Iodides-buliding-blocks

Povie, Guillaume published the artcileRadical chain repair: The hydroalkylation of polysubstituted unactivated alkenes, COA of Formula: C5H9IO2, the publication is Science Advances (2018), 4(7), eaat6031, database is CAplus and MEDLINE.

The concept of repair is widely used by nature to heal mols. such as proteins, lipids, sugars, and DNA that are damaged by hydrogen atom abstraction resulting from oxidative stress. We show that this strategy, rather undocumented in the field of synthetic organic chem., can be used in a radical chain reaction to enable notoriously intractable transformations. By overcoming the radical chain inhibitor properties of substituted alkenes, the radical-mediated hydroalkylation of mono-, di-, tri-, and even tetrasubstituted unactivated olefins could be performed under mild conditions. With a remarkable functional group tolerance, this reaction provides a general coupling method for the derivatization of olefin-containing natural products.

Science Advances published new progress about 31253-08-4. 31253-08-4 belongs to iodides-buliding-blocks, auxiliary class Iodide,Ester, name is Ethyl 2-Iodopropionate, and the molecular formula is C5H9IO2, COA of Formula: C5H9IO2.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Huang, Qi published the artcileA Giese reaction for electron-rich alkenes, Recommanded Product: Ethyl 2-Iodopropionate, the publication is Chemical Science (2021), 12(6), 2225-2230, database is CAplus and MEDLINE.

A general method for the hydroalkylation of electron-rich terminal and non-terminal alkenes such as enol esters, alkenyl sulfides, enol ethers, silyl enol ethers, enamides and enecarbamates has been developed. The reactions are carried out at room temperature under air initiation in the presence of triethylborane acting as a chain transfer reagent and 4-tert-butylcatechol (TBC) as a source of hydrogen atom. The efficacy of the reaction is best explained by very favorable polar effects supporting the chain process and minimizing undesired polar reactions. The stereoselective hydroalkylation of chiral N-(alk-1-en-1-yl)oxazolidin-2-ones takes place with good to excellent diastereocontrol.

Chemical Science published new progress about 31253-08-4. 31253-08-4 belongs to iodides-buliding-blocks, auxiliary class Iodide,Ester, name is Ethyl 2-Iodopropionate, and the molecular formula is C5H9IO2, Recommanded Product: Ethyl 2-Iodopropionate.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Zhang, Guobing published the artcileSmall molecules based on strongly electron-deficient aza-isatinylidene malononitrile for solution-processed n-type field-effect transistors, Recommanded Product: 1-Iodohexane, the publication is Synthetic Metals (2022), 117071, database is CAplus.

In this paper, three donor-acceptor (D/A) small mols. (M1, M2, and M3) based on aza-isatinylidene malononitrile (AIMN) and diketopyrrolopyrrole (DPP) containing different N-alkyl chains in AIMN unit were synthesized and characterized for application in solution-processable organic field-effect transistors (OFETs). The D/A small mols. with strongly electron-withdrawing AIMN and DPP units exhibited broad absorption spectra, low bandgaps, and deep LUMO energy levels (< – 4.0 eV). Consequently, OFET devices displayed unipolar electron transport characteristics with the highest electron mobilities of 0.26, 0.22, and 0.0079 cm2V-1s-1 for M1, M2, and M3, resp. The small mols. with linear side chains showed much higher field-effect performances than that of branched side chains- based small mol., due to the strong π-π stacking and appropriate morphol. This work indicated that the strongly electron-deficient AIMN should be a potential unit for constructing the n-type solution-processable small mol. semiconductors.

Synthetic Metals published new progress about 638-45-9. 638-45-9 belongs to iodides-buliding-blocks, auxiliary class Iodide,Aliphatic hydrocarbon chain, name is 1-Iodohexane, and the molecular formula is C9H7F3O3, Recommanded Product: 1-Iodohexane.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Sun, Mingxiang published the artcileSmall molecule semiconductors based on hemi-isoindigo and diketopyrrolopyrrole for solution-processed organic field-effect transistors, Product Details of C6H13I, the publication is Synthetic Metals (2021), 116833, database is CAplus.

