Iodides-buliding-blocks

612-55-5, A common compound: 612-55-5, name is 2-Iodonaphthalene, belongs to iodides-buliding-blocks compound, it can change the direction of chemical reaction, and react with certain compounds to generate new functional products. A new synthetic method of this compound is introduced below.

General procedure: To a Schlenk tube were added aryl iodides 1 (0.2 mmol, 1.0 equiv),1,2-diphenylethynes 2 (0.2 mmol, 1.0 equiv), 2-bromobenzoic acid 3 (0.24 mmol, 1.2equiv), PdCl2(dppf) (0.01 mmol, 5 mol %), K2CO3 (0.6 mmol, 3.0 equiv), Me4NOAc(0.6 mmol, 3.0 equiv), and DMSO (0.2 M, 1 mL). Then the tube was charged with nitrogen, and was stirred at 140 oC (oil bath temperature) for the indicated time until complete consumption of starting material as monitored by TLC analysis. After the reaction was finished, the resulting suspension was filtered and washed with ethyl acetate. The combined filtrates were concentrated under reduced pressure and purifiedon a silica-gel column chromatography (petroleum ether/EtOAc) to give product 4.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-Iodonaphthalene, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Deng, Guobo; Liang, Yun; Luo, Xiai; Yang, Xiumei; Yang, Yuan; Yang, Yuzhong; Zhou, Liwei; Synthesis; vol. 52; 8; (2020); p. 1223 – 1230;,
Iodide – Wikipedia,
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Adding some certain compound to certain chemical reactions, such as: 696-41-3, name is 3-Iodobenzaldehyde, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 696-41-3. 696-41-3

General procedure: Aryl iodide 3 (0.2 mmol, 1.0 equiv), acrylate/styrene 4 (0.202 mmol, 1.01 equiv), DIPEA (28.4 mg, 0.22 mmol, 1.1 equiv), and Pd(I)-iodo dimer 2 (1.3 mg, 0.0015 mmol, 0.75 mol%) were weighed into a 4 mL screw cap vial, purged with argon, and dissolved in anhydrous toluene(1.5 mL). The vial was capped with a PTFE-lined screw cap and sealed with PTFE tape prior to heating to 100 C under stirring by using an aluminum heating block outside the glovebox. After 15 h, the reaction mixture was allowed to cool to r.t. and diluted with EtOAc (to 20 mL); excess base was quenched by the addition of sat. aq NH4Cl (20 mL). The organic phase was separated and the aqueous layer was extracted with EtOAc (2*20 mL). The combined organic layer was dried over MgSO4 and the solvent was removed under reduced pressure. The obtained crude product was purified by flash column chromatography.

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 3-Iodobenzaldehyde.

Reference:
Article; Sperger, Theresa; Stirner, Christopher K.; Schoenebeck, Franziska; Synthesis; vol. 49; 1; (2017); p. 115 – 120;,
Iodide – Wikipedia,
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77317-55-6, A common compound: 77317-55-6, name is Methyl 2-amino-5-iodobenzoate, belongs to iodides-buliding-blocks compound, it can change the direction of chemical reaction, and react with certain compounds to generate new functional products. A new synthetic method of this compound is introduced below.

Preparation 49 Methyl 5-Iodo-2-((methylsulfonyl)amino)benzoate [BW.2] To a solution of 5-iodoanthranilic acid methyl ester (1.00 g) and triethylamine (1.01 mL) in CH2Cl2 (25 mL) is added methanesulfonyl chloride (0.59 mL) at 0 C. The ice bath is removed and after 3 h at room temperature the solution is poured into water (20 mL) and extracted with CH2Cl2 (2*20 mL). The organic layers are combined, dried over MgSO4 and the solvent removed in vacuo. The resulting residue is dissolved in CH3OH (20 mL) and sodium methoxide (20 mL) is added. After 45 min, the solvent is removed in vacuo. The residue is diluted with Et2O (20 mL) and washed with water (20 mL). The organic layer is separated, dried over MgSO4, filtered, and concentrated in vacuo. The crude black liquid is purified by silica gel column chromatography (4/1, hexanes/EtOAc) to afford 0.58g (46%) of the title compound as a brown solid. Physical characteristics: m.p. 119-120 C.; 1H NMR (300 MHz, CDCl3) delta 10.41, 8.36, 7.82, 7.52, 3.94, 3.06; IR (diffuse reflectance) 1700, 1682, 1483, 1385, 1335, 1328, 1307, 1249, 1213, 1159, 1147, 1093, 1086, 978, 971 cm-1; MS (FAB) m/z 356 (MH+); HRMS (FAB) m/z 355.9447 (C9H10INO4S+H). Anal. Found: C, 30.49; H, 2.88; N, 3.96.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Methyl 2-amino-5-iodobenzoate, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Bundy, Gordon L.; Ciske, Fred L.; Genin, Michael J.; Heasley, Steven E.; Larsen, Scott D.; Lee, Byung Hyun; May, Paul D.; Palmer, John R.; Schnute, Mark E.; Vaillancourt, Valerie A.; Thorarensen, Atli; Wolf, Allison J.; Wicnienski, Nancy Anne; Wilhite, David; US2002/25960; (2002); A1;,
Iodide – Wikipedia,
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Adding a certain compound to certain chemical reactions, such as: 19094-56-5, name is 2-Chloro-5-iodobenzoic acid, belongs to iodides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 19094-56-5, 19094-56-5

