Iodides-buliding-blocks

Adding a certain compound to certain chemical reactions, such as: 18698-96-9, name is 2-(2-Iodophenyl)acetic acid, belongs to iodides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 18698-96-9, category: iodides-buliding-blocks

2-(2-Iodophenyl)acetamide (107-2). HATU (50.8 g, 134 mmol) was added to a stirred solution of 107-1 (28 g, 107 mmol), NH3 (321 ml, 160 mmol, 0.5 M/dioxane), iV-methylmorpholine (23.5 ml, 214 mmol) in . DMF (300 ml). The mixture was stirred for 16 hours and then was diluted with EtOAc and washed with H2O, sat NaHCO3, brine, dried over anhydrous MgSO4, filtered and 2/3 solvent was removed in vacuo. The solid was collected, washed with diethyl ether and dried in vacuo to afford 29-2 11.2g, 40.2percent) as a white solid.1H NMR (500 MHz, CDCl3) delta7.i (d, 1 H, J = 8 Hz), 7.36 (m, 2 H), 7.00 (m, 1 H), 5.38 (s, 2 H), 3.75 (s, 2H).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

Reference:
Patent; MERCK & CO., INC.; WO2008/51532; (2008); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Related Products of 699016-40-5, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 699016-40-5, name is 2-Fluoro-4-iodobenzaldehyde, This compound has unique chemical properties. The synthetic route is as follows.

Step 1-B: To a solution of 2-fluoro-4-iodo-benzaldehyde (17.40 g, 69.60 mmol) in anhydrous tetrahydrofuran (300 mL) at -10 C. under an atmosphere of nitrogen was added 3.0 M methylmagnesium chloride in tetrahydrofuran (27.84 mL, 83.52 mmol) via syringe at such a rate as to maintain the temperature of the reaction mixture below 0 C. The reaction was stirred for 30 minutes while warming to room temperature. Saturated aqueous ammonium chloride solution was added and the mixture was diluted with ethyl acetate (200 mL). The organic layer was separated and the aqueous layer was extracted with ethyl acetate (2*50 mL). The organic extracts were combined, washed with water (1*50 mL), brine, dried over sodium sulfate, filtered and concentrated in vacuo. The crude product was purified by chromatography over silica gel gradient eluted with 15 to 40% v/v ethyl acetate/hexanes to give 1-(2-fluoro-4-iodo-phenyl)-ethanol (15.50 g, 84%).

The chemical industry reduces the impact on the environment during synthesis 2-Fluoro-4-iodobenzaldehyde. I believe this compound will play a more active role in future production and life.

Reference:
Patent; Chen, Shaoqing; Huby, Nicholas J.S.; Kong, Norman; Moliterni, Jonh Anthony; Morales, Omar Jose; US2009/170920; (2009); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Adding a certain compound to certain chemical reactions, such as: 7681-82-5, name is Sodium iodide, belongs to iodides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 7681-82-5, Recommanded Product: Sodium iodide

Complex [Pd(P,P)Cl2] (0.070?g, 0.113?mmol) was dissolved at room temperature in aceton (10?mL), followed by the addition of NaI in stoichiometric excess (0.070?g, 0.452?mmol), affording a dark yellow solution, which was stirred at room temperature for 24?h. The reaction mixture was then concentrated to dryness and the solid residue was re-dissolved in dichloromethane (10?mL). This solution was filtrated through celite in order to remove the remaining NaI or NaCl formed during the reaction. The filtrate was concentrated to 4?mL, n-hexane (10?mL) were then added to allow precipitation of the expected product, that was collected by filtration, and dried under vacuum to afford 0.060?g (67% yield) of a dark yellow powder, m.p. (dec.)?>?200?C. IR (KBr, cm-1): 506 (s), 528 (m), 562 (s), 591 (m), 692 (s), 748 (s), 867 (s) nu(P-N-P), 995 (m), 1101 (s), 1097 (s), 1176 (s), 1224 (s), 1245 (s), 1307 (w), 1375 (m), 1434 (s) nu(P-Ph), 1457 (s), 1480 (s). 1H NMR (600?MHz, CDCl3): delta 8.23 (m, 8H, Ar), 7.68-7.65 (m, 4H, Ar), 7.61-7.59 (m, 8H, Ar), 0.96 (s, 9H, tBu). 31P{1H} NMR (121.5?MHz, CDCl3): delta 25.09. HRMS (positive ESI-MS): calcd for C28H29INP2Pd [M?-?I]+ 673.9849, found 673.9877; calcd for C28H29I2NNaP2Pd [M+Na]+ 823.8792, found 823.8830.

