Tag: 200-300

Highly Efficient and Chemoselective Reduction of Nitroarenes Using Hybrid Ni@g-C₃N₄ as Reusable Catalyst was written by Payra, Soumen;Banerjee, Subhash. And the article was included in ChemistrySelect in 2019.SDS of cas: 160938-18-1 This article mentions the following:

Hybrid Ni@g-C₃N₄-catalyzed highly chemoselective reduction of nitroarenes to anilines with high turnover frequency was demonstrated using NaBH₄ as source of hydrogen. Here, g-C₃N₄ provided excellent stability to Ni(0) nanoparticles on its nitrogen rich surface and also facilitated the dissociation of NaBH₄ resulting formation of active Ni-H⁺ and Ni-H^– via cooperative effect. In the experiment, the researchers used many compounds, for example, 4-Chloro-2-iodo-1-nitrobenzene (cas: 160938-18-1SDS of cas: 160938-18-1).

4-Chloro-2-iodo-1-nitrobenzene (cas: 160938-18-1) belongs to iodide derivatives. Iodide-containing intermediates are common in organic synthesis, because of the easy formation and cleavage of the C–I bond. Polyiodoorganic compounds are sometimes employed as X-ray contrast agents, in fluoroscopy, a type of medical imaging. This application exploits the X-ray absorbing ability of the heavy iodine nucleus.SDS of cas: 160938-18-1

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Palladium-catalyzed synthesis of ammonium sulfinates from aryl halides and a sulfur dioxide surrogate. A gas- and reductant-free process was written by Emmett, Edward J.;Hayter, Barry R.;Willis, Michael C.. And the article was included in Angewandte Chemie, International Edition in 2014.Safety of 3-Iodobenzo[b]thiophene This article mentions the following:

Described herein is a simple reaction system consisting of the sulfur dioxide surrogate DABSO, triethylamine, and a palladium(0) catalyst for effective conversion of a broad range of aryl and heteroaryl halides into the corresponding ammonium sulfinates. Key features of this gas- and reductant-free reaction include the low loadings of palladium (1 mol%) and ligand (1.5 mol%) which can be employed, and the use of iso-Pr alc. as both a solvent and formal reductant. The ammonium sulfinate products are converted in situ into a variety of sulfonyl-containing functional groups, including sulfones, sulfonyl chlorides, and sulfonamides. © Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim. In the experiment, the researchers used many compounds, for example, 3-Iodobenzo[b]thiophene (cas: 36748-88-6Safety of 3-Iodobenzo[b]thiophene).

3-Iodobenzo[b]thiophene (cas: 36748-88-6) belongs to iodide derivatives. Organic iodides are widely used in organic synthesis. Halogenation of aromatic hydrocarbons is a very important reaction via an electrophilic aromatic substitution. In the chemical industry, alkyl iodides serve as excellent alkylating agents and, specifically, methyl iodide is used as a methylating agent in the synthesis of various pharmaceutical drugs.Safety of 3-Iodobenzo[b]thiophene

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Palladium-catalyzed C(sp³)-H arylation of lactic acid: efficient synthesis of chiral β-aryl-α-hydroxy acids was written by Chen, Kai;Li, Xin;Zhang, Shuo-Qing;Shi, Bing-Feng. And the article was included in Organic Chemistry Frontiers in 2016.Recommanded Product: 4-Iodo-1,2-dimethoxybenzene This article mentions the following:

Pd-catalyzed enantioselective arylation of lactic acid substrates employing 8-aminoquinoline as the directing group was reported. The protocol was found to be compatible with a broad range of synthetically useful functional groups, thus providing a practical route to chiral aryl-alkoxy-N-(quinolinyl)propanamides, e.g., I. Further, the new reaction was also applied to the synthesis of pharmaceutically important α-hydroxy acids, such as LY519818 and tesaglitazar. In the experiment, the researchers used many compounds, for example, 4-Iodo-1,2-dimethoxybenzene (cas: 5460-32-2Recommanded Product: 4-Iodo-1,2-dimethoxybenzene).

