Iodides-buliding-blocks

Reference of 608-28-6,Some common heterocyclic compound, 608-28-6, name is 2-Iodo-1,3-dimethylbenzene, molecular formula is C8H9I, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

To a test tube containing a magnetic rod was added 4-iodotoluene, 1.0 mmol, Cu2O (14.3 mg, 0.1 mmol), KOH (169 mg, 3.0 mmol), 2-dimethylaminoethanol , 0.3 mL, 3.0 mmol) and DMSO / H2O (1.5 mL / 0.5 mL). After flushing with argon, the mixture was stirred at 100 & lt; 0 & gt; C for 24 hours in a preheated oil bath. After cooling to ambient temperature, the reaction mixture was distributed in aqueous HCl (5%) and ethyl acetate. The organic layer was washed with water and brine, dried over anhydrous MgSO4 and concentrated in vacuo. The crude product was purified by column chromatography (EtOAc / n-Hexane) to give phenol.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 2-Iodo-1,3-dimethylbenzene, its application will become more common.

Reference:
Patent; SUNGSHIN WOMEN`S UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATION; CHAE, Junghyun; KIM, KIM; (13 pag.)KR2017/91976; (2017); A;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 6293-83-0, name is 2-Iodo-4-nitroaniline, A new synthetic method of this compound is introduced below., category: iodides-buliding-blocks

iV-Benzyl-5-bromo-2-iodobenzamide (805 mg, 1 .93 mmol), 2-iodo-4-nitroaniline (425 mg, 1 61 mmol), copper 1 ) iodide (123 mg, 0.65 mmol), and potassium carbonate (1.11 g, 8.0 mmol) were taken up in anhydrous DMSO (11 mL). The resulting reaction mixture was first stirred at 80C for 2 hr, followed by heating to 135 C for another 16 hr. After cooling to room temperature, the mixture was diluted with an excess of Et20 and washed with water. The organic layer was dried over Na2S04, filtered and concentrated. The residue was purified by flash column chromatography (EtOAc : Hex = 0 : 100 to 100 : 0) to give 10- benzyl-2-bromo-8-nitro-5,l 0-dihydro-ri //-dibenzo| 7,e] l ,4|diazepin-l l -one (179 mg, 26

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; DANA-FARBER CANCER INSTITUTE, INC.; GRAY, Nathanael S.; DE CLERCQ, Dries; JANG, Jaebong; JANNE, Pasi; TO, Ciric; ECK, Michael; PARK, Eunyoung; HEPPNER, David; (0 pag.)WO2019/164953; (2019); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Related Products of 640280-28-0, A common heterocyclic compound, 640280-28-0, name is 1-Bromo-2-iodo-4-(trifluoromethyl)benzene, molecular formula is C7H3BrF3I, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Intermediate J: tert-Butyl 4-(2-bromo-5-(trifluoromethyl)phenyl)-5,6- dihydropyridine- 1 (2H)-carboxylate A solution of l-bromo-2-iodo-4-(trifluoromethyl)benzene (1.408 ml, 8.55 mmol), tert-butyl 4-(4,4,5,5-tetramethyl-l,3,2-dioxaborolan-2-yl)-5,6- dihydropyridine-l(2H)-carboxylate (Frontier Scientific, Logan, UT, 2.78 g, 8.98 mmol), Pd(dppf)Cl2-CH2Cl2 adduct (Strem Chemicals Inc., Newburyport, MA, 0.349 g, 0.427 mmol), and potassium carbonate (2.052 g, 34.2 mmol) in dioxane (32.1 ml) and water (10.69 ml) was stirred at 70 C for three hours. (LC-MS MH+ 430.1) The reaction was diluted with ethyl acetate and washed with water. The aqueous layer was extracted with ethyl acetate, and the combined organic layers were dried with sodium sulfate, filtered, and concentrated. The material was purified via column chromatography (silica gel 80g, gradient elution 0 to 100% Et20:Heptane) to afford tert-butyl 4-(2-bromo-5-(trifluoromethyl)phenyl)-5,6-dihydropyridine- 1 (2H)- carboxylate (2.54 g, 6.25 mmol) as a light yellow oil. [M+H]+ = 428.0. XH NMR (400 MHz, CHLOROFORM-d) delta ppm = 7.69 (d, J= 8.3 Hz, 1 H), 7.43 (d, J= 2.2 Hz, 1 H), 7.41 – 7.36 (m, 1 H), 5.69 (br. s., 1 H), 4.08 (q, J= 2.7 Hz, 2 H), 3.66 (t, J= 5.6 Hz, 2 H), 2.48 – 2.40 (m, 2 H), 1.52 (s, 9 H)

