Tag: 200-300

Microwave-Assisted Nickel-Catalyzed Synthesis of Benzimidazoles: Ammonia as a Cheap and Nontoxic Nitrogen Source was written by Ke, Fang;Zhang, Peng;Xu, Yiwen;Lin, Xiaoyan;Lin, Jin;Lin, Chen;Xu, Jianhua. And the article was included in Synlett in 2018.Product Details of 220185-63-7 This article mentions the following:

An efficient and convenient Ni-catalyzed C-N bond formation for the synthesis of various benzimidazoles from various 2-haloanilines, aldehydes and ammonia in a concise manner was reported. This protocol used a com. available, nonhazardous, clean ammonia as a reaction partner instead of other nitrogen sources. Benzimidazoles, as the sole products, were obtained in high to excellent yields (up to 95%). In the experiment, the researchers used many compounds, for example, 4,5-Dichloro-2-iodoaniline (cas: 220185-63-7Product Details of 220185-63-7).

4,5-Dichloro-2-iodoaniline (cas: 220185-63-7) belongs to iodide derivatives. Typical reactions of alkyl iodides include nucleophilic substitution, elimination, reduction, and the formation of organometallics. In the chemical industry, alkyl iodides serve as excellent alkylating agents and, specifically, methyl iodide is used as a methylating agent in the synthesis of various pharmaceutical drugs.Product Details of 220185-63-7

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Enhancing charge mobilities in selectively fluorinated oligophenyl organic semiconductors: a design approach based on experimental and computational perspectives was written by Maiti, Buddhadev;Wang, Kunlun;Bhandari, Srijana;Bunge, Scott D.;Twieg, Robert J.;Dunietz, Barry D.. And the article was included in Journal of Materials Chemistry C: Materials for Optical and Electronic Devices in 2019.Recommanded Product: 64248-57-3 This article mentions the following:

Fluorination can be used to tune optoelectronic properties at the mol. level. A series of oligophenyls with various difluorinations of the Ph rings has been synthesized, crystalized, structurally resolved and computationally analyzed for charge mobility. We find that difluorination of the Ph rings at para positions leads to oligophenyls that are stacked in sym. overlap with significantly enhanced hole mobility as well as the highest electron mobility of the mols. considered. Other difluorinations lead to relatively shifted mol. units in the π-stacked crystal and therefore to lower mobilities. The selectively fluorinated oligophenyls were synthesized using the Suzuki-Miyaura cross coupling reaction. The structures of the products were characterized by X-ray diffraction (XRD), ¹H, ¹³C, ¹⁹F NMR spectroscopy and gas chromatog. (GC)/mass spectroscopy (MS) measurements. Computational anal. of the materials based on state-of-the-art tools are used to predict their charge transport properties in the crystal phase. In short, we establish a mol. design approach based on fluorination of oligophenyls to achieve enhanced hole mobilities and relatively high electron mobilities. In the experiment, the researchers used many compounds, for example, 1,2-Difluoro-3-iodobenzene (cas: 64248-57-3Recommanded Product: 64248-57-3).

1,2-Difluoro-3-iodobenzene (cas: 64248-57-3) belongs to iodide derivatives. Organic iodides can be alkyl, alkenyl, or alkynyl, and all of them are very reactive toward with many kinds of nucleophiles. Polyiodoorganic compounds are sometimes employed as X-ray contrast agents, in fluoroscopy, a type of medical imaging. This application exploits the X-ray absorbing ability of the heavy iodine nucleus.Recommanded Product: 64248-57-3

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

A practical and scalable system for heteroaryl amino acid synthesis was written by Aycock, R. A.;Vogt, D. B.;Jui, N. T.. And the article was included in Chemical Science in 2017.Product Details of 153034-88-9 This article mentions the following:

A robust system for the preparation of β-heteroaryl α-amino acid derivatives has been developed using photoredox catalysis. This system operates via regiospecific activation of halogenated pyridines (or other heterocycles) and conjugate addition to dehydroalanine derivatives to deliver a wide range of unnatural amino acids. This process was conducted with good efficiency on large scale, the application of these conditions to amino ketone synthesis is shown, and a simple protocol is given for the preparation of enantioenriched amino acid synthesis, from a number of radical precursors. In the experiment, the researchers used many compounds, for example, 2-Chloro-4-iodo-3-methylpyridine (cas: 153034-88-9Product Details of 153034-88-9).