4-Iodo-1,2-dimethoxybenzene (cas: 5460-32-2) belongs to iodide derivatives. In general, organic iodides are light-sensitive and turn yellow during storage, owing to the formation of iodine. In the chemical industry, alkyl iodides serve as excellent alkylating agents and, specifically, methyl iodide is used as a methylating agent in the synthesis of various pharmaceutical drugs.Recommanded Product: 4-Iodo-1,2-dimethoxybenzene

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Researches in stoichiometry. I. The heat of fusion of organic compounds was written by Timmermans, Jean. And the article was included in Bulletin des Societes Chimiques Belges in 1935.HPLC of Formula: 160938-18-1 This article mentions the following:

By means of the freezing curves of binary mixtures which proved to be ideal solutions, the following heats of fusion (in cal. per g.-mol.) were determined: o-C₆H₄Me 2300, p- 3100, o-BrC₆H₄Me 2300, p-3.500, o-O₂NC₆H₄CH₂Cl 4900, P- 5200, o-O₂NC₆H₄CHCl₂ 3850, m- 4800, p- 3850, o-BrC₆H₄OH 2700, m-ClC₆H₄CO₂H 5600, P-O₂NC₆H₄OH 3800, m- 4550, p-O₂NC₆H₄NH₂ 4800, P-O₂NC₆H₄NHOCH 7600, p-ClC₆H₄NHOCH 5400, m-O₂NC₆H₄NHOCCH₃ 5400, p-ClO₂SC₆H₄COCl 4800, p-C₆H₄(SO₂Cl)₂ 3500, p-MeC₆H₄SO₂Cl 5400, o-MeC₆H₄SO₂NH₂ 6700, p- 5850, 1,2,3-Cl₃C₆H₃ 4150, 1,3,5-Cl₃C₆H₃ 4150, p-O₂NC₆H₄I 6900, 1,2,4-Br₂C₆H₃NO₂ 3100, 1,2,4-dinitroanisole 3900, 2,3-Cl₂C₆H₃CO₂H 6700, 2,5- 6100, 4,2-nitrochlorotoluene 4400, 6,2- 3900, 5,2- 3350, 3,2-3650, 1,2,4-nitrobromotoluene 4800, 1,3,4- 3850, 4,3,1-fluorochloronitrobenzene 4950, 3,4,1- 4700, 3,6,1- 4300, 1,3,6-chloroiodonitrobenzene 4000, 1,3,4- 4200, 1,3,4-chloronitroaniline 6800, 1,3,6- 5500, 1,2,4- 5600, 1,2,5-6000, 1,4,3- 5300, 1,2,6- 4900, 1,3,4-chloronitroacetanilide 5200, 1,2,5-nitrosalicylic acid 7800, α-cymenesulfonamide 6400, β- 6600, 2,4,5-Br₃C₆H₂Me 5000, 2,3,4- 3900, 2,3,6-4600, 2,4,6- 4800, 3,4,5- 4700, α-trinitrotoluene 4100, γ-4100, 2,6-dinitro-p-dichlorobenzene 7500, 2,3- 4400, 4,6-dibromo-3-aminomethylbenzene 5600, 2,6- 3700, phthalic acid 12,500, 4-chloroacetanilide 6900, trinitro-m-xylene 9500, 2,4-dinitrophenetole 5300, β-naphthol 5400, 3-chloroacenaphthene 4100, C₅H₁₂ 2000, CHCl₃ 2280, CH₂Cl₂ 1000, MeCHCl₂ 1250, EtBr 1400, PrBr 1560, BuBr 1600, iso-BuBr 600, tert-BuCl 500, PhF 1950, PhCl 1800, PhBr 2000, CS₂ 1350, methylal 1900, MeCOEt 1780, propionic acid 1800, isobutyric acid 1200, isovaleric acid 1750, valeric acid 1850, MeO₂CH 1800, EtO₂CH 2200, MeCN 2130, PrCN 1200, EtCN 1450, valeronitrile 1130, m-toluidine 930. Tentative correlations are appended. In the experiment, the researchers used many compounds, for example, 4-Chloro-2-iodo-1-nitrobenzene (cas: 160938-18-1HPLC of Formula: 160938-18-1).