Two small semiconductor mols. based on diketopyrrolopyrrole (DPP) and hemi-isoindigo units with and without fluorination were designed and synthesized for investigating the solution-processed organic field-effect transistors (OFETs). Bottom-gate/top-contact (BG/TC) OFETs were fabricated to explore carrier transport characteristics. The combination of d. functional theory (DFT) calculation, grazing incidence X-ray diffraction (GIXD), and at. force microscopy (AFM) allowed us to understand the relationship between structures and properties. The results revealed the small mol. with fluorination (DPP-T-FMI) exhibited better field-effect performance owing to the improved crystal packing and morphol. of thin-films.

Synthetic Metals published new progress about 638-45-9. 638-45-9 belongs to iodides-buliding-blocks, auxiliary class Iodide,Aliphatic hydrocarbon chain, name is 1-Iodohexane, and the molecular formula is C6H8O4, Product Details of C6H13I.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Zhang, Guangyu published the artcileDiverse and chemoselective sigmatropic shift rearrangements of multisubstituted N,O-diarylhydroxylamines, COA of Formula: C7H3IN2O2, the publication is Organic & Biomolecular Chemistry (2022), 20(27), 5470-5480, database is CAplus and MEDLINE.

Possible N/O[1,3] sigmatropic shift rearrangements of multisubstituted N,O-diarylhydroxylamines were investigated exptl. with rationally designed substrates, which were generally in situ prepared from suitable nitroaryl halides and N-arylhydroxylamines via aromatic nucleophilic substitution. The results indicate that both N- and O-(2,4,6-trimethylphenyl)hydroxylamines still favor the [3,3] sigmatropic shift followed by tautomerization rather than N[1,3] and O[1,3] sigmatropic shifts and the rearranged products of N-(2,4,6-trimethylphenyl)hydroxylamines further undergo an intramol. nucleophilic addition to afford dibenzo[b,d]furan-4a(9bH)-amine derivatives I [R = H, NO₂; EWG = NO₂, CN], while N-(4-mono- and 3,5-disubstituted phenyl)-O-(2,4,6-trinitrophenyl)hydroxylamines favorably first undergo the O[1,3] sigmatropic shift followed by tandem Smiles rearrangement and amide/ester exchange reactions, generating 2-arylaminoaryl benzoate derivatives N-Phenyl-O-(2,4,6-trinitrophenyl)hydroxylamines undergo tandem double O[1,3] sigmatropic shift rearrangement to produce formal O[1,5] shift products. However, O-(2,6-dinitrophenyl)-N-(4-substituted phenyl)hydroxylamines undergo tandem O[1,3] and double [3,3] sigmatropic shift rearrangements to give formal 3,5-shift products. The proposed mechanism was rationalized by d. functional theory (DFT) calculations The current investigation provided not only a comprehensive understanding of the chemoselective sigmatropic shift rearrangements of N,O-diarylhydroxylamines, but also some novel synthetic strategies for dibenzo[b,d]furanamines, diarylamines, diaryl ethers, 2′-amino-[1,1′-biphenyl]-2(1H)-one, and 2′-amino-[1,1′-biaryl]-4-ol derivatives

Organic & Biomolecular Chemistry published new progress about 101420-79-5. 101420-79-5 belongs to iodides-buliding-blocks, auxiliary class Nitrile,Nitro Compound,Iodide,Benzene,Benzene Compounds, name is 4-Iodo-3-nitrobenzonitrile, and the molecular formula is C10H10O2, COA of Formula: C7H3IN2O2.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Ling, Mingjian published the artcileNIR-II emissive dye based polymer nanoparticle targeting EGFR for oral cancer theranostics, Related Products of iodides-buliding-blocks, the publication is Nano Research (2022), 15(7), 6288-6296, database is CAplus.