At the same time, in my other blogs, there are other synthetic methods of this type of compound, Sodium iodide, and friends who are interested can also refer to it.

Reference:
Article; Ioannou, Polydoros-Chrysovalantis; Arbez-Gindre, Cecile; Zoumpanioti, Maria; Raptopoulou, Catherine P.; Psycharis, Vassilis; Kostas, Ioannis D.; Kyritsis, Panayotis; Journal of Organometallic Chemistry; vol. 879; (2019); p. 40 – 46;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 68507-19-7, name is 3-Iodo-4-methoxybenzoic acid belongs to iodides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. HPLC of Formula: C8H7IO3

General procedure: To a solution of the alcohol (1 equiv) in dried THF at 0 C under a nitrogen atmosphere was added the acid (1.5 equiv) and triphenylphosphine (1.7 equiv), respectively. Then diisopropyl azodicarboxylate (1.7 equiv) was added slowly. The reaction mixture was stirred overnight, quenched with saturated NaHCO3, concentrated, and extracted with ethyl acetate for three times. The combined organic phase was dried over Na2SO4, concentrated, and the residue was purified with column chromatography to give the substrate in 60-85% yield.

The synthetic route of 68507-19-7 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Xing, Xiangyou; Zhao, Yaohong; Xu, Chen; Zhao, Xinyang; Wang, David Zhigang; Tetrahedron; vol. 68; 36; (2012); p. 7288 – 7294;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Adding a certain compound to certain chemical reactions, such as: 401-81-0, name is 1-Iodo-3-(trifluoromethyl)benzene, belongs to iodides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 401-81-0, SDS of cas: 401-81-0

To a solution of 1-trifluoromethyl-3-iodobenzene 13 (20 g, 73.5 mmol) in THF (200 mL) was added Pd(PPh3)2Cl2 (1.3 g, 0.18 mmol) and CuI (0.35 g, 0.18 mmol). Nitrogen was passed through the mixture while stirring for 20 minutes. Propargyl alcohol (4.9 g, 88.2 mmol) was added to the mixture followed by triethylamine (8.9 g, 88.2 mmol). The resulting exothermic reaction raised the temperature of the mixture to approximately 40 C. which was maintained with external heating for 2 hr, then the reaction mixture was stirred overnight. The mixture was cooled to room temperature, diluted with MTBE (200 mL) and filtered through a pad of Celite. The filtrate was washed with brine (200 mL), dried over sodium sulfate and solvent was removed under reduced pressure. The crude product was purified by column chromatography (200 g silica gel, eluted by 10-50% ethyl acetate/heptane gradient) to give the product 31 (14 g, 95% yield) as a yellow oil.

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 1-Iodo-3-(trifluoromethyl)benzene, and friends who are interested can also refer to it.

Reference:
Patent; Liu, Julie F.; Imagire, Jillian; US2008/261926; (2008); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Application of 5326-47-6, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 5326-47-6, name is 2-Amino-5-iodobenzoic acid, This compound has unique chemical properties. The synthetic route is as follows.

