Tag: 200-300

One-pot synthesis of 6H-benzo[b]benzo[4,5]imidazo[1,2-d][1,4]oxazines via a copper-catalyzed process was written by Huang, Aiping;Liu, Huanhuan;Ma, Chen. And the article was included in RSC Advances in 2013.Recommanded Product: 207115-22-8 This article mentions the following:

A convenient and efficient copper-catalyzed one-pot process for the construction of 6H-benzo[b]benzo[4,5]imidazo[1,2-d][1,4]oxazines through reactions of 2-halophenols with 2-(chloromethyl)-1H-benzo[d]imidazoles under mild conditions is described. The reactions afforded a variety of products in good to excellent yields. In the experiment, the researchers used many compounds, for example, 4-Bromo-2-iodophenol (cas: 207115-22-8Recommanded Product: 207115-22-8).

4-Bromo-2-iodophenol (cas: 207115-22-8) belongs to iodide derivatives. Typical reactions of alkyl iodides include nucleophilic substitution, elimination, reduction, and the formation of organometallics. The C–I bond is the weakest of the carbon–halogen bonds. These bond strengths correlate with the electronegativity of the halogen, decreasing in the order F > Cl > Br > I.Recommanded Product: 207115-22-8

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Iodothiophenes and Related Compounds as Coupling Partners in Copper-Mediated N-Arylation of Anilines was written by Bouarfa, Salima;Bentabed-Ababsa, Ghenia;Erb, William;Picot, Laurent;Thiery, Valerie;Roisnel, Thierry;Dorcet, Vincent;Mongin, Florence. And the article was included in Synthesis in 2021.Synthetic Route of C8H5IS This article mentions the following:

N-Arylation of various 2-acylated anilines 2-NH₂-5-R-C₆H₃C(O)R¹ (R = H, Cl; R¹ = H, Me, Ph) with different electron-rich heteroaryl iodides R²I (R² = thiophen-2-yl, 1-benzothiophen-3-yl, furan-2-yl, etc.) was achieved by using activated copper and potassium carbonate in di-Bu ether at reflux. The reactivity of the different heteroaryl iodides and anilines employed was discussed and rationalized on the basis of their electronic features. Subsequent cyclization by aromatic electrophilic substitution easily took place in the case of C2-free (benzo)thienyl I (X = O, S) or C3-free (benzo)furyl derivatives, II affording original tri- and tetracycles. The antiproliferative activity of most of them was evaluated in A2058 melanoma cells and revealed four chlorinated tetracycles as effective growth inhibitors. In the experiment, the researchers used many compounds, for example, 3-Iodobenzo[b]thiophene (cas: 36748-88-6Synthetic Route of C8H5IS).

3-Iodobenzo[b]thiophene (cas: 36748-88-6) belongs to iodide derivatives. Organoiodine compounds occur widely in organic chemistry, but are relatively rare in nature. Organoiodine lubricants can be used with titanium, stainless steels, and other metals which tend to seize up with conventional lubricants: organoiodine lubricants can be used in turbines and spacecraft, and as a cutting oil in machining.Synthetic Route of C8H5IS

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Microwave-assisted efficient synthesis of 2-arylbenzo[b]furans and 2-ferrocenylbenzo[b]furans from readily prepared propargylic alcohols and o-iodophenols was written by Wu, Liansheng;Shi, Xiaokang;Xu, Xiaoyun;Liang, Fen;Huang, Guosheng. And the article was included in Journal of Chemical Sciences (Bangalore, India) in 2011.Computed Properties of C6H4BrIO This article mentions the following:

A simple, efficient, and expeditious method for the synthesis of 2-aryl- and 2-ferrocenylbenzofurans from readily prepared propargylic alcs. and 2-iodophenols using SiO₂ and PdCl₂(PPh₃)₂ (2 mol%)/CuI (2 mol%) catalyst by microwave-promoted Sonogashira coupling/cyclization was developed. The methodol. gives good to excellent yields. In addition, this method can also be completed in one-pot with PhI, 2-methyl-3-butyn-2-ol, and 2-iodo-4-methylphenol as reactants. In the experiment, the researchers used many compounds, for example, 4-Bromo-2-iodophenol (cas: 207115-22-8Computed Properties of C6H4BrIO).

4-Bromo-2-iodophenol (cas: 207115-22-8) belongs to iodide derivatives. Organic iodides can be alkyl, alkenyl, or alkynyl, and all of them are very reactive toward with many kinds of nucleophiles. Iodo alkanes participate in a variety of organic synthesis reactions, which include the Simmons–Smith reaction (cyclopropanation using iodomethane), Williamson ether synthesis, Wittig reaction, Grignard reaction, alkyl coupling reactions, and Wurtz reaction.Computed Properties of C6H4BrIO

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Pd-Catalyzed C-H Annulation of Five-Membered Heteroaryl Halides with Norbornene Derivatives was written by Padhi, Birakishore;Kang, Geunhee;Kim, Eunmin;Ha, Jeongmin;Kim, Hyun Tae;Lim, Jeewoo;Joo, Jung Min. And the article was included in ACS Catalysis in 2020.Formula: C4H5IN2 This article mentions the following:

Complementary to Catellani-type reactions and 1:1 coupling of six-membered halo(hetero)arenes and norbornene (NBE) derivatives, Pd-catalyzed 1:2 coupling of five-membered haloheteroarenes with NBEs was achieved to afford rigid nonplanar heterocycles. Pyrazole, thiophene, furan, and indole underwent exo- and trans-selective annulation. Two strained alkene groups of the resulting products were further manipulated to afford 1-alkylindazoles and ladder polymers. The type of heteroarenes and position of halides along with the choice of ligands and bases were critical to set a preference between C-H annulation and Catellani reactions, which will be useful for the development of Pd-catalyzed, NBE-mediated reactions of heteroarenes. In the experiment, the researchers used many compounds, for example, 5-Iodo-1-methyl-1H-pyrazole (cas: 34091-51-5Formula: C4H5IN2).

5-Iodo-1-methyl-1H-pyrazole (cas: 34091-51-5) belongs to iodide derivatives. Iodide-containing intermediates are common in organic synthesis, because of the easy formation and cleavage of the C–I bond. Organoiodine lubricants can be used with titanium, stainless steels, and other metals which tend to seize up with conventional lubricants: organoiodine lubricants can be used in turbines and spacecraft, and as a cutting oil in machining.Formula: C4H5IN2

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Copper-Catalyzed Diaryl Ether Formation from (Hetero)aryl Halides at Low Catalytic Loadings was written by Zhai, Yuntong;Chen, Xiaofei;Zhou, Wei;Fan, Mengyang;Lai, Yisheng;Ma, Dawei. And the article was included in Journal of Organic Chemistry in 2017.Recommanded Product: 3-Iodobenzo[b]thiophene This article mentions the following:

Diaryl formation is achieved by coupling phenols and (hetero)aryl halides under the catalysis of CuI/N,N’-bis(2-phenylphenyl) oxalamide (BPPO) or CuI/N-(2-phenylphenyl)-N’-benzyl oxalamide (PPBO) at 90 °C using DMF or MeCN as the solvent. Only 0.2-2 mol % CuI and ligand are required for complete conversion, which represents the lowest catalytic loadings for a general Cu/ligand-catalyzed diaryl ether formation. In the experiment, the researchers used many compounds, for example, 3-Iodobenzo[b]thiophene (cas: 36748-88-6Recommanded Product: 3-Iodobenzo[b]thiophene).

3-Iodobenzo[b]thiophene (cas: 36748-88-6) belongs to iodide derivatives. Iodide-containing intermediates are common in organic synthesis, because of the easy formation and cleavage of the C–I bond. The C–I bond is the weakest of the carbon–halogen bonds. These bond strengths correlate with the electronegativity of the halogen, decreasing in the order F > Cl > Br > I. This periodic order also follows the atomic radius of halogens and the length of the carbon-halogen bond.Recommanded Product: 3-Iodobenzo[b]thiophene

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Mechanochemical Synthesis of Diarylethynes from Aryl Iodides and CaC² was written by van Bonn, Pit;Bolm, Carsten. And the article was included in Synlett in 2022.Recommanded Product: 5460-32-2 This article mentions the following:

A mechanochem. synthesis of diarylethynes ArC≡CAr [Ar = Ph, 4-MeC₆H₄, 4-ClC₆H₄, etc.] from aryl iodides and calcium carbide as acetylene source was reported. The reaction was catalyzed by a palladium catalyst in the presence of copper salt, base, and ethanol as liquid assisting grinding (LAG) additive. Various aryl and heteroaryl iodides were converted in up to excellent yields. In the experiment, the researchers used many compounds, for example, 4-Iodo-1,2-dimethoxybenzene (cas: 5460-32-2Recommanded Product: 5460-32-2).

4-Iodo-1,2-dimethoxybenzene (cas: 5460-32-2) belongs to iodide derivatives. Iodide-containing intermediates are common in organic synthesis, because of the easy formation and cleavage of the C–I bond. The C–I bond is the weakest of the carbon–halogen bonds. These bond strengths correlate with the electronegativity of the halogen, decreasing in the order F > Cl > Br > I. This periodic order also follows the atomic radius of halogens and the length of the carbon-halogen bond.Recommanded Product: 5460-32-2

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Formal synthesis of (±)-indolizidine 209B was written by Liou, Bo-Sian;Jhang, Ruei-Fong;Chou, Shang-Shing P.. And the article was included in Tetrahedron in 2014.Application In Synthesis of 1-Chloro-4-iodobutane This article mentions the following:

A new method for the synthesis of cis-C-8 methylated indolizidines and quinolizidines was developed. Straightforward transformations including an isomerization to the trans configuration led to a formal synthesis of (±)-indolizidine 209B. In the experiment, the researchers used many compounds, for example, 1-Chloro-4-iodobutane (cas: 10297-05-9Application In Synthesis of 1-Chloro-4-iodobutane).

