Iodides-buliding-blocks

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 276866-90-1, name is 4-Chloro-3-iodobenzaldehyde, This compound has unique chemical properties. The synthetic route is as follows., Recommanded Product: 4-Chloro-3-iodobenzaldehyde

General procedure: 2-Methoxyphenylboronic acid 6 (1.2mmol), Pd(PPh3)4 (0.1mmol) and Na2CO3 (1.5mmol) were added to a solution of benzaldehyde 5 (1.0mmol) in DMF (20ml). The mixture was stirred for overnight at 150 C. After cooling down to room temperature, the reaction mixture was quenched with saturated NaHCO3 and then extracted with EtOAc. The combined organic layers were dried over MgSO4, filtered, and evaporated. The residue was purified by column chromatography on silica gel (Hexane:Ether=10:1) to obtain desired product 7 in 64-98% yields.5.1.1.1 6-Chloro-2′-methoxy-[1,1′-biphenyl]-3-carbaldehyde (7b) 64% Yield (as a white solid): mp 82-83 C; 1H NMR (400 MHz, CDCl3) delta 9.99 (s, CHO), 7.81-7.78 (m, 2ArH), 7.61 (d, J = 8.8 Hz, ArH), 7.43-7.39 (m, ArH), 7.20 (dd, J = 7.6, 2.0 Hz, ArH), 7.04 (td, J = 7.6, 0.8 Hz, ArH), 7.00 (d, J = 8.4 Hz, ArH), 3.78 (s, OCH3); 13C NMR (CDCl3, 100 MHz) delta 191.09, 156.64, 140.80, 138.90, 134.75, 133.30, 130.79, 130.25, 130.01, 129.01, 127.21, 120.54, 111.04, 55.58; HRMS (ESI+) calcd for C14H11ClNaO2+ [M + Na]+ 269.0340, found 269.0343.

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 276866-90-1.

Reference:
Article; Kim, Youngjae; Park, Hyeri; Lee, Jeongeun; Tae, Jinsung; Kim, Hak Joong; Min, Sun-Joon; Rhim, Hyewhon; Choo, Hyunah; European Journal of Medicinal Chemistry; vol. 123; (2016); p. 180 – 190;,
Iodide – Wikipedia,
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Application of 6828-35-9,Some common heterocyclic compound, 6828-35-9, name is 5-Chloro-2-iodoaniline, molecular formula is C6H5ClIN, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

c) To a stirred solution of 1-(4-ethynylbenzyl)-3,5-dimethyl-1 H-pyrazol-4-yl-acetic acid tert.- butyl ester (4.4g) and 5-chloro-2-iodophenylamine (3.4 g) in tetrahydrofuran (100 ml) at room temperature is added diisopropylethylamine (5.8 ml). The reaction is degassed and put under argon. Copper(l)iodide (260 mg) and bis(triphenylphosphine)palladiumdichloride (475 mg) are added. After 18 h, the reaction mixture is absorbed onto Extrelut and purified by flash chromatography (7:3 isocratic – cyclohexane:ethyl acetate) to yield a solid (4.3g; HPLC retention time 1.66 min (Method J)). The solid (4.2 g) is dissolved in N-methyl-2-pyrrolidone (25 ml) and the solution degassed and put under argon. Potassium tert-butoxide (4.1 g) is added and the reaction is then heated to 50C. After 15 h, further potassium tert-butoxide (1.0 g) is added. After 15 h the reaction temperature is increased to 75C. After 3 h, the reaction mixture is allowed to cool to room temperature and a copious amount of water is added. The reaction mixture is extracted twice with ethyl acetate and the aqueous phase is acidified to pH 3 with 1 M aqueous hydrochloric acid. The resultant precipitate is filtered off and triturated with hot acetonitrile to yield (1-[4-(6-Chloro-1 H-indol-2-yl)-benzyl]-3,5-dimethyl- 1 H-pyrazol-4-yl)-acetic acid (2.0 g; [M+H] = 394; HPLC retention time 1.51 min (Method E)).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 5-Chloro-2-iodoaniline, its application will become more common.

