Tag: 200-300

Synthesis of polyfluorinated polycyano negative dielectric anisotropy liquid crystalline compounds was written by Guo, Jian;Sui, Yan;Cao, Jian-hua;Meng, Jin-song;Hua, Rui-mao. And the article was included in Yejing Yu Xianshi in 2014.Reference of 64248-57-3 This article mentions the following:

In order to meet the different demands of the LCD, two novel polyfluorinated polycyano neg. dielec. anisotropy liquid crystalline compounds were synthesized. These compounds were synthesized from phthalonitrile and 1,2-difluorobenzene by several steps. Their constructions were confirmed by NMR and elemental anal. The parameters and the performances of these products were measured by POM, DSC and rotary viscometer. These polyfluorinated polycyano compounds have small optical anisotropy (Δn=0.096-0.107), large neg. dielec. anisotropy (Δε= -15.2 – -16.7) and high viscosity (γ₁=234.8-248.6 mPa6f0s). These compounds can be used in the LCD matrix to improve partial performance of the LCD. The preparation method is of simple operation and low cost, which can also realize industrialization easily. In the experiment, the researchers used many compounds, for example, 1,2-Difluoro-3-iodobenzene (cas: 64248-57-3Reference of 64248-57-3).

1,2-Difluoro-3-iodobenzene (cas: 64248-57-3) belongs to iodide derivatives. Organoiodine compounds occur widely in organic chemistry, but are relatively rare in nature. Alkyl iodides react at a faster rate than alkyl fluorides due to the weak C-I bond.Reference of 64248-57-3

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Design, synthesis and SAR of piperidyl-oxadiazoles as 11β-hydroxysteroid dehydrogenase 1 inhibitors was written by Xia, Guangxin;You, Xiaodi;Liu, Lin;Liu, Haiyan;Wang, Jianfa;Shi, Yufang;Li, Ping;Xiong, Bing;Liu, Xuejun;Shen, Jingkang. And the article was included in European Journal of Medicinal Chemistry in 2013.COA of Formula: C8H7IO2 This article mentions the following:

The potential roles of 11β-HSD1 inhibitors in metabolic syndrome, T2D and obesity were well established and currently several classes of 11β-HSD1 inhibitors have been developed as promising agents against metabolic diseases. To find potent compounds with good pharmacokinetics, the authors used the bioisosterism approach, and designed the compounds I (R = Ph, cyclohexyl) bearing a 1,2,4-oxadiazole ring to replace the amide group in compound II. Guided by docking study, they then transformed compound I (R = phenyl) into a potent lead compound III by changing the sulfonamide group to an amide. To elaborate this series of piperidyl-oxadiazole derivatives as human 11β-HSD1 inhibitors, they explored the structure-activity relationship of several parts of the lead compound Based on their potency toward human 11β-HSD1 two compounds IV (R¹ = 2-Me-3-Br-C₆H₃, cyclohexyl) were advanced to pharmacokinetic study. It was found that compounds IV are potent and selective human 11β-HSD1 inhibitors with better pharmacokinetic properties than those of the original piperidine-3-carboxamide compound II, and suitable for further in vivo preclin. study in primate model. In the experiment, the researchers used many compounds, for example, 3-Iodo-2-methylbenzoic acid (cas: 133232-56-1COA of Formula: C8H7IO2).

3-Iodo-2-methylbenzoic acid (cas: 133232-56-1) belongs to iodide derivatives. Organic iodides can be alkyl, alkenyl, or alkynyl, and all of them are very reactive toward with many kinds of nucleophiles. In the chemical industry, alkyl iodides serve as excellent alkylating agents and, specifically, methyl iodide is used as a methylating agent in the synthesis of various pharmaceutical drugs.COA of Formula: C8H7IO2

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Dehydroxyalkylative halogenation of C(aryl)-C bonds of aryl alcohols was written by Liu, Mingyang;Zhang, Zhanrong;Liu, Huizhen;Wu, Tianbin;Han, Buxing. And the article was included in Chemical Communications (Cambridge, United Kingdom) in 2020.Name: 4-Chloro-2-iodo-1-nitrobenzene This article mentions the following:

Synthesis of aromatic halogen compounds Ar-X [Ar = 2-O₂NC₆H₄, 2-furyl, 2-thienyl, etc.; X = Cl, Br, I] were prepared using environmentally benign mol. oxygen as oxidant and Cu-based catalysts-mediated side-directed dehydroxyalkylative halogenation of aryl alcs. C(aryl)-C bonds of aryl alcs. were effectively cleaved and afforded the corresponding aryl chlorides, bromides and iodides in excellent yields. Aryl alcs. could served as both aromatic electrophilic and radical synthetic equivalent during the reaction. In the experiment, the researchers used many compounds, for example, 4-Chloro-2-iodo-1-nitrobenzene (cas: 160938-18-1Name: 4-Chloro-2-iodo-1-nitrobenzene).

