Tag: 200-300

《C(sp2)-H Functionalization of Imidazole at the C2- and C4-Position via Palladium-Catalyzed Isocyanide Insertion Leading to Indeno[1,2-d]imidazole and Imidazo[1,2-a]indole Derivatives》 was written by Ren, Zhi-Lin; Cai, Shuang; Liu, Ying-Ying; Xie, Yin-Qing; Yuan, Ding; Lei, Min; He, Ping; Wang, Long. HPLC of Formula: 63069-48-7 And the article was included in Journal of Organic Chemistry in 2020. The article conveys some information:

An efficient strategy for the construction of fused imidazole derivatives through a palladium-catalyzed isocyanide insertion reaction has been accomplished. The methodol. provides an operationally simple and versatile route for the synthesis of indeno[1,2-d]imidazole and imidazo[1,2-a]indole skeletons which are rarely reported. The key features of the protocol are construction of sequential C-C/C-C/C-N bonds via C(sp2)-H functionalization of imidazole at the C2- and C4-position, resp. The compounds can be synthesized with diverse scaffolds, easily accessible starting materials, and moderate to good yields.4-Chloro-2-iodoaniline(cas: 63069-48-7HPLC of Formula: 63069-48-7) was used in this study.

4-Chloro-2-iodoaniline(cas: 63069-48-7) belongs to anime. Reaction with nitrous acid (HNO2), which functions as an acylating agent that is a source of the nitrosyl group (―NO), converts aliphatic primary amines to nitrogen and mixtures of alkenes and alcohols corresponding to the alkyl group in a complex process. This reaction has been used for analytical determination of primary amino groups in a procedure known as the Van Slyke method.HPLC of Formula: 63069-48-7

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

《Accessing Dihydro-1,2-oxazine via Cloke-Wilson type Annulation of Cyclopropyl Carbonyls: Application towards the Diastereoselective Synthesis of Pyrrolo[1,2-b][1,2]oxazine》 was published in Journal of Organic Chemistry in 2020. These research results belong to Kumar, Pankaj; Kumar, Rakesh; Banerjee, Prabal. Safety of Trimethylsulfoxonium iodide The article mentions the following:

A convenient additive-free synthesis of dihydro-4H-1,2-oxazines via a Cloke-Wilson type ring expansion of the aryl substituted cyclopropane carbaldehydes (ACC) with the hydroxylamine salt was introduced. Comparatively less active cyclopropyl ketones also followed a similar protocol if supplemented by catalytic pTSA.H2O. The transformation was performed in an open-to-air flask as it showed negligible sensitivity towards air/moisture. Dihydro-4H-1,2-oxazines when subjected to cycloaddition with the cyclopropane diester, afforded a trouble-free formulation of the valued hexahydro-2H-pyrrolo[1,2-b][1,2]oxazine derivatives Cascade one-pot variant of this two-step strategy offered a comparable overall yield of the final product. In the experiment, the researchers used Trimethylsulfoxonium iodide(cas: 1774-47-6Safety of Trimethylsulfoxonium iodide)

Trimethylsulfoxonium iodide(cas: 1774-47-6) is a sulfoxonium salt. It is used to generate dimethyloxosulfonium methylide by reaction with sodium hydride. The latter compound is used as a methylene-transfer reagent, and is used to prepare epoxides.Safety of Trimethylsulfoxonium iodide

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

《Silver-Mediated Intermolecular Iodotrifluoromethoxylation of Alkenes》 was published in Journal of Organic Chemistry in 2020. These research results belong to Huang, Qingyun; Tang, Pingping. Reference of 1-Iodopyrrolidine-2,5-dione The article mentions the following:

For the first time, intermol. iodotrifluoromethoxylation between alkenes and NIS with AgF as the catalyst and TFMS as the trifluoromethoxylation reagent has been explored. The practical processes, good functional group tolerance, and easy scalability make this reaction an attractive protocol for the synthesis of trifluoromethoxylated iodides, which can be readily used for further synthetic manipulation. The experimental part of the paper was very detailed, including the reaction process of 1-Iodopyrrolidine-2,5-dione(cas: 516-12-1Reference of 1-Iodopyrrolidine-2,5-dione)