4-Chloro-2-iodo-1-nitrobenzene (cas: 160938-18-1) belongs to iodide derivatives. Organic iodides are widely used in organic synthesis. Halogenation of aromatic hydrocarbons is a very important reaction via an electrophilic aromatic substitution. In the chemical industry, alkyl iodides serve as excellent alkylating agents and, specifically, methyl iodide is used as a methylating agent in the synthesis of various pharmaceutical drugs.HPLC of Formula: 160938-18-1

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Efficient one-pot transformation of aminoarenes to haloarenes using halodimethylsulfonium halides generated in situ was written by Baik, Woonphil;Luan, Wanqiang;Lee, Hyun Joo;Yoon, Cheol Hun;Koo, Sangho;Kim, Byeong Hyo. And the article was included in Canadian Journal of Chemistry in 2005.Related Products of 160938-18-1 This article mentions the following:

Halodimethylsulfonium halides, which were readily formed in situ from hydrohalic acids and DMSO, was a good nucleophilic halide. This activated nucleophilic halide rapidly converted aryldiazonium salt prepared in situ by the same hydrohalic acid and nitrite ion to aryl chlorides, bromides, or iodides in good yield. The combined action of nitrite ion and hydrohalic acid in DMSO was required for the direct transformation of aromatic amines, which resulted in the production of aryl halides. Substituted compounds with electron-donating or -withdrawing groups or sterically hindered aromatic amines were also smoothly transformed to the corresponding aromatic halides. The only observed byproduct was the deaminated arene. The isolated aryldiazonium salts can also be converted to the corresponding aryl halides using the halodimethylsulfonium halides. The present method offers a facile, one-step procedure for transforming aminoarenes to haloarenes and lacks the environmental pollutants that usually accompany the Sandmeyer reaction using copper halides. In the experiment, the researchers used many compounds, for example, 4-Chloro-2-iodo-1-nitrobenzene (cas: 160938-18-1Related Products of 160938-18-1).

4-Chloro-2-iodo-1-nitrobenzene (cas: 160938-18-1) belongs to iodide derivatives. Organic iodides are organic compounds containing a carbon-iodine (C-I) bond. The carbon-iodine bond is weaker than other carbon-halogen bonds due to the poor electronegative nature of the iodine atom. Organoiodine lubricants can be used with titanium, stainless steels, and other metals which tend to seize up with conventional lubricants: organoiodine lubricants can be used in turbines and spacecraft, and as a cutting oil in machining.Related Products of 160938-18-1

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Light-Up “Channel Dyes” for Haloalkane-Based Protein Labeling in Vitro and in Bacterial Cells was written by Clark, Spencer A.;Singh, Vijay;Vega Mendoza, Daniel;Margolin, William;Kool, Eric T.. And the article was included in Bioconjugate Chemistry in 2016.Synthetic Route of C4H8ClI This article mentions the following:

The authors describe a novel mol. strategy for engendering a strong light-up signal in fluorescence tagging of the genetically encoded HaloTag protein domain. The authors designed a set of haloalkane-derivatized dyes having twisted internal charge transfer (TICT) structures potentially narrow enough to partially fit into the enzyme’s haloalkane-binding channel. Testing a range of short chain lengths revealed a number of active dyes, with seven carbons yielding optimum light-up signal. The dimethylaminostilbazolium chloroheptyl dye (1d) yields a 27-fold fluorescence emission enhancement (λ_ex = 535 nm; Em_(max) = 616 nm) upon reaction with the protein. The control compound with standard 12-atom linkage shows less efficient signaling, consistent with the authors’ channel-binding hypothesis. For emission further to the red, the authors also prepared a chloroheptyl naphthalene-based dye; compound 2 emits at 653 nm with strong fluorescence enhancement upon reaction with the HaloTag domain. The two dyes (1d, 2) were successfully tested in wash-free imaging of protein localization in bacteria, using a HaloTag fusion of the filamenting temperature-sensitive mutant Z (FtsZ) protein in Escherichia coli (E. coli). The new dye conjugates are inexpensive and easily synthesized enzyme substrates with low background and large Stokes shifts, offering substantial benefits over known fluorescent substrates for the HaloTag enzyme. In the experiment, the researchers used many compounds, for example, 1-Chloro-4-iodobutane (cas: 10297-05-9Synthetic Route of C4H8ClI).

1-Chloro-4-iodobutane (cas: 10297-05-9) belongs to iodide derivatives. Iodide-containing intermediates are common in organic synthesis, because of the easy formation and cleavage of the C–I bond. In the chemical industry, alkyl iodides serve as excellent alkylating agents and, specifically, methyl iodide is used as a methylating agent in the synthesis of various pharmaceutical drugs.Synthetic Route of C4H8ClI

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Synthesis of 3-[4(5)-imidazolylmethyl]-2-methylbenzoic acid, a metabolite of the drug detomidine was written by Cardin, Christine J.;Convery, Maire A.;Kavanagh, Pierce V.;Lambert, Michael T. B.;McKenna, Brian;McMurray, T. Brian H.. And the article was included in Journal of Chemical Research, Synopses in 1992.Reference of 133232-56-1 This article mentions the following:

The synthesis of the title compound I (R = H, R¹ = CO₂H, X = H₂), a metabolite of detomidine I (R = H, R¹ = Me, X = H₂), is reported. A key step of the synthesis is the Grignard reaction of iodobenzyl alc. derivative II with 1-tritylimidazole-4-carboxaldehyde to give I (R = CPh₃, R¹ = CH₂OCH₂OMe, X = H, OH), which was converted in 6 steps to the title compound The crystal structure of I (R = H, R¹ = CO₂Me, X = H,H) was determined In the experiment, the researchers used many compounds, for example, 3-Iodo-2-methylbenzoic acid (cas: 133232-56-1Reference of 133232-56-1).

3-Iodo-2-methylbenzoic acid (cas: 133232-56-1) belongs to iodide derivatives. In general, organic iodides are light-sensitive and turn yellow during storage, owing to the formation of iodine. A typical method for synthesis of aromatic iodides is diazotization of primary aromatic amines followed by treatment of potassium iodide. Aliphatic alcohols are converted to alkyl iodides by treating with hydrogen iodide.Reference of 133232-56-1

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Metal-Free Catalytic Asymmetric Fluorination of Keto Esters Using a Combination of Hydrogen Fluoride (HF) and Oxidant: Experiment and Computation was written by Pluta, Roman;Krach, Patricia E.;Cavallo, Luigi;Falivene, Laura;Rueping, Magnus. And the article was included in ACS Catalysis in 2018.Synthetic Route of C8H7IO4 This article mentions the following:

In the presence of nonracemic iodoarenes I [R = H, 3,5-(F₃C)₂C₆H₃], fused β-keto esters such as Et 1-oxo-2-indanecarboxylate underwent enantioselective fluorination with Et₃N·5 HF mediated by mCPBA in CHCl₃ to yield α-fluoro-β-keto esters such as II in 18-71% yields and in 83:17-96:4 er; thus, nucleophilic fluoride sources could be used as fluorinating reagents. The mechanism of the fluorination was studied using DFT calculations of transition states and intermediates and their free energies; attempted fluorination using a nonracemic aryliodine difluoride did not give fluorination product, indicating the importance of HF in the fluorination. In the experiment, the researchers used many compounds, for example, Methyl 3,5-dihydroxy-4-iodobenzoate (cas: 338454-02-7Synthetic Route of C8H7IO4).

