Iodides-buliding-blocks

Billion, H. published the artcileThe distribution of radioactive Perabrodil M in humans and its application in renal clearance, Application of 2-(3,5-Diiodo-4-oxopyridin-1(4H)-yl)acetic acid, the publication is Klinische Wochenschrift (1955), 1089-93, database is CAplus.

Human subjects were treated intravenously with 200-2250 mg. of Perabrodil M (I) labeled with radioactive iodine. Serum and urine radioactivity was determined for 180 min. as a measure of the I concentration Excretion of I in the urine paralleled the decline in serum I concentration At dose levels of 200-400 mg. and 2250 mg. the urinary excretion of I was 79.1 and 94.1%, resp., in 3 hrs., with half-time values of 44.5 and 32 min., resp. Renal clearance values obtained by slow infusion of I compared favorably with those obtained using p-aminohippuric acid.

Klinische Wochenschrift published new progress about 101-29-1. 101-29-1 belongs to iodides-buliding-blocks, auxiliary class Pyridine,Iodide,Carboxylic acid,Ketone, name is 2-(3,5-Diiodo-4-oxopyridin-1(4H)-yl)acetic acid, and the molecular formula is C7H5I2NO3, Application of 2-(3,5-Diiodo-4-oxopyridin-1(4H)-yl)acetic acid.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Dickerhof, Nina published the artcileMacrophage migration inhibitory factor (MIF) is rendered enzymatically inactive by myeloperoxidase-derived oxidants but retains its immunomodulatory function, SDS of cas: 41270-96-6, the publication is Free Radical Biology & Medicine (2015), 498-511, database is CAplus and MEDLINE.

Macrophage migration inhibitory factor (MIF) is an important player in the regulation of the inflammatory response. Elevated plasma MIF is found in sepsis, arthritis, cystic fibrosis and atherosclerosis. Immunomodulatory activities of MIF include the ability to promote survival and recruitment of inflammatory cells and to amplify pro-inflammatory cytokine production MIF has an unusual nucleophilic N-terminal proline with catalytic tautomerase activity. It remains unclear whether tautomerase activity is required for MIF function, but small mols. that inhibit tautomerase activity also inhibit the pro-inflammatory activities of MIF. A prominent feature of the acute inflammatory response is neutrophil activation and production of reactive oxygen species, including myeloperoxidase (MPO)-derived hypochlorous acid and hypothiocyanous acid. We hypothesized that MPO-derived oxidants would oxidize the N-terminal proline of MIF and alter its biol. activity. MIF was exposed to hypochlorous acid and hypothiocyanous acid and the oxidative modifications on MIF were examined by LC-MS/MS. Imine formation and carbamylation was observed on the N-terminal proline in response to MPO-dependent generation of hypochlorous and hypothiocyanous acid, resp. These modifications led to a complete loss of tautomerase activity. However, modified MIF still increased CXCL-8/IL-8 production by peripheral blood mononuclear cells (PBMCs) and blocked neutrophil apoptosis, indicating that tautomerase activity is not essential for these biol. functions. Pre-treatment of MIF with hypochlorous acid protected the protein from covalent modification by the MIF inhibitor 4-iodo-6-phenylpyrimidine (4-IPP). Therefore, oxidant generation at inflammatory sites may protect MIF from inactivation by more disruptive electrophiles, including drugs designed to target the tautomerase activity of MIF.

Free Radical Biology & Medicine published new progress about 41270-96-6. 41270-96-6 belongs to iodides-buliding-blocks, auxiliary class Pyrimidine,Iodide,Benzene,Immunology/Inflammation,MIF, name is 4-Iodo-6-phenylpyrimidine, and the molecular formula is C10H7IN2, SDS of cas: 41270-96-6.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Jones, Brian P. published the artcileThe synthesis of an aminohexyl-containing analog of the chromanol leukotriene B₄ receptor antagonist CP-195543: a scaffold for the preparation of derivatized analogs, Safety of Dimethyl 2-iodoterephthalate, the publication is Heterocycles (2000), 53(8), 1713-1724, database is CAplus.

In order to allow the preparation of labeled derivatives of the leukotriene B₄ (LTB₄) antagonist CP-195543 for the study and/or “visualization” of LTB₄ receptors in in vitro and in vivo settings, we have synthesized an aminohexyl-containing analog as a scaffold from which the requisite compounds can be prepared The key reactions in the preparation of the analog include the DAST-mediated introduction of a difluoromethylene group in the presence of an azide and a Suzuki coupling between this highly functionalized benzoate and a chromanol-derived boronic acid. 2-(3S,4R)-(3-Benzyl-4-hydroxychroman-7-yl)-4-(1,1-difluoro-7-methanesulfonamidoheptyl)benzoic acid, prepared from the analog by methanesulfonylation and saponification, is a potent LTB₄ receptor antagonist but displays a high degree of non-specific binding.

Heterocycles published new progress about 165534-79-2. 165534-79-2 belongs to iodides-buliding-blocks, auxiliary class Iodide,Benzene,Ester, name is Dimethyl 2-iodoterephthalate, and the molecular formula is C10H9IO4, Safety of Dimethyl 2-iodoterephthalate.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Benoit, Adam R. published the artcileSynthesis and evaluation of N-alkyl-9-aminoacridines with antibacterial activity, SDS of cas: 165534-79-2, the publication is Bioorganic & Medicinal Chemistry Letters (2014), 24(14), 3014-3017, database is CAplus and MEDLINE.

A series of 9-(alkylamino)acridine derivatives was prepared and evaluated for activity against two strains of methicillin-resistant and one strain of methicillin-sensitive Staphylococcus aureus. Results are presented that show a clear structure activity relationship between the N-alkyl chain length and antibacterial activity with peak MIC₉₉ values of 2-3 μM for alkyl chains ranging from 10 to 14 carbons in length. Although prior work has linked the function of acridine-based compounds to intercalation and topoisomerase inhibition, the present results show that 9-(alkylamino)acridine derivatives likely function as amphiphilic membrane-active disruptors potentially in a similar manner as quaternary ammonium antimicrobial agents. The synthesis of the target compounds was achieved by a reaction (substitution) of 9-(phenoxy)acridine or (4-methyl-1-piperazinyl)(9-phenoxy-3-acridinyl)methanone or 9,10-dihydro-9-oxo-3-acridinecarboxylic acid (amidation) with 1-alkanamine derivatives The title compounds thus formed included N-(alkyl)-9-acridinamine derivatives and (4-methyl-1-piperazinyl)[9-[(alkyl)amino]-3-acridinyl)methanone derivatives and 9,10-dihydro-9-oxo-N-alkyl-3-acridinecarboxamide derivatives

Bioorganic & Medicinal Chemistry Letters published new progress about 165534-79-2. 165534-79-2 belongs to iodides-buliding-blocks, auxiliary class Iodide,Benzene,Ester, name is Dimethyl 2-iodoterephthalate, and the molecular formula is C10H9IO4, SDS of cas: 165534-79-2.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Ramos, S. S. published the artcileSome new symmetric rigidified triheterocyclic heptamethinecyanine dyes absorbing in the near infrared, Computed Properties of 606-55-3, the publication is Dyes and Pigments (2002), 53(2), 143-152, database is CAplus.

Several new rigidified heptamethine cyanine dyes bearing different N-alkyl chains were readily prepared by a novel semi-catalyzed method. All dyes displayed absorption within the so-called “phototherapeutic window”. In order to improve the structural versatility of the dyes, a Cl atom was incorporated in the exocyclic conjugated bridge present in the polymethine chain. In some cases the Cl underwent an unexpected in-situ substitution by a third oxygenated heterocyclic group, depending on the solubility of the chloro dye in the reaction solvent. Two possible mechanisms for the formation of these triheterocyclic dyes are proposed. The full spectroscopic characterization of all the cyanines synthesized is described.

Dyes and Pigments published new progress about 606-55-3. 606-55-3 belongs to iodides-buliding-blocks, auxiliary class Quinoline,Salt, name is 1-Ethyl-2-methylquinolin-1-ium iodide, and the molecular formula is C12H14IN, Computed Properties of 606-55-3.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Pelcman, Benjamin published the artcile3-Substituted pyrazoles and 4-substituted triazoles as inhibitors of human 15-lipoxygenase-1, Computed Properties of 141998-77-8, the publication is Bioorganic & Medicinal Chemistry Letters (2015), 25(15), 3024-3029, database is CAplus and MEDLINE.

Investigation of 1N-substituted pyrazole-3-carboxanilides as 15-lipoxygenase-1 (15-LOX-1) inhibitors demonstrated that the 1N-substituent was not essential for activity or selectivity. Addnl. halogen substituents on the pyrazole ring, however, increased activity. Further development led to triazole-4-carboxanilides and 2-(3-pyrazolyl) benzoxazoles, which are potent and selective 15-LOX-1 inhibitors.

Bioorganic & Medicinal Chemistry Letters published new progress about 141998-77-8. 141998-77-8 belongs to iodides-buliding-blocks, auxiliary class Pyrazole,Iodide,Ester,Pyrazole, name is Ethyl 5-iodo-1H-pyrazole-3-carboxylate, and the molecular formula is C6H7IN2O2, Computed Properties of 141998-77-8.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Nagrimanov, Ruslan N. published the artcileAdditive scheme of solvation enthalpy for halogenated aliphatic hydrocarbons at 298.15 K., Safety of 1-Iodohexane, the publication is Thermochimica Acta (2022), 179155, database is CAplus.

In this work, an additive scheme for the estimation of solvation enthalpy of halogenated aliphatic hydrocarbons in n-heptane was developed. The proposed structural fragments for halogen group contributions are dependent on the nature of neighboring atoms. A linear relationship between solvation and vaporization enthalpy at 298.15 K for mono- and di-α,ω-halogen aliphatic compounds was found. These relationships can be used for the quick estimation of standard vaporization and solution enthalpies at 298.15 K. Proposed approaches for estimation of solvation, solution and vaporization enthalpies at 298.15 K were verified by conventional methods. In most cases, absolute deviations between exptl. and estimated values for halogenated aliphatic hydrocarbons do not exceed 1-2 kJ mol^-1.

Thermochimica Acta published new progress about 638-45-9. 638-45-9 belongs to iodides-buliding-blocks, auxiliary class Iodide,Aliphatic hydrocarbon chain, name is 1-Iodohexane, and the molecular formula is C6H13I, Safety of 1-Iodohexane.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Andrade, Carolina Horta published the artcileThree-dimensional quantitative structure-activity relationships for a large series of potent antitubercular agents, Name: 4-Iodobenzohydrazide, the publication is Letters in Drug Design & Discovery (2008), 5(6), 377-387, database is CAplus.

Comparative mol. field anal. (CoMFA) studies were conducted on a series of 100 isoniazid derivatives as anti-tuberculosis agents using two receptor-independent structural data set alignment strategies: (1) rigid-body fit, and (2) pharmacophore-based. Significant cross-validated correlation coefficients were obtained (CoMFA(1), q² = 0,75 and CoMFA(2), q² = 0.74), indicating the potential of the models for untested compounds The models were then used to predict the inhibitory potency of 20 test set compounds that were not included in the training set, and the predicted values were in good agreement with the exptl. results.

Letters in Drug Design & Discovery published new progress about 39115-95-2. 39115-95-2 belongs to iodides-buliding-blocks, auxiliary class Iodide,Hydrazine,Amine,Benzene,Hydrazide,Amide, name is 4-Iodobenzohydrazide, and the molecular formula is C7H7IN2O, Name: 4-Iodobenzohydrazide.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Andrade, Carolina H. published the artcileFragment-based and classical quantitative structure-activity relationships for a series of hydrazides as antituberculosis agents, Recommanded Product: 4-Iodobenzohydrazide, the publication is Molecular Diversity (2008), 12(1), 47-59, database is CAplus and MEDLINE.

Worldwide, tuberculosis (TB) is the leading cause of death among curable infectious diseases. Multidrug-resistant Mycobacterium tuberculosis is an emerging problem of great importance to public health, and there is an urgent need for new anti-TB drugs. In the present work, classical 2D quant. structure-activity relationships (QSAR) and hologram QSAR (HQSAR) studies were performed on a training set of 91 isoniazid derivatives Significant statistical models (classical QSAR, q ² = 0.68 and r ² = 0.72; HQSAR, q ² = 0.63 and r ² = 0.86) were obtained, indicating their consistency for untested compounds The models were then used to evaluate an external test set containing 24 compounds which were not included in the training set, and the predicted values were in good agreement with the exptl. results (HQSAR,; classical QSAR).

Molecular Diversity published new progress about 39115-95-2. 39115-95-2 belongs to iodides-buliding-blocks, auxiliary class Iodide,Hydrazine,Amine,Benzene,Hydrazide,Amide, name is 4-Iodobenzohydrazide, and the molecular formula is C7H7IN2O, Recommanded Product: 4-Iodobenzohydrazide.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Patnaik, Lalit N. published the artcileSolvent effects on the absorption spectra of merocyanine dyes, HPLC of Formula: 606-55-3, the publication is Journal of Solution Chemistry (1994), 23(12), 1317-30, database is CAplus.

Solvent effects on the lowest-energy electronic transitions of 2 merocyanines derived from quinoline were studied using 9 different solvent parameters reported in the literature. Relative merits and deficiencies of different parameters were assessed. From the correlation results, attempts were made to propose a solute-solvent interaction mechanism. For an assorted set of 19 solvents, as well as for a set of 9 hydroxylic solvents, excellent results are obtained with correlation equation involving E_T(30) and Hilderbrand’s solubility parameter δ_H.

Journal of Solution Chemistry published new progress about 606-55-3. 606-55-3 belongs to iodides-buliding-blocks, auxiliary class Quinoline,Salt, name is 1-Ethyl-2-methylquinolin-1-ium iodide, and the molecular formula is C12H14IN, HPLC of Formula: 606-55-3.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com