Tag: 200-300

Hu, Qunxian et al. published their research in ARKIVOC (Gainesville, FL, United States) in 2012 | CAS: 207115-22-8

4-Bromo-2-iodophenol (cas: 207115-22-8) belongs to iodide derivatives. Organic iodides can be alkyl, alkenyl, or alkynyl, and all of them are very reactive toward with many kinds of nucleophiles. Polyiodoorganic compounds are sometimes employed as X-ray contrast agents, in fluoroscopy, a type of medical imaging. This application exploits the X-ray absorbing ability of the heavy iodine nucleus.Synthetic Route of C6H4BrIO

Copper-catalyzed one-pot synthesis of 2H-1,4-benzoxazin-3-(4H)-ones from 2-(o-haloaryloxy)acyl chlorides and primary amines was written by Hu, Qunxian;Xia, Ziming;Fan, Ling;Zheng, Jiening;Wang, Xiaoxia;Lv, Xin. And the article was included in ARKIVOC (Gainesville, FL, United States) in 2012.Synthetic Route of C6H4BrIO This article mentions the following:

A facile and efficient Cu(I)-catalyzed one-pot synthesis of 2H-1,4-benzoxazin-3(4H)-one derivatives has been developed. The condensation between 2-(o-haloaryloxy)acyl chlorides and primary amines followed by Cu(I)-catalyzed intramol. C-N bond coupling afforded a variety of 2H-1,4-benzoxazin-3-(4H)-ones in good to excellent yields. Diversified substituents on the 4-position could be conveniently introduced. In the experiment, the researchers used many compounds, for example, 4-Bromo-2-iodophenol (cas: 207115-22-8Synthetic Route of C6H4BrIO).

4-Bromo-2-iodophenol (cas: 207115-22-8) belongs to iodide derivatives. Organic iodides can be alkyl, alkenyl, or alkynyl, and all of them are very reactive toward with many kinds of nucleophiles. Polyiodoorganic compounds are sometimes employed as X-ray contrast agents, in fluoroscopy, a type of medical imaging. This application exploits the X-ray absorbing ability of the heavy iodine nucleus.Synthetic Route of C6H4BrIO

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Handa, Sachin et al. published their research in ACS Catalysis in 2016 | CAS: 531508-54-0

2,2-Difluoro-4-iodobenzo[d][1,3]dioxole (cas: 531508-54-0) belongs to iodide derivatives. Organoiodine compounds occur widely in organic chemistry, but are relatively rare in nature. Polyiodoorganic compounds are sometimes employed as X-ray contrast agents, in fluoroscopy, a type of medical imaging. This application exploits the X-ray absorbing ability of the heavy iodine nucleus.Category: iodides-buliding-blocks

Synergistic and Selective Copper/ppm Pd-Catalyzed Suzuki-Miyaura Couplings: In Water, Mild Conditions, with Recycling was written by Handa, Sachin;Smith, Justin D.;Hageman, Matthew S.;Gonzalez, Monica;Lipshutz, Bruce H.. And the article was included in ACS Catalysis in 2016.Category: iodides-buliding-blocks This article mentions the following:

Copper-catalyzed Suzuki-Miyaura couplings can be carried out exclusively on aryl iodides under very mild conditions, which is made possible by synergistic effects due to the presence of ppm levels of palladium as cocatalyst. The coupling requires a hemilabile P(O)-N ligand, together with the benefits of micellar catalysis using water as the recyclable reaction medium. In the experiment, the researchers used many compounds, for example, 2,2-Difluoro-4-iodobenzo[d][1,3]dioxole (cas: 531508-54-0Category: iodides-buliding-blocks).

2,2-Difluoro-4-iodobenzo[d][1,3]dioxole (cas: 531508-54-0) belongs to iodide derivatives. Organoiodine compounds occur widely in organic chemistry, but are relatively rare in nature. Polyiodoorganic compounds are sometimes employed as X-ray contrast agents, in fluoroscopy, a type of medical imaging. This application exploits the X-ray absorbing ability of the heavy iodine nucleus.Category: iodides-buliding-blocks

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Zhou, Ziniu et al. published their research in Molecules in 2016 | CAS: 10297-05-9

1-Chloro-4-iodobutane (cas: 10297-05-9) belongs to iodide derivatives. Organic iodides are organic compounds containing a carbon-iodine (C-I) bond. The carbon-iodine bond is weaker than other carbon-halogen bonds due to the poor electronegative nature of the iodine atom. The C–I bond is the weakest of the carbon–halogen bonds. These bond strengths correlate with the electronegativity of the halogen, decreasing in the order F > Cl > Br > I.Synthetic Route of C4H8ClI

