Tag: 200-300

Design, synthesis and preliminary biological evaluation of acridine compounds as potential agents for a combined targeted chemo-radionuclide therapy approach to melanoma was written by Desbois, Nicolas;Gardette, Maryline;Papon, Janine;Labarre, Pierre;Maisonial, Aurelie;Auzeloux, Philippe;Lartigue, Claire;Bouchon, Bernadette;Debiton, Eric;Blache, Yves;Chavignon, Olivier;Teulade, Jean-Claude;Maublant, Jean;Madelmont, Jean-Claude;Moins, Nicole;Chezal, Jean-Michel. And the article was included in Bioorganic & Medicinal Chemistry in 2008.Electric Literature of C7H6INO2 This article mentions the following:

Various iodo-acridone and acridine carboxamides have been prepared and evaluated as agents for targeted radionuclide and/or chemotherapy for melanoma, due to their structural similarity to benzamides which are known to possess specific affinity for melanin. Three of these carboxamides selected for their in vitro cytotoxic properties were radioiodinated with [¹²⁵I]NaI at high specific activity. Biodistribution studies carried out in B16F0 murine melanoma tumor-bearing mice highlighted that acridone 8f and acridine 9d, presented high, long-lasting tumor concentrations together with an in vivo kinetic profile favorable to application in targeted radionuclide therapy. In the experiment, the researchers used many compounds, for example, 2-Amino-4-iodobenzoic acid (cas: 20776-54-9Electric Literature of C7H6INO2).

2-Amino-4-iodobenzoic acid (cas: 20776-54-9) belongs to iodide derivatives. In general, organic iodides are light-sensitive and turn yellow during storage, owing to the formation of iodine. Alkyl iodides react at a faster rate than alkyl fluorides due to the weak C-I bond.Electric Literature of C7H6INO2

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Crystal Growth, Structure, and Polymorphic Behavior of an Ionic Liquid: Phthalate Derivative of N-Butyl,N-methylimidazolium Hexafluorophosphate was written by Brandel, Clement;Gbabode, Gabin;Cartigny, Yohann;Martin, Claudette;Gouhier, Geraldine;Petit, Samuel;Coquerel, Gerard. And the article was included in Chemistry of Materials in 2014.Reference of 10297-05-9 This article mentions the following:

After the multistep synthesis of an original imidazolium hexafluorophosphate ionic liquid, [pbmim][PF₆], two polymorphic forms were isolated from methanolic solution and characterized by XRPD, DSC, and Raman spectroscopy. Stable Form A (mp 90.3 °C) was obtained by conventional crystallization at a moderate cooling rate (<10 K/min), whereas metastable Form B (mp 83.2 °C) was spontaneously produced from a liquid-liquid demixing (oiling out) when a faster cooling rate (>10 K/min) was applied. Structural analyses carried out by using single-crystal (Form A) and powder (Form B) X-ray diffraction revealed a rotational disorder of anionic octahedrons and, more interestingly, large conformational differences between cationic moieties caused by their mol. flexibility. Crystal growth of [pbmim][PF₆] (Form A) in methanol often leads to numerous crystal defects and revealed that most of them consist of liquid inclusions. The supersaturation ratio (β) appeared to be the predominant factor influencing the crystal growth behavior under isothermal and stagnant conditions. At low β values, a morphol. transition from rod-shaped crystals to platelets was observed, presumably caused by a change in the growth mechanism of specific faces. Using high β values promotes either the formation of microscopic (<5 μm) liquid inclusions that become easily detectable upon heating or the appearance of macroscopic inclusions with an hourglass shape. In the experiment, the researchers used many compounds, for example, 1-Chloro-4-iodobutane (cas: 10297-05-9Reference of 10297-05-9).

