptl. operations can be carried out in air. Our operationally simple protocol enables the rapid development of novel cross-electrophile-coupling reactions mediated by arylcalcium nucleophiles, which are rather difficult using conventional Grignard reagents. This method will allow synthetic chemists to readily access the novel and unique reactivity of organocalcium nucleophiles. In the experiment, the researchers used many compounds, for example, 1-Chloro-4-iodobutane (cas: 10297-05-9Computed Properties of C4H8ClI).

1-Chloro-4-iodobutane (cas: 10297-05-9) belongs to iodide derivatives. Generally organic iodides can be divided into two classes of alkyl iodides and aryl iodides. Typical reactions of alkyl iodides include nucleophilic substitution, elimination, reduction, and the formation of organometallics. Iodo alkanes participate in a variety of organic synthesis reactions, which include the Simmons–Smith reaction (cyclopropanation using iodomethane), Williamson ether synthesis, Wittig reaction, Grignard reaction, alkyl coupling reactions, and Wurtz reaction.Computed Properties of C4H8ClI

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Room temperature charge-transfer phosphorescence from organic donor-acceptor Co-crystals was written by Garain, Swadhin;Ansari, Shagufi Naz;Kongasseri, Anju Ajayan;Chandra Garain, Bidhan;Pati, Swapan K.;George, Subi J.. And the article was included in Chemical Science in 2022.COA of Formula: C10H12I2 This article mentions the following:

Engineering the electronic excited state manifolds of organic mols. can give rise to various functional outcomes, including ambient triplet harvesting, that has received prodigious attention in the recent past. Herein, we introduce a modular, non-covalent approach to bias the entire excited state landscape of an organic mol. using tunable ‘through-space charge-transfer’ interactions with appropriate donors. Although charge-transfer (CT) donor-acceptor complexes have been extensively explored as functional and supramol. motifs in the realm of soft organic materials, they could not imprint their potentiality in the field of luminescent materials, and it still remains as a challenge. Thus, in the present study, we investigate the modulation of the excited state emission characteristics of a simple pyromellitic diimide derivative on complexation with appropriate donor mols. of varying electronic characteristics to demonstrate the selective harvesting of emission from its locally excited (LE) and CT singlet and triplet states. Remarkably, co-crystallization of the pyromellitic diimide with heavy-atom substituted and electron-rich aromatic donors leads to an unprecedented ambient CT phosphorescence with impressive efficiency and notable lifetime. Further, gradual minimizing of the electron-donating strength of the donors from 1,4-diiodo-2,3,5,6-tetramethylbenzene (or 1,2-diiodo-3,4,5,6-tetramethylbenzene) to 1,2-diiodo-4,5-dimethylbenzene and 1-bromo-4-iodobenzene modulates the source of ambient phosphorescence emission from the ³CT excited state to ³LE excited state. Through comprehensive spectroscopic, theor. studies, and single-crystal analyses, we elucidate the unparalleled role of intermol. donor-acceptor interactions to toggle between the emissive excited states and stabilize the triplet excitons. We envisage that the present study will be able to provide new and innovative dimensions to the existing mol. designs employed for triplet harvesting. In the experiment, the researchers used many compounds, for example, 1,4-Diiodo-2,3,5,6-tetramethylbenzene (cas: 3268-21-1COA of Formula: C10H12I2).

1,4-Diiodo-2,3,5,6-tetramethylbenzene (cas: 3268-21-1) belongs to iodide derivatives. Organic iodides can be alkyl, alkenyl, or alkynyl, and all of them are very reactive toward with many kinds of nucleophiles. In the chemical industry, alkyl iodides serve as excellent alkylating agents and, specifically, methyl iodide is used as a methylating agent in the synthesis of various pharmaceutical drugs.COA of Formula: C10H12I2

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com