Solid-phase synthesis of amine/carboxyl substituted prolines and proline homologs: scope and limitations was written by Zhou, Ziniu;Scott, William L.;O’Donnell, Martin J.. And the article was included in Molecules in 2016.Synthetic Route of C4H8ClI This article mentions the following:

A solid-phase procedure is used to synthesize racemic peptidomimetics based on the fundamental peptide unit. The peptidomimetics are constructed around proline or proline homologues variably substituted at the amine and carbonyl sites. The procedure expands the diversity of substituted peptidomimetic mols. available to the Distributed Drug Discovery (D3) project. Using a BAL-based solid-phase synthetic sequence the proline or proline homolog subunit is both constructed and incorporated into the peptidomimetic by an α-alkylation, hydrolysis and intramol. cyclization sequence. Further transformations on solid-phase provide access to a variety of piperazine derivatives representing a class of mols. known to exhibit central nervous system activity. The procedure works well with proline cores, but with larger six- and seven-membered ring homologues the nature of the carboxylic acid acylating the cyclic amine can lead to side reactions and result in poor overall yields. In the experiment, the researchers used many compounds, for example, 1-Chloro-4-iodobutane (cas: 10297-05-9Synthetic Route of C4H8ClI).

1-Chloro-4-iodobutane (cas: 10297-05-9) belongs to iodide derivatives. Organic iodides are organic compounds containing a carbon-iodine (C-I) bond. The carbon-iodine bond is weaker than other carbon-halogen bonds due to the poor electronegative nature of the iodine atom. The C–I bond is the weakest of the carbon–halogen bonds. These bond strengths correlate with the electronegativity of the halogen, decreasing in the order F > Cl > Br > I.Synthetic Route of C4H8ClI

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Desroches, Maude et al. published their research in Journal of Organic Chemistry in 2015 | CAS: 207115-22-8

4-Bromo-2-iodophenol (cas: 207115-22-8) belongs to iodide derivatives. Organic iodides can be alkyl, alkenyl, or alkynyl, and all of them are very reactive toward with many kinds of nucleophiles. The C–I bond is the weakest of the carbon–halogen bonds. These bond strengths correlate with the electronegativity of the halogen, decreasing in the order F > Cl > Br > I. This periodic order also follows the atomic radius of halogens and the length of the carbon-halogen bond.Application In Synthesis of 4-Bromo-2-iodophenol

Synthesis and properties of rhomboidal macrocyclic subunits of graphdiyne-like nanoribbons was written by Desroches, Maude;Courtemanche, Marc-Andre;Rioux, Genevieve;Morin, Jean-Francois. And the article was included in Journal of Organic Chemistry in 2015.Application In Synthesis of 4-Bromo-2-iodophenol This article mentions the following:

Rhomboidal macrocyclic subunits of graphdiyne-like nanoribbon (GDNR) bearing both alkyne and diyne units, allowing for multichannel π-conjugation, were synthesized using an oxidative Glaser-type ring closing reaction. These subunits, called the “meshes” of the nanoribbon, possess Ph groups with decyloxy solubilizing chains on each corner. The yields of the ring closing reaction highly depend on the metal (Cu or Pd) catalyst used for the macrocyclization step. Increasing the width of the meshes from one macrocycle to two fused macrocycles resulted in a decrease of the bandgap by 0.23 eV as shown by optical spectroscopy. The optimized geometries of the meshes alongside their HOMO and LUMO orbitals were calculated using DFT calculations at the B3LYP/6-31+G** level of theory. The results showed a nearly planar conformation for both meshes with HOMO and LUMO orbitals entirely delocalized over the mols. In the experiment, the researchers used many compounds, for example, 4-Bromo-2-iodophenol (cas: 207115-22-8Application In Synthesis of 4-Bromo-2-iodophenol).

