Iodides-buliding-blocks

Iodothyronine Deiodinase Mimics. Deiodination of o,o’-Diiodophenols by Selenium and Tellurium Reagents was written by Vasil’ev, Andrei A.;Engman, Lars. And the article was included in Journal of Organic Chemistry in 1998.SDS of cas: 207115-22-8 This article mentions the following:

To better understand, and in the extension mimic, the action of the three selenium-containing iodothyronine deiodinases, o,o’-diiodophenols were reacted under acidic conditions with sodium hydrogen telluride, benzenetellurol, sodium hydrogen selenide, or benzeneselenol and under basic conditions with the corresponding deprotonated reagents. Sodium hydrogen telluride was found to selectively remove one iodine from a variety of 4-substituted o,o’-diiodophenols, including a protected form of thyroxine. Thus, it mimics the D1 variety of the iodothyronine deiodinases. Sodium telluride was a more reactive deiodinating agent toward o,o’-diiodophenols, often causing removal of both halogens. Benzenetellurol and sodium benzenetellurolate sometimes showed useful selectivity for monodeiodination. However, the products were often contaminated by small amounts of organotellurium compounds Sodium hydrogen selenide, sodium selenide, benzeneselenol, and sodium benzeneselenolate were essentially unreactive toward o,o’-diiodophenols. In the experiment, the researchers used many compounds, for example, 4-Bromo-2-iodophenol (cas: 207115-22-8SDS of cas: 207115-22-8).

4-Bromo-2-iodophenol (cas: 207115-22-8) belongs to iodide derivatives. Generally organic iodides can be divided into two classes of alkyl iodides and aryl iodides. Typical reactions of alkyl iodides include nucleophilic substitution, elimination, reduction, and the formation of organometallics. The C–I bond is the weakest of the carbon–halogen bonds. These bond strengths correlate with the electronegativity of the halogen, decreasing in the order F > Cl > Br > I.SDS of cas: 207115-22-8

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

ortho-Metalation of Unprotected 3-Bromo and 3-Chlorobenzoic Acids with Hindered Lithium Dialkylamides was written by Gohier, Frederic;Mortier, Jacques. And the article was included in Journal of Organic Chemistry in 2003.Recommanded Product: 503821-94-1 This article mentions the following:

Upon treatment of 3-chloro/bromobenzoic acids with hindered lithium dialkylamides (LDA or LTMP) at -50 °C, lithium 3-chloro/bromo-2-lithiobenzoates are generated. These dianions can be trapped as such to afford after electrophilic quenching a variety of simple 2-substituted-3-chloro/bromobenzoic acids. The 3-bromo-2-lithiobenzoate is less stable than the 3-chloro analog and partly eliminates lithium bromide, thus setting free lithium 2,3- and 3,4-dehydrobenzoates that can be intercepted in situ with the hindered base. In the experiment, the researchers used many compounds, for example, 3-Bromo-2-iodobenzoic acid (cas: 503821-94-1Recommanded Product: 503821-94-1).

3-Bromo-2-iodobenzoic acid (cas: 503821-94-1) belongs to iodide derivatives. Organic iodides are widely used in organic synthesis. Halogenation of aromatic hydrocarbons is a very important reaction via an electrophilic aromatic substitution. In the chemical industry, alkyl iodides serve as excellent alkylating agents and, specifically, methyl iodide is used as a methylating agent in the synthesis of various pharmaceutical drugs.Recommanded Product: 503821-94-1

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Oxidation of Non-Activated Anilines to Generate N-Aryl Nitrenoids was written by Deng, Tianning;Mazumdar, Wrickban;Ford, Russell L.;Jana, Navendu;Izar, Ragda;Wink, Donald J.;Driver, Tom G.. And the article was included in Journal of the American Chemical Society in 2020.Quality Control of 4-Chloro-2-iodo-1-nitrobenzene This article mentions the following:

A low temperature, protecting group-free oxidation of 2-substituted anilines was developed to generate an electrophilic N-aryl nitrenoid intermediate that can engage in C-NAr bond formation to constructed functionalized N-heterocycles. Exposure of 2-substituted anilines to PIFA and trifluoroacetic acid or 10 mol % of Sc(OTf)₃ triggers nitrenoid formation, followed by productive and selective C-NAr and C-C bond formation to yield spirocyclic- or bicyclic 3H-indoles or benzazepinones. Our experiments demonstrated the breadth of these oxidative processes, uncover underlying fundamental elements that control selectivity and demonstrate how the distinct reactivity patterns embedded in N-aryl nitrenoid reactive intermediates can enable access to functionalized 3H-indoles or benzazepinones. In the experiment, the researchers used many compounds, for example, 4-Chloro-2-iodo-1-nitrobenzene (cas: 160938-18-1Quality Control of 4-Chloro-2-iodo-1-nitrobenzene).

4-Chloro-2-iodo-1-nitrobenzene (cas: 160938-18-1) belongs to iodide derivatives. Iodide-containing intermediates are common in organic synthesis, because of the easy formation and cleavage of the C–I bond. Alkyl iodides react at a faster rate than alkyl fluorides due to the weak C-I bond.Quality Control of 4-Chloro-2-iodo-1-nitrobenzene

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

A General Approach to Optically Pure [5]-, [6]-, and [7]Heterohelicenes was written by Zadny, Jaroslav;Jancarik, Andrej;Andronova, Angelina;Samal, Michal;Vacek Chocholousova, Jana;Vacek, Jaroslav;Pohl, Radek;Saman, David;Cisarova, Ivana;Stara, Irena G.;Stary, Ivo. And the article was included in Angewandte Chemie, International Edition in 2012.COA of Formula: C6H4BrIO This article mentions the following:

A general method for the preparation of optically pure [5]-, [6]-, and [7]heterohelicenes is based on a Co^I– or Ni⁰-catalyzed diastereoselective [2+2+2] cycloisomerization of centrally chiral triynes to deliver helicenes containing two 2H-pyran rings. The configuration, which can be predicted, does not depend on helicene length or functional groups present. In the experiment, the researchers used many compounds, for example, 4-Bromo-2-iodophenol (cas: 207115-22-8COA of Formula: C6H4BrIO).

4-Bromo-2-iodophenol (cas: 207115-22-8) belongs to iodide derivatives. Organic iodides can be alkyl, alkenyl, or alkynyl, and all of them are very reactive toward with many kinds of nucleophiles. Polyiodoorganic compounds are sometimes employed as X-ray contrast agents, in fluoroscopy, a type of medical imaging. This application exploits the X-ray absorbing ability of the heavy iodine nucleus.COA of Formula: C6H4BrIO

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Molybdenum-Mediated Carbonylation of Aryl Halides with Nucleophiles Using Microwave Irradiation was written by Roberts, Bryan;Liptrot, David;Alcaraz, Lilian;Luker, Tim;Stocks, Michael J.. And the article was included in Organic Letters in 2010.SDS of cas: 77350-52-8 This article mentions the following:

A new, efficient, and practical molybdenum-mediated carbonylation of aryl and heteroaryl halides with a variety of nucleophiles is described using microwave irradiation A range of reactions illustrating the wide scope of this chem. were carried out and proceeded in good to excellent yields. In the experiment, the researchers used many compounds, for example, N,N-Diethyl-4-iodobenzamide (cas: 77350-52-8SDS of cas: 77350-52-8).

N,N-Diethyl-4-iodobenzamide (cas: 77350-52-8) belongs to iodide derivatives. Organic iodides are widely used in organic synthesis. Halogenation of aromatic hydrocarbons is a very important reaction via an electrophilic aromatic substitution. The C–I bond is the weakest of the carbon–halogen bonds. These bond strengths correlate with the electronegativity of the halogen, decreasing in the order F > Cl > Br > I.SDS of cas: 77350-52-8

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Evolution of N-Heterocycle-Substituted Iodoarenes (NHIAs) to Efficient Organocatalysts in Iodine(I/III)-Mediated Oxidative Transformations was written by Boelke, Andreas;Nachtsheim, Boris J.. And the article was included in Advanced Synthesis & Catalysis in 2020.Electric Literature of C7H4ClIO2 This article mentions the following:

The reactivity of ortho-functionalized N-heterocycle-substituted iodoarenes (NHIAs) as organocatalysts in iodine(I/III)-mediated oxidations was systematically investigated in the α-tosyloxylation of ketones as the model reaction. During a systematic catalyst evolution, it was found that NH-triazoles and benzoxazoles have the most significant pos. influence on the reactivity of the central iodine atom. A further catalyst improvement which focused on the substitution pattern of the arene revealed a remarkable ortho-effect. By introduction of an o-OMe group we were able to generate a novel NHIA with a so far unseen catalytic efficiency. This new catalyst is not only easy to synthesize but also enabled the α-tosyloxylation of carbonyl compounds at the lowest reported catalyst loading of only 1 mol%. Finally, the performance of this iodine(I) catalyst was successfully demonstrated in intramol. oxidative couplings of biphenyls and oxidative rearrangements. In the experiment, the researchers used many compounds, for example, 3-Chloro-2-iodobenzoic acid (cas: 123278-03-5Electric Literature of C7H4ClIO2).

3-Chloro-2-iodobenzoic acid (cas: 123278-03-5) belongs to iodide derivatives. Iodide-containing intermediates are common in organic synthesis, because of the easy formation and cleavage of the C–I bond. In the chemical industry, alkyl iodides serve as excellent alkylating agents and, specifically, methyl iodide is used as a methylating agent in the synthesis of various pharmaceutical drugs.Electric Literature of C7H4ClIO2

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Catalytic, Diastereoselective 1,2-Difluorination of Alkenes was written by Banik, Steven M.;Medley, Jonathan William;Jacobsen, Eric N.. And the article was included in Journal of the American Chemical Society in 2016.Recommanded Product: 338454-02-7 This article mentions the following:

We describe a direct, catalytic approach to the 1,2-difluorination of alkenes. The method utilizes a nucleophilic fluoride source and an oxidant in conjunction with an aryl iodide catalyst and is applicable to alkenes with all types of substitution patterns. In general, the vicinal difluoride products are produced with high diastereoselectivities. The observed sense of stereoinduction implicates anchimeric assistance pathways in reactions of alkenes bearing neighboring Lewis basic functionality. In the experiment, the researchers used many compounds, for example, Methyl 3,5-dihydroxy-4-iodobenzoate (cas: 338454-02-7Recommanded Product: 338454-02-7).

Methyl 3,5-dihydroxy-4-iodobenzoate (cas: 338454-02-7) belongs to iodide derivatives. Organic iodides are widely used in organic synthesis. Halogenation of aromatic hydrocarbons is a very important reaction via an electrophilic aromatic substitution. Polyiodoorganic compounds are sometimes employed as X-ray contrast agents, in fluoroscopy, a type of medical imaging. This application exploits the X-ray absorbing ability of the heavy iodine nucleus.Recommanded Product: 338454-02-7

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Pd-catalyzed cross-electrophile Coupling/C-H alkylation reaction enabled by a mediator generated via C(sp³)-H activation was written by Wu, Zhuo;Jiang, Hang;Zhang, Yanghui. And the article was included in Chemical Science in 2021.COA of Formula: C8H7IO2 This article mentions the following:

Pd-catalyzed cascade cross-electrophile coupling and C-H alkylation reaction of 2-iodo-alkoxylarenes with alkyl chlorides were reported. Methoxy and benzyloxy groups, which were ubiquitous functional groups and common protecting groups, were utilized as crucial mediators via primary or secondary C(sp³)-H activation. The reaction provided an innovative and convenient access for the synthesis of alkylated phenol derivatives, which were widely found in bioactive compounds and organic functional materials. In the experiment, the researchers used many compounds, for example, 3-Iodo-4-methoxybenzaldehyde (cas: 2314-37-6COA of Formula: C8H7IO2).

