Tag: 200-300

Alizadeh, Abdolali; Farajpour, Behnaz published their research in Heterocyclic Letters in 2021. The article was titled 《Efficient synthesis of coumarin-based α-acyloxy amides as promising starting materials for diverse post-condensation reactions》.Reference of 4-Iodobenzoic acid The article contains the following contents:

The passerini three-component reaction for the straight-forward synthesis of coumarin-based α-acyloxy amides by employing 4-chloro-3-formylcoumarin were described. This reaction was compatible with various isocyanides and carboxylic acids. Furthermore, synthesized products can be rendered as potential starting materials for divergent post-condensation reactions and was efficiently converted into precious follow-up structures. Simple and available starting materials, catalyst-free selective process, valuable and diverse structures, and easy purification are some highlighted advantages of the synthesized coumarin-based α-acyloxy amides. In addition to this study using 4-Iodobenzoic acid, there are many other studies that have used 4-Iodobenzoic acid(cas: 619-58-9Reference of 4-Iodobenzoic acid) was used in this study.

4-Iodobenzoic acid(cas: 619-58-9) belongs to organic iodides. Alkyl iodides react at a faster rate than alkyl fluorides due to the weak C-I bond.Reference of 4-Iodobenzoic acidIodo alkanes participate in a variety of organic synthesis reactions, which include the Simmons–Smith reaction (cyclopropanation using iodomethane), Williamson ether synthesis, Wittig reaction, Grignard reaction, alkyl coupling reactions, and Wurtz reaction.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

《Electrochemical and spectroscopic study of 2-iodobenzoic acid and 2-iodosobenzoic acid anodic oxidation in aqueous environment》 was written by Devadas, Balamurugan; Svoboda, Jan; Krupicka, Martin; Bystron, Tomas. Computed Properties of C7H5IO2 And the article was included in Electrochimica Acta in 2020. The article conveys some information:

2-Iodosobenzoic acid and especially IBX represent interesting selective and green hypervalent I oxidants. Mainly due to issues connected with their preparation, use of these compounds is limited to laboratory scale. From this point of view, the electrochem. synthesis represents interesting platform for inherently safer production of these highly valued oxidants. To provoke and allow more intense study in this direction, this work aimed to present basic aspects of electrochem. behavior of these compounds in aqueous environment using several anode materials. A combination of various exptl. approaches in combination with time-dependent d. functional theory calculations allowed determining compounds speciation in a wide range of pH values. The most interesting in this sense is iodoxol ring opening after/during deprotonation of 2-iodosobenzoic acid to 2-iodosobenzoate. This process is accompanied by addition of H2O mol. to the I atom. Using voltammetry and controlled potential preparative batch electrolysis allowed constructing approx. form of Pourbaix diagram of the studied compounds Finally, diffusion coefficients of studied compounds and anodic charge transfer coefficients of oxidation reactions were determined based on detailed anal. of linear voltammograms. The results provide a solid base for further study of electrochem. synthesis of 2-iodosobenzoic acid and IBX in aqueous environment. After reading the article, we found that the author used 2-Iodobenzoic acid(cas: 88-67-5Computed Properties of C7H5IO2)

2-Iodobenzoic acid(cas: 88-67-5) belongs to organic iodides. The carbon-iodine bond is weaker than other carbon-halogen bonds due to the poor electronegative nature of the iodine atom. Computed Properties of C7H5IO2 Organic iodides can be alkyl, alkenyl, or alkynyl, and all of them are very reactive toward with many kinds of nucleophiles.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

《Methylene C(sp3)-H β,β’-Diarylation of Cyclohexanecarbaldehydes Promoted by a Transient Directing Group and Pyridone Ligand》 was published in Organic Letters in 2020. These research results belong to St John-Campbell, Sahra; White, Andrew J. P.; Bull, James A.. Reference of 1-Iodo-4-methylbenzene The article mentions the following:

A hindered β-amino amide transient directing group effects di-trans-arylation of cyclohexanecarbaldehydes. The amide N-substituents were shown to affect yield and it was enhance the rate of arylation compared with the α-amino acid. Addition of a pyridone ligand further enhanced reactivity. The reaction was successful for a range of aryl iodides, and various substituted cyclohexane carboxaldehydes, providing functionalized products from simple feedstocks. A mechanism was proposed evoking a transient enamine. After reading the article, we found that the author used 1-Iodo-4-methylbenzene(cas: 624-31-7Reference of 1-Iodo-4-methylbenzene)

1-Iodo-4-methylbenzene(cas: 624-31-7) undergoes Suzuki-Miyaura coupling reaction with phenylboronic acid catalyzed by (Ni,Mg)3Si2O5(OH)4 solid-solution nanotubes loaded with palladium.Reference of 1-Iodo-4-methylbenzene

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

《Copper-Catalyzed Three-Component Redox-Neutral Ring Opening of Benzothiazoles to 1-Amino-N-(2-(phenylthio)phenyl)methanimine》 was published in Journal of Organic Chemistry in 2020. These research results belong to Zheng, Nian; Liu, Ce; Ding, Ya-Nan; Shi, Wei-Yu; Zhang, Bo-Sheng; Liang, Yong-Min. SDS of cas: 90-14-2 The article mentions the following:

Copper-catalyzed three-component redox-neutral ring opening of benzothiazoles with aryl iodides and O-benzoyl hydroxylamines for the synthesis of 1-amino-N-(2-(phenylthio)phenyl)methanimine has been developed. This one-pot reaction undergoes C-S and N-O bond cleavage and new C-S and C-N bond construction. Several control experiments excluded a free radical procedure and also demonstrated the secondary amine as a possible intermediate, which was vital to the catalytic reaction. Meanwhile, the deuteration experiment got rid of the C-H activation dehydroisomerization of the benzothiazole mechanism. The experimental part of the paper was very detailed, including the reaction process of 1-Iodonaphthalene(cas: 90-14-2SDS of cas: 90-14-2)

1-Iodonaphthalene(cas: 90-14-2) is one of organic iodides. Organic iodides are used in veterinary products (Organic Iodide Powder) as a nutritional source of iodine. In the chemical industry, alkyl iodides serve as excellent alkylating agents and, specifically, methyl iodide is used as a methylating agent in the synthesis of various pharmaceutical drugs. Oceanic alkyl iodides are believed to be the principal source of atmospheric iodine.SDS of cas: 90-14-2

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

《Ortho C-H arylation of arenes at room temperature using visible light ruthenium C-H activation》 was published in Chemical Science in 2020. These research results belong to Sagadevan, Arunachalam; Charitou, Anastasios; Wang, Fen; Ivanova, Maria; Vuagnat, Martin; Greaney, Michael F.. Application In Synthesis of 1-Bromo-4-iodobenzene The article mentions the following:

A ruthenium-catalyzed ortho C-H arylation process is described using visible light. Using the readily available catalyst [RuCl2(p-cymene)]2, visible light irradiation was found to enable arylation of 2-aryl-pyridines I (R1 = 4-methoxyphenyl, naphthalen-2-yl, thiophen-2-yl, etc.; R2 = H, 2-Me, 4-Me, 5-Me) at room temperature for a range of aryl halides R3X (R3 = 2-methoxyphenyl, 4-phenylphenyl, thiophen-2-yl, etc.; X = I, Br). In the experimental materials used by the author, we found 1-Bromo-4-iodobenzene(cas: 589-87-7Application In Synthesis of 1-Bromo-4-iodobenzene)

1-Bromo-4-iodobenzene(cas: 589-87-7) has been employed as reagent for in situ desilylation and coupling of silylated alkynes, as starting reagent in the total syntheses of ent-conduramine A and ent-7-deoxypancratistatin (alkaloids), as substrate in copper-free Sonogashira coupling in aqueous acetone in synthesis of β,β,dibromostyrenesApplication In Synthesis of 1-Bromo-4-iodobenzene

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

The author of 《Pd nanocatalyst adorning coral reef nanocomposite for the synthesis of nitriles: utility of Cucurbita pepo leaf extract as a stabilizing and reducing agent》 were Nasrollahzadeh, Mahmoud; Ghorbannezhad, Fatemeh; Sajadi, S. Mohammad; Varma, Rajender S.. And the article was published in Nanomaterials in 2019. Formula: C5H4IN The author mentioned the following in the article:

A simple procedure for the palladium-catalyzed cyanation of aryl halides is described via a nucleophilic non-toxic cyanide source, K4[Fe(CN)6] in the presence of Pd/coral reef nanocomposite as a heterogeneous catalyst; the protocol provides a useful and easy method for the synthesis of aryl nitriles that are generated from the corresponding variant aryl halides, with sodium carbonate as a base. The nanocatalyst was prepared by a biol. process using aqueous extract of leaves of Cucurbita pepo as a stabilizing and reducing agent and coral reef as a natural support, without deploying any hazardous chems. The catalyst, that is easily separable from the reaction mixture and reused multiple times, was characterized by FT-IR (Fourier-Transform IR Spectroscopy), ICP-AES (Inductively Coupled Plasma Atomic Emission Spectroscopy), XRD (X-ray Diffraction), TEM (Transmission Electron Microscopy), FE-SEM (Field Emission SEM), EDS (Energy Dispersive X-ray Spectroscopy) and elemental mapping. In the part of experimental materials, we found many familiar compounds, such as 4-Iodopyridine(cas: 15854-87-2Formula: C5H4IN)

4-Iodopyridine(cas: 15854-87-2) is used as a reagent in the synthesis of indazolylamides as glucocorticoid receptor agonists. 4-Iodopyridine is a halogenated heterocycle that is a building block for proteomics research.Formula: C5H4IN

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

The author of 《Anode interfacial layer formation via reductive ethyl detaching of organic iodide in lithium-oxygen batteries》 were Zhang, Xiao-Ping; Sun, Yi-Yang; Sun, Zhuang; Yang, Chu-Shu; Zhang, Tao. And the article was published in Nature Communications in 2019. Electric Literature of C3H9IOS The author mentioned the following in the article:

As soluble catalysts, redox mediators can reduce the high charging overpotential of lithium-oxygen batteries by providing sufficient liquid-solid interface for lithium peroxide decomposition However, the redox mediators usually introduce undesirable reactions. In particular, the so-called “”shuttle effect”” leads to the loss of both the redox mediators and elec. energy efficiency. In this study, an organic compound, triethylsulfonium iodide, is found to act bifunctionally as both a redox mediator and a solid electrolyte interphase-forming agent for lithium-oxygen batteries. During charging, the organic iodide exhibits comparable lithium peroxide-oxidizing capability with inorganic iodides. Meanwhile, it in situ generates an interfacial layer on lithium anode via reductive Et detaching and the subsequent oxidation This layer prevents the lithium anode from reacting with the redox mediators and allows efficient lithium-ion transfer leading to dendrite-free lithium anode. Significantly improved cycling performance has been achieved by the bifunctional organic iodide redox mediator. In the part of experimental materials, we found many familiar compounds, such as Trimethylsulfoxonium iodide(cas: 1774-47-6Electric Literature of C3H9IOS)

Trimethylsulfoxonium iodide(cas: 1774-47-6) reacts with sodium hydride to prepare dimethyloxosulfonium methylide, which is used as a methylene-transfer reagent in synthetic chemistry. It is used to prepare ylide, which reacts with carbonyl compounds to get epoxides. Further, it reacts with alfa,beta-unsaturated esters to get cyclopropyl esters.Electric Literature of C3H9IOS

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

The author of 《Microwave-Assisted Synthesis of Core-Crosslinked Star Polymers with Benzophenone Derivatives in the Core》 were Kang, Tae-Hyeon; Lee, Hyung-il. And the article was published in Macromolecular Research in 2019. Recommanded Product: 4-Iodobenzoic acid The author mentioned the following in the article:

Core-crosslinked star polymers, which have polyethylene oxide (PEO) as a shell and cross-linked poly(2-{4′-iodobenzoyloxy}-Et methacrylate) (PIEMA) with benzophenone derivatives as a core, have been successfully synthesized by an “”arm-first”” method. PEO-b-PIEMA was prepared via atom transfer radical polymerization (ATRP) of 2-{4′-iodobenzoyloxy}-Et methacrylate (4-IEMA) with preformed PEO-Br as a macroinitiator. Core-crosslinked star polymers (CCSP) were efficiently synthesized by ultrafast carbonylation reactions under air by flash microwave irradiation in the presence of dicobalt octacarbonyl in 6 min. Gel permeation chromatog. (GPC) trace of CCSP showed a drastic shift to a higher mol. weight when compared to precursor polymer, PEO-b-PIEMA diblock copolymer, indicating that the carbonylation reaction was fully progressed. The CCSP with benzophenone was successfully immobilized on a silicon wafer through a photochem. reaction under UV irradiation The results came from multiple reactions, including the reaction of 4-Iodobenzoic acid(cas: 619-58-9Recommanded Product: 4-Iodobenzoic acid)

4-Iodobenzoic acid(cas: 619-58-9) belongs to organic iodides.Recommanded Product: 4-Iodobenzoic acid The carbon-iodine bond is weaker than other carbon-halogen bonds due to the poor electronegative nature of the iodine atom. In general, organic iodides are light-sensitive and turn yellow during storage, owing to the formation of iodine.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

The author of 《Mechanism of Hypervalent Iodine Promoted Fluorocyclization of Unsaturated Alcohols: Metathesis via Double Acids Activation》 were Shu, Siwei; Li, Yinwu; Jiang, Jingxing; Ke, Zhuofeng; Liu, Yan. And the article was published in Journal of Organic Chemistry in 2019. Product Details of 624-31-7 The author mentioned the following in the article:

Lewis/Bronsted acid activation plays a key role in hypervalent iodine reagent-mediated reactions. In addition to generally accepted cis-activation or trans-activation, this study reveals another important Lewis/Bronsted acid activation mode, the double-activation. Different from the generally proposed iodine(III)iranium SN2 mechanism, the hypervalent difluoro-iodoarene-promoted fluorocyclization of unsaturated alc. prefers to undergo the metathesis mechanism via an iodine(III)-π intermediate. The results came from multiple reactions, including the reaction of 1-Iodo-4-methylbenzene(cas: 624-31-7Product Details of 624-31-7)

1-Iodo-4-methylbenzene(cas: 624-31-7) is used in wide range of medicals industrial applications as well as in pharmaceutical intermediates, polarizing films for Liquid Crystal Display (LCD) chemicals.Product Details of 624-31-7

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

The author of 《A Mild and Regioselective Synthesis of α-Fluoroketones via Gold and Selectfluor Partnership》 were Chen, Xi; Martini, Sophie; Michelet, Veronique. And the article was published in Advanced Synthesis & Catalysis in 2019. Computed Properties of C6H4BrI The author mentioned the following in the article:

Alkynylaryl aldehydes and Me ketones such as I underwent regioselective fluorohydroxylation with Selectfluor in aqueous EtOH in the presence of Ph3PAuCl at ambient temperature to yield α-fluoro ketones such as II. The mechanism of the reaction was studied by the (lack of) reaction of diphenylacetylene and by deuterium labeling and intermediate studies. Selected fluoroketone, including II, were converted to 3-substituted 4-fluoroisoquinolines such as III. In the experiment, the researchers used many compounds, for example, 1-Bromo-3-iodobenzene(cas: 591-18-4Computed Properties of C6H4BrI)

1-Bromo-3-iodobenzene(cas: 591-18-4) has been used in the preparation of 1-(3′-bromophenyl)-3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,10-heptadecafluorodec-1-ene and 1-(3′-bromophenyl)-3,3,4,4,5,5,6,6,7,7,8,8,8-tridecafluorooct-1-ene.Computed Properties of C6H4BrI

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com