Iodides-buliding-blocks

Powell, D. B. published the artcileInfrared spectra and the stabilities of chelate metal-ethylenediamine complexes, Formula: C5H5ClIN, the publication is Journal of the Chemical Society (1961), 1112-14, database is CAplus.

cf. CA 54, 18078i. The suggestion that type A spectra are confined to complexes in which the ethylenediamine adapts the gauche configuration, while in the type B spectra the ligand has the cis configuration, has been abandoned because of x-ray studies. The spectra of PtCl₄^— salts of the ethylenediamine complex cations of Pt(II), Rh(III), Co(III), Pd(II), Cr(III), Hg(II), Cu(II), Ni(II), Co(II), Zn(II), and Cd(II) were studied. Frequencies of 2 bands assigned to N-H rocking and a band assigned to metal-N stretching decreased in the same order as the decrease in log K_av. The N-H rocking bands occur, 800-600 cm.^-1, while the metal-N stretching bands are at 585-478 cm.^-1.

Journal of the Chemical Society published new progress about 6443-90-9. 6443-90-9 belongs to iodides-buliding-blocks, auxiliary class Pyridines, name is Pyridine Iodochloride complex, and the molecular formula is C5H5ClIN, Formula: C5H5ClIN.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Lin, Shizhuo published the artcileLayered Double Hydroxides as Reusable Catalysts for Cyclocondensation of Amidines and Aminoalcohols: Access to Multi-functionalized Oxazolines, Computed Properties of 134322-01-3, the publication is Journal of Organic Chemistry (2022), 87(2), 1366-1376, database is CAplus and MEDLINE.

An efficient catalytic protocol based on reusable MgAl-layered double hydroxides has been developed for the synthesis of multi-functionalized oxazolines via the cyclocondensation of amidines and aminoalcs. The developed method has a broad substrate scope and excellent functional group tolerance and uses a reusable catalyst. The catalyst can be conveniently recycled by filtration and reused for at least five times without obvious deactivation. Addnl., the selective ortho C-H silylation of oxazolines was performed using Ru(II) as the catalyst and tri-Et silane as the silylating reagent, which proved to be a convenient and practical method for the synthesis of versatile organosilyl-functionalized oxazolines with advantageous biol. and phys. properties.

Journal of Organic Chemistry published new progress about 134322-01-3. 134322-01-3 belongs to iodides-buliding-blocks, auxiliary class Salt,Iodide,Amine,Amidine,Benzene, name is 4-Iodobenzimidamide hydrochloride, and the molecular formula is C7H8ClIN2, Computed Properties of 134322-01-3.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Aitov, I. A. published the artcileReaction of quinolinium salts with 2-cyano-2-(ethoxymethylene)acetanilide, Application of 1-Ethyl-2-methylquinolin-1-ium iodide, the publication is Zhurnal Organicheskoi Khimii (1994), 30(2), 291-4, database is CAplus.

Reaction of quinolinium halides I (R = Me, Et, allyl; R¹ = H, Me; X = I, Br) with EtOCH:C(CN)CONHPh (II) in the presence of Et₃N gave merocyanines III in 16-79% yield. Reaction of phenacylquinolinium bromides IV (R² = H, Cl, Br) with II gave merocyanines V and inner salts VI.

Zhurnal Organicheskoi Khimii published new progress about 606-55-3. 606-55-3 belongs to iodides-buliding-blocks, auxiliary class Quinoline,Salt, name is 1-Ethyl-2-methylquinolin-1-ium iodide, and the molecular formula is C12H14IN, Application of 1-Ethyl-2-methylquinolin-1-ium iodide.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Shi, Guangfa published the artcileSilver-Catalyzed C-H Trifluoromethylation of Arenes Using Trifluoroacetic Acid as the Trifluoromethylating Reagent, Quality Control of 364-12-5, the publication is Organic Letters (2015), 17(1), 38-41, database is CAplus and MEDLINE.