1-Chloro-4-iodobutane (cas: 10297-05-9) belongs to iodide derivatives. Organoiodine compounds occur widely in organic chemistry, but are relatively rare in nature. Iodo alkanes participate in a variety of organic synthesis reactions, which include the Simmons–Smith reaction (cyclopropanation using iodomethane), Williamson ether synthesis, Wittig reaction, Grignard reaction, alkyl coupling reactions, and Wurtz reaction.Reference of 10297-05-9

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Catalytic Enantioselective α-Alkylation of Amides by Unactivated Alkyl Electrophiles was written by Tong, Xiaoyu;Schneck, Felix;Fu, Gregory C.. And the article was included in Journal of the American Chemical Society in 2022.SDS of cas: 10297-05-9 This article mentions the following:

Herein the achievement of this objective, demonstrating that a nickel catalyst could accomplish enantioselective intermol. alkylations of racemic Reformatsky reagents with unactivated electrophiles; the resulting α-alkylated carbonyl compounds could be converted in one addnl. step into a diverse array of ubiquitous families of chiral mols was described. Applying a broad spectrum of mechanistic tools, have gained insight into key intermediates (including the alkylnickel(II) resting state) and elementary steps of the catalytic cycle. In the experiment, the researchers used many compounds, for example, 1-Chloro-4-iodobutane (cas: 10297-05-9SDS of cas: 10297-05-9).

1-Chloro-4-iodobutane (cas: 10297-05-9) belongs to iodide derivatives. Generally organic iodides can be divided into two classes of alkyl iodides and aryl iodides. Typical reactions of alkyl iodides include nucleophilic substitution, elimination, reduction, and the formation of organometallics. The C–I bond is the weakest of the carbon–halogen bonds. These bond strengths correlate with the electronegativity of the halogen, decreasing in the order F > Cl > Br > I.SDS of cas: 10297-05-9

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Approach to the synthesis of bryophyte constituents was written by Sagrera, G. J.;Lopez, G. V.;Pandolfi, E. M.;Seoane, G. A.;Eicher, T.. And the article was included in Informacion Tecnologica in 1998.Recommanded Product: 2314-37-6 This article mentions the following:

The synthesis of 2,2-bilunularin (I), a bis(bibenzyl)phenolic compound isolated from bryophytes, is described. The main transformations involve the formation of an aromatic carbon-carbon bond by Ullmann’s reaction and the formation of aliphatic carbon-carbon bonds by Wittig’s reactions. A simple model structure was used to optimize the cyclization conditions to obtain flavanone. Based on the results, biflavanone was synthesized, an advanced intermediate for the preparation of some flavonoids isolated from bryophytes. In the experiment, the researchers used many compounds, for example, 3-Iodo-4-methoxybenzaldehyde (cas: 2314-37-6Recommanded Product: 2314-37-6).

3-Iodo-4-methoxybenzaldehyde (cas: 2314-37-6) belongs to iodide derivatives. In general, organic iodides are light-sensitive and turn yellow during storage, owing to the formation of iodine. Polyiodoorganic compounds are sometimes employed as X-ray contrast agents, in fluoroscopy, a type of medical imaging. This application exploits the X-ray absorbing ability of the heavy iodine nucleus.Recommanded Product: 2314-37-6

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Unified Strategy for Nickel-Catalyzed C-2 Alkylation of Indoles through Chelation Assistance was written by Soni, Vineeta;Jagtap, Rahul A.;Gonnade, Rajesh G.;Punji, Benudhar. And the article was included in ACS Catalysis in 2016.Category: iodides-buliding-blocks This article mentions the following:

A nickel-catalyzed direct C-2 alkylation of indoles through monodentate-chelation assistance has been described. This reaction proceeds via an unusual strategy by the use of a well-designed and defined (quinolinyl)amido-nickel catalyst, [{κ^N,κ^N,κ^N-Et₂NCH₂C(O)(μ-N)C₉H₆N}Ni(OAc)], providing a solution to the limitations associated with bidentate-chelate auxiliaries. The method allows coupling of indoles with various unactivated primary and secondary alkyl halides with ample substrate scope. This uniquely strategized alkylation proceeded through crucial C-H activation and via an alkyl radical intermediate. The reaction by this approach represents a rare example of Ni-catalyzed monodentate-chelate-assisted C-H functionalization. In the experiment, the researchers used many compounds, for example, 1-Chloro-4-iodobutane (cas: 10297-05-9Category: iodides-buliding-blocks).