3-Iodo-4-methoxybenzaldehyde (cas: 2314-37-6) belongs to iodide derivatives. Organic iodides can be alkyl, alkenyl, or alkynyl, and all of them are very reactive toward with many kinds of nucleophiles. Iodo alkanes participate in a variety of organic synthesis reactions, which include the Simmons–Smith reaction (cyclopropanation using iodomethane), Williamson ether synthesis, Wittig reaction, Grignard reaction, alkyl coupling reactions, and Wurtz reaction.COA of Formula: C8H7IO2

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Nickel-catalyzed carbonylative synthesis of dihydrobenzofurans was written by Geng, Hui-Qing;Wang, Wei;Wu, Xiao-Feng. And the article was included in Catalysis Communications in 2021.Name: 1-Chloro-4-iodobutane This article mentions the following:

A nickel-catalyzed carbonylative synthesis of dihydrobenzofurans has been developed. With Mo(CO)6 as the CO source and manganese metal as the reductant, alkyl halides were reacted with aryl iodides to give the desired products in moderate to good yields. In the experiment, the researchers used many compounds, for example, 1-Chloro-4-iodobutane (cas: 10297-05-9Name: 1-Chloro-4-iodobutane).

1-Chloro-4-iodobutane (cas: 10297-05-9) belongs to iodide derivatives. Organoiodine compounds occur widely in organic chemistry, but are relatively rare in nature. Alkyl iodides react at a faster rate than alkyl fluorides due to the weak C-I bond.Name: 1-Chloro-4-iodobutane

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Anti-selective [3+2] (Hetero)annulation of non-conjugated alkenes via directed nucleopalladation was written by Ni, Hui-Qi;Kevlishvili, Ilia;Bedekar, Pranali G.;Barber, Joyann S.;Yang, Shouliang;Tran-Dube, Michelle;Romine, Andrew M.;Lu, Hou-Xiang;McAlpine, Indrawan J.;Liu, Peng;Engle, Keary M.. And the article was included in Nature Communications in 2020.Product Details of 207115-22-8 This article mentions the following:

A method that enables direct access to these core structures, e.g., I from non-conjugated alkenyl amides RNHC(O)CH(R²)CH=CHR¹ [R = quinolin-8-yl, pyridin-2-yl; R¹ = H, Me, Et; R² = H, CH₃, CH₂C₆H₅, 3-CH₃OC₆H₄(CH₂)₂, (CH₂)₂OCH₂C₆H₅, (CH₂)₂CH=CH₂] and N-3-buten-1-yl-2-pyridinecarboxamide and ortho-iodoanilines, e.g., 4-iodopyridin-3-amine/phenols II (R³ = Me, Br, t-Bu, etc.; R⁴ = H, Br; R⁵ = H, I; X = O) has been described. Under palladium(II) catalysis this [3 + 2] heteroannulation proceeds in an anti-selective fashion and tolerates a wide variety of functional groups. N-Acetyl, -tosyl, and -alkyl substituted ortho-iodoanilines, as well as free -NH₂ variants, are all effective. Preliminary results with carbon-based coupling partners like Et 2-cyano-2-(2-iodophenyl)acetate, di-Me 2-(2-iodophenyl)malonate and Et 2-(benzenesulfonyl)-2-(2-iodophenyl)acetate also demonstrate the viability of forming indane core structures III (R⁶ = C(O)₂Me, C(O)₂Et; R⁷ = C(O)₂Me, CN, S(O)₂Ph) using this approach. Exptl. and computational studies on reactions with phenols support a mechanism involving turnover-limiting, endergonic directed oxypalladation, followed by intramol. oxidative addition and reductive elimination. In the experiment, the researchers used many compounds, for example, 4-Bromo-2-iodophenol (cas: 207115-22-8Product Details of 207115-22-8).

4-Bromo-2-iodophenol (cas: 207115-22-8) belongs to iodide derivatives. Organic iodides can be alkyl, alkenyl, or alkynyl, and all of them are very reactive toward with many kinds of nucleophiles. The C–I bond is the weakest of the carbon–halogen bonds. These bond strengths correlate with the electronegativity of the halogen, decreasing in the order F > Cl > Br > I.Product Details of 207115-22-8

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com