Direct trifluoromethylation of arenes using TFA as the trifluoromethylating reagent was achieved with Ag as the catalyst. This reaction not only provides a new protocol for aryl C-H trifluoromethylation, but the generation of CF₃· from TFA may prove useful in other contexts and could potentially be extended to other trifluoromethylation reactions.

Organic Letters published new progress about 364-12-5. 364-12-5 belongs to iodides-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Bromide,Iodide,Benzene, name is 5-Bromo-2-iodobenzotrifluoride, and the molecular formula is C11H12O4, Quality Control of 364-12-5.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

McCaffery, E. L. published the artcilePolymetallophilic organic compounds. III. Competitive intramolecular Grignard coupling reactions, Application In Synthesis of 31253-08-4, the publication is Journal of Organometallic Chemistry (1972), 44(2), 227-31, database is CAplus.

Ring formation via an intramol. Grignard coupling reaction of trihalo alkanes is presented. 2-Methyl-2-(chloromethyl)-1,5-dichloropentane was prepared and treated with two equivalent Mg in THF to study the possible ring formation through 1,5 and/or 1,3 coupling reactions. A 1,3 Grignard coupling reaction was shown to occur preferentially, and a cyclopropane derivative I was formed. A 1,5 coupling reaction could not be realized under the prevailing reaction conditions. A diradical mechanism for the Grignard coupling reaction is proposed to account for the behavior of this compound and other similar polymetallophilic systems in their reaction with Mg.

Journal of Organometallic Chemistry published new progress about 31253-08-4. 31253-08-4 belongs to iodides-buliding-blocks, auxiliary class Iodide,Ester, name is Ethyl 2-Iodopropionate, and the molecular formula is C5H9IO2, Application In Synthesis of 31253-08-4.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Aurelio, Luigi published the artcileFrom Sphingosine Kinase to Dihydroceramide Desaturase: A Structure-Activity Relationship (SAR) Study of the Enzyme Inhibitory and Anticancer Activity of 4-((4-(4-Chlorophenyl)thiazol-2-yl)amino)phenol (SKI-II), Quality Control of 39115-95-2, the publication is Journal of Medicinal Chemistry (2016), 59(3), 965-984, database is CAplus and MEDLINE.

The sphingosine kinase (SK) inhibitor, SKI-II, has been employed extensively in biol. investigations of the role of SK1 and SK2 in disease and has demonstrated impressive anticancer activity in vitro and in vivo. However, interpretations of results using this pharmacol. agent are complicated by several factors: poor SK1/2 selectivity, addnl. activity as an inducer of SK1-degradation, and off-target effects, including its recently identified capacity to inhibit dihydroceramide desaturase-1 (Des1). In this study, we have delineated the structure-activity relationship (SAR) for these different targets and correlated them to that required for anticancer activity and determined that Des1 inhibition is primarily responsible for the antiproliferative effects of SKI-II and its analogs. In the course of these efforts, a series of novel SK1, SK2, and Des1 inhibitors have been generated, including compounds with significantly greater anticancer activity.

Journal of Medicinal Chemistry published new progress about 39115-95-2. 39115-95-2 belongs to iodides-buliding-blocks, auxiliary class Iodide,Hydrazine,Amine,Benzene,Hydrazide,Amide, name is 4-Iodobenzohydrazide, and the molecular formula is C7H7IN2O, Quality Control of 39115-95-2.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Milzarek, Tobias M. published the artcileEvaluation of the Substrate Promiscuity of SorbC for the Chemo-Enzymatic Total Synthesis of Structurally Diverse Sorbicillinoids, Safety of 1-Iodohexane, the publication is ACS Catalysis (2022), 12(3), 1898-1904, database is CAplus.

In the present work, the effects of structural changes to the natural substrate sorbicillin was systematically screened by HPLC-based anal. and comparative determination of key kinetic parameters. This not only provided important insight into substrate promiscuity of SorbC but also facilitated the efficient chemo-enzymic preparation of unnatural dimeric sorbicillinoids possessing modified backbones or hydroxylated sorbyl side chains. In addition, the total syntheses of the natural saturnispol C, saturnispol D, and trichosorbicillin A, as well as of demethyltrichosorbicillin A and dihydroxybisorbicillinol, both not yet known in nature, were reported.