Oral cancer is a common malignant tumor of the head and neck, and surgery combined with radiotherapy and chemotherapy is the primary treatment modality. However, a pos. resection margin that may lead to recurrence after surgery has always been a critical issue to address. Furthermore, radiotherapy and chemotherapy also have shortcomings such as resistance to chemotherapy and radiation, lack of targeting, and severe side effects. Therefore, exploring new methods of tumor surgical navigation and tumor treatment is of great significance for oral cancer. Although, the emerging near-IR II (NIR-II, 1,000-1,700 nm) region fluorescent imaging has revolutionized surgical navigation, a high tumor-targeting fluorescent probe remains lacking. Furthermore, while emerging photothermal therapy (PTT) can overcome chemoradiotherapy’s shortcomings and achieve precise treatment of tumors, its clin. application is still limited by the lack of high photothermal conversion efficiency, high photothermal stability, and highly penetrating materials. Herein, a NIR-II dye SQ890 is developed for tumor imaging and PTT of oral cancer. By assembling into nanoparticles (NPs) and being modified with epithelial growth factor receptor (EGFR)-targeting peptides GE11, SQ890 NPs-Pep can specifically accumulate in tumor sites via active targeting, and realize photoacoustic/NIR-II fluorescence dual-modality imaging-guided PTT of oral cancer.

Nano Research published new progress about 638-45-9. 638-45-9 belongs to iodides-buliding-blocks, auxiliary class Iodide,Aliphatic hydrocarbon chain, name is 1-Iodohexane, and the molecular formula is C6H13I, Related Products of iodides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Tian, Minggang published the artcileDual-Emissive Probe for Reversible Visualization of ΔΨ_m Revealing Voltage Heterogeneity in a Single Mitochondrion, Synthetic Route of 638-45-9, the publication is Analytical Chemistry (Washington, DC, United States) (2021), 93(7), 3493-3501, database is CAplus and MEDLINE.

Mitochondrial membrane potential (ΔΨ_m) is a fundamentally important parameter in eukaryotic cells playing central roles in various vital biol. processes. Precise visualization of ΔΨ_m depends on the robust ratiometric fluorescent probes. In this work, a new dual-emissive fluorescent probe has been fabricated for ratiometric visualization of ΔΨ_m. The unique probe can form near-IR emissive aggregates (~670 nm) in mitochondria with high ΔΨ_m, which turned to green-emitting monomers (530 nm) with loss of ΔΨ_m. The reversible changes of ΔΨ_m can be clearly observed, and the ultralarge emission shift (~140 nm) is greatly favorable for the clear observation of voltage distribution under a super-resolution microscope. With the robust probe, the heterogenous voltage distribution in a single mitochondrion has been revealed for the first time, which can facilitate the in-depth understanding of fine structures in mitochondria. The cell damages induced by various reagents were successfully visualized using the innovative probe, demonstrating its pronounced potential for biol. research.

Analytical Chemistry (Washington, DC, United States) published new progress about 638-45-9. 638-45-9 belongs to iodides-buliding-blocks, auxiliary class Iodide,Aliphatic hydrocarbon chain, name is 1-Iodohexane, and the molecular formula is C10H9IO4, Synthetic Route of 638-45-9.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Zhou, Fang published the artcileA new red-emitting fluorescence probe for rapid and effective visualization of bisulfite in food samples and live animals, Application In Synthesis of 606-55-3, the publication is Journal of Agricultural and Food Chemistry (2019), 67(15), 4375-4383, database is CAplus and MEDLINE.

The development of new methods for rapid and effective detection of bisulfite (HSO₃^–) in food samples and imaging of HSO₃^– intake in animals is of significant importance due to the key roles of HSO₃^– in food quality assurance and community health. In this work, a new responsive fluorescence probe, EQC, is reported for the quant. detection of HSO₃^– in food samples and visualization of HSO₃^– intake in animals. Upon addition of HSO₃^–, the UV-vis absorption and red emission of EQC were significantly decreased within 120 s. The changes in absorption and emission spectra of EQC were rationalized by theor. computations. The proposed reaction mechanism of EQC with HSO₃^– was confirmed by high-resolution mass spectrometry (HRMS) and spectroscopic titration measurements. EQC has the advantages of high sensitivity, selectivity (a detection limit of 18.1 nM), and fast response toward HSO₃^–, which enable rapid and effective HSO₃^– detection in buffer solution The practical applications of EQC were demonstrated by the detection of HSO₃^– in food samples and the imaging of HSO₃^– intake in live animals.