1-Iodopyrrolidine-2,5-dione(cas: 516-12-1) is used in the preparation of vinyl sulfones from olefins and benzenesulfinic acid. It acts as a source for I+ and involved in Hunsdiecker reactions for the conversion of cinnamic acids, and propiolic acids to the corresponding alfa-halostyrenes and 1-halo-1-alkynes respectively. Reference of 1-Iodopyrrolidine-2,5-dione

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

In 2019,Organic & Biomolecular Chemistry included an article by Li, Tongyu; Liu, Chang; Wu, Shaonan; Chen, Chen; Zhu, Bolin. Category: iodides-buliding-blocks. The article was titled 《Rhodium(III)-catalyzed unreactive C(sp3)-H alkenylation of N-alkyl-1H-pyrazoles with alkynes》. The information in the text is summarized as follows:

The first example of pyrazole-directed rhodium(III)-catalyzed unreactive C(sp3)-H alkenylation with alkynes has been described, which showed a relatively broad substrate scope with good functional group compatibility. Moreover, authors demonstrated that the transitive coordinating center pyrazole could be easily removed under mild conditions. In addition to this study using 1-Chloro-3-iodobenzene, there are many other studies that have used 1-Chloro-3-iodobenzene(cas: 625-99-0Category: iodides-buliding-blocks) was used in this study.

1-Chloro-3-iodobenzene(cas: 625-99-0) belongs to organic iodides. The carbon-iodine bond is weaker than other carbon-halogen bonds due to the poor electronegative nature of the iodine atom. Category: iodides-buliding-blocks Alkyl iodides react at a faster rate than alkyl fluorides due to the weak C-I bond.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

In 2019,ChemistrySelect included an article by Ghasemzadeh, Maryam Sadat; Akhlaghinia, Batool. HPLC of Formula: 15164-44-0. The article was titled 《FMMWCNTs@CPA@SMTU@PdII NPs: As a Versatile Ferromagnetic Nanostructured Catalyst for Sonogashira-Hagihara Cross-Coupling Reaction in Solvent-Free Conditions》. The information in the text is summarized as follows:

This study deals with the designing and preparation of PdII immobilized on ferromagnetic multi-walled carbon nanotubes functionalized by aminated 2-chloroethylphosphonic acid with S-methylisothiourea (FMMWCNTs@CPA@SMTU@PdII NPs) as a versatile ferromagnetic nanostructured catalyst. The results show that FMMWCNTs@CPA@SMTU@PdII NPs with decorated MWCNTs by Fe3O4 NPs exhibited ferromagnetic properties with a uniform rod-like morphol. and particle sizes of about 20-30 nm. The catalytic performance of FMMWCNTs@CPA@SMTU@PdII NPs was evaluated in Sonogashira-Hagihara cross-coupling reaction at room temperature and in solvent-free conditions. Under appropriate condition, all reactions proceeded at a faster initial rate while exhibiting excellent activity and selectivity and the desired products were obtained in relatively excellent yields. In the experimental materials used by the author, we found 4-Iodobenzaldehyde(cas: 15164-44-0HPLC of Formula: 15164-44-0)

4-Iodobenzaldehyde(cas: 15164-44-0) is used in synthesis of 4-[2-(trimethylsilyl)ethynyl]benzaldehyde, 5,15-dimesityl-10-(3-[2-(trimethylsilyl)ethynyi]phenyl}-20-(4-iodophenyl)porphyrin, and 5,15-dimesityl-10-[3,5-bis{2-[4-(N,N’-difluoroboryl-1,9-dimethyidipyrrin-5-yl)-phenyl]ethynyl}phenyl]-20-(4-iodophenyl)porphyrin.HPLC of Formula: 15164-44-0

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

In 2017,Kreyenschmidt, Anne-Kathrin; Bachmann, Sebastian; Niklas, Thomas; Stalke, Dietmar published 《Molecular Weight Estimation of Molecules Incorporating Heavier Elements from van-der-Waals Corrected ECC-DOSY》.ChemistrySelect published the findings.Application In Synthesis of 1,2-Diiodoethane The information in the text is summarized as follows:

Aggregate formation of organometallic compounds can be straightforwardly observed and interpreted through DOSY mol. weight (MW) estimation Recently, the power-law approach and preparation of external calibration curves (ECCs) has propelled the applicability of this DOSY MW estimation However, effective prediction of MWs of mols. containing heavier elements (e. g. halogenated compounds) has not been sufficiently accounted for. Hence, we introduce specialized ECCs for various halogenated mols. In an innovative attempt we propose a correction factor for standard ECCs that scales with mol. features to extend considerably the range of mols. that can be investigated by ECC-DOSY. The results came from multiple reactions, including the reaction of 1,2-Diiodoethane(cas: 624-73-7Application In Synthesis of 1,2-Diiodoethane)

1,2-Diiodoethane(cas: 624-73-7) is one of organic iodides. Alkyl iodides react at a faster rate than alkyl fluorides due to the weak C-I bond. Iodo alkanes participate in a variety of organic synthesis reactions, which include the Simmons–Smith reaction (cyclopropanation using iodomethane), Williamson ether synthesis, Wittig reaction, Grignard reaction, alkyl coupling reactions, and Wurtz reaction.Application In Synthesis of 1,2-Diiodoethane

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

《Transmetalation Reactions Triggered by Electron Transfer between Organocopper Complexes》 was written by Lozano-Lavilla, Olmo; Gomez-Orellana, Pablo; Lledos, Agusti; Casares, Juan A.. COA of Formula: C7H5IOThis research focused ontransmetalation reaction triggered electron transfer organocopper complex. The article conveys some information:

[Cu(bipy)(C6F5)] reacts with most aryl iodides to form heterobiphenyls by cross-coupling, but when Rf-I is used (Rf = 3,5-dicholoro-2,4,6-trifluorophenyl), homocoupling products are also formed. Kinetic studies suggest that, for the homocoupling reaction, a mechanism based on transmetalation from [Cu(bipy)(C6F5)] to Cu(III) intermediates formed in the oxidative addition step is at work. D. functional theory calculations show that the interaction between these Cu(III) species and the starting Cu(I) complex involves a Cu(I)-Cu(III) electron transfer concerted with the formation of an iodine bridge between the metals and that a fast transmetalation takes place in a dimer in a triplet state between two Cu(II) units. In addition to this study using 4-Iodobenzaldehyde, there are many other studies that have used 4-Iodobenzaldehyde(cas: 15164-44-0COA of Formula: C7H5IO) was used in this study.

4-Iodobenzaldehyde(cas: 15164-44-0) is used in synthesis of 4-[2-(trimethylsilyl)ethynyl]benzaldehyde, 5,15-dimesityl-10-(3-[2-(trimethylsilyl)ethynyi]phenyl}-20-(4-iodophenyl)porphyrin, and 5,15-dimesityl-10-[3,5-bis{2-[4-(N,N’-difluoroboryl-1,9-dimethyidipyrrin-5-yl)-phenyl]ethynyl}phenyl]-20-(4-iodophenyl)porphyrin.COA of Formula: C7H5IO

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

《Stimuli-Responsive Polycycles Based on Hetero-Buckybowl Trithiasumanene》 was written by Wang, Wenbo; Feng, Lijun; Hua, Xinqiang; Yuan, Chengshan; Shao, Xiangfeng. Recommanded Product: 15164-44-0This research focused ontrithiasumanene dioxide preparation photophys property sulfide ion detection; oxazolo fused trithiasumanene preparation oxidation photophys property; quinone trithiasumanene three component Dubus Radziszewski reaction aldehyde. The article conveys some information:

Herein, a series of hetero polycycles which show optical response toward chem. stimuli were synthesized from trithiasumanene (I, TTS). TTS is transformed into the ortho-quinone form II, which then undergoes three-component Debus-Radziszewski reaction with aldehydes RCHO (R = H, C6H5, 4-CH3C6H4, 4-IC6H4, Q) and ammonia to give oxazole-fused TTS III. The thiophene rings on III (R = C6H5, 4-CH3C6H4, 4-IC6H4) are selectively oxidized to thiophene-S,S-dioxides, affording IV. It was found that the electronic structures of these compounds III and IV are governed by the substituents on the oxazole moiety and oxidation state of the thiophene ring. Moreover, these hetero-polycycles exhibit optical responses toward different chem. stimuli. Particularly, compounds III (R = Q) and IV (R = C6H5) can serve as fluorescence detectors for harmful chem. sulfide ions (S2-/HS-) and aniline, resp. This work indicates that TTS is a promising precursor for the creation of responsive materials. In the part of experimental materials, we found many familiar compounds, such as 4-Iodobenzaldehyde(cas: 15164-44-0Recommanded Product: 15164-44-0)