EXAMPLE 55A A solution of 2-chloro-5-iodobenzoic acid (600 mg) in THF (7 mL) at 0 C. was treated with a 1M LiAlH4 in THF (1.17 mL), stirred for 30 minutes, quenched with water (5 mL), diluted with ethyl acetate, washed with 1M HCl, 1M NaOH and brine and concentrated. The concentrate was flash chromatographed on silica gel with 20% ethyl acetete/hexanes.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-Chloro-5-iodobenzoic acid, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Wendt, Michael D.; Sun, Chaohong; Sauer, Daryl R.; Elmore, Steven W.; Kunzer, Aaron R.; US2007/72833; (2007); A1;,
Iodide – Wikipedia,
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63262-06-6, These common heterocyclic compound, 63262-06-6, name is 1,4-Dibromo-2,5-diiodobenzene, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Under an argon atmosphere, dibromodiiodobenzene (4.00 g, 8.20 mmol), compound 1-2 (6.81 g, 16.8 mmol, 1.05 eq.), and Pd(PPh3)4 (474 mg, 0.41 mmol, 5% Pd) were dissolved in 1 ,2-dimethoxyethane (800 mE) and water (200 mE) in which K3P04 (10.4 g, 49.2 mmol) was dissolved was added thereto, and the mixture was stirred with heating at 500 C. for 24 hours. Afier completion of the reaction, extraction with ethyl acetate was conducted, and the solvent was concentrated. The resulting solid was purified by column chromatography, whereby obtaining a white solid (5.0 g, yield: 77%). The obtained solid was compound 1-3, which is an intended product, and by mass spectrum analysis, it was confirmed that it had an mle value of 790 with respect to a molecular weight of 790.

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 63262-06-6.

Reference:
Patent; IDEMITSU KOSAN CO., LTD.; Takahashi, Ryota; Ikeda, Hidetsugu; Seda, Keita; Nakano, Yuki; (152 pag.)US10249832; (2019); B1;,
Iodide – Wikipedia,
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915095-86-2, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 915095-86-2, name is (2-Chloro-5-iodophenyl)(4-fluorophenyl)methanone, This compound has unique chemical properties. The synthetic route is as follows.

General procedure: To a stirred solution of 1 (0.01 mol) in 30 mL of CH2Cl2and 30 mL of CH3CN at 0 ¡ãC were added Et3SiH(4.79 mL,0.03 mol), then BF3¡¤Et2O(2.53 mL, 0.02 mol), and theresulting mixture was warmed to room temperature andstirred for 3?8 h. The mixture was poured into saturatedaqueous NaHCO3 and extracted with CH2Cl2 twice. Thecombined organic layers were washed with brine, dried overMgSO4, and concentrated. The residual solid was crystallizedfrom ethanol to give as white solid.According to this procedure the following compoundswere prepared. 1-chloro-2-(4-fluorobenzyl)-4-iodobenzene (2a)White solid, yield 83percent, m.p. 52?54 ¡ãC. 1H NMR (400MHz, DMSO-d6): delta 4.02(s, 2H), 7.10?7.13(m, 2H), 7.22?7.25(m, 3H), 7.60(dd, J = 0.8, 6.8 Hz, 1H), 7.72(d, J = 0.8Hz, 1H). 13C NMR (100 MHz, DMSO-d6): delta 36.94, 92.85,115.21(d, J = 68 Hz), 130.30(d, J = 24 Hz), 131.32,133.16, 134.87, 136.82, 139.44, 140.77, 159.80, 161.73.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

Reference:
Article; Hu, Shengquan; Sun, Wuji; Wang, Yeming; Yan, Hong; Medicinal Chemistry Research; vol. 28; 4; (2019); p. 465 – 472;,
Iodide – Wikipedia,
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18698-96-9, A common compound: 18698-96-9, name is 2-(2-Iodophenyl)acetic acid, belongs to iodides-buliding-blocks compound, it can change the direction of chemical reaction, and react with certain compounds to generate new functional products. A new synthetic method of this compound is introduced below.