2-Amino-5-iodoben- zoic acid (0.6616 g, 2.52 mmol) was refluxed overnight in CH3OH with TMSC1 (1.3689 g, 12.60 mmol) to esteriFy the carboxylic group. The solvent was evaporated. Afier that EtOAc was added, and it was extracted with saturated NaHCO3, water, and brine solution. After that it was purified with column chromatography (5% EtOAc in hexane) to yield yellow solid (3 9.29%). ?H-NMR (500 MHz, CDC13) oe 8.14 (d, J=2.2 Hz, 1H), 7.47 (dd, J=8.7, 2.2 Hz, 1H), 6.46 (d, J=8.7 Hz, 1H), 3.86 (s, 3H); ?3C-NMR (126 MHz, CDC13) oe 167.5, 149.9, 142.4, 139.6, 119.0, 113.0, 76.1, 51.9. Theterminal alkyne was prepared by method described above and purified by column chromatography (5% EtOAc in hexane) to obtain yellow solid (84.78%). Then, itwas desilylated before purification by column chromatography (10% EtOAc in hexane) to obtain pale yellow solid(50.72%).

The chemical industry reduces the impact on the environment during synthesis 2-Amino-5-iodobenzoic acid. I believe this compound will play a more active role in future production and life.

Reference:
Patent; THE REGENTS OF THE UNIVERSITY OF CALIFORNIA; THE SCRIPPS RESEARCH INSTITUTE; MAHIDOL UNIVERSITY; TAYLOR, Palmer; YAMAUCHI, John; TALLEY, Todd T.; ARUNRUNGVICHIAN, Kuntarat; VAJRAGUPTA, Opa; FOKIN, Valery; (79 pag.)US2018/244653; (2018); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 58313-23-8, name is Ethyl-3-iodobenzoate, A new synthetic method of this compound is introduced below., Formula: C9H9IO2

General procedure: A dry and argon-flushed Schlenk tube, equipped with a magnetic stirring bar and a rubber septum was charged with Ni(acac)2 (12.8 mg, 0.05 mmol, 0.05 equiv) as catalyst, 4-fluorostyrene (24.4 mg, 0.20 mmol, 0.20 equiv), the aryl iodide or heteroaryl chloride 3 as electrophile (1.00 mmol, 1.00 equiv), and freshly distilled THF (1 mL). The resulting suspension was cooled to 0 C and the prior prepared bis-(aryl)manganese solution (0.70 mmol, 0.70 equiv) was added dropwise at the prior adjusted temperature. The reaction conversion was monitored by GC analysis of hydrolyzed aliquots. After full conversion of the electrophile, the reaction mixture was quenched with a sat. aq NH4Cl and extracted with EtOAc (3 ¡Á 75 mL). The combined organic layers were dried (MgSO4), filtered, and concentrated under reduced pressure. Purification of the crude product by flash column chromatography afforded the desired products.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Article; Benischke, Andreas D.; Desaintjean, Alexandre; Juli, Thomas; Cahiez, Gerard; Knochel, Paul; Synthesis; vol. 49; 24; (2017); p. 5396 – 5412;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 41252-95-3, name is 1-Chloro-4-iodo-2-nitrobenzene, This compound has unique chemical properties. The synthetic route is as follows., Application In Synthesis of 1-Chloro-4-iodo-2-nitrobenzene

To a jacketed reactor, N,N-dimethylacetamide (DMAc) (960 mL) and sodium methylate (Na- OMe) powder (77.8 g) is charged at 20 C. Dimethyl malonate (191 g) is added dropwise into the above mixture while keeping internal temperature at around 10 C. After finishing addition, warm up the mixture to 20 C, and continue to stirr for another 10 minutes. Then, 2-chloro-5- iodonitrobenzene (136 g) is added in one portion, and heat the mixture to 78 C and stir for usually at least 2.5 hours until process monitor shows almost complete conversion. The resulting mixture is cooled down to 20 C, and it is quenched by 2 N cold aq. HCI solution (1440 mL). Then, the mixture is stirred for another 1 hour. Collect the solid by filtration and wash the solid with water (500 mL) to afford 2-(4-iodo-2-nitrobenzene)-dimethlymalonate (146 g) as pale yellow solid in 80% yield and 97% HPLC purity (Rt = 13.9 min).1H NMR (400 MHz, CDCI3) delta 3.79 (s, 6H), 5.26 (s, 1 H), 7.25-7.27 (m, 1 H), 7.95-7.98 (dd, J = 8.3, 1 .8 Hz, 1 H), 8.36-8.37 (d, J = 1 .8 Hz, 1 H);13C NMR (100 MHz, CDCI3) delta 53.3, 53.6, 93.4, 127.4, 132.8, 133.8, 142.4, 148.9, 167.1 ; MS (ESI): m/z 378.96 (M+1 ).