ACS Catalysis published new progress about 638-45-9. 638-45-9 belongs to iodides-buliding-blocks, auxiliary class Iodide,Aliphatic hydrocarbon chain, name is 1-Iodohexane, and the molecular formula is C6H13I, Safety of 1-Iodohexane.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Qian, Yong published the artcileActivity-Based Proteome Profiling Probes Based on Woodward’s Reagent K with Distinct Target Selectivity, COA of Formula: C10H7IN2, the publication is Angewandte Chemie, International Edition (2016), 55(27), 7766-7771, database is CAplus and MEDLINE.

Woodward’s reagent K (WRK) is a reactive heterocyclic compound that has been employed in protein chem. to covalently and unspecifically label proteins at nucleophilic amino acids, notably at histidine and cysteine. The authors have developed a panel of WRK-derived activity-based probes and show that surprisingly and unexpectedly, these probes are fairly selective for a few proteins in the human proteome. The WRK-derived probes show unique reactivity towards the catalytic N-terminal proline in the macrophage migration inhibitory factor (MIF) and can be used to label and, if equipped with a fluorophore, to image MIF activities in living cells.

Angewandte Chemie, International Edition published new progress about 41270-96-6. 41270-96-6 belongs to iodides-buliding-blocks, auxiliary class Pyrimidine,Iodide,Benzene,Immunology/Inflammation,MIF, name is 4-Iodo-6-phenylpyrimidine, and the molecular formula is C10H7IN2, COA of Formula: C10H7IN2.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Rassadin, Valentin A. published the artcileSynthesis of benzannulated sultams by intramolecular Pd-catalyzed arylation of tertiary sulfonamides, SDS of cas: 101420-79-5, the publication is Beilstein Journal of Organic Chemistry (2017), 1932-1939, database is CAplus and MEDLINE.

A new and efficient approach to five- and six-membered benzannulated sultams I [R = H, Me, 4-MeOC₆H₄CH₂; R¹ = H, Me, Cl, CO₂Me, CO₂Et; R² = H, OMe, CN; n = 0, 1] by intramol. C-arylation of tertiary 1-(methoxycarbonyl)methanesulfonamides under palladium catalysis was described. In case of the α-toluenesulfonamide derivative, an unexpected formation of a 2,3-diarylindole was observed under the same conditions. The 4-methoxybenzyl group was a suitable protective group for the sultam synthesis since it was stable under the reaction conditions and could be easily removed by acidolysis with trifluoroacetic acid.

Beilstein Journal of Organic Chemistry published new progress about 101420-79-5. 101420-79-5 belongs to iodides-buliding-blocks, auxiliary class Nitrile,Nitro Compound,Iodide,Benzene,Benzene Compounds, name is 4-Iodo-3-nitrobenzonitrile, and the molecular formula is C7H3IN2O2, SDS of cas: 101420-79-5.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Tong, Xiaoyu published the artcileCatalytic Enantioselective α-Alkylation of Amides by Unactivated Alkyl Electrophiles, Formula: C6H13I, the publication is Journal of the American Chemical Society (2022), 144(32), 14856-14863, database is CAplus and MEDLINE.

Herein the achievement of this objective, demonstrating that a nickel catalyst could accomplish enantioselective intermol. alkylations of racemic Reformatsky reagents with unactivated electrophiles; the resulting α-alkylated carbonyl compounds could be converted in one addnl. step into a diverse array of ubiquitous families of chiral mols was described. Applying a broad spectrum of mechanistic tools, have gained insight into key intermediates (including the alkylnickel(II) resting state) and elementary steps of the catalytic cycle.

Journal of the American Chemical Society published new progress about 638-45-9. 638-45-9 belongs to iodides-buliding-blocks, auxiliary class Iodide,Aliphatic hydrocarbon chain, name is 1-Iodohexane, and the molecular formula is C21H33BN2O6S, Formula: C6H13I.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com