Iodides-buliding-blocks

Koraiem, A. I. M. published the artcileStudies on the synthesis and spectral behaviour of polyfunctional heterocycle cyanine dyes, Computed Properties of 606-55-3, the publication is Aswan Science & Technology Bulletin (2002), 22-35, database is CAplus.

Unsym. (sym.) incorporated cyano pyrazolo (pyrazolium) (4,5-d)oxazine (quinoxaline) 6[2(4)] or 3[4(1)] mono- and bis-3,6[4(2)] monomethine and/or substituted cyano pyrazolo(4,5-d)oxazine [quinoxaline-6-imine (one)]-N-bridgehead heterocyclic zero methine cyanine dyes were prepared The new synthesized cyanines were established by elemental and spectral anal. The spectral behavior in the visible absorption region was discussed on the basis of color – structure relationships.

Aswan Science & Technology Bulletin published new progress about 606-55-3. 606-55-3 belongs to iodides-buliding-blocks, auxiliary class Quinoline,Salt, name is 1-Ethyl-2-methylquinolin-1-ium iodide, and the molecular formula is C12H14IN, Computed Properties of 606-55-3.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Butler, Jeffrey D. published the artcileA Facile Synthesis of New 5H-Indazolo[3,2-b]benzo[d]-1,3-oxazines via One-Pot Intramolecular Bis-heterocyclizations, Safety of (2-Amino-5-iodophenyl)methanol, the publication is Journal of Organic Chemistry (2008), 73(1), 234-240, database is CAplus and MEDLINE.

The parent 5H-indazolo[3,2-b]benzo[d]-1,3-oxazine heterocycle (I) as well as a series of novel analogs have been synthesized utilizing two subsequent intramol. heterocyclizations in one pot. A variety of diversity groups were added to explore the scope of this reaction and to provide a number of new compounds for biol. screening (no data).

Journal of Organic Chemistry published new progress about 53279-83-7. 53279-83-7 belongs to iodides-buliding-blocks, auxiliary class Iodide,Amine,Benzene,Alcohol, name is (2-Amino-5-iodophenyl)methanol, and the molecular formula is C7H8INO, Safety of (2-Amino-5-iodophenyl)methanol.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Zubenko, Alexander A. published the artcileSystems with annulated thioxo azepinone moiety: an access through heterocyclic carbodithioate ring expansion, Application of 1-Iodohexane, the publication is Mendeleev Communications (2021), 31(4), 545-547, database is CAplus.

New 1-oxo-2-thioxo-1,2,4,5-tetrahydrobenz[d]azepines I [R¹ = H, MeO; R² = H, OH, OMe; R³ = Me, Et, n-Bu, n-hexyl, PhO(CH₂)₂] and 1-oxo-2-thioxo-1,2,4,5-tetrahydroazepino[4,5-b]indole were conveniently obtained by the novel recyclization reaction of (methylthio)carbonothioylsubstituted heterocyclic quaternary salts with expansion of the dihydropyridine ring.

Mendeleev Communications published new progress about 638-45-9. 638-45-9 belongs to iodides-buliding-blocks, auxiliary class Iodide,Aliphatic hydrocarbon chain, name is 1-Iodohexane, and the molecular formula is C7H10O4, Application of 1-Iodohexane.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Manhas, Neha published the artcileCytotoxicity and Antibacterial Evaluation of O-Alkylated/Acylated Quinazolin-4-one Schiff Bases, Application of 1-Iodohexane, the publication is Chemistry & Biodiversity (2021), 18(5), e2100096, database is CAplus and MEDLINE.

A series of quinazolin-4-one Schiff bases were synthesized and tested in vitro for their cytotoxicity against two cancerous cell lines (MCF-7, Caco-2) and a human embryonic cell line (HEK-293) including their antibacterial evaluation against two Gram-pos. and four Gram-neg. bacterial strains. Most of the quinazoline-Schiff bases exhibited potent cytotoxicity against Caco-2. 3-[(Z)-({4-[(But-2-yn-1-yl)oxy]phenyl}methylidene)amino]-2-methylquinazolin-4(3H)-one (6f) with the O-butyne functional group displayed three-fold higher cytotoxic activity (IC50=376.8μM) as compared to 5-fluorouracil (5-FU; IC50=1086.1μM). However, all compounds were found to be toxic to HEK-293, except for 3-[(Z)-({4-[(2,4-difluorophenyl)methoxy]phenyl}methylidene)amino]-2-methylquinazolin-4(3H)-one (6h) that showed ∼three-fold lower toxicity and higher selectivity index than 5-FU. Structure-activity relationship (SAR) anal. revealed that O-alkylation generally increased the anticancer activity and selectivity of quinazoline-4-one Schiff bases toward Caco-2 cells. The fluorinated Schiff-base generally exhibited even more significant cytotoxic activity compared to their chlorine analogs. Surprisingly, none of the quinazoline-4-one Schiff bases displayed encouraging antibacterial activity against the bacterial strains investigated. Most of the compounds were predicted to show compliance with the Lipinski parameters and ADMET profiles, indicating their drug-like properties.