4-Iodobenzaldehyde(cas: 15164-44-0) is used in synthesis of 4-[2-(trimethylsilyl)ethynyl]benzaldehyde, 5,15-dimesityl-10-(3-[2-(trimethylsilyl)ethynyi]phenyl}-20-(4-iodophenyl)porphyrin, and 5,15-dimesityl-10-[3,5-bis{2-[4-(N,N’-difluoroboryl-1,9-dimethyidipyrrin-5-yl)-phenyl]ethynyl}phenyl]-20-(4-iodophenyl)porphyrin.Recommanded Product: 15164-44-0

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Category: iodides-buliding-blocksIn 2021 ,《A novel approach for the detection and identification of sulfur mustard using liquid chromatography-electrospray ionization-tandem mass spectrometry based on its selective oxidation to sulfur mustard monoxide with N-iodosuccinimide》 was published in Journal of Mass Spectrometry. The article was written by Prihed, Hagit; Shifrovich, Avital; Shamai Yamin, Tamar; Madmon, Moran; Smolkin, Boris; Chen, Ravit; Blanca, Merav; Weissberg, Avi. The article contains the following contents:

A new derivatization strategy for the detection and identification of sulfur mustard (HD) via liquid chromatog.-electrospray ionization-tandem mass spectrometry (LC-ESI-MS/MS) is developed. The method incorporates selective oxidation of the sulfide group by the electrophilic iodine reagent N-iodosuccinimide (NIS) to produce sulfur mustard monoxide (HDSO). The derivatization reaction efficiencies were evaluated with acetonitrile extracts of soil, asphalt, cloth, Formica, and linoleum spiked with HD at concentrations of 50-5000 pg/mL and found to be similar to that with pure acetonitrile. The current derivatization approach is the first to preserve the identity of chloride groups and support HD regulation and evidentiary findings. In the part of experimental materials, we found many familiar compounds, such as 1-Iodopyrrolidine-2,5-dione(cas: 516-12-1Category: iodides-buliding-blocks)

1-Iodopyrrolidine-2,5-dione(cas: 516-12-1) is used in the preparation of vinyl sulfones from olefins and benzenesulfinic acid. It acts as a source for I+ and involved in Hunsdiecker reactions for the conversion of cinnamic acids, and propiolic acids to the corresponding alfa-halostyrenes and 1-halo-1-alkynes respectively. Category: iodides-buliding-blocks

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Category: iodides-buliding-blocksIn 2019 ,《A Convenient Synthesis of Sulfones via Light Promoted Coupling of Sodium Sulfinates and Aryl Halides》 was published in Advanced Synthesis & Catalysis. The article was written by Chen, Lei; Liang, Jie; Chen, Zhen-yu; Chen, Jie; Yan, Ming; Zhang, Xue-jing. The article contains the following contents:

A convenient and efficient synthesis of sulfones RS(O)2R1 (R = Me, cyclopropyl, 4-methoxyphenyl, pyridin-3-yl, etc.; R1 = 4-cyanophenyl, pyridin-3-yl, pyrimidin-5-yl, etc.) from sulfinates RS(O)2Na and aryl halides R1X (X = Br, I, Cl) was developed. The reaction occurred under UV irradiation without transition metal catalyst or photocatalyst. A radical pathway via single-electron transfer (SET) of electron donor-acceptor (EDA) complex was proposed based on UV-vis spectroscopy, radical inhibiting and trapping experiments The experimental part of the paper was very detailed, including the reaction process of 4-Iodobenzaldehyde(cas: 15164-44-0Category: iodides-buliding-blocks)

4-Iodobenzaldehyde(cas: 15164-44-0) is used in synthesis of 4-[2-(trimethylsilyl)ethynyl]benzaldehyde, 5,15-dimesityl-10-(3-[2-(trimethylsilyl)ethynyi]phenyl}-20-(4-iodophenyl)porphyrin, and 5,15-dimesityl-10-[3,5-bis{2-[4-(N,N’-difluoroboryl-1,9-dimethyidipyrrin-5-yl)-phenyl]ethynyl}phenyl]-20-(4-iodophenyl)porphyrin.Category: iodides-buliding-blocks

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com