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 41252-95-3.

Reference:
Patent; BOEHRINGER INGELHEIM INTERNATIONAL GMBH; BOEHRINGER INGELHEIM INTERNATIONAL TRADING (SHANGHAI) CO., LTD.; SHI, Wenjian; SONG, Yanli; BAO, Yuhui; LU, Jun; HUANG, Yao; WEBER, Dirk; WO2014/37307; (2014); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Synthetic Route of 333447-42-0, These common heterocyclic compound, 333447-42-0, name is 1,5-Difluoro-2-iodo-4-methylbenzene, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Step B – Synthesis of Compound CC2; A solution of compound CCl (7.11 g, 28.0 mmol), zinc cyanide (1.97 g, 16.8 mmol) and tetrakis(triphenylphosphine)palladium(0) (3.23 g, 2.80 mmol) in DMF (30 mL) was heated to 900C and allowed to stir at this temperature for 1.5 hours. The reaction mixture was concentrated in vacuo and the residue obtained was taken up in water (400 mL) and extracted with ether (400 mL). The organic extract was washed with aqueous ammonium hydroxide solution (IN). The organic layer was dried (MgSO4) filtered, concentrated in vacuo to provide a residue that was purified using flash column chromatography (SiO2, EtOAc/Hexanes) to provide a mixture that contained product and triphenylphosphine. This mixture was further purified using sublimation at 1 mm/Hg at 45 0C to provide compound CC2 (1.8 g; Yield = 42%).

Statistics shows that 1,5-Difluoro-2-iodo-4-methylbenzene is playing an increasingly important role. we look forward to future research findings about 333447-42-0.

Reference:
Patent; SCHERING CORPORATION; WO2008/82484; (2008); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 21740-00-1, name is 5-Bromo-2-iodobenzoic acid, A new synthetic method of this compound is introduced below., name: 5-Bromo-2-iodobenzoic acid

Add 5-bromo-2-iodobenzoic acid (1998 g, 6.11 mol) portion wise to a 20 C solution of sulfuric acid (100 mL) in methanol (13 L). Heat the suspension to reflux for 24 hours, then cool to 20 C and remove the solvent under reduced pressure. Pour the residue into a 1 : 1 mixture of methyl-ieri-butyl ether and ice water (20 L) and separate the phases. Extract the aqueous phase with methyl-tert-butyl ether (1.5 L), combine the organic phases and wash with aqueous 0.2 M NaOH (5 L), wash with saturated aqueous sodium chloride, dry over sodium sulfate, filter, and evaporate under reduced pressure. Dissolve the crude product in 40-45 C petroleum ether (10 L), filter through a pad of diatomaceous earth and evaporate under reduced pressure. Dissolve the residue in petroleum ether (5 L) and cool to -50 C, filter the first crop solids, wash the solid with ice cold petroleum ether. Evaporate the mother liquor, redissolve the solid in petroleum ether (1 L), cool to -50 C, and filter a second crop. Combine first and second crops and dry in open air to provide the title compound as a yellow solid (1880 g, 90%).

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; ELI LILLY AND COMPANY; DALLY, Robert Dean; WOODS, Timothy Andrew; WO2014/143601; (2014); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com