Tag: 200-300

Solid-phase total synthesis of scytalidamide A was written by Gu, Wenxin;Silverman, Richard B.. And the article was included in Journal of Organic Chemistry in 2003.Safety of 3-Iodo-4-methoxybenzaldehyde This article mentions the following:

The first total synthesis of the natural cyclic heptapeptide scytalidamide A was achieved on solid phase using two different linker resins, a phenylalanine silane resin and a 4-methoxybenzaldehyde backbone linker resin. The synthetic product confirms the structure of the natural product reported in the preceding paper in this issue (Tan, L. T. at al.). In the experiment, the researchers used many compounds, for example, 3-Iodo-4-methoxybenzaldehyde (cas: 2314-37-6Safety of 3-Iodo-4-methoxybenzaldehyde).

3-Iodo-4-methoxybenzaldehyde (cas: 2314-37-6) belongs to iodide derivatives. Organoiodine compounds occur widely in organic chemistry, but are relatively rare in nature. The C–I bond is the weakest of the carbon–halogen bonds. These bond strengths correlate with the electronegativity of the halogen, decreasing in the order F > Cl > Br > I. This periodic order also follows the atomic radius of halogens and the length of the carbon-halogen bond.Safety of 3-Iodo-4-methoxybenzaldehyde

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Catalytic Enantioselective Approach to the Stereodivergent Synthesis of (+)-Lasubines I and II was written by Garcia Mancheno, Olga;Gomez Arrayas, Ramon;Adrio, Javier;Carretero, Juan C.. And the article was included in Journal of Organic Chemistry in 2007.Related Products of 10297-05-9 This article mentions the following:

A concise and efficient approach to the stereodivergent synthesis of (+)-lasubines I (I) and II (II) is described. The key common intermediate is a chiral N-sulfonyl 2,3-dihydropyridone obtained by a novel Cu-catalyzed asym. formal aza-Diels-Alder reaction between N-tosyl aldimines and Danishefsky’s diene. In the experiment, the researchers used many compounds, for example, 1-Chloro-4-iodobutane (cas: 10297-05-9Related Products of 10297-05-9).

1-Chloro-4-iodobutane (cas: 10297-05-9) belongs to iodide derivatives. Organic iodides can be alkyl, alkenyl, or alkynyl, and all of them are very reactive toward with many kinds of nucleophiles. In the chemical industry, alkyl iodides serve as excellent alkylating agents and, specifically, methyl iodide is used as a methylating agent in the synthesis of various pharmaceutical drugs.Related Products of 10297-05-9

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Direct Bis-Arylation of Cyclobutanecarboxamide via Double C-H Activation: An Auxiliary-Aided Diastereoselective Pd-Catalyzed Access to Trisubstituted Cyclobutane Scaffolds Having Three Contiguous Stereocenters and an All-cis Stereochemistry [Erratum to document cited in CA160:007081] was written by Parella, Ramarao;Gopalakrishnan, Bojan;Babu, Srinivasarao Arulananda. And the article was included in Journal of Organic Chemistry in 2014.Recommanded Product: 4-Iodo-1,2-dimethoxybenzene This article mentions the following:

Upon further anal. the authors discovered the proton NMR processing software was set to use fewer significant digits, which was not realized during data processing; the reprocessed NMR spectra are provided and the conclusions are unaffected. In the experiment, the researchers used many compounds, for example, 4-Iodo-1,2-dimethoxybenzene (cas: 5460-32-2Recommanded Product: 4-Iodo-1,2-dimethoxybenzene).

4-Iodo-1,2-dimethoxybenzene (cas: 5460-32-2) belongs to iodide derivatives. Organic iodides are widely used in organic synthesis. Halogenation of aromatic hydrocarbons is a very important reaction via an electrophilic aromatic substitution. Organoiodine lubricants can be used with titanium, stainless steels, and other metals which tend to seize up with conventional lubricants: organoiodine lubricants can be used in turbines and spacecraft, and as a cutting oil in machining.Recommanded Product: 4-Iodo-1,2-dimethoxybenzene

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Isolation of macrocyclic metacyclophanes from the attempted synthesis of [7.0]metacyclophanes of the myricanone series by Thorpe-Ziegler intramolecular cyclization of diaryls substituted by ω-cyanoalkyl chains was written by Dansou, Benedicte;Pichon, Christophe;Dhal, Robert;Brown, Eric;Mille, Stephane. And the article was included in European Journal of Organic Chemistry in 2000.Electric Literature of C8H7IO2 This article mentions the following:

The syntheses of biphenyls I and II substituted by two ω-cyanoalkyl chains (one on each ring) are described. Treatment of the unsym. I with NaN(Me)Ph in a Thorpe-Ziegler reaction failed to give any definite product. Under the same conditions, sym. II led to an isomeric mixture of dimeric enamino nitriles III [X = CH₂C(NH₂):C(CN), X¹ = CH₂C(NH₂):C(CN) or C(CN):C(NH₂)CH₂]. Mild acidic hydrolysis of the latter yielded the isomeric β-keto nitriles III [X = CH₂COCH(CN), X¹ = CH(CN)COCH₂], whereas more drastic hydrolytic conditions led to the macrocyclic diketone III (X, X¹ = CH₂COCH₂). In the experiment, the researchers used many compounds, for example, 3-Iodo-4-methoxybenzaldehyde (cas: 2314-37-6Electric Literature of C8H7IO2).

3-Iodo-4-methoxybenzaldehyde (cas: 2314-37-6) belongs to iodide derivatives. Organoiodine compounds occur widely in organic chemistry, but are relatively rare in nature. In the chemical industry, alkyl iodides serve as excellent alkylating agents and, specifically, methyl iodide is used as a methylating agent in the synthesis of various pharmaceutical drugs.Electric Literature of C8H7IO2

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

A general synthesis of five, six and seven-membered silasultones via dehydrative cyclisation was written by Braddock, D. Christopher;Peyralans, Jerome J.-P.. And the article was included in Tetrahedron in 2005.COA of Formula: C4H8ClI This article mentions the following:

Five, six and seven-membered silasultones (I) can be conveniently prepared in good yield by dehydrative cyclization of siloxane disulfonic acids HO₃S(CH₂)_nCH₂SiR₂OSiR₂CH₂(CH₂)_nSO₃H (n = 1-3). The siloxanes are prepared by protodesilylation of the corresponding phenylsilane sulfonic acids. The sulfonate group is introduced either by free-radical sulfonation of vinyl silanes, or by S_N2 sulfite displacement of a long chain alkyl chloride. In the experiment, the researchers used many compounds, for example, 1-Chloro-4-iodobutane (cas: 10297-05-9COA of Formula: C4H8ClI).

1-Chloro-4-iodobutane (cas: 10297-05-9) belongs to iodide derivatives. In general, organic iodides are light-sensitive and turn yellow during storage, owing to the formation of iodine. Iodo alkanes participate in a variety of organic synthesis reactions, which include the Simmons–Smith reaction (cyclopropanation using iodomethane), Williamson ether synthesis, Wittig reaction, Grignard reaction, alkyl coupling reactions, and Wurtz reaction.COA of Formula: C4H8ClI

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Enantioselective Synthesis of 3-Fluorochromanes via Iodine(I)/Iodine(III) Catalysis was written by Sarie, Jerome C.;Thiehoff, Christian;Neufeld, Jessica;Daniliuc, Constantin G.;Gilmour, Ryan. And the article was included in Angewandte Chemie, International Edition in 2020.Quality Control of Methyl 3,5-dihydroxy-4-iodobenzoate This article mentions the following:

The chromane nucleus is common to a plenum of bioactive small mols. where it is frequently oxidized at position 3. Motivated by the importance of this position in conferring efficacy, and the prominence of bioisosterism in drug discovery, an iodine(I)/iodine(III) catalysis strategy to access enantioenriched 3-fluorochromanes is disclosed (up to 7:93 e.r.). In situ generation of ArIF₂ enables the direct fluorocyclization of allyl Ph ethers to generate novel scaffolds that manifest the stereoelectronic gauche effect. Mechanistic interrogation using deuterated probes confirms a stereospecific process consistent with a type II_inv pathway. In the experiment, the researchers used many compounds, for example, Methyl 3,5-dihydroxy-4-iodobenzoate (cas: 338454-02-7Quality Control of Methyl 3,5-dihydroxy-4-iodobenzoate).

