Tag: 200-300

Palladium-Catalyzed Pyrazole-Directed sp³ C-H Bond Arylation for the Synthesis of β-Phenethylamines was written by Gulia, Nurbey;Daugulis, Olafs. And the article was included in Angewandte Chemie, International Edition in 2017.Product Details of 5460-32-2 This article mentions the following:

We have developed a method for palladium-catalyzed, pyrazole-directed sp³ C-H bond arylation by aryl iodides. The reaction employs a Pd(OAc)₂ catalyst at 5-10 mol % loading and silver(I) oxide as a halide-removal agent, and it proceeds in acetic acid or acetic acid/hexafluoroisopropanol solvent. Ozonolysis of the pyrazole moiety affords pharmaceutically important β-phenethylamines. In the experiment, the researchers used many compounds, for example, 4-Iodo-1,2-dimethoxybenzene (cas: 5460-32-2Product Details of 5460-32-2).

4-Iodo-1,2-dimethoxybenzene (cas: 5460-32-2) belongs to iodide derivatives. Organoiodine compounds occur widely in organic chemistry, but are relatively rare in nature. Polyiodoorganic compounds are sometimes employed as X-ray contrast agents, in fluoroscopy, a type of medical imaging. This application exploits the X-ray absorbing ability of the heavy iodine nucleus.Product Details of 5460-32-2

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Cope rearrangements in the benzo[b]thiophene series was written by Sura, Tushar P.;MacDowell, Denis W. H.. And the article was included in Journal of Organic Chemistry in 1993.Synthetic Route of C8H5IS This article mentions the following:

The inability to observe Cope rearrangement products at elevated temperatures for di-Et α-allyl-2-naphthalenemalonate and di-Et α-allyl-9-phenanthrenemalonate does not extend to analogous systems resulting from replacement of the aromatic units by 2- and 3-benzo[b]thiophene nuclei. Thermal rearrangement of di-Et α-allyl-3-benzo[b]thiophenemalonate at 215-255°C for 11 h gave the expected Cope rearrangement product di-Et 2-allyl-3-benzo[b]thiophenemalonate (8%) accompanied by trans- and cis-Et 2,3-dihydro-1-(ethoxycarbonyl)-1H-benzo[b]cyclopenta[d]thiopehen-2-acetate in 10% yield 5% yield, resp. The attempted structure verification of 2-allyl-3-benzo[b]thiophenemalonate by an independent route gave di-Et 2-(1-propenyl)-3-benzo[b]thiophenemalonate which when heated at 230-240°C for 18 h gave 1-carbethoxy-2-hydroxy-3-methyldibenzothiophene as a major product. Similar results were observed with 2-substituted analogs of di-Et α-allyl-3-benzo[b]thiophenemalonate, both di-Et 3-allyl-2-benzo[b]thiophenemalonate and Et 1,2-dihydro-3-(ethoxycarbonyl)-3H-benzo[b]cyclopenta[d]thiophene-2-acetate were formed. In the experiment, the researchers used many compounds, for example, 3-Iodobenzo[b]thiophene (cas: 36748-88-6Synthetic Route of C8H5IS).

3-Iodobenzo[b]thiophene (cas: 36748-88-6) belongs to iodide derivatives. Organoiodine compounds occur widely in organic chemistry, but are relatively rare in nature. The C–I bond is the weakest of the carbon–halogen bonds. These bond strengths correlate with the electronegativity of the halogen, decreasing in the order F > Cl > Br > I.Synthetic Route of C8H5IS

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Pd/Cu bimetallic catalyst immobilized on PEI capped cellulose-polyamidoamine dendrimer was written by Fan, Xuetao;Lin, Dongtao;Xu, Zhian;Li, Yiqun. And the article was included in Colloids and Surfaces, A: Physicochemical and Engineering Aspects in 2022.Application of 207115-22-8 This article mentions the following:

Polyamidoamine dendrimer (PAMAM) is an efficient material for immobilization of Pd(II) complex due to its unique tree-like structure and properties. To the purpose of enhancing of the loading of Cu(II) ions, a polyethyleneimine end-capped microcrystn. cellulose-polyamidoamine dendrimer (G2.5) (MCC-PAMAMG2.5-PEI) was designed and synthesized. The resultant MCC-PAMAMG2.5-PEI was furtherly treated by PdCl₂ and CuSO₄ solution to afford the corresponding dendrimer-supported Pd/Cu bimetallic catalyst (Pd/[email protected]). As a result, both Pd(II) and Cu(II) ions were well selectively immobilized within the interior architectures and exterior PEI layers of dendrimers, resp. The as-prepared catalyst was fully characterized by elemental anal. (EA), inductively coupled plasma at. emission spectrometry (ICP-AES), Fourier transform IR spectrometer (FTIR), XPS, X-ray diffraction (XRD), field emission SEM (FESEM), elemental mappings, energy-dispersive X-ray spectra (EDX), field emission transmission electron microscopy (FETEM), and thermogravimetry anal. (TGA) techniques. The presence of required Pd and Cu elements were confirmed from ICP-AES, XPS, EDX, and elemental mappings anal., resp. The synergetic effect between Pd and Cu can be observed by comparing it to the dendrimer supported monometallic Pd and Cu as well as the mixture of dendrimer supported Pd and Cu. The catalyst showed excellent performance in the synthesis of alkynes and benzofurans via Sonogashira reactions and could be reused for seven successive runs without any noteworthy loss of activity. Moreover, its efficiency was compared with other reported catalysts in the same transformations. In the experiment, the researchers used many compounds, for example, 4-Bromo-2-iodophenol (cas: 207115-22-8Application of 207115-22-8).

4-Bromo-2-iodophenol (cas: 207115-22-8) belongs to iodide derivatives. Iodide-containing intermediates are common in organic synthesis, because of the easy formation and cleavage of the C–I bond. Organoiodine lubricants can be used with titanium, stainless steels, and other metals which tend to seize up with conventional lubricants: organoiodine lubricants can be used in turbines and spacecraft, and as a cutting oil in machining.Application of 207115-22-8

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Isoquinolinium Dichromate and Chlorochromate as Efficient Catalysts for Oxidative Halogenation of Aromatic Compounds Under Acid-Free Conditions was written by Rao, A. Sambashiva;Rajanna, K. C.;Reddy, K. Rajendar;Kulkarni, Subhash. And the article was included in Synthesis and Reactivity in Inorganic, Metal-Organic, and Nano-Metal Chemistry in 2016.Reference of 207115-22-8 This article mentions the following:

Isoquinolinium dichromate and isoquinolinium chlorochromate were found as efficient catalysts to trigger oxidative bromination and iodination of aromatic hydrocarbons with KBr/KI and KHSO₄ under acid-free conditions. Reaction times reduced highly significantly under sonication, followed by corresponding mono bromo derivatives in very good yield with high regioselectivity. In the experiment, the researchers used many compounds, for example, 4-Bromo-2-iodophenol (cas: 207115-22-8Reference of 207115-22-8).

4-Bromo-2-iodophenol (cas: 207115-22-8) belongs to iodide derivatives. Organic iodides are widely used in organic synthesis. Halogenation of aromatic hydrocarbons is a very important reaction via an electrophilic aromatic substitution. Organoiodine lubricants can be used with titanium, stainless steels, and other metals which tend to seize up with conventional lubricants: organoiodine lubricants can be used in turbines and spacecraft, and as a cutting oil in machining.Reference of 207115-22-8

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Highly Enantioselective Cross-Electrophile Aryl-Alkenylation of Unactivated Alkenes was written by Tian, Zhi-Xiong;Qiao, Jin-Bao;Xu, Guang-Li;Pang, Xiaobo;Qi, Liangliang;Ma, Wei-Yuan;Zhao, Zhen-Zhen;Duan, Jicheng;Du, Yun-Fei;Su, Peifeng;Liu, Xue-Yuan;Shu, Xing-Zhong. And the article was included in Journal of the American Chemical Society in 2019.Related Products of 877264-43-2 This article mentions the following:

Enantioselective cross-electrophile reactions remain a challenging subject in metal catalysis, and with respect to data, studies have mainly focused on stereoconvergent reactions of racemic alkyl electrophiles. Here, the authors report an enantioselective cross-electrophile aryl-alkenylation reaction of unactivated alkenes. This method provides access to a number of biol. important chiral mols. such as dihydrobenzofurans, indolines, and indanes. The incorporated alkenyl group is suitable for further reactions that can increases mol. diversity and complexity. The reaction proceeds under mild conditions at room temperature, and an easily accessible chiral pyrox ligand was used to afford products with high enantioselectivity. The synthetic utility of this method is demonstrated by enabling the modification of complex mols. such as peptides, indometacin, and steroids. In the experiment, the researchers used many compounds, for example, (5-Fluoro-2-iodophenyl)methanol (cas: 877264-43-2Related Products of 877264-43-2).