4-Chloro-2-iodo-1-nitrobenzene (cas: 160938-18-1) belongs to iodide derivatives. Organoiodine compounds occur widely in organic chemistry, but are relatively rare in nature. Iodo alkanes participate in a variety of organic synthesis reactions, which include the Simmons–Smith reaction (cyclopropanation using iodomethane), Williamson ether synthesis, Wittig reaction, Grignard reaction, alkyl coupling reactions, and Wurtz reaction.Name: 4-Chloro-2-iodo-1-nitrobenzene

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Dendritic Zirconium-Peroxotungstosilicate Hybrids: Synthesis, Characterization, and Use as Recoverable and Reusable Sulfide Oxidation Catalysts was written by Jahier, Claire;Mal, Sib Sankar;Kortz, Ulrich;Nlate, Sylvain. And the article was included in European Journal of Inorganic Chemistry in 2010.Name: 1-Chloro-4-iodobutane This article mentions the following:

Dendrimer-containing polyoxometalates (DENDRIPOMs) were synthesized by coupling zirconium-peroxotungstosilicate [Zr₂(O₂)₂(SiW₁₁O₃₉)₂]^12- with ammonium dendrons by electrostatic bonding. These DENDRIPOMs were successfully characterized by standard physicochem. techniques (e.g. IR and NMR spectroscopy and MS), and they represent the 1st examples of dendritic POMs based on zirconium-substituted polytungstates. The data obtained are consistent with structures in which the anionic POM is surrounded by cationic ammonium dendrons. In contrast to the potassium salt of [Zr₂(O₂)₂(SiW₁₁O₃₉)₂]^12-, the dendritic counterparts are soluble in common organic solvents, an important feature for the use of DENDRIPOMs in homogeneous catalysis. The authors’ DENDRIPOMs are stable, efficient, recoverable, and reusable catalysts for the oxidation of sulfides in aqueous/CDCl₃ biphasic media, with hydrogen peroxide as the oxidant, in contrast to their nondendritic Bu ammonium counterpart. Two cycles of catalytic reactions were performed without any appreciable loss of activity. Also the reaction kinetics and selectivity of the DENDRIPOMs are influenced by the structure of the countercation used. In the experiment, the researchers used many compounds, for example, 1-Chloro-4-iodobutane (cas: 10297-05-9Name: 1-Chloro-4-iodobutane).

1-Chloro-4-iodobutane (cas: 10297-05-9) belongs to iodide derivatives. Organic iodides are organic compounds containing a carbon-iodine (C-I) bond. The carbon-iodine bond is weaker than other carbon-halogen bonds due to the poor electronegative nature of the iodine atom. The C–I bond is the weakest of the carbon–halogen bonds. These bond strengths correlate with the electronegativity of the halogen, decreasing in the order F > Cl > Br > I.Name: 1-Chloro-4-iodobutane

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Ortholithiation of unprotected benzoic acids: application for novel 2-chloro-6-substituted benzoic acid syntheses was written by Gohier, Frederic;Castanet, Anne-Sophie;Mortier, Jacques. And the article was included in Synthetic Communications in 2005.Formula: C7H4ClIO2 This article mentions the following:

2-Chloro-6-substituted benzoic acids were prepared by the tandem metalation sequence from 2-chlorobenzoic acid with the 1:1 complex sec-butyllithium/TMEDA in THF at -78°C followed by quenching with electrophiles. In the experiment, the researchers used many compounds, for example, 2-Chloro-6-iodobenzoic acid (cas: 13420-63-8Formula: C7H4ClIO2).

2-Chloro-6-iodobenzoic acid (cas: 13420-63-8) belongs to iodide derivatives. Typical reactions of alkyl iodides include nucleophilic substitution, elimination, reduction, and the formation of organometallics. Organoiodine lubricants can be used with titanium, stainless steels, and other metals which tend to seize up with conventional lubricants: organoiodine lubricants can be used in turbines and spacecraft, and as a cutting oil in machining.Formula: C7H4ClIO2

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

2-[(Neopentyl glycolato)boryl]phenyl Triflates and Halides for Fluoride Ion-Mediated Generation of Functionalized Benzynes was written by Ikawa, Takashi;Yamamoto, Rika;Takagi, Akira;Ito, Toyohiro;Shimizu, Kazunori;Goto, Masahiko;Hamashima, Yoshitaka;Akai, Shuji. And the article was included in Advanced Synthesis & Catalysis in 2015.HPLC of Formula: 207115-22-8 This article mentions the following:

2-[(Neopentyl glycolato)boryl]phenyl trifluoromethanesulfonates (triflates) and halides were developed as new benzyne precursors, which generated benzynes at 120° in the presence of a fluoride ion. There were two major features of these types of precursors. First, they generated benzynes bearing various reactive functional groups, such as carbonyl, cyano, bromo, and primary amino groups. Second, these precursors were directly synthesized through either the palladium-catalyzed Miyaura borylation of 2-iodophenol derivatives or ortho-selective iodination of the corresponding boronic acids as key steps without using any protecting groups. The in-situ-generated benzynes underwent [4+2], (3+2) and [2+2] cycloadditions to give the benzo-fused multicyclic compounds while maintaining such functional groups. In particular, 4-aminobenzyne was generated for the first time and underwent the Diels-Alder reaction with the free primary amino group remaining intact. In the experiment, the researchers used many compounds, for example, 4-Bromo-2-iodophenol (cas: 207115-22-8HPLC of Formula: 207115-22-8).

4-Bromo-2-iodophenol (cas: 207115-22-8) belongs to iodide derivatives. Typical reactions of alkyl iodides include nucleophilic substitution, elimination, reduction, and the formation of organometallics. Organoiodine lubricants can be used with titanium, stainless steels, and other metals which tend to seize up with conventional lubricants: organoiodine lubricants can be used in turbines and spacecraft, and as a cutting oil in machining.HPLC of Formula: 207115-22-8

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

A highly sensitive and selective two-photon fluorescent probe for real-time sensing of cytochrome P450 1A1 in living systems was written by Ning, Jing;Tian, Zhenhao;Wang, Bo;Ge, Guangbo;An, Yue;Hou, Jie;Wang, Chao;Zhao, Xinyu;Li, Yannan;Tian, Xiangge;Yu, Zhenlong;Huo, Xiaokui;Sun, Chengpeng;Feng, Lei;Cui, Jingnan;Ma, Xiaochi. And the article was included in Materials Chemistry Frontiers in 2018.Recommanded Product: 10297-05-9 This article mentions the following:

Cytochrome P 450 1A1 (CYP1A1), a heme-containing monooxygenase, is of particular importance for human health because of its vital role in the metabolic activation of pro-carcinogenic compounds to their ultimate carcinogens. However, CYP1A1 protein levels are extraordinarily low in normal and cancer tissues. Thus, a practical method for ultra-sensitive and real-time monitoring of CYP1A1 activity in complex biol. systems is highly sought after. In the present study, we developed a highly specific and sensitive two-photon fluorescent probe for monitoring CYP1A1 activity on the basis of the substrate preferences of this key enzyme. A panel of O-alkylated derivatives was designed and synthesized using HBN as the basic fluorophore. After screening and optimization, the derivative iPrBN was selected for further study as it displayed excellent specificity, high sensitivity and fast turn-on response to CYP1A1 relative to other human CYP isoforms. The detection limit of iPrBN for CYP1A1 was 0.036 nM, suggesting that it would be sensitive and versatile enough to detect endogenous CYP1A1 activity. Indeed, we successfully applied iPrBN to the real-time monitoring of CYP1A1 activity in human cancer cell lines and performed high-throughput screening of CYP1A1 modulators. iPrBN was also applied for the first time to the two-photon imaging of intracellular CYP1A1 in living cancer tissues and zebrafish, and our results showed that iPrBN exhibited high imaging resolution and fast response towards CYP1A1. These findings suggest that this probe is capable of accurately sensing CYP1A1 activity in complex biol. systems, which will facilitate further investigations of CYP1A1-associated physiol. and pathol. processes. In the experiment, the researchers used many compounds, for example, 1-Chloro-4-iodobutane (cas: 10297-05-9Recommanded Product: 10297-05-9).

1-Chloro-4-iodobutane (cas: 10297-05-9) belongs to iodide derivatives. Iodide-containing intermediates are common in organic synthesis, because of the easy formation and cleavage of the C–I bond. The C–I bond is the weakest of the carbon–halogen bonds. These bond strengths correlate with the electronegativity of the halogen, decreasing in the order F > Cl > Br > I.Recommanded Product: 10297-05-9

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Palladium-Catalyzed Decarbonylative Iodination of Aryl Carboxylic Acids Enabled by Ligand-Assisted Halide Exchange was written by Boehm, Philip;Martini, Tristano;Lee, Yong Ho;Cacherat, Bastien;Morandi, Bill. And the article was included in Angewandte Chemie, International Edition in 2021.Product Details of 5460-32-2 This article mentions the following:

An efficient and broadly applicable palladium-catalyzed iodination of inexpensive and abundant aryl and vinyl carboxylic acids via in situ activation to the acid chloride and formation of a phosphonium salt is reported. The use of 1-iodobutane as iodide source in combination with a base and a deoxychlorinating reagent gives access to a wide range of aryl and vinyl iodides under Pd/Xantphos catalysis, including complex drug-like scaffolds. Stoichiometric experiments and kinetic anal. suggest a unique mechanism involving C-P reductive elimination to form the Xantphos phosphonium chloride, which subsequently initiates an unusual halogen exchange by outer sphere nucleophilic substitution. In the experiment, the researchers used many compounds, for example, 4-Iodo-1,2-dimethoxybenzene (cas: 5460-32-2Product Details of 5460-32-2).