Journal of Agricultural and Food Chemistry published new progress about 606-55-3. 606-55-3 belongs to iodides-buliding-blocks, auxiliary class Quinoline,Salt, name is 1-Ethyl-2-methylquinolin-1-ium iodide, and the molecular formula is C21H24O8, Application In Synthesis of 606-55-3.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Shigemitsu, Yasuhiro published the artcileSynthesis and electronic spectra of novel merocyanine dyes bearing a maleimide ring incorporated into the methine chains, Name: 1-Ethyl-2-methylquinolin-1-ium iodide, the publication is Dyes and Pigments (2003), 56(2), 167-179, database is CAplus.

The present article describes the synthesis of new polymethine dyes with a heterocyclic ring incorporated into the methine chain. 1-Alkyl-2- or 4-methylpyridinium salts and related compounds reacted at the exocyclic double bond with cyano- or methoxycarbonyl heterocycles bearing a methylthio group to give new polymethine dyes in good yield. This reaction occurred by an addition-elimination mechanism, involving nucleophilic attack of cyclic enamines at deficient carbon atoms on the heterocycles followed by elimination of MeSH. The polymethine dyes obtained are red, violet, and blue in color with absorption peaks at 524-614 nm. Semi-empirical as well as ab-initio quantum chem. calculations were used to theor. characterize their π-π absorption maxima in the visible region which plays a decisive role in their color appearances.

Dyes and Pigments published new progress about 606-55-3. 606-55-3 belongs to iodides-buliding-blocks, auxiliary class Quinoline,Salt, name is 1-Ethyl-2-methylquinolin-1-ium iodide, and the molecular formula is C13H10O3, Name: 1-Ethyl-2-methylquinolin-1-ium iodide.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Sivakumar, Ganesan published the artcileSingle-Molecular Mn(I)-Complex-Catalyzed Tandem DoubleDehydrogenative Cross-Coupling of (Amino)Alcohols under Solventless Conditions with the Liberation of H₂ and H₂O, Recommanded Product: (2-Amino-5-iodophenyl)methanol, the publication is ACS Sustainable Chemistry & Engineering (2022), 10(22), 7362-7373, database is CAplus.

Sustainable chem. production requires fundamentally new types of catalysts and catalytic technologies. The development of coherent and robust catalytic systems based on earth-abundant transition metals is essential but extremely challenging. Herein, authors report the first report on a single Mn(I)-PNP catalyzed tandem C-C and C-N bond formation via double dehydrogenative coupling of amino alcs. with primary alcs. The current method covers a wide range of substrates, including aryl, aliphatic acyclic, and cyclic primary alcs., as well as amino alcs., to provide diverse N-heterocyclic compounds (pyridine and quinoline derivatives) in good to excellent yields (50 examples). The reaction proceeds under benign, solventless conditions with the liberation of mol. hydrogen and water as the only byproducts. Various control and labeling experiments and kinetic, NMR, and mechanistic studies suggest that the reaction operates via the acceptorless double dehydrogenative coupling pathway, selectively assimilating to provide desired N-heterocycles. Several selective bond activation/formation reactions occur sequentially via amine-amide metal-ligand cooperation.

ACS Sustainable Chemistry & Engineering published new progress about 53279-83-7. 53279-83-7 belongs to iodides-buliding-blocks, auxiliary class Iodide,Amine,Benzene,Alcohol, name is (2-Amino-5-iodophenyl)methanol, and the molecular formula is C8H7ClO3, Recommanded Product: (2-Amino-5-iodophenyl)methanol.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com