Chemistry & Biodiversity published new progress about 638-45-9. 638-45-9 belongs to iodides-buliding-blocks, auxiliary class Iodide,Aliphatic hydrocarbon chain, name is 1-Iodohexane, and the molecular formula is C6H13I, Application of 1-Iodohexane.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Loiseau, Francois published the artcileRadical Couplings as Key Steps for the Preparation of Derivatives of Nonactic Acid, Application In Synthesis of 31253-08-4, the publication is Monatshefte fuer Chemie (2007), 138(2), 121-129, database is CAplus.

Free radical couplings from furan, as cheap starting material, were studied in view of developing a rapid strategy en route to the synthesis of derivatives of nonactin. The chain containing the alc. function was introduced in one or two steps in 86% yield. For the introduction of the second chain with the ester function two different coupling methods were tested. Starting from the advanced intermediates obtained by this method, nonactin analogs, such s I (R = CMe₃, CH₂Me), were prepared by catalytic hydrogenation of the furan ring.

Monatshefte fuer Chemie published new progress about 31253-08-4. 31253-08-4 belongs to iodides-buliding-blocks, auxiliary class Iodide,Ester, name is Ethyl 2-Iodopropionate, and the molecular formula is C5H9IO2, Application In Synthesis of 31253-08-4.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Bombaca, Ana Cristina S. published the artcileNovel N,N-di-alkylnaphthoimidazolium derivative of β-lapachone impaired Trypanosoma cruzi mitochondrial electron transport system, Name: 1-Iodohexane, the publication is Biomedicine & Pharmacotherapy (2021), 111186, database is CAplus and MEDLINE.

The current treatments are based on benznidazole and nifurtimox; however, these drugs have important limitations and limited efficacy during the chronic phase, reinforcing the necessity of an alternative chemotherapy. Here, we show the synthesis of a novel β-lapachone-derived naphthoimidazolium named N4 and assess its activity on T. cruzi stages and the mechanism of action. The new compound was very active on all parasite stages (IC50/24 h in the range of 0.8-7.9 μM) and had a selectivity index of 5.4. Mechanistic analyses reveal that mitochondrial ROS production begins after short treatment starts and primarily affects the activity of complexes II-III. After 24 h treatment, a partial restoration of mitochondrial physiol. (normal complexes II-III and IV activities and controlled H2O2 release) was observed; however, an extensive injury in its morphol. was still detected. During treatment with N4, we also observed that trypanothione reductase activity increased in a time-dependent manner and concomitant with increased oxidative stress. Mol. docking calculations indicated the ubiquinone binding site of succinate dehydrogenase as an important interaction point with N4, as with the FMN binding site of dihydroorotate dehydrogenase. The results presented here may be a good starting point for the development of alternative treatments for Chagas disease and for understanding the mechanism of naphthoimidazoles in T. cruzi.

Biomedicine & Pharmacotherapy published new progress about 638-45-9. 638-45-9 belongs to iodides-buliding-blocks, auxiliary class Iodide,Aliphatic hydrocarbon chain, name is 1-Iodohexane, and the molecular formula is C6H13I, Name: 1-Iodohexane.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Majumdar, K. C. published the artcileThe synthesis and optical properties of novel triphenylamine containing 1,3,4-oxadiazole derivatives, Safety of 4-Iodobenzohydrazide, the publication is Journal of Luminescence (2013), 321-327, database is CAplus.

Sym. 4,4′,4”-trisubstituted triphenylamine derivatives containing 1,3,4-oxadiazole moiety bearing long aliphatic chains have been synthesized by employing convenient and simple synthetic protocols. The structures of these target mols. were established by their anal. and spectral data. They exhibit good fluorescence properties with high quantum yield and show very efficient fluorescence quenching in presence of p-nitrotoluene.

Journal of Luminescence published new progress about 39115-95-2. 39115-95-2 belongs to iodides-buliding-blocks, auxiliary class Iodide,Hydrazine,Amine,Benzene,Hydrazide,Amide, name is 4-Iodobenzohydrazide, and the molecular formula is C7H7IN2O, Safety of 4-Iodobenzohydrazide.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Schweez, Christopher published the artcileSynthesis and Dynamics of Nanosized Phenylene-Ethynylene-Butadiynylene Rotaxanes and the Role of Shape Persistence, Application In Synthesis of 165534-79-2, the publication is Angewandte Chemie, International Edition (2016), 55(10), 3328-3333, database is CAplus and MEDLINE.