(5-Fluoro-2-iodophenyl)methanol (cas: 877264-43-2) belongs to iodide derivatives. Organic iodides are organic compounds containing a carbon-iodine (C-I) bond. The carbon-iodine bond is weaker than other carbon-halogen bonds due to the poor electronegative nature of the iodine atom. Iodo alkanes participate in a variety of organic synthesis reactions, which include the Simmons–Smith reaction (cyclopropanation using iodomethane), Williamson ether synthesis, Wittig reaction, Grignard reaction, alkyl coupling reactions, and Wurtz reaction.Related Products of 877264-43-2

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

F^– Nucleophilic-Addition-Induced [3 + 2] Annulation: Direct Access to CF₃-Substituted Indenes was written by Tang, Hai-Jun;Zhang, Yu-Feng;Jiang, Yi-Wen;Feng, Chao. And the article was included in Organic Letters in 2018.Quality Control of (5-Fluoro-2-iodophenyl)methanol This article mentions the following:

An efficient [3 + 2] annulation of (2,2-difluorovinyl)-2-iodoarenes and internal alkynes was developed for the synthesis of 1-(trifluoromethyl)-1H-indenes, e.g., I. The success of this strategy hinged upon a well-balanced process for the generation of two transient reactive species, specifically trifluoroethylsilver and alkenylpalladium intermediates, in the same mol., as well as a smooth transmetalation step, which delicately joined together these two different metallic intermediates. In the experiment, the researchers used many compounds, for example, (5-Fluoro-2-iodophenyl)methanol (cas: 877264-43-2Quality Control of (5-Fluoro-2-iodophenyl)methanol).

(5-Fluoro-2-iodophenyl)methanol (cas: 877264-43-2) belongs to iodide derivatives. Iodide-containing intermediates are common in organic synthesis, because of the easy formation and cleavage of the C–I bond. A typical method for synthesis of aromatic iodides is diazotization of primary aromatic amines followed by treatment of potassium iodide. Aliphatic alcohols are converted to alkyl iodides by treating with hydrogen iodide.Quality Control of (5-Fluoro-2-iodophenyl)methanol

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

N³-Substituted thymidine analogues. Part III: radiosynthesis of N³-[(4-[¹⁸F]fluoromethyl-phenyl)butyl]thymidine ([¹⁸F]-FMPBT) and N³-[(4-[¹⁸F]fluoromethyl-phenyl)pentyl] thymidine ([¹⁸F]-FMPPT) for PET was written by Ghosh, Pradip;Gelovani, Juri G.;Alauddin, Mian M.. And the article was included in Journal of Labelled Compounds and Radiopharmaceuticals in 2007.Reference of 10297-05-9 This article mentions the following:

Radiosyntheses of two N³-substituted thymidine analogs, N³-[(4-[¹⁸F]fluoromethyl-phenyl)butyl- and -pentyl]thymidine ([¹⁸F]FMPBT and [¹⁸F]FMPPT, resp.), are reported. The precursor compounds, tetrahydropyranyl ether-protected chloromethyl compounds, were synthesized in six steps and the unlabeled standard compounds were synthesized from these precursors. For radiosynthesis, the precursors were fluorinated with Bu₄N[¹⁸F] and subsequently hydrolyzed by acid. The crude products were purified by HPLC to obtain [¹⁸F]FMPBT and [¹⁸F]FMPPT. The average decay-corrected radiochem. yield for [¹⁸F]FMPBT was 15% in 5 runs, and that for [¹⁸F]FMPPT was 10% in 4 runs. The radiochem. purity was >99% and the specific activity was >74 GBq/μmol at the end of synthesis. The synthesis time was 80-90 min from the end of bombardment. In the experiment, the researchers used many compounds, for example, 1-Chloro-4-iodobutane (cas: 10297-05-9Reference of 10297-05-9).

1-Chloro-4-iodobutane (cas: 10297-05-9) belongs to iodide derivatives. Organoiodine compounds occur widely in organic chemistry, but are relatively rare in nature. Iodo alkanes participate in a variety of organic synthesis reactions, which include the Simmons–Smith reaction (cyclopropanation using iodomethane), Williamson ether synthesis, Wittig reaction, Grignard reaction, alkyl coupling reactions, and Wurtz reaction.Reference of 10297-05-9

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

An Amphiphilic Polymer-Supported Strategy Enables Chemical Transformations under Anhydrous Conditions for DNA-Encoded Library Synthesis was written by Ruff, Yves;Martinez, Roberto;Pelle, Xavier;Nimsgern, Pierre;Fille, Pascale;Ratnikov, Maxim;Berst, Frederic. And the article was included in ACS Combinatorial Science in 2020.Synthetic Route of C6H4INO2 This article mentions the following:

The use of DNA-encoded libraries has emerged as a powerful hit generation technol. Combining the power of combinatorial chem. to enumerate large compound collections with the efficiency of affinity selection in pools, the methodol. makes it possible to interrogate vast chem. space against biol. targets of pharmaceutical relevance. Thus, the chem. transformations employed for the synthesis of encoded libraries play a crucial role in the identification of diverse and drug-like starting points. Currently established transformations have mostly been limited to water-compatible reactions to accommodate the growing oligonucleotide tag. Herein, we describe the development of a practical catch-and-release methodol. utilizing a cationic, amphiphilic PEG-based polymer to perform chem. transformations on immobilized DNA conjugates under anhydrous conditions. We demonstrate the usefulness of our APTAC (amphiphilic polymer-facilitated transformations under anhydrous conditions) approach by performing several challenging transformations on DNA-conjugated small mols. in pure organic solvents: the addition of a carbanion equivalent to a DNA-conjugated ketone in THF, the synthesis of saturated heterocycles using the tin (Sn) amine protocol (SnAP) in dichloromethane, and the dual-catalytic (Ir/Ni) metallaphotoredox decarboxylative cross-coupling of carboxylic acids to DNA-conjugated aryl halides in DMSO. In addition, we demonstrate the feasibility of the latter in multititer-plate format. In the experiment, the researchers used many compounds, for example, 5-Iodonicotinic acid (cas: 15366-65-1Synthetic Route of C6H4INO2).

5-Iodonicotinic acid (cas: 15366-65-1) belongs to iodide derivatives. Organic iodides are organic compounds containing a carbon-iodine (C-I) bond. The carbon-iodine bond is weaker than other carbon-halogen bonds due to the poor electronegative nature of the iodine atom. Alkyl iodides react at a faster rate than alkyl fluorides due to the weak C-I bond.Synthetic Route of C6H4INO2

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Tributyltin hydride and 1-ethylpiperidine hypophosphite mediated intermolecular radical additions to 2,4,6-trichlorophenyl vinyl sulfonate was written by Edetanlen-Elliot, Oluwabusola;Fitzmaurice, Richard J.;Wilden, Jonathan D.;Caddick, Stephen. And the article was included in Tetrahedron Letters in 2007.Computed Properties of C4H8ClI This article mentions the following:

2,4,6-Trichlorophenyl vinyl sulfonate smoothly undergoes intermol. radical addition under mild initiation conditions mediated by tributyltin hydride and 1-ethylpiperidine hypophosphite (EPHP) to generate a range of functionalized alkyl sulfonamide precursors. This methodol. can be used to prepare bifunctional pentafluorophenyl/2,4,6-trichlorophenyl sulfonates in good yields. In the experiment, the researchers used many compounds, for example, 1-Chloro-4-iodobutane (cas: 10297-05-9Computed Properties of C4H8ClI).

1-Chloro-4-iodobutane (cas: 10297-05-9) belongs to iodide derivatives. In general, organic iodides are light-sensitive and turn yellow during storage, owing to the formation of iodine. Iodo alkanes participate in a variety of organic synthesis reactions, which include the Simmons–Smith reaction (cyclopropanation using iodomethane), Williamson ether synthesis, Wittig reaction, Grignard reaction, alkyl coupling reactions, and Wurtz reaction.Computed Properties of C4H8ClI

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Synthesis of marine sponge alkaloid hachijodine B and a comment on the structure of ikimine B and on the absolute configuration of niphatesine D was written by Romeril, Stuart P.;Lee, Victor;Baldwin, Jack E.. And the article was included in Tetrahedron Letters in 2004.Formula: C4H8ClI This article mentions the following:

The syntheses of the proposed structures of hachijodine B (I; R = CH₂NHOMe), ikimine B (I; R = CH=NOMe) and niphatesine D (I; R = CH₂NH₂) from S-citronellol are described. Our results suggest that the gross structures of hachijodine B and niphatesine D are correct, but that ikimine B was incorrectly assigned. The authors have also established that the previous absolute stereochem. assignment for niphatesine D is unreliable. In the experiment, the researchers used many compounds, for example, 1-Chloro-4-iodobutane (cas: 10297-05-9Formula: C4H8ClI).

1-Chloro-4-iodobutane (cas: 10297-05-9) belongs to iodide derivatives. Organic iodides can be alkyl, alkenyl, or alkynyl, and all of them are very reactive toward with many kinds of nucleophiles. Iodo alkanes participate in a variety of organic synthesis reactions, which include the Simmons–Smith reaction (cyclopropanation using iodomethane), Williamson ether synthesis, Wittig reaction, Grignard reaction, alkyl coupling reactions, and Wurtz reaction.Formula: C4H8ClI

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com