1-Chloro-4-iodobutane (cas: 10297-05-9) belongs to iodide derivatives. Organic iodides are widely used in organic synthesis. Halogenation of aromatic hydrocarbons is a very important reaction via an electrophilic aromatic substitution. Alkyl iodides react at a faster rate than alkyl fluorides due to the weak C-I bond.Category: iodides-buliding-blocks

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Synthesis of 1,2-Bis(trifluoromethylthio)arenes via Aryne Intermediates was written by Mesgar, Milad;Daugulis, Olafs. And the article was included in Organic Letters in 2017.Quality Control of 4-Iodo-1,2-dimethoxybenzene This article mentions the following:

A general method for synthesis of 1,2-bis-trifluoromethylthioarenes has been developed. Arynes generated from silylaryl triflates or halides react with bis(trifluoromethyl)disulfide to afford 1,2-bis-trifluoromethylthioarenes. Aryl, alkyl, ester, halide, and methoxy functionalities are compatible with reaction conditions. Use of bis(perfluoroaryl)disulfides gave moderate yields of aryne disulfenylation or cyclization to fluorinated dibenzothiophenes. In the experiment, the researchers used many compounds, for example, 4-Iodo-1,2-dimethoxybenzene (cas: 5460-32-2Quality Control of 4-Iodo-1,2-dimethoxybenzene).

4-Iodo-1,2-dimethoxybenzene (cas: 5460-32-2) belongs to iodide derivatives. Organic iodides are widely used in organic synthesis. Halogenation of aromatic hydrocarbons is a very important reaction via an electrophilic aromatic substitution. The C–I bond is the weakest of the carbon–halogen bonds. These bond strengths correlate with the electronegativity of the halogen, decreasing in the order F > Cl > Br > I.Quality Control of 4-Iodo-1,2-dimethoxybenzene

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Stereocontrolled synthesis of unnatural cyclic dipeptides containing an L-valine unit was written by Balducci, Daniele;Grandi, Alessandro;Porzi, Gianni;Sandri, Sergio. And the article was included in Tetrahedron: Asymmetry in 2005.Safety of 1-Chloro-4-iodobutane This article mentions the following:

Stereoselective synthesis of unusual nonproteinogenic dipeptides I (Y = C:CH₂, R¹ = CO₂Et, R² = H; Y = C:CH₂, R¹ = Me, R² = CO₂Et; Y = CH₂CH₂, R¹ = CO₂Et, R² = H; Y = CH₂CH₂, R¹ = Me, R² = CO₂H; H Y = o-C₆H₄, R¹ = Me, R² = CO₂H), containing an L-valine unit and a cyclic unnatural α-amino acid, has been accomplished starting from the L-valine derived chiral synthon II via alkylation with dihalo derivatives as a key step. The absolute configurations of the new stereocentres were assigned on the basis of ¹H NMR spectra. In the experiment, the researchers used many compounds, for example, 1-Chloro-4-iodobutane (cas: 10297-05-9Safety of 1-Chloro-4-iodobutane).

1-Chloro-4-iodobutane (cas: 10297-05-9) belongs to iodide derivatives. Iodide-containing intermediates are common in organic synthesis, because of the easy formation and cleavage of the C–I bond. The C–I bond is the weakest of the carbon–halogen bonds. These bond strengths correlate with the electronegativity of the halogen, decreasing in the order F > Cl > Br > I. This periodic order also follows the atomic radius of halogens and the length of the carbon-halogen bond.Safety of 1-Chloro-4-iodobutane

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Enantioselective Copper-Catalyzed Formal [2+1] and [4+1] Annulations of Diynes with Ketones via Carbonyl Ylides was written by Qi, Lin-Jun;Li, Cui-Ting;Huang, Zheng-Qi;Jiang, Jia-Tian;Zhu, Xin-Qi;Lu, Xin;Ye, Long-Wu. And the article was included in Angewandte Chemie, International Edition in 2022.Synthetic Route of C8H9IO2 This article mentions the following:

Carbonyl ylides have proven to be powerful synthons for the efficient construction of various valuable O-heterocycles, and the formation of carbonyl ylides by the reaction of metal carbenes with carbonyls has attracted increasing attention over the past decades. However, a catalyst-controlled highly enantioselective reaction of carbonyl ylides from metal carbenes is extremely challenging. Herein, a novel copper-catalyzed asym. formal [2+1] and [4+1] annulations of diynes with ketones via carbonyl