Methyl 3,5-dihydroxy-4-iodobenzoate (cas: 338454-02-7) belongs to iodide derivatives. Iodide-containing intermediates are common in organic synthesis, because of the easy formation and cleavage of the C–I bond. The C–I bond is the weakest of the carbon–halogen bonds. These bond strengths correlate with the electronegativity of the halogen, decreasing in the order F > Cl > Br > I. This periodic order also follows the atomic radius of halogens and the length of the carbon-halogen bond.Quality Control of Methyl 3,5-dihydroxy-4-iodobenzoate

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Spiroannulation by alkylation and reductive cyclization of nitriles was written by Rychnovsky, Scott D.;Takaoka, Leo R.. And the article was included in Angewandte Chemie, International Edition in 2003.Recommanded Product: 10297-05-9 This article mentions the following:

Spirocyclic rings were prepared from 2-cyanotetrahydropyrans. E.g., lithiation of 2-cyano-2-alkenyltetrahydropyran I (R = n-C₅H₁₁), prepared from 2-cyano-6-pentyltetrahydropyran, by lithium di-tert-butylbiphenylide led to the spirocyclic compound II. This two step sequence, alkylation and reductive cyclization, is used to generate five- and six-membered rings, and is highly stereoselective. In the experiment, the researchers used many compounds, for example, 1-Chloro-4-iodobutane (cas: 10297-05-9Recommanded Product: 10297-05-9).

1-Chloro-4-iodobutane (cas: 10297-05-9) belongs to iodide derivatives. In general, organic iodides are light-sensitive and turn yellow during storage, owing to the formation of iodine. Iodo alkanes participate in a variety of organic synthesis reactions, which include the Simmons–Smith reaction (cyclopropanation using iodomethane), Williamson ether synthesis, Wittig reaction, Grignard reaction, alkyl coupling reactions, and Wurtz reaction.Recommanded Product: 10297-05-9

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

A Modular Access to (±)-Tubocurine and (±)-Curine – Formal Total Synthesis of Tubocurarine was written by Otto, Nicola;Ferenc, Dorota;Opatz, Till. And the article was included in Journal of Organic Chemistry in 2017.SDS of cas: 2314-37-6 This article mentions the following:

Two consecutive Cu-catalyzed Ullmann-type C-O couplings permitted the first successful entry towards the curare alkaloids (±)-tubocurine and (±)-curine. Starting from vanillin, the synthetic sequence comprises of 15 linear steps and includes a total of 24 transformations. In addition, the total synthesis of tubocurine represents a formal total synthesis of the famous arrow poison alkaloid tubocurarine. In the experiment, the researchers used many compounds, for example, 3-Iodo-4-methoxybenzaldehyde (cas: 2314-37-6SDS of cas: 2314-37-6).

3-Iodo-4-methoxybenzaldehyde (cas: 2314-37-6) belongs to iodide derivatives. Iodide-containing intermediates are common in organic synthesis, because of the easy formation and cleavage of the C–I bond. The C–I bond is the weakest of the carbon–halogen bonds. These bond strengths correlate with the electronegativity of the halogen, decreasing in the order F > Cl > Br > I. This periodic order also follows the atomic radius of halogens and the length of the carbon-halogen bond.SDS of cas: 2314-37-6

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Chlorination of iodophenols. V. m-Iodophenol was written by Buchan, Samuel;McCombie, Hamilton. And the article was included in Journal of the Chemical Society in 1932.Application of 289039-26-5 This article mentions the following:

M-IC₆H₄OH (I) in CCl₄ and Cl give a series of unstable iododichlorides and ring-substituted decomposition products very similar to those obtained from the p- and o-isomers (C. A. 25, 1504). I gives an acetate, m. 38°; the iododichloride, m. 91-2° (decomposition), decomposes over 7 days. The benzyl ether m. 52°; iododichloride, m. 70° (decomposition), decomposes over 2 days. Benzoate, m. 72-3°; iododichloride, m. 106° (decomposition), stable. p-Toluenesulfonate, m. 60-1°; iododichloride, m. 97-9° (decomposition), stable. Et carbonate, b₁₁, 163-4°; iododichloride, m. 79-80° (decomposition), stable for 4 months. Iodophenyl carbonate, m. 141°; bis(iododichloride), m. 115° (decomposition), stable. Me ether, b₁₄ 123°; iododichloride, m. 74° (decomposition), very unstable. Et ether, b₁₅ 133-4°, iododichloride, m. 64° (decomposition), unstable. Allyl ether, b₁₁ 154-6°. Dibromopropyl ether, oily; iododichloride, m. 78° (decomposition), decomposes overnight. Phenylcarbamate, m. 138°; iododichloride, m. 120° (decomposition), moderately stable. 3-Iododiphenyl ether, b₁₄ 185°; iododichloride, m. 58°, decomposes over 2 days. ω-3′-Iodophenoxyacetophenone, m. 104°; iododichloride, m. 94°, decomposes over a period of several days. I in CCl₄ and Cl give an iododichloride, which gives with KI and AcOH 6-chloro-3-iodophenol, m. 56°; its acetate b₁₁ 149° (iododichloride, m. 89° (decomposition), decomposes after 2 days); the benzyl ether b₁₁ 250-60° (iododichloride, m. 72° (decomposition), decomposes after 2 days). 2,4-I(O₂N)C₆H₃NH₂ gives 4-chloro-3-iodophenol, m. 78°. Chlorination of I in CCl₄ at 0° gives an iododichloride, m. 59°, which decomposes to give 4,6-dichloro-3-iodophenol (II), m. 104°; its iododichloride, m. 68-9° (decomposition), decomposes to give 2,4,6-trichloro-3-iodophenol (III), m. 104°. II yields an acetate, m. 95° (iododichloride, m. 104° (decomposition), stable). Benzyl ether, m. 82° (iododichloride, m. 86° (decomposition), decomposes after several days). III gives a benzyl ether, m. 80-1°). Neither III nor its derivatives yield iododichlorides. Chlorination of I at 60-70° in CCl₄ gives almost pure III; further chlorination gives the tetra-Cl derivative and Cl₅C₆OH. In the experiment, the researchers used many compounds, for example, 2-Chloro-5-iodophenol (cas: 289039-26-5Application of 289039-26-5).

2-Chloro-5-iodophenol (cas: 289039-26-5) belongs to iodide derivatives. Organic iodides are organic compounds containing a carbon-iodine (C-I) bond. The carbon-iodine bond is weaker than other carbon-halogen bonds due to the poor electronegative nature of the iodine atom. The C–I bond is the weakest of the carbon–halogen bonds. These bond strengths correlate with the electronegativity of the halogen, decreasing in the order F > Cl > Br > I.Application of 289039-26-5

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Novel cyanocombretastatins as potent tubulin polymerisation inhibitors was written by Jalily, Pouria H.;Hadfield, John A.;Hirst, Nicholas;Rossington, Steven B.. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2012.Electric Literature of C8H7IO2 This article mentions the following:

A series of novel cyanocombretastatins bearing a 3,4,5-trimethoxyphenyl moiety combined with a variety of substituted Ph rings, were synthesized and their antitumor activity was evaluated. The Z-cyanocombretastatins were synthesized in a one-step protocol in high purity and yield. Fluoro, bromo, iodo, and derivatives with boronic acid and an ethyne function at meta position of the B ring were synthesized. In vitro MTT bioassays against human chronic myelogenous leukemia (K562) and transfected breast adenocarcinoma (MDA NQO1) cell lines, revealed promising IC₅₀ inhibitory values in nanomolar range (<50 nM). Introduction of a nitrile function on the olefinic bond not only increased the cytotoxicity of the less active Z-isomers but rendered the analogs as moderate to potent inhibitors of tubulin polymerization comparable to that of CA-4 (IC₅₀ = 2.2 μM). Thus, compound I (IC₅₀ = 6.7 μM) was identified as a lead candidate for a further evaluation. In the experiment, the researchers used many compounds, for example, 3-Iodo-4-methoxybenzaldehyde (cas: 2314-37-6Electric Literature of C8H7IO2).

3-Iodo-4-methoxybenzaldehyde (cas: 2314-37-6) belongs to iodide derivatives. Organic iodides are widely used in organic synthesis. Halogenation of aromatic hydrocarbons is a very important reaction via an electrophilic aromatic substitution. Iodo alkanes participate in a variety of organic synthesis reactions, which include the Simmons–Smith reaction (cyclopropanation using iodomethane), Williamson ether synthesis, Wittig reaction, Grignard reaction, alkyl coupling reactions, and Wurtz reaction.Electric Literature of C8H7IO2

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com