4-Iodo-1,2-dimethoxybenzene (cas: 5460-32-2) belongs to iodide derivatives. In general, organic iodides are light-sensitive and turn yellow during storage, owing to the formation of iodine. Alkyl iodides react at a faster rate than alkyl fluorides due to the weak C-I bond.Product Details of 5460-32-2

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Selective Synthesis of Functionalized Trifluoromethylated Pyrrolidines, Piperidines, and Azepanes Starting from 1-Tosyl-2-(trifluoromethyl)aziridine was written by Dolfen, Jeroen;Kenis, Sara;Van Hecke, Kristof;De Kimpe, Norbert;D’Hooghe, Matthias. And the article was included in Chemistry – A European Journal in 2014.Name: 1-Chloro-4-iodobutane This article mentions the following:

Substituted trifluoromethyl-substituted aziridines I (R = H, Me, ClCH₂XCH₂CH₂; X = bond, CH₂) were prepared; tandem substitution and cyclization reactions of I (R = ClCH₂XCH₂CH₂; X = bond, CH₂) yielded trifluoromethyl-substituted pyrrolidinemethanamines and piperidinemethanamines II (R¹ = Cl, i-PrNH, i-BuNH, NC, thiocyanato, MeO, EtO; X = bond, CH₂) in 14-98% yields (all but two cases in > 50% yields). Lithiation of I (R = H) [prepared in two steps from F₃CCH(OH)CH₂NH₂] with BuLi in the presence of HMPA at -100° and alkylation with RI (R = Me, ClCH₂XCH₂CH₂; X = bond, CH₂) yielded I (R = Me, ClCH₂XCH₂CH₂; X = bond, CH₂); the presence of an equivalent of HMPA and low temperature were required to obtain the alkylated products. Reaction of I (R = ClCH₂XCH₂CH₂; X = bond, CH₂) with LiCl, isopropyl- and isobutylamines, NaCN, KSCN, and sodium methoxide and ethoxide yielded II (R¹ = Cl, i-PrNH, i-BuNH, NC, thiocyanato, MeO, EtO; X = bond, CH₂); reaction of I [R = (CH₂)₄Cl] with isopropylamine and isobutylamine gave trifluoromethyl azepinemethylamines III (R² = i-Pr, i-Bu) as the major products. The structures of II (R¹ = MeO, EtO; X = bond, CH₂) and III (R² = i-Pr) were determined by X-ray crystallog. In the experiment, the researchers used many compounds, for example, 1-Chloro-4-iodobutane (cas: 10297-05-9Name: 1-Chloro-4-iodobutane).

1-Chloro-4-iodobutane (cas: 10297-05-9) belongs to iodide derivatives. Organic iodides are widely used in organic synthesis. Halogenation of aromatic hydrocarbons is a very important reaction via an electrophilic aromatic substitution. Alkyl iodides react at a faster rate than alkyl fluorides due to the weak C-I bond.Name: 1-Chloro-4-iodobutane

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Study on mercaptopyridinecarboxylic acids. Part III. Preparation of esters, ethers and ether-esters of mercaptopyridinecarboxylic acids was written by Lejeune, R.;Thunus, L.. And the article was included in Journal de Pharmacie de Belgique in 1980.Quality Control of 5-Iodonicotinic acid This article mentions the following:

Pyridinecarboxylic acids I (R = halo) were treated with thiourea, KSH, and Na₂S-S and the products were converted to the resp. mercapto acids II. Thus, 2-chloro-3-pyridinecarboxylic acid was heated with thiourea, and the product was treated with N₂H₄ to yield the resp. II. II were etherified by MeI and esterified by MeOH and CH₂N₂. In the experiment, the researchers used many compounds, for example, 5-Iodonicotinic acid (cas: 15366-65-1Quality Control of 5-Iodonicotinic acid).

5-Iodonicotinic acid (cas: 15366-65-1) belongs to iodide derivatives. Organic iodides can be alkyl, alkenyl, or alkynyl, and all of them are very reactive toward with many kinds of nucleophiles. Iodo alkanes participate in a variety of organic synthesis reactions, which include the Simmons–Smith reaction (cyclopropanation using iodomethane), Williamson ether synthesis, Wittig reaction, Grignard reaction, alkyl coupling reactions, and Wurtz reaction.Quality Control of 5-Iodonicotinic acid

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com