1-Chloro-4-iodobutane (cas: 10297-05-9) belongs to iodide derivatives. Generally organic iodides can be divided into two classes of alkyl iodides and aryl iodides. Typical reactions of alkyl iodides include nucleophilic substitution, elimination, reduction, and the formation of organometallics. The C–I bond is the weakest of the carbon–halogen bonds. These bond strengths correlate with the electronegativity of the halogen, decreasing in the order F > Cl > Br > I. This periodic order also follows the atomic radius of halogens and the length of the carbon-halogen bond.Application In Synthesis of 1-Chloro-4-iodobutane

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Mode of action and quantitative structure-activity correlations of tuberculostatic drugs of the isonicotinic acid hydrazide type was written by Seydel, Joachim K.;Schaper, Klaus J.;Wempe, Ellen;Cordes, Hans P.. And the article was included in Journal of Medicinal Chemistry in 1976.Safety of 2-Iodopyridine-4-carboxylic acid This article mentions the following:

Quant. structure-activity studies were made for 18 isoniazid (I) [54-85-3] 2-substituted derivatives by correlating electronic, steric, and lipophilic properties of the substituents with biol. activity from dilution tests with Mycobacterium tuberculosis. The reaction rates for the quaternization of corresponding 2-substituted pyridines with MeI gave rate constants showing a dependence on steric and electronic effects of substituents similar to the effects on the bactericidal activities of the I derivatives The correlations indicate that reactivity of the pyridine [110-86-1] N is essential for biol. activity of the I derivatives, and that the I derivatives are incorporated into an NAD analog. In the experiment, the researchers used many compounds, for example, 2-Iodopyridine-4-carboxylic acid (cas: 58481-10-0Safety of 2-Iodopyridine-4-carboxylic acid).

2-Iodopyridine-4-carboxylic acid (cas: 58481-10-0) belongs to iodide derivatives. Organic iodides are widely used in organic synthesis. Halogenation of aromatic hydrocarbons is a very important reaction via an electrophilic aromatic substitution. A typical method for synthesis of aromatic iodides is diazotization of primary aromatic amines followed by treatment of potassium iodide. Aliphatic alcohols are converted to alkyl iodides by treating with hydrogen iodide.Safety of 2-Iodopyridine-4-carboxylic acid

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Study on mercaptopyridinecarboxylic acids. Part III. Preparation of esters, ethers and ether-esters of mercaptopyridinecarboxylic acids was written by Lejeune, R.;Thunus, L.. And the article was included in Journal de Pharmacie de Belgique in 1980.Formula: C6H4INO2 This article mentions the following:

Pyridinecarboxylic acids I (R = halo) were treated with thiourea, KSH, and Na₂S-S and the products were converted to the resp. mercapto acids II. Thus, 2-chloro-3-pyridinecarboxylic acid was heated with thiourea, and the product was treated with N₂H₄ to yield the resp. II. II were etherified by MeI and esterified by MeOH and CH₂N₂. In the experiment, the researchers used many compounds, for example, 3-Iodopicolinic acid (cas: 73841-32-4Formula: C6H4INO2).

3-Iodopicolinic acid (cas: 73841-32-4) belongs to iodide derivatives. Generally organic iodides can be divided into two classes of alkyl iodides and aryl iodides. Typical reactions of alkyl iodides include nucleophilic substitution, elimination, reduction, and the formation of organometallics. In the chemical industry, alkyl iodides serve as excellent alkylating agents and, specifically, methyl iodide is used as a methylating agent in the synthesis of various pharmaceutical drugs.Formula: C6H4INO2

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Synthesis of gem-difluoromethylenated biflavonoid via the Suzuki coupling reaction was written by Zheng, Xing;Meng, Wei-Dong;Qing, Feng-Ling. And the article was included in Tetrahedron Letters in 2004.Computed Properties of C8H7IO2 This article mentions the following:

Gem-Difluoromethylenated biflavonoid I was synthesized via the Suzuki coupling reaction. The key intermediate 6-iodinated flavone was regioselectively synthesized by the use of AgOAc/I₂ under mild conditions without handling of a strongly toxic reagent. The key step was the formation of a flavone 3′-boronate using a palladium-catalyzed exchange of the corresponding 3′-iodinated flavone with a diboron reagent. In the experiment, the researchers used many compounds, for example, 3-Iodo-4-methoxybenzaldehyde (cas: 2314-37-6Computed Properties of C8H7IO2).

3-Iodo-4-methoxybenzaldehyde (cas: 2314-37-6) belongs to iodide derivatives. Organic iodides are organic compounds containing a carbon-iodine (C-I) bond. The carbon-iodine bond is weaker than other carbon-halogen bonds due to the poor electronegative nature of the iodine atom. Iodo alkanes participate in a variety of organic synthesis reactions, which include the Simmons–Smith reaction (cyclopropanation using iodomethane), Williamson ether synthesis, Wittig reaction, Grignard reaction, alkyl coupling reactions, and Wurtz reaction.Computed Properties of C8H7IO2

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com