Reference:
Patent; BOEHRINGER INGELHEIM INTERNATIONAL GMBH; MARTYRES, Domnic; ANDERSKEWITZ, Ralf; HOENKE, Christoph; KRIEGL, Jan; OOST, Thorsten; RIST, Wolfgang; SEITHER, Peter; WO2012/130633; (2012); A1;,
Iodide – Wikipedia,
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Application of 455-13-0, The chemical industry reduces the impact on the environment during synthesis 455-13-0, name is 4-Iodobenzotrifluoride, I believe this compound will play a more active role in future production and life.

General procedure: NH-containing heterocycle (1.4 mmol) and DMF (2.0 mL) were added to a mixture of CuCl (15.0 mol%) and ligand 1 (20.0 mol%) in DMF (2.0 mL), aryl iodide (1.0 mmol), NaOH (2.0 mmol). The mixture was vigorously stirred at 120 C for 14 h under a dry nitrogen atmosphere. After completion of the reaction (as monitored by TLC), H2O was added and the organic layer was extracted with EtOAc, washed with brine and dried over MgSO4. The solution was filtered and the solvent was evaporated under reduced pressure. The residue was purified by column chromatography. The purity of the compounds was checked by 1H NMR and yields are based on aryl iodide. All the products are known and the spectroscopic data (FT-IR and NMR) and melting points were consistent with those reported in the literature.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 4-Iodobenzotrifluoride, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Sajadi, S. Mohammad; Maham, Mehdi; Journal of Chemical Research; vol. 38; 2; (2014); p. 128 – 129;,
Iodide – Wikipedia,
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Adding a certain compound to certain chemical reactions, such as: 62720-29-0, name is 1,3-Dibromo-5-fluoro-2-iodobenzene, belongs to iodides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 62720-29-0, Application In Synthesis of 1,3-Dibromo-5-fluoro-2-iodobenzene

Example 101a 2,6-Dibromo-4-fluorobenzaldehyde 101a A solution of 1,3-dibromo-5-fluoro-2-iodobenzene (50 g, 132 mmol) in anhydrous toluene (300 mL) was cooled to -35 C. A solution of isopropylmagnesium chloride (84 mL, 171 mmol, 2.0 M in diethyl ether) over a period of 30 minutes while maintaining the internal temperature below -25 C. See . A clear brown solution was obtained. Stirring was continued for 1.5 h. Then anhydrous DMF (34 mL, 436 mmol) was added over a period of 30 minutes. The temperature of the reaction mixture increased to -19 C. The reaction mixture was warmed to 10 C. (room temperature) over 1 h and stirred at this temperature for 1.5 h. The reaction was quenched with saturated aqueous NH4Cl (100 mL), filtered and evaporated under reduced pressure. The residue was purified by silica-gel column chromatography (eluting with petroleum ether/ethyl acetate:from 50:1 to 20:1) to give 101a (20 g, yield 54%) as a yellow solid.

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 1,3-Dibromo-5-fluoro-2-iodobenzene, and friends who are interested can also refer to it.

Reference:
Patent; GENENTECH, INC.; Crawford, James John; Young, Wendy B.; US2013/116245; (2013); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Adding a certain compound to certain chemical reactions, such as: 387-48-4, name is 3-Fluoro-2-iodobenzoic acid, belongs to iodides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 387-48-4, HPLC of Formula: C7H4FIO2

Intermediate 93: 3-Fluoro-2-(1 H-pyrazol-1 -yl)benzoic acid.3-Fluoro-2-(1 H-pyrazol-1 -yl)benzoic acid. To a mixture of 3-fluoro-2- iodobenzoic acid (1 .4 g, 5.26 mmol), 1 H-pyrazole (0.72 g, 10.5 mmol), trans- N,N’-dimethyl-cyclohexane-1 ,2-diamine (0.17 mL, 1 .05 mmol), Cul (50.1 mg, 0.26 mmol), dioxane (50 mL) and water (0.028 mL) was added Cs2C03 (3.43 g, 10.5 mmol). The reaction mixture was heated to 100 C for 1 h. The reaction mixture was cooled to ambient temperature then diluted with water. The aqueous layer was acidified to pH2 and extracted with EtOAc (30 mL) three times. The organic layers were combined, dried over Na2S04, filtered and concentrated. Purification (FCC), (DCM to 10% MeOH/1 %HOAC/DCM) afforded the title compound as a colorless oil (790 mg, 72%). 1H NMR (400 MHz, CDCIs): 7.85 – 7.73 (m, 1 H), 7.54 – 7.44 (m, 1 H), 7.44 – 7.34 (m, 1 H), 6.55 (s, 1 H).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 3-Fluoro-2-iodobenzoic acid, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; JANSSEN PHARMACEUTICA NV; LETAVIC, Michael; RUDOLPH, Dale, A.; SAVALL, Brad, M.; SHIREMAN, Brock, T.; SWANSON, Devin; WO2012/145581; (2012); A1;,
Iodide – Wikipedia,
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In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 852569-38-1, name is 5-Chloro-4-fluoro-2-iodoaniline belongs to iodides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. COA of Formula: C6H4ClFIN

