Tag: 200-300

Intramolecular Pd-Catalyzed Arylation of 1-Amidosugars: A New Route to N-Glycosyl Quinolin-2-ones was written by Luong, Thi Thanh Huyen;Brion, Jean-Daniel;Lescop, Ewen;Alami, Mouad;Messaoudi, Samir. And the article was included in Organic Letters in 2016.Related Products of 877264-43-2 This article mentions the following:

The synthesis of N-glycosylated quinolin-2-ones via an intramol. N-arylation of glycosylamides is reported. The coupling involves the use of only Pd(OAc)₂ as the catalyst and nBu₄NOAc as the base in 1,4-dioxane. This versatile approach allows the synthesis of various N-glycosylated quinolin-2-ones with exclusive α or β selectivity. In the experiment, the researchers used many compounds, for example, (5-Fluoro-2-iodophenyl)methanol (cas: 877264-43-2Related Products of 877264-43-2).

(5-Fluoro-2-iodophenyl)methanol (cas: 877264-43-2) belongs to iodide derivatives. Typical reactions of alkyl iodides include nucleophilic substitution, elimination, reduction, and the formation of organometallics. Alkyl iodides react at a faster rate than alkyl fluorides due to the weak C-I bond.Related Products of 877264-43-2

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Copper-Catalyzed Azide-Ynamide Cyclization to Generate α-Imino Copper Carbenes: Divergent and Enantioselective Access to Polycyclic N-Heterocycles was written by Liu, Xin;Wang, Ze-Shu;Zhai, Tong-Yi;Luo, Chen;Zhang, Yi-Ping;Chen, Yang-Bo;Deng, Chao;Liu, Rai-Shung;Ye, Long-Wu. And the article was included in Angewandte Chemie, International Edition in 2020.Category: iodides-buliding-blocks This article mentions the following:

Here an efficient copper-catalyzed cascade cyclization of azide-ynamides via α-imino copper carbene intermediates is reported, representing the first generation of α-imino copper carbenes from alkynes. This protocol enables the practical and divergent synthesis of an array of polycyclic N-heterocycles, e.g., I, in generally good to excellent yields with broad substrate scope and excellent diastereoselectivities. Moreover, an asym. azide-ynamide cyclization has been achieved with high enantioselectivities (up to 98:2 e.r.) by employing BOX-Cu complexes as chiral catalysts. Thus, this protocol constitutes the first example of an asym. azide-alkyne cyclization. The proposed mechanistic rationale for this cascade cyclization is further supported by theor. calculations In the experiment, the researchers used many compounds, for example, (5-Fluoro-2-iodophenyl)methanol (cas: 877264-43-2Category: iodides-buliding-blocks).

(5-Fluoro-2-iodophenyl)methanol (cas: 877264-43-2) belongs to iodide derivatives. Typical reactions of alkyl iodides include nucleophilic substitution, elimination, reduction, and the formation of organometallics. Polyiodoorganic compounds are sometimes employed as X-ray contrast agents, in fluoroscopy, a type of medical imaging. This application exploits the X-ray absorbing ability of the heavy iodine nucleus.Category: iodides-buliding-blocks

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Aliphatic C-H Bond Iodination by a N-Iodoamide and Isolation of an Elusive N-Amidyl Radical was written by Artaryan, Alexander;Mardyukov, Artur;Kulbitski, Kseniya;Avigdori, Idan;Nisnevich, Gennady A.;Schreiner, Peter R.;Gandelman, Mark. And the article was included in Journal of Organic Chemistry in 2017.Application of 10297-05-9 This article mentions the following:

Contrary to C-H chlorination and bromination, the direct iodination of alkanes represents a great challenge. We reveal a new N-iodoamide that is capable of a direct and efficient C-H bond iodination of various cyclic and acyclic alkanes providing iodoalkanes in good yields. This is the first use of N-iodoamide for C-H bond iodination. The method also works well for benzylic C-H bonds, thereby constituting the missing version of the Wohl-Ziegler iodination reaction. Mechanistic details were elucidated by DFT computations, and the N-centered radical derived from the used N-iodoamide, which is the key intermediate in this process, was matrix-isolated in a solid argon matrix and characterized by UV-vis as well as IR spectroscopy. In the experiment, the researchers used many compounds, for example, 1-Chloro-4-iodobutane (cas: 10297-05-9Application of 10297-05-9).

1-Chloro-4-iodobutane (cas: 10297-05-9) belongs to iodide derivatives. Typical reactions of alkyl iodides include nucleophilic substitution, elimination, reduction, and the formation of organometallics. Iodo alkanes participate in a variety of organic synthesis reactions, which include the Simmons–Smith reaction (cyclopropanation using iodomethane), Williamson ether synthesis, Wittig reaction, Grignard reaction, alkyl coupling reactions, and Wurtz reaction.Application of 10297-05-9

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Phenylpropiolic acids. VIII. Self-condensation of 3-halo-4-methoxyphenylpropiolic acids was written by Baddar, Fawzi G.;Moussa, G. E. M.;Omar, M. T.. And the article was included in Journal of the Chemical Society [Section] C: Organic in 1968.COA of Formula: C8H7IO2 This article mentions the following:

3-Halo-4-methoxyphenylpropiolic acids are converted by Ac2O into a mixture of 6- and 8-halo-7-methoxy-1-(3-halo-4-methoxyphenyl)naphthalene-2,3-dicarboxylic anhydrides. The structure of 6-bromo-7-methoxy-1-(3-bromo-4 – methoxyphenyl)naphthalene-2,3-dicarboxylic anhydride was established by its conversion into the corresponding 6,7-dimethoxy derivative The structure of the remaining anhydrides were established by ir and uv spectroscopy. The anhydrides are isomerized by AlCl3 to the corresponding 7H-benzo[c]fluoren-7-one. In the experiment, the researchers used many compounds, for example, 3-Iodo-4-methoxybenzaldehyde (cas: 2314-37-6COA of Formula: C8H7IO2).

3-Iodo-4-methoxybenzaldehyde (cas: 2314-37-6) belongs to iodide derivatives. Typical reactions of alkyl iodides include nucleophilic substitution, elimination, reduction, and the formation of organometallics. The C–I bond is the weakest of the carbon–halogen bonds. These bond strengths correlate with the electronegativity of the halogen, decreasing in the order F > Cl > Br > I. This periodic order also follows the atomic radius of halogens and the length of the carbon-halogen bond.COA of Formula: C8H7IO2

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Modular C-H Functionalization Cascade of Aryl Iodides was written by Shi, Hang;Babinski, David J.;Ritter, Tobias. And the article was included in Journal of the American Chemical Society in 2015.HPLC of Formula: 133232-56-1 This article mentions the following:

We report the first example of ipso-borylation for the modular 1,2-bisfunctionalization of aryl iodides via C-H functionalization. The carbon-boron bond is used as a lynch pin to access ipso carbon-carbon, carbon-nitrogen, carbon-oxygen, and carbon-halogen (Cl, Br, I) bonds. The utility of our methodol. is illustrated through quick, modular syntheses of the pharmaceuticals Abilify and Flunixin. In the experiment, the researchers used many compounds, for example, 3-Iodo-2-methylbenzoic acid (cas: 133232-56-1HPLC of Formula: 133232-56-1).

3-Iodo-2-methylbenzoic acid (cas: 133232-56-1) belongs to iodide derivatives. In general, organic iodides are light-sensitive and turn yellow during storage, owing to the formation of iodine. A typical method for synthesis of aromatic iodides is diazotization of primary aromatic amines followed by treatment of potassium iodide. Aliphatic alcohols are converted to alkyl iodides by treating with hydrogen iodide.HPLC of Formula: 133232-56-1

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Electrophilic aromatic substitution. 26. Regioselective halo- and carbodesilylation of (trimethylsilyl)-1-methylpyrazoles was written by Effenberger, Franz;Krebs, Andreas. And the article was included in Journal of Organic Chemistry in 1984.SDS of cas: 34091-51-5 This article mentions the following:

The isomeric 3-, 4-, and 5-(trimethylsilyl)- (I) as well as the 3,4- (II), 3,5- (III), and 4,5-bis(trimethylsilyl)-1-methylpyrazoles (IV) are obtained by methylation of the corresponding (trimethylsilyl)-1H-pyrazoles or by silylation of Grignard or lithio derivatives of appropriate 1-methylpyrazoles with ClSiMe₃. II and IV are halodesilylated regioselectively in the 4-position by Br or ICl, yielding V (R = SiMe₃, R¹ = H; R = H, R¹ = SiMe₃). With addnl. Br, these monobromo compounds suffer exclusively bromodesilylation to give 3,4- and 4,5-dibromo-1-methylpyrazole. These findings are in accord with the electrophilic substitution reactivity indexes for 1-methylpyrazole and with the ipso-directing influence of the Me₃Si group. The reaction of II with I₂, unexpectedly, occurs preferentially at the 3-position. Regioselective carbodesilylation in the 5-position is observed in the fluoride-catalyzed reactions of I, III, and IV with electrophiles. The high regiospecificity of this reaction is rationalized in terms of carbanion stabilization at the individual pyrazole positions. In the experiment, the researchers used many compounds, for example, 5-Iodo-1-methyl-1H-pyrazole (cas: 34091-51-5SDS of cas: 34091-51-5).

5-Iodo-1-methyl-1H-pyrazole (cas: 34091-51-5) belongs to iodide derivatives. Typical reactions of alkyl iodides include nucleophilic substitution, elimination, reduction, and the formation of organometallics. A typical method for synthesis of aromatic iodides is diazotization of primary aromatic amines followed by treatment of potassium iodide. Aliphatic alcohols are converted to alkyl iodides by treating with hydrogen iodide.SDS of cas: 34091-51-5

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

On the balance between nematic and smectic phases in 2′,3′-difluoro-4,4″-dialkyl-p-terphenyls was written by Wachala, Agata;Pytlarczyk, Marta;Kula, Przemyslaw. And the article was included in Liquid Crystals in 2019.Formula: C6H3F2I This article mentions the following:

The full homologous series of 2′,3′-difluoro-4,4”-dialkyl-p-terphenyls, where alkyl chains are from Me to nonyl length, have been synthesized and mesomorphic properties, phase transition temperatures and enthalpies were measured. The influence of the terminal chain length on thermal mesophase range, phase sequence has been analyzed and discussed. The odd-even and sym.-non-sym. effects have also been studied and its influence on smectic to nematic balance was analyzed. In the experiment, the researchers used many compounds, for example, 1,2-Difluoro-3-iodobenzene (cas: 64248-57-3Formula: C6H3F2I).

1,2-Difluoro-3-iodobenzene (cas: 64248-57-3) belongs to iodide derivatives. Generally organic iodides can be divided into two classes of alkyl iodides and aryl iodides. Typical reactions of alkyl iodides include nucleophilic substitution, elimination, reduction, and the formation of organometallics. In the chemical industry, alkyl iodides serve as excellent alkylating agents and, specifically, methyl iodide is used as a methylating agent in the synthesis of various pharmaceutical drugs.Formula: C6H3F2I

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Arylselenyl Radical-Mediated Cyclization of N-(2-Alkynyl)anilines: Access to 3-Selenylquinolines was written by Zhu, Changlei;Nurko, Max;Day, Cynthia S.;Lukesh, John C. III. And the article was included in Journal of Organic Chemistry in 2022.HPLC of Formula: 5460-32-2 This article mentions the following:

An efficient and novel approach to accessing 3-selenylquinolines I [R¹ = H, 6-I, 8-Me, etc.; R² = n-Bu, Ph, 3-thienyl, etc.; R³ = Ph, 2-MeC₆H₄, 3-thienyl, etc.] from diaryl diselenides and acyclic, selenium-free substrates was described. Preliminary mechanistic studies indicated that the combination of CuCl₂ and air afforded an appropriate environment for producing arylselenyl radicals that initiated the cascade cyclization of N-(2-alkynyl)anilines, forming key Se-C and C-C bonds in a single step. Using this chem., a wide variety of 3-selenylquinolines were produced in moderate to excellent yield under mild conditions, highlighting the versatility and usefulness of this new method. In the experiment, the researchers used many compounds, for example, 4-Iodo-1,2-dimethoxybenzene (cas: 5460-32-2HPLC of Formula: 5460-32-2).

4-Iodo-1,2-dimethoxybenzene (cas: 5460-32-2) belongs to iodide derivatives. Organoiodine compounds occur widely in organic chemistry, but are relatively rare in nature. Polyiodoorganic compounds are sometimes employed as X-ray contrast agents, in fluoroscopy, a type of medical imaging. This application exploits the X-ray absorbing ability of the heavy iodine nucleus.HPLC of Formula: 5460-32-2

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Manipulation of Intraparticle Charge Delocalization by Selective Complexation of Transition-Metal Ions with Histidine Moieties was written by Kang, Xiongwu;Li, Xiang;Hewitt, William M.;Zuckerman, Nathaniel B.;Konopelski, Joseph P.;Chen, Shaowei. And the article was included in Analytical Chemistry (Washington, DC, United States) in 2012.Related Products of 2314-37-6 This article mentions the following:

Ruthenium nanoparticles were cofunctionalized with pyrene and histidine moieties through Ru = carbene π bonds. The selective complexation of the histidine moiety with transition-metal ions led to a marked diminishment of the emission peak at 490 nm which arose from the nanoparticle-bridged pyrene moieties that behaved analogously to pyrene dimers with a conjugated spacer. This is accounted for by the polarization of the core electrons by the added pos. charge that impacted the intraparticle charge delocalization between the particle-bound pyrene moieties. This electronic interaction was likely facilitated by the π interactions between the metal ions and the imidazole ring as well as by the conjugated mol. backbone that linked the imidazole ring to the nanoparticle cores. Within the present exptl. context, of all the metal ions tested, the impacts were much more drastic with Pb²⁺, Co²⁺, and Hg²⁺ than with Li⁺, K⁺, Rb⁺, Mg²⁺, Ca²⁺, and Zn²⁺ ions, with the most sensitive variation observed with Pb²⁺. This is ascribed to the enhanced π interactions of the histidine moiety with the Pb²⁺, Co²⁺, and Hg²⁺ ions because of their capability of donating d electrons, a behavior consistent with prior studies based on conventional histidine-metal ion complexes. In the experiment, the researchers used many compounds, for example, 3-Iodo-4-methoxybenzaldehyde (cas: 2314-37-6Related Products of 2314-37-6).

3-Iodo-4-methoxybenzaldehyde (cas: 2314-37-6) belongs to iodide derivatives. Organic iodides are widely used in organic synthesis. Halogenation of aromatic hydrocarbons is a very important reaction via an electrophilic aromatic substitution. A typical method for synthesis of aromatic iodides is diazotization of primary aromatic amines followed by treatment of potassium iodide. Aliphatic alcohols are converted to alkyl iodides by treating with hydrogen iodide.Related Products of 2314-37-6

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Study of the reaction of several ketone enolates with 3-iodobenzo[b]thiophene under thermally initiated S_RN1 reaction conditions was written by Prats, Montserrat;Galvez, Carmen;Beltran, Lluis. And the article was included in Heterocycles in 1992.HPLC of Formula: 36748-88-6 This article mentions the following:

The reaction of 3-iodobenzo[b]thiophene with the potassium enolates of cyclohexanone, acetone, and acetophenone in DMSO for 1 h at room temperature in the dark gave the desired α-hetaryl ketones I [RR¹ = (CH₂)₄; R = H, R¹ = Me, Ph] in low yield. The thermally activated S_RN1 reaction with the ion enolate of cyclohexanone was studied in more detail. The radical chain S_RN1 mechanism could compete with one of ionic character. In the experiment, the researchers used many compounds, for example, 3-Iodobenzo[b]thiophene (cas: 36748-88-6HPLC of Formula: 36748-88-6).

3-Iodobenzo[b]thiophene (cas: 36748-88-6) belongs to iodide derivatives. Organic iodides can be alkyl, alkenyl, or alkynyl, and all of them are very reactive toward with many kinds of nucleophiles. In the chemical industry, alkyl iodides serve as excellent alkylating agents and, specifically, methyl iodide is used as a methylating agent in the synthesis of various pharmaceutical drugs.HPLC of Formula: 36748-88-6

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com