4-Bromo-2-iodophenol (cas: 207115-22-8) belongs to iodide derivatives. Organic iodides can be alkyl, alkenyl, or alkynyl, and all of them are very reactive toward with many kinds of nucleophiles. The C–I bond is the weakest of the carbon–halogen bonds. These bond strengths correlate with the electronegativity of the halogen, decreasing in the order F > Cl > Br > I. This periodic order also follows the atomic radius of halogens and the length of the carbon-halogen bond.Application In Synthesis of 4-Bromo-2-iodophenol

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Urbanaite, Aurelija et al. published their research in European Journal of Organic Chemistry in 2015 | CAS: 5460-32-2

4-Iodo-1,2-dimethoxybenzene (cas: 5460-32-2) belongs to iodide derivatives. In general, organic iodides are light-sensitive and turn yellow during storage, owing to the formation of iodine. In the chemical industry, alkyl iodides serve as excellent alkylating agents and, specifically, methyl iodide is used as a methylating agent in the synthesis of various pharmaceutical drugs.Formula: C8H9IO2

Electrophile-Mediated Reactions of Functionalized Propargylic Substrates was written by Urbanaite, Aurelija;Jonusis, Mantas;Buksnaitiene, Rita;Balkaitis, Simonas;Cikotiene, Inga. And the article was included in European Journal of Organic Chemistry in 2015.Formula: C8H9IO2 This article mentions the following:

Metal-free halogen, chalcogen, or (oxo)carbenium ion mediated yne-carbonyl or yne-thioxo transformations of a range of N- and O-propargylic compounds have been studied. This investigation has led to the development of a mild, economic, and effective method for the synthesis of functionalized 4H-1,3-oxazines, 4H-1,3-thiazines, 4,5-dihydrothiazoles, and α-substituted enones. The structure of the propargylic substrate and the nature of electrophile influence both the outcome and regioselectivity of processes. The synthesis of the target compounds was achieved using propargyl compounds as starting materials, such as N-[3-(4-methoxyphenyl)-2-propynyl]benzamide (alkyne-amide), N-[3-(4-methoxyphenyl)-2-propynyl]carbamic acid dimethylethyl ester (alkyne-carbamate), N-[3-(4-methoxyphenyl)-2-propynyl]-N‘-(phenylmethyl)urea (alkyne-urea). In the experiment, the researchers used many compounds, for example, 4-Iodo-1,2-dimethoxybenzene (cas: 5460-32-2Formula: C8H9IO2).

4-Iodo-1,2-dimethoxybenzene (cas: 5460-32-2) belongs to iodide derivatives. In general, organic iodides are light-sensitive and turn yellow during storage, owing to the formation of iodine. In the chemical industry, alkyl iodides serve as excellent alkylating agents and, specifically, methyl iodide is used as a methylating agent in the synthesis of various pharmaceutical drugs.Formula: C8H9IO2

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Miller, J. Richard et al. published their research in Chemical Biology & Drug Design in 2010 | CAS: 20776-54-9

2-Amino-4-iodobenzoic acid (cas: 20776-54-9) belongs to iodide derivatives. In general, organic iodides are light-sensitive and turn yellow during storage, owing to the formation of iodine. A typical method for synthesis of aromatic iodides is diazotization of primary aromatic amines followed by treatment of potassium iodide. Aliphatic alcohols are converted to alkyl iodides by treating with hydrogen iodide.Recommanded Product: 20776-54-9

The use of biochemical and biophysical tools for triage of high-throughput screening hits – a case study with Escherichia coli phosphopantetheine adenylyltransferase was written by Miller, J. Richard;Thanabal, Venkataraman;Melnick, Michael M.;Lall, Manjinder;Donovan, Charles;Sarver, Ronald W.;Lee, Doh-Yeel;Ohren, Jeff;Emerson, Don. And the article was included in Chemical Biology & Drug Design in 2010.Recommanded Product: 20776-54-9 This article mentions the following:

High-throughput screening is utilized by pharmaceutical researchers and, increasingly, academic investigators to identify agents that act upon enzymes, receptors, and cellular processes. Screening hits include mols. that specifically bind the target and a greater number of non-specific compounds It is necessary to ‘triage’ these hits to identify the subset worthy of further exploration. As part of our antibacterial drug discovery effort, we applied a suite of biochem. and biophys. tools to accelerate the triage process. We describe application of these tools to a series of 9-oxo-4,9-dihydropyrazolo[5,1-b]quinazoline-2-carboxylic acids (PQ) hits from a screen of Escherichia coli phosphopantetheine adenylyltransferase (PPAT). Initial confirmation of specific binding to phosphopantetheine adenylyltransferase was obtained using biochem. and biophys. tools, including a novel orthogonal assay, isothermal titration calorimetry, and saturation transfer difference NMR. To identify the phosphopantetheine adenylyltransferase sub-site bound by these inhibitors, two techniques were utilized: steady-state enzyme kinetics and a novel 19F NMR method in which fluorine-containing fragments that bind the ATP and/or phosphopantetheine sites serve as competitive reporter probes. These data are consistent with PQs binding the ATP sub-site. In addition to identification of a series of PPAT inhibitors, the described hit triage process is broadly applicable to other enzyme targets in which milligram quantities of purified target protein are available. In the experiment, the researchers used many compounds, for example, 2-Amino-4-iodobenzoic acid (cas: 20776-54-9Recommanded Product: 20776-54-9).