Potassium t-butoxide (12.52 g, 111.6 mmol) is added at room temperature to a solution of 5-chloro-4-fluoro-2-iodoaniline (5.0 g, 22.3 mmol) in 250 mL of anhydrous THF under nitrogen. After stirring for 15 minutes, a solution of 1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazole-4-carboxylic acid fluoride (5.67 g, 24.6 mmol) in 30 mL of anhydrous THF is added dropwise. The reaction mixture is stirred for 4 hours at room temperature and then poured into saturated aqueous NaHCO3 solution and extracted with EtOAc. The organic phase is washed with saturated aqueous NaCl solution, dried over Na2SO4 and concentrated to dryness. After purification by flash chromatography on silica (cyclohexene/EtOAc:95/5 to 80/20), a red solid is obtained, which is purified by flash chromatography on amine phase (DCM) to give 2.84 g of a white solid (yield: 31%). [0871] LCMS (Method E): MH+=404.0, RT=2.29 min

The synthetic route of 852569-38-1 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; SANOFI; Benazet, Alexandre; Duclos, Olivier; Guillo, Nathalie; Lassalle, Gilbert; Macary, Karim; Vin, Valerie; US2014/235616; (2014); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Adding a certain compound to certain chemical reactions, such as: 628-77-3, name is 1,5-Diiodopentane, belongs to iodides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 628-77-3, Application In Synthesis of 1,5-Diiodopentane

Intermediate 3 was prepared by a similar procedure from intermediate 1 (500 mg, 1.1 mmol), 1 ,5-diiodopentane (1.1 g, 0.5 ml, 3.3 mmol), 1 M aqueous sodium hydroxide (3 ml, 3 mmol), tetra-n-butylammonium iodide (45 mg, 0.12 mmol) and water (3 ml). Purification was achieved via column chromatography (loaded onto diatomaceous earth) using 0-14% step gradient of EtOAc in cyclohexane (2% steps ) as eluent, followed by EPO 100% cyclohexane, followed by 30% EtOAc in cyclohexane to afford the product as a colorless gum.Yield: 324 mg (46%)LC-MS (Method 3): Rt 4.79 min, m/z 642 [MH+]

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1,5-Diiodopentane, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; ARGENTA DISCOVERY LTD.; WO2007/42815; (2007); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Application of 18698-96-9, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 18698-96-9, name is 2-(2-Iodophenyl)acetic acid, This compound has unique chemical properties. The synthetic route is as follows.

Key Intermediate 1: 2-(2-Ethynylphenyl)butanamide (KI)(a) 2-(2-Iodophenyl)butanoic acid (Ii)Lithium diisopropylamide solution (2.0 M in THF/heptane/ethylbenzene, 3.82 mL, 7.63 mmol) was added to dry THF (10 mL) under an atmosphere of nitrogen and cooled to 0 00. A solution of 2-(2-iodophenyl)acetic acid (500 mg, 1.91 mmol) in dryTHF (15 mL) was then added dropwise. This solution was stirred for 40 minutes at 000 before the addition of iodoethane (0.92 mL, 11 mmol). The solution was returnedto room temperature and stirred for 4 hours. The resulting mixture was quenched with the addition of H20 (10 mL) and then 2 M HCI (20 mL). The aqueous layer was extracted with EtOAc (3 x 30 mL), the organic layers were combined and washedwith brine, dried over Mg504 and the solvent was evaporated under reducedpressure. The residue was adsorbed onto silica gel and purified using columnchromatography (Biotage Isolera, 5i02 cartridge, 0-40percent EtOAc in petroleum benzine40-60 00) to give the title compound Ii as a pale yellow oil (479 mg, 87percent); 1H NMR(400 MHz, d6-DMSO) O 12.49 (5, 1H), 7.88 (dd, J= 7.9, 1.2 Hz, 1H), 7.39 (td, J= 7.6,1.2 Hz, 1H), 7.32 (dd, J= 7.8, 1.7 Hz, 1H), 7.01 (Jm, 1H), 3.77 (t, J= 7.5 Hz, 1H),1.98?1.86 (m, 1H), 1.73?1.60 (m, 1H), 0.85 (t, J= 7.3 Hz, 3H).JH2Ii 12 13 Ki