2-Chloro-4-iodo-3-methylpyridine (cas: 153034-88-9) belongs to iodide derivatives. Organic iodides are organic compounds containing a carbon-iodine (C-I) bond. The carbon-iodine bond is weaker than other carbon-halogen bonds due to the poor electronegative nature of the iodine atom. A typical method for synthesis of aromatic iodides is diazotization of primary aromatic amines followed by treatment of potassium iodide. Aliphatic alcohols are converted to alkyl iodides by treating with hydrogen iodide.Product Details of 153034-88-9

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Nucleophilic C-H Etherification of Heteroarenes Enabled by Base-Catalyzed Halogen Transfer was written by Puleo, Thomas R.;Klaus, Danielle R.;Bandar, Jeffrey S.. And the article was included in Journal of the American Chemical Society in 2021.COA of Formula: C8H5IS This article mentions the following:

A general protocol for the direct C-H etherification of N-heteroarenes is reported. Potassium tert-butoxide catalyzes halogen transfer from 2-halothiophenes to N-heteroarenes to form N-heteroaryl halide intermediates that undergo tandem base-promoted alc. substitution. Thus, the simple inclusion of inexpensive 2-halothiophenes enables regioselective oxidative coupling of alcs. with 1,3-azoles, pyridines, diazines, and polyazines under basic reaction conditions. In the experiment, the researchers used many compounds, for example, 3-Iodobenzo[b]thiophene (cas: 36748-88-6COA of Formula: C8H5IS).

3-Iodobenzo[b]thiophene (cas: 36748-88-6) belongs to iodide derivatives. Organic iodides can be alkyl, alkenyl, or alkynyl, and all of them are very reactive toward with many kinds of nucleophiles. The C–I bond is the weakest of the carbon–halogen bonds. These bond strengths correlate with the electronegativity of the halogen, decreasing in the order F > Cl > Br > I. This periodic order also follows the atomic radius of halogens and the length of the carbon-halogen bond.COA of Formula: C8H5IS

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Palladium-catalyzed intramolecular C-H arylation of 2-halo-N-Boc-N-arylbenzamides for the synthesis of N-H phenanthridinones was written by Hu, Quan-Fang;Gao, Tian-Tao;Shi, Yao-Jie;Lei, Qian;Yu, Luo-Ting. And the article was included in RSC Advances in 2018.Application of 73841-32-4 This article mentions the following:

A palladium catalyzed synthesis of N-H phenanthridinones was developed via C-H arylation. The protocol gives phenanthridinones regioselectively by one-pot reaction without deprotection. It exhibits broad substrate scope and affords targets in up to 95% yields. Importantly, it could be applied for the less reactive o-chlorobenzamides. In the experiment, the researchers used many compounds, for example, 3-Iodopicolinic acid (cas: 73841-32-4Application of 73841-32-4).

3-Iodopicolinic acid (cas: 73841-32-4) belongs to iodide derivatives. Organic iodides are widely used in organic synthesis. Halogenation of aromatic hydrocarbons is a very important reaction via an electrophilic aromatic substitution. Polyiodoorganic compounds are sometimes employed as X-ray contrast agents, in fluoroscopy, a type of medical imaging. This application exploits the X-ray absorbing ability of the heavy iodine nucleus.Application of 73841-32-4

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

A Convenient Synthesis of 2-Arylbenzo[b]furans from Aryl Halides and 2-Halophenols by Catalytic One-Pot Cascade Method was written by Bosiak, Mariusz Jan. And the article was included in ACS Catalysis in 2016.COA of Formula: C6H4BrIO This article mentions the following:

The development of a multicatalytic one-pot synthesis of 2-arylbenzofurans starting from aryl halides and 2-halophenols is described. The protocol involves two Sonogashira coupling reactions, followed by 2-ethynylphenol cyclization leading to 2-arylbenzofuran derivatives The process occurs smoothly under mild conditions, giving products in good yields, and can be applied to many 2-arylbenzofurans substituted both at 2-aryl position and in the benzodifuran moiety. Substituents such as halogens, hydroxyl, cyano, nitro, and amino groups are tolerated, enabling further functionalization of the system. In the experiment, the researchers used many compounds, for example, 4-Bromo-2-iodophenol (cas: 207115-22-8COA of Formula: C6H4BrIO).