Aminoester 76 (0.92 g, 4.50 mmol) and 2-(2-iodophenyl)acetic acid (1.36 g, 5.2 mmol) were dissolved in 23 ml butyl acetate. 1-Propanephosphonic anhydride solution (T3P, 7 ml, 11.7 mmol) was added and the mixture was stirred for 1 h at room termpature and then 1 h at reflux. The mixture was allowed to cool to room temperature and was washed twice with 4percent sodium bicarbonate solution. The organics were dried over anhydrous sodium sulphate, filtrered and evaporated under reduced pressure. The residue was purified using the SP-1 purification system (ethyl acetate-hexane gradient, 0:100 rising to 30:70) to give 77 (1.1 g, 2.62 mmol, 58percent yield) as a pale yellow solid. Purity 100percent. 1H NMR spectrum not recorded. UPLC/MS (3 min) retention time 1.76 min. LRMS: m/z 421 (M+1).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-(2-Iodophenyl)acetic acid, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Buil, Maria Antonia; Calbet, Marta; Castillo, Marcos; Castro, Jordi; Esteve, Cristina; Ferrer, Manel; Forns, Pilar; Gonzalez, Jacob; Lopez, Sara; Roberts, Richard S.; Sevilla, Sara; Vidal, Bernat; Vidal, Laura; Vilaseca, Pere; European Journal of Medicinal Chemistry; vol. 113; (2016); p. 102 – 133;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

2265-93-2, Name is 2,4-Difluoroiodobenzene, 2265-93-2, belongs to iodides-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows.

EXAMPLE 4; 2,4-Bis-(2,4-difluorophenyI)-3-l(3-pyridyl)hydroxymethyI]thiophene; To a suspension of 1.54gm (ll.lmmol) of potassium carbonate, 1.44gm (4.46mmol) of tetrabutylammonium bromide, and .05gm (0.22mmol) of palladium(II) diacetate in 1.ImL of acetonitrile/H2O (9:1) under a N2 atmosphere was added 1.83gm (6.69mmol) of 2,4-difluoro-l-iodobenzene and 0.50gm (4.46mmol) of thiorhohene-3-carboxaldehyde. The mixture was heated at 800C for 3days, and then diluted with ethyl acetate. The ethyl acetate solution was washed with water and dried over magnesium sulfate. The drying agent was filtered off, and the solvent was removed by rotoevaporation to give a red-brown solid which was purified by flash column chromatography on silica gel to give a mixture of 2-(2,4- difluorophenyl)thiophene-3-carboxaldehyde and 2,4-bis-(2,4- difluorophenyl)thiophene-3-carboxaldehyde which was used in the next reaction.

Statistics shows that 2,4-Difluoroiodobenzene is playing an increasingly important role. we look forward to future research findings about 2265-93-2.

Reference:
Patent; SYNGENTA LIMITED; WO2007/75487; (2007); A2;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

These common heterocyclic compound, 610-97-9, name is Methyl 2-iodobenzoate, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. 610-97-9

Example 15A Methyl 5-bromo-2-iodobenzoate To a stirred slurry of methyl 2-iodo-benzoate (5.0 g, 0.019 mol) and N-bromosuccinimide (3.74 g, 0.021 mol) in acetic acid (10 mL) was added concentrated H2SO4 (10 mL) dropwise, keeping the temperature at 20-40 C. The mixture was stirred at room temperature for 88 hours and then heated at 50 C. for 4 hours. The mixture was cooled to 10 C., treated with 40 g of ice water, and extracted with 50 mL of CH2Cl2. The organic phase was washed in succession with 2*50 mL 5% NaHCO3, 50 mL 10% Na2S2O3, 50 mL water, and concentrated to colorless oil. The residue was purified by column chromatography (silica gel, 10:90 EtOAc:hexane) to provide the title compound. 1H NMR (CDCl3, 400 MHz) delta 7.92 (d, J=4 Hz, 1H), 7.83 (d, J=8 Hz, 1H), 7.27 (dd, J=8, 4 Hz, 1H), 3.92 (s, 3H); MS (DCl/NH3) [M+NH4]+at 358, [M+NH3.NH4]+ at 375.

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 610-97-9.

Reference:
Patent; Altenbach, Robert J.; Black, Lawrence A.; Chang, Sou-Jen; Cowart, Marlon D.; Faghih, Ramin; Gfesser, Gregory A.; Ku, Yi-Yin; Liu, Huaqing; Lukin, Kirill A.; Nersesian, Diana L.; Pu, Yu-ming; Curtis, Michael P.; US2005/272736; (2005); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

112671-42-8, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 112671-42-8, name is 4-Bromo-1-iodo-2-nitrobenzene belongs to iodides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

The starting material, phenylboronic acid (76.84g, 630.2mmol) was dissolved in a THF (2780ml) in a round bottom flask, 4-bromo-1-iodo-2-nitrobenzene (309.96g, 945.3mmol), Pd (PPh3) 4 ( 36.41g, 31.5mmol), was added K2CO3 (261.3g, 1890.6mmol), water (1390ml) and the resulting mixture was stirred at 80 . Once the reaction is complete, the organic layer extracted with water and CH2Cl2After the dried over MgSO4 and concentrated to a silicagel column and the resulting compound was recrystallized 122.68g product (yield: 70%)It was obtained.

The synthetic route of 4-Bromo-1-iodo-2-nitrobenzene has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Duksan Neolux Co, Ltd.; Moon, Song Yoon; Lee, Son Hui; Park, Jong Cheol; Kim, Dae Song; Lee, Bom Song; Park, Song Jae; (89 pag.)KR101550768; (2015); B1;,
Iodide – Wikipedia,
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