The chemical industry reduces the impact on the environment during synthesis 2-(2-Iodophenyl)acetic acid. I believe this compound will play a more active role in future production and life.

Reference:
Patent; CANCER THERAPEUTICS CRC PTY LIMITED; FOITZIK, Richard Charles; MORROW, Benjamin Joseph; HEMLEY, Catherine Fae; LUNNISS, Gillian Elizabeth; CAMERINO, Michelle Ang; GANAME, Danny; STUPPLE, Paul Anthony; LESSENE, Romina; KERSTEN, Wilhelmus Johannes Antonius; HARVEY, Andrew John; HOLMES, Ian Peter; WO2014/26243; (2014); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 610-97-9, name is Methyl 2-iodobenzoate, A new synthetic method of this compound is introduced below., Computed Properties of C8H7IO2

30 g (114 mmol) methyl 2-iodobenzoate, N, N-dimethylformamide in 1 L round bottom flaskAfter adding 360ml, trimethylsilylacetylene 22.5g (229mmol), 114.9 ml (801 mmol) triethylamineNitrogen was bubbled for 20 minutes by addition of 8 g (11 mmol) of dichloro (bistriphenylphosphine) palladium (II),I put 2.2 g (11 mmol) of Cooper (I) iodideHeat stirred at 80 C. for 3 h.When the reaction was terminated, the reaction solution was purified by a column to obtain 23 g (yield: 86%) of the compound represented by [Formula 191-d].

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; SFC Ltd.; Park Seok-bae; Lee Se-jin; Kim Jeong-su; (92 pag.)KR101996647; (2019); B1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Related Products of 82777-09-1,Some common heterocyclic compound, 82777-09-1, name is 2′-Iodo-1,1′:3′,1”-terphenyl, molecular formula is C18H13I, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: The outline of our synthetic routes to the 6 compounds listed in Fig. 1 is shown in Scheme 1. They were synthesized by Suzuki-Miyaura coupling of 2,6-dibromodithieno[3,2-b:2?,3?-d]thiophene each with the corresponding boronic acid. Compounds 5 and 7 in Fig. 1 were also synthesized by Suzuki-Miyaura coupling of 3,7-bis(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)dibenzo[b,d]thiophene and 2,6-bis(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)dithieno[3,2-b:2?,3?-d]thiophene with 2?-iodo-1,1?:3?,1?-terphenyl, respectively. The typical procedure is following. A mixture of 2,6-dibromo-dithieno[3,2-b:2?,3?-d]thiophene (174.0 mg, 0.5 mmol), boronic acid of counterpart (1.5 mmol), tetrakis (triphenylphosphine) palladium (81.5 mg, 0.08 mmol) and Cs2CO3 (2.0 mL, 2.0 M in aqueous) in 8 mL solvent of toluene: THF = 1:1 was stirred at reflux temperature for 8 h. All reactions were carried out under nitrogen atmosphere with anhydrous solvents. The mixture was poured into water (30 mL) and extracted with CH2Cl2 (20 mL ¡Á 3). The combined extract was washed with brine (40 mL), dried (Na2SO4), and concentrated in vacuo. Column chromatography on silica gel eluted with CHCl3:toluene = 1:1. All compounds were characterized by 1H and 13C NMR and mass spectroscopy.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 2′-Iodo-1,1′:3′,1”-terphenyl, its application will become more common.

Reference:
Article; Okada, Shinjiro; Yamada, Kenji; Journal of Molecular Structure; vol. 1037; (2013); p. 256 – 263;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com