2-Amino-4-iodobenzoic acid (cas: 20776-54-9) belongs to iodide derivatives. In general, organic iodides are light-sensitive and turn yellow during storage, owing to the formation of iodine. A typical method for synthesis of aromatic iodides is diazotization of primary aromatic amines followed by treatment of potassium iodide. Aliphatic alcohols are converted to alkyl iodides by treating with hydrogen iodide.Recommanded Product: 20776-54-9

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Garnes-Portoles, Francisco et al. published their research in Nature Catalysis in 2021 | CAS: 877264-43-2

(5-Fluoro-2-iodophenyl)methanol (cas: 877264-43-2) belongs to iodide derivatives. In general, organic iodides are light-sensitive and turn yellow during storage, owing to the formation of iodine. Organoiodine lubricants can be used with titanium, stainless steels, and other metals which tend to seize up with conventional lubricants: organoiodine lubricants can be used in turbines and spacecraft, and as a cutting oil in machining.Computed Properties of C7H6FIO

Regioirregular and catalytic Mizoroki-Heck reactions was written by Garnes-Portoles, Francisco;Greco, Rossella;Oliver-Meseguer, Judit;Castellanos-Soriano, Jorge;Consuelo Jimenez, M.;Lopez-Haro, Miguel;Hernandez-Garrido, Juan Carlos;Boronat, Mercedes;Perez-Ruiz, Raul;Leyva-Perez, Antonio. And the article was included in Nature Catalysis in 2021.Computed Properties of C7H6FIO This article mentions the following:

Here, the ligand-free, few-atom palladium clusters in solution catalyze the α-selective intramol. Mizoroki-Heck coupling of iodoaryl cinnamates, and mechanistic studies support the formation of a sterically encumbered cinnamate-palladium cluster intermediate was showed. Following this rationale, the α-selective intermol. coupling of aryl iodides with styrenes was also achieved with palladium clusters encapsulated within fine-tuned and sterically restricted zeolite cavities to produce 1,1-bisarylethylenes, which are further engaged with aryl halides by a metal-free photoredox-catalyzed coupling. These ligand-free methodologies significantly expand the chem. space of the Mizoroki-Heck coupling. In the experiment, the researchers used many compounds, for example, (5-Fluoro-2-iodophenyl)methanol (cas: 877264-43-2Computed Properties of C7H6FIO).

(5-Fluoro-2-iodophenyl)methanol (cas: 877264-43-2) belongs to iodide derivatives. In general, organic iodides are light-sensitive and turn yellow during storage, owing to the formation of iodine. Organoiodine lubricants can be used with titanium, stainless steels, and other metals which tend to seize up with conventional lubricants: organoiodine lubricants can be used in turbines and spacecraft, and as a cutting oil in machining.Computed Properties of C7H6FIO

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Suzuki, Hitomi et al. published their research in Chemische Berichte in 1994 | CAS: 160938-18-1

4-Chloro-2-iodo-1-nitrobenzene (cas: 160938-18-1) belongs to iodide derivatives. Typical reactions of alkyl iodides include nucleophilic substitution, elimination, reduction, and the formation of organometallics. The C–I bond is the weakest of the carbon–halogen bonds. These bond strengths correlate with the electronegativity of the halogen, decreasing in the order F > Cl > Br > I.Related Products of 160938-18-1

A convenient one-pot preparation of bis(nitroaryl) tellurides using a tellurium-copper couple as the telluration reagent was written by Suzuki, Hitomi;Nakamura, Tohru. And the article was included in Chemische Berichte in 1994.Related Products of 160938-18-1 This article mentions the following:

The Te-Cu couple generated in situ by the reaction of disodium telluride with copper(I) iodide in dry N-methyl-2-pyrrolidone has been a convenient telluration reagent for some activated iodoarenes. Using this reagent system, the authors have prepared by a one-pot synthesis in satisfactory yields several bis(nitroaryl) tellurides, which are otherwise laborious to obtain. Thus, reaction of Na2Te with CuI in N-methyl-2-pyrrolidone followed by treatment with 2-O2NC6H4I gave 83% (2-O2NC6H4)2Te. In the experiment, the researchers used many compounds, for example, 4-Chloro-2-iodo-1-nitrobenzene (cas: 160938-18-1Related Products of 160938-18-1).