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; AMGEN INC.; DINEEN, Thomas; KREIMAN, Charles; WEISS, Matthew; GEUNS-MEYER, Stephanie; WO2013/134518; (2013); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Some common heterocyclic compound, 460-37-7, name is 1,1,1-Trifluoro-3-iodopropane, molecular formula is C3H4F3I, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Computed Properties of C3H4F3I

To a solution of 2,6-dichloro-4-[1-(4-hydroxyphenyl)-1-methylethyl]phenol (1) (0.2 g, 0.67 mmol) in DMF (2 mL) were added 1,1,1-trifluoro-3-iodo-propane (2) (1.5 g, 6.7 mmol) and Cs2CO3 (0.66 g, 2.0 mmol). The resulting reaction was stirred at 60 C. for 16 hours. TLC showed the reaction was completed. The mixture was cooled down and poured into water (10 mL), extracted with EtOAc (10 mL¡Á3). The combined organic layers were washed with brine (10 mL¡Á3), dried over Na2SO4, filtered and concentrated. The residue was purified by p-TLC to give 4-[1-[3,5-dichloro-4-(3,3,3-trifluoropropoxy)phenyl]-1-methylethyl]phenol (3) (80 mg, yield: 30.2%) as colorless oil. 1H NMR (400 MHz, CHCl3-d) delta 7.13 (s, 2H), 7.09-7.05 (m, 2H), 6.78-6.75 (m, 2H), 4.71 (s, 1H), 4.21 (t, J=6.8 Hz, 2H), 2.78-2.66 (m, 2H), 1.62 (s, 6H).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 460-37-7, its application will become more common.

Reference:
Patent; ESSA Pharma, Inc.; Zhou, Han-Jie; Virsik, Peter; (216 pag.)US2020/123117; (2020); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Adding a certain compound to certain chemical reactions, such as: 2974-94-9, name is 1-Iodo-4-phenoxybenzene, belongs to iodides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 2974-94-9, Product Details of 2974-94-9

270.1 g (2.0 mol) of 4-aminopyrazolo[3,4-d]pyrimidine and 295.9 g (1.0 mol) of 4-iododiphenyl ether were added to 1 L of DMSO.Thereafter, 448.8 g (4.0 mol) of potassium t-butoxide was added. After the addition was completed, the mixture was purged with nitrogen, heated to 120 C, and reacted for 24 hours.Upon completion of the HPLC, the end of the reaction was completed when the 4-iododiphenyl ether was consumed.After cooling to room temperature, 5 L of methyl tert-butyl ether was added, followed by 3 washes with 5 L of water.The organic phase was dried over anhydrous sodium sulfate and concentrated under reduced pressure, the residue was purified by column chromatography on a conventional crude product obtained was recrystallized using DMF solvent to give3-(4-Phenoxyphenyl)-4-amino-1H-pyrazolo[3,4-d]pyrimidine (248.5 g, 82%, HPLC purity: 99.7%).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

Reference:
Patent; Haimen Hui Ju Pharmaceutical Co., Ltd.; Li Yanjie; Qiu Xiaolong; Zou Ping; Hu Lin; Chen Jun; Cao Lei; (7 pag.)CN109134474; (2019); A;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Synthetic Route of 116632-39-4,Some common heterocyclic compound, 116632-39-4, name is 5-Bromo-2-iodotoluene, molecular formula is C7H6BrI, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

A solution of isopropylmagnesium bromide in tetrahydrofuran (1.0 M, 7.6 mL, 7.6 mmol) was added into a solution of 4-bromo-1-iodo-2-methylbenzene (2.1 g, 7.0 mmol) in tetrahydrofuran (10.0 mL) under an atmosphere of nitrogen at -40 C. The mixture was warmed to room temperature and stirred for 30 min, then was cooled to -78 C. To the mixture was added ethyl 4-oxocyclohexanecarboxylate (1.0 g, 5.9 mol) in tetrahydrofuran (2.0 mL). The reaction mixture was allowed to warm slowly to room temperature, and stirred at room temperature for an additional 30 min. The mixture was quenched with sat. aqueous NH4Cl solution, and extracted with ethyl acetate. The organic layer was washed with brine, dried over Na2SO4, and filtered. The filtrate was concentrated. The residue was purified by flash chromatography (ethyl acetate in hexane: 0-50%) to give ethyl 4-(4-bromo-2-methylphenyl)-4-hydroxycyclohexanecarboxylate (0.46 g, 23%).

The synthetic route of 116632-39-4 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Zhuo, Jincong; Li, Yun-Long; Xu, Meizhong; He, Chunhong; Yao, Wenqing; US2007/208001; (2007); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Related Products of 26059-40-5, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 26059-40-5, name is 2-(2-Iodophenyl)ethan-1-ol belongs to iodides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

(1) weighing 2-iodo-phenethyl alcohol 1.0g in 100mL single-necked flask,Join 20mL THF room temperature stirring to dissolve,2.8 g of di-tert-butyl azodicarboxylate and 3.2 g of triphenylphosphine solid were sequentially added,The reaction was stirred at room temperature for 1.5h,The reaction solution was washed once with 20 mL of 1 mol / L diluted hydrochloric acid,20mL saturated sodium bicarbonate once, 20mL saturated brine once,The organic phase is dried over anhydrous magnesium sulphate, filtered and the filtrate is removed by rotary evaporation to give 5.8 g of crude product. The crude product was purified by column chromatography on silica gel eluting with PE: EA = 20: 1 to give 1.6 g of a white solid,Namely N, N’-di-tert-butoxycarbonyl-2-iodophenethylhydrazine,Yield86%.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-(2-Iodophenyl)ethan-1-ol, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Wuxi Jiehua Pharmaceutical Technology Co., Ltd.; Gou Yuancheng; (7 pag.)CN107033090; (2017); A;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Electric Literature of 4949-69-3, These common heterocyclic compound, 4949-69-3, name is 4-Iodo-3-methylaniline, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

3-Thiophenecarboxylic acid (2.0 g, 15.6 mmol) was dissolved in methylene chloride (100 mL) and 2 drops of DMF were added. The mixture was cooled to 0 0C and oxalyl chloride (1.5 mL, 17.1 mmol) was added slowly and allowed to warm to room temperature. Gas evolution was observed during warming. 3-Methyl-4-iodoaniline (5.45 g, 23.5 mmol), 4 drops of pyridine and K2CO3 (2.58 g, 18.7 mmol) are dissolved in CH2Cl2 (10 mL) and cooled to about 0 0C. After about Ih, the acid chloride mixture is slowly added to the cooled aniline mixture and allowed to warm to room temperature and stirred for about 18h. The resulting mixture is filtered, washed with ethyl acetate and the filtrate is concentrated to a brown oil. The crude material was purified via flash chromatography (10-30% ethyl acetate in hexanes) to afford the title compound (1.56 g, 29%) as an off-white solid.

The synthetic route of 4949-69-3 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; GLAXO GROUP LIMITED; WO2007/147109; (2007); A2;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

116632-41-8, name is 2-Chloro-5-iodotoluene, belongs to iodides-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. SDS of cas: 116632-41-8

Step A: NaOH (4M, 443.13uL, 4.00eq) was added to a solution of compound 51 (200.00mg, 443.13umol,1.00eq), 4-chloro-1-iodo-2-toluene (156.63mg, 620.38umol, 1.40eq), Pd(dppf)Cl2 (16.21mg, 22.16umol, 0.05eq) in 12mL2-methyltetrahydrofuran, the reaction solution was purged with nitrogen for three times, then stirred at 65C for 12 hours,gradually turned from yellow to black. 20mL water was added to the above solution, and the mixture was extracted threetimes with ethyl acetate (20mL*3). The organic phase was combined, washed with 20mL saturated brine, dried overanhydrous sodium sulfate and filtered. The filtrate was concentrated under reduced pressure to give a crude product,which was purified by silica gel column chromatography (400 mesh, PE_EA=1:0 to 20:1) to give the compound 73(170.00mg, 325.53umol, yield 73.46%, purity 90%).

The synthetic route of 116632-41-8 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Luoxin Biotechnology (Shanghai) Co., Ltd.; Shandong Luoxin Pharmaceutical Group Stock Co., Ltd.; LU, Jianyu; DING, Charles Z.; HU, Lihong; HE, Huijun; CHEN, Shuhui; DONG, Jiaqiang; WANG, Tie-lin; (124 pag.)EP3434668; (2019); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 199786-58-8, name is (5-Bromo-2-iodophenyl)methanol, A new synthetic method of this compound is introduced below., Application In Synthesis of (5-Bromo-2-iodophenyl)methanol

General procedure: A magnetic stirring bar, 2-iodobenzyl alcohol (1a, 116.0 mg, 0.5 mmol), NEt3 (251.6 mg, 2.5 mmol), and MeCN (10 mL) were placed in a stainless steel autoclave equipped with an inserted Pyrex glass liner. The autoclave was closed, purged three times with carbon monoxide, pressurized with 65 atm of CO and then heated at 250 C by salt bath with stirring for 16 h. After the reaction, excess CO was discharged at room temperature. The solvent was removed under reduced pressure, and the residue was purified by flash chromatography on silica gel (hexane/EtOAc = 3/1) to give 2a (60.4 mg, 91%) as a white solid.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Article; Fukuyama, Takahide; Bando, Takanobu; Ryu, Ilhyong; Synthesis; vol. 50; 15; (2018); p. 3015 – 3021;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com