Phenylacetylene-based [2]rotaxanes were synthesized by a covalent-template approach by aminolysis of the corresponding prerotaxanes. The wheel and the bulky stoppers are made of phenylene-ethynylene-butadiynylene macrocycles of the same size. The stoppers are large enough to enable the synthesis and purification of the rotaxane. However, the wheel unthreads from the axle at elevated temperatures The deslipping kinetics and the activation parameters were determined We described theor. the unthreading by state-of-the-art DFT-based mol.-mechanics models and a string method for the simulation of rare events. This approach enabled us to characterize in detail the unthreading mechanism, which involves the folding of the stopper during its passage through the wheel opening, a process that defies intuitive geometrical considerations. The conformational and energetic features of the transition allowed us to infer the mol. residues controlling the disassembly timescale.

Angewandte Chemie, International Edition published new progress about 165534-79-2. 165534-79-2 belongs to iodides-buliding-blocks, auxiliary class Iodide,Benzene,Ester, name is Dimethyl 2-iodoterephthalate, and the molecular formula is C12H13NO3, Application In Synthesis of 165534-79-2.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

de Azevedo, Ricardo A. published the artcileMIF inhibition as a strategy for overcoming resistance to immune checkpoint blockade therapy in melanoma, Recommanded Product: 4-Iodo-6-phenylpyrimidine, the publication is OncoImmunology (2020), 9(1), 1846915/1, database is CAplus and MEDLINE.

Immune checkpoint blockade (ICB) has demonstrated an impressive outcome in patients with metastatic melanoma, yet, durable complete response; even with Ipilimumab/Nivolumab combo are under 30%. Primary and acquired resistance in response to ICB is commonly due to a tumor immune escape mechanism dictated by the tumor microenvironment (TME). Macrophage Migratory Inhibition Factor (MIF) has emerged as an immunosuppressive factor secreted in the TME. We have previously demonstrated that blockade of the MIF-CD74 signaling on macrophages and dendritic cells restored the anti-tumor immune response against melanoma. Here, we report that inhibition of the MIF-CD74 axis combined with ipilimumab could render resistant melanoma to better respond to anti-CTLA-4 treatment. We provide evidence that blocking the MIF-CD74 signaling potentiates CD8+ T-cells infiltration and drives pro-inflammatory M1 conversion of macrophages in the TME. Furthermore, MIF inhibition resulted in reprogramming the metabolic pathway by reducing lactate production, HIF-1αand PD-L1 expression in the resistant melanoma cells. Melanoma patient data extracted from the TCGA database supports the hypothesis that high MIF expression strongly correlates with poor response to ICB therapy. Our findings provide a rationale for combining anti-CTLA-4 with MIF inhibitors as a potential strategy to overcome resistance to ICB therapy in melanoma, turning a “cold” tumor into a “hot” one mediated by the activation of innate immunity and reprogramming of tumor metabolism and reduced PD-L1 expression in melanoma cells.

OncoImmunology published new progress about 41270-96-6. 41270-96-6 belongs to iodides-buliding-blocks, auxiliary class Pyrimidine,Iodide,Benzene,Immunology/Inflammation,MIF, name is 4-Iodo-6-phenylpyrimidine, and the molecular formula is C10H7IN2, Recommanded Product: 4-Iodo-6-phenylpyrimidine.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Nugent, Jeremy published the artcileSynthesis of All-Carbon Disubstituted Bicyclo[1.1.1]pentanes by Iron-Catalyzed Kumada Cross-Coupling, Category: iodides-buliding-blocks, the publication is Angewandte Chemie, International Edition (2020), 59(29), 11866-11870, database is CAplus and MEDLINE.

1,3-Disubstituted bicyclo[1.1.1]pentanes (BCPs) are important motifs in drug design as surrogates for p-substituted arenes and alkynes. Access to all-carbon disubstituted BCPs via cross-coupling has to date been limited to use of the BCP as the organometallic component, which restricts scope due to the harsh conditions typically required for the synthesis of metalated BCPs. Here the authors report a general method to access 1,3-C-disubstituted BCPs from 1-iodo-bicyclo[1.1.1]pentanes (iodo-BCPs) by direct iron-catalyzed cross-coupling with aryl and heteroaryl Grignard reagents. This chem. represents the first general use of iodo-BCPs as electrophiles in cross-coupling, and the first Kumada coupling of tertiary iodides. Benefiting from short reaction times, mild conditions, and broad scope of the coupling partners, it enables the synthesis of a wide range of 1,3-C-disubstituted BCPs including various drug analogs.

Angewandte Chemie, International Edition published new progress about 31253-08-4. 31253-08-4 belongs to iodides-buliding-blocks, auxiliary class Iodide,Ester, name is Ethyl 2-Iodopropionate, and the molecular formula is C5H9IO2, Category: iodides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com