4-Chloro-2-iodo-1-nitrobenzene (cas: 160938-18-1) belongs to iodide derivatives. Typical reactions of alkyl iodides include nucleophilic substitution, elimination, reduction, and the formation of organometallics. The C–I bond is the weakest of the carbon–halogen bonds. These bond strengths correlate with the electronegativity of the halogen, decreasing in the order F > Cl > Br > I.Related Products of 160938-18-1

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Badir, Shorouk O. et al. published their research in Organic Letters in 2020 | CAS: 20776-54-9

2-Amino-4-iodobenzoic acid (cas: 20776-54-9) belongs to iodide derivatives. Organic iodides can be alkyl, alkenyl, or alkynyl, and all of them are very reactive toward with many kinds of nucleophiles. In the chemical industry, alkyl iodides serve as excellent alkylating agents and, specifically, methyl iodide is used as a methylating agent in the synthesis of various pharmaceutical drugs.Application of 20776-54-9

Multi-functional Building Blocks Compatible with Photo-redox-Mediated Alkylation for DNA-Encoded Library Synthesis was written by Badir, Shorouk O.;Sim, Jaehoon;Billings, Katelyn;Csakai, Adam;Zhang, Xuange;Dong, Weizhe;Molander, Gary A.. And the article was included in Organic Letters in 2020.Application of 20776-54-9 This article mentions the following:

DNA-encoded library (DEL) technol. has emerged as a novel interrogation modality for ligand discovery in the pharmaceutical industry. Given the increasing demand for a higher proportion of C(sp3)-hybridized centers in DEL platforms, a photoredox-mediated cross-coupling and defluorinative alkylation process is introduced using com. available alkyl bromides and structurally diverse α-silylamines. Notably, no protecting group strategies for amines are necessary for the incorporation of a variety of amino-acid-based organo-silanes, providing crucial branching points for further derivatization. In the experiment, the researchers used many compounds, for example, 2-Amino-4-iodobenzoic acid (cas: 20776-54-9Application of 20776-54-9).

2-Amino-4-iodobenzoic acid (cas: 20776-54-9) belongs to iodide derivatives. Organic iodides can be alkyl, alkenyl, or alkynyl, and all of them are very reactive toward with many kinds of nucleophiles. In the chemical industry, alkyl iodides serve as excellent alkylating agents and, specifically, methyl iodide is used as a methylating agent in the synthesis of various pharmaceutical drugs.Application of 20776-54-9

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Tang, Bo-Cheng et al. published their research in Nature Communications in 2020 | CAS: 64248-57-3

1,2-Difluoro-3-iodobenzene (cas: 64248-57-3) belongs to iodide derivatives. Organoiodine compounds occur widely in organic chemistry, but are relatively rare in nature. Organoiodine lubricants can be used with titanium, stainless steels, and other metals which tend to seize up with conventional lubricants: organoiodine lubricants can be used in turbines and spacecraft, and as a cutting oil in machining.Synthetic Route of C6H3F2I

Quadruple C-H activation coupled to hydrofunctionalization and C-H silylation/borylation enabled by weakly coordinated palladium catalyst was written by Tang, Bo-Cheng;Lin, Wen-Xuan;Chen, Xiang-Long;He, Cai;Ma, Jin-Tian;Wu, Yan-Dong;Lan, Yu;Wu, An-Xin. And the article was included in Nature Communications in 2020.Synthetic Route of C6H3F2I This article mentions the following:

A quadruple C-H activation cascade as well as hydro-functionalization, C-H silylation/borylation sequence based on weakly coordinated palladium catalyst was reported . The hydroxyl group modulated the intrinsic direction of the Heck reaction, and then acts as an interrupter that biases the reaction away from the classic β-H elimination and toward C-H functionalization. Mechanistically, d. functional theory calculation provides important insights into the key six-membered oxo-palladacycle intermediates, and indicates that the β-H elimination was unfavorable both thermodynamically and kinetically. In this article, the versatility of this approach, which was a strategic expansion of the Heck reaction was focused. In the experiment, the researchers used many compounds, for example, 1,2-Difluoro-3-iodobenzene (cas: 64248-57-3Synthetic Route of C6H3F2I).

1,2-Difluoro-3-iodobenzene (cas: 64248-57-3) belongs to iodide derivatives. Organoiodine compounds occur widely in organic chemistry, but are relatively rare in nature. Organoiodine lubricants can be used with titanium, stainless steels, and other metals which tend to seize up with conventional lubricants: organoiodine lubricants can be used in turbines and spacecraft, and as a cutting oil in machining.Synthetic Route of C6H3F2I

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com