4-Bromo-2-iodophenol (cas: 207115-22-8) belongs to iodide derivatives. Organic iodides are organic compounds containing a carbon-iodine (C-I) bond. The carbon-iodine bond is weaker than other carbon-halogen bonds due to the poor electronegative nature of the iodine atom. The C–I bond is the weakest of the carbon–halogen bonds. These bond strengths correlate with the electronegativity of the halogen, decreasing in the order F > Cl > Br > I.COA of Formula: C6H4BrIO

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Synthesis, configuration judgment and potentiation activity of (2S,3S,E)-4-(3,4- dihydroxybenzylidene)-3-(3,4-dihydroxyphenyl)- 5-oxotetrahydrofuran-2-carboxylic acid was written by Zhang, Jun-Liang;Lv, Zhi-Liang;Zhong, Jia-Liang;Chen, Dai-Jie;Li, Mo-Ying;Zhang, Jian-Bin. And the article was included in Chinese Journal of Structural Chemistry in 2017.Formula: C8H9IO2 This article mentions the following:

The title compound (2S,3S,E)-4-(3,4-dihydroxybenzylidene)-3-(3,4-dihydroxyphenyl)- 5-oxotetrahydrofuran-2-carboxylic acid was synthesized and the 2D structure was characterized by 1H-NMR 13C-NMR and LCMS. The absolute configuration was determined by single-crystal X-ray diffraction of the key intermediate (2S,3S,E)-Et 4-(3,4-dimethoxybenzylidene)- 3-(3,4-dimethoxyphenyl)-5-oxotetrahydrofuran-2-carboxylate. The crystal belongs to tetragonal system, space group P41 with a = 13.0665(2), b = 13.0665(2), c = 13.4735(2) Å, V = 2300.4(6) Å3, Z = 4, Dc = 1.278 g/cm3, μ(CuKa) = 0.801 mm-1, F(000) = 936, S = 1.050, R = 0.0364 and wR (I > 2s(I)) = 0.1071. X-ray diffraction results showed that the mol. structure is stabilized totally by Van der Waals force. The antibacterial activity tests showed that the title compound possesses slight synergistic effect against MRSA and Acinetobacter baumanii. In the experiment, the researchers used many compounds, for example, 4-Iodo-1,2-dimethoxybenzene (cas: 5460-32-2Formula: C8H9IO2).

4-Iodo-1,2-dimethoxybenzene (cas: 5460-32-2) belongs to iodide derivatives. Organoiodine compounds occur widely in organic chemistry, but are relatively rare in nature. Alkyl iodides react at a faster rate than alkyl fluorides due to the weak C-I bond.Formula: C8H9IO2

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Carbo-Carboxylation of Alkenes via Intramolecular Heck Carbonylation Utilizing CO₂ and Hydrosilane was written by Wang, Meng-Meng;Lu, Sheng-Mei;Li, Can. And the article was included in ACS Catalysis in 2022.Quality Control of 4-Bromo-2-iodophenol This article mentions the following:

Starting from diverse alkene-tethered aryl halides 2-X-3-R-4-R¹-5-R²C₆HYZ(CH₂)_nC(=CH₂)R³ [R = H, OMe, Cl; R¹ = H, Me, t-Bu, Br, F, Cl; R² = H, OMe, Cl, COOMe; R³ = Me, n-Bu, methoxymethyl; X = Br, I; Y = Z = O, CH₂; n = 0, 1] and silyl formate formed in situ from CO₂ and PMHS (polymethylhydrosiloxane), the carbo-carboxylation of alkenes has been achieved using an easily accessible Pd/monophosphine ligand combination as the catalyst. This protocol provides competent access to construct a series of 2,3-dihydrobenzofurans, chromans, isochroman, indanes and tetralins bearing a β-acid moiety I in moderate to excellent yield. Addnl., the example of domino carbo-carbonylation reactions has been demonstrated using diene-tethered aryl iodide as starting material, forming oxygen-containing bicyclic products I in good yield. It is speculated that the carbo-carboxylation reaction of alkenes proceeds via a carbo-silyloxycarbonylation pathway. In the experiment, the researchers used many compounds, for example, 4-Bromo-2-iodophenol (cas: 207115-22-8Quality Control of 4-Bromo-2-iodophenol).