Methyl 3,5-dihydroxy-4-iodobenzoate (cas: 338454-02-7) belongs to iodide derivatives. Organic iodides can be alkyl, alkenyl, or alkynyl, and all of them are very reactive toward with many kinds of nucleophiles. Organoiodine lubricants can be used with titanium, stainless steels, and other metals which tend to seize up with conventional lubricants: organoiodine lubricants can be used in turbines and spacecraft, and as a cutting oil in machining.Synthetic Route of C8H7IO4

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Selenium-catalyzed intramolecular atom- and redox-economical transformation of o-nitrotoluenes into anthranilic acids was written by Li, Yiming;Wang, Yuhong;Yang, Tilong;Lin, Zhenyang;Jiang, Xuefeng. And the article was included in Green Chemistry in 2021.COA of Formula: C7H6INO2 This article mentions the following:

Herein, a straightforward strategy to transform abundant o-nitrotoluenes into biol. and pharmaceutically significant AAs without any extra reductants, oxidants and protecting groups was demonstrated. Various sensitive groups, such as halogens, sulfide, aldehyde, pyridines, quinolines, etc., can be tolerated in this transformation. A hundred-gram-scale operation was realized efficiently with almost quant. selenium recycling. Further mechanistic studies and DFT calculations disclosed the proposed atom-exchange processes and the key roles of the selenium species. In the experiment, the researchers used many compounds, for example, 2-Amino-4-iodobenzoic acid (cas: 20776-54-9COA of Formula: C7H6INO2).

2-Amino-4-iodobenzoic acid (cas: 20776-54-9) belongs to iodide derivatives. Typical reactions of alkyl iodides include nucleophilic substitution, elimination, reduction, and the formation of organometallics. Organoiodine lubricants can be used with titanium, stainless steels, and other metals which tend to seize up with conventional lubricants: organoiodine lubricants can be used in turbines and spacecraft, and as a cutting oil in machining.COA of Formula: C7H6INO2

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Base- and Additive-Free Ir-Catalyzed ortho-Iodination of Benzoic Acids: Scope and Mechanistic Investigations was written by Erbing, Elis;Sanz-Marco, Amparo;Vazquez-Romero, Ana;Malmberg, Jesper;Johansson, Magnus J.;Gomez-Bengoa, Enrique;Martin-Matute, Belen. And the article was included in ACS Catalysis in 2018.Recommanded Product: 133232-56-1 This article mentions the following:

A protocol for the C-H activation/iodination of benzoic acids catalyzed by a simple iridium complex has been developed. The method described in this paper allows the ortho-selective iodination of a variety of benzoic acids under extraordinarily mild conditions in the absence of any additive or base in 1,1,1,3,3,3-hexafluoroisopropanol as the solvent. The iridium catalyst used tolerates air and moisture, and selectively gives ortho-iodobenzoic acids with high conversions. Mechanistic investigations revealed that an Ir(III)/Ir(V) catalytic cycle operates, and that the unique properties of HFIP enables the C-H iodination using the carboxylic moiety as a directing group. In the experiment, the researchers used many compounds, for example, 3-Iodo-2-methylbenzoic acid (cas: 133232-56-1Recommanded Product: 133232-56-1).

3-Iodo-2-methylbenzoic acid (cas: 133232-56-1) belongs to iodide derivatives. Organic iodides are widely used in organic synthesis. Halogenation of aromatic hydrocarbons is a very important reaction via an electrophilic aromatic substitution. A typical method for synthesis of aromatic iodides is diazotization of primary aromatic amines followed by treatment of potassium iodide. Aliphatic alcohols are converted to alkyl iodides by treating with hydrogen iodide.Recommanded Product: 133232-56-1

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com