4-Bromo-2-iodophenol (cas: 207115-22-8) belongs to iodide derivatives. Organic iodides are widely used in organic synthesis. Halogenation of aromatic hydrocarbons is a very important reaction via an electrophilic aromatic substitution. In the chemical industry, alkyl iodides serve as excellent alkylating agents and, specifically, methyl iodide is used as a methylating agent in the synthesis of various pharmaceutical drugs.Quality Control of 4-Bromo-2-iodophenol

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

The Catalyst-Controlled Regiodivergent Chlorination of Phenols was written by Maddox, Sean M.;Dinh, Andrew N.;Armenta, Felipe;Um, Joann;Gustafson, Jeffrey L.. And the article was included in Organic Letters in 2016.Product Details of 289039-26-5 This article mentions the following:

Different catalysts are demonstrated to overcome or augment a substrate’s innate regioselectivity. Nagasawa’s bis-thiourea catalyst was found to overcome the innate para-selectivity of electrophilic phenol chlorination, yielding ortho-chlorinated phenols that are not readily obtainable via canonical electrophilic chlorinations. Conversely, a phosphine sulfide derived from 2,2′-Bis(diphenylphosphino)-1,1′-binaphthyl (BINAP) was found to enhance the innate para-preference of phenol chlorination. In the experiment, the researchers used many compounds, for example, 2-Chloro-5-iodophenol (cas: 289039-26-5Product Details of 289039-26-5).

2-Chloro-5-iodophenol (cas: 289039-26-5) belongs to iodide derivatives. Iodide-containing intermediates are common in organic synthesis, because of the easy formation and cleavage of the C–I bond. In the chemical industry, alkyl iodides serve as excellent alkylating agents and, specifically, methyl iodide is used as a methylating agent in the synthesis of various pharmaceutical drugs.Product Details of 289039-26-5

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Palladium-catalyzed triple coupling of 2-iodoanisoles with aryl iodides to access 6H-dibenzopyrans was written by Chen, Li-Ping;Cheng, Shu-Lin;Fan, Xin-Yue;Zhu, Ji-Fa;Wang, Bi-Qin;Feng, Chun;Xiang, Shi-Kai. And the article was included in Organic Chemistry Frontiers in 2022.Quality Control of 3-Iodo-4-methoxybenzaldehyde This article mentions the following:

A palladium-catalyzed triple coupling of 2-iodoanisoles with aryl iodides was developed. 3-Methyl-2-pyridone was used as a ligand to accelerate the cross-coupling and suppress the homo-coupling of 2-iodoanisoles. A variety of 6H-dibenzopyran derivatives such as I [R = H, F, Cl, etc., R¹ = 4-Me, 4-F, 4-MeO, etc.; R² = 8-Me, 8-Cl, 8-Ph, etc.] was prepared by this method. In the experiment, the researchers used many compounds, for example, 3-Iodo-4-methoxybenzaldehyde (cas: 2314-37-6Quality Control of 3-Iodo-4-methoxybenzaldehyde).

3-Iodo-4-methoxybenzaldehyde (cas: 2314-37-6) belongs to iodide derivatives. Organic iodides can be alkyl, alkenyl, or alkynyl, and all of them are very reactive toward with many kinds of nucleophiles. The C–I bond is the weakest of the carbon–halogen bonds. These bond strengths correlate with the electronegativity of the halogen, decreasing in the order F > Cl > Br > I.Quality Control of 3-Iodo-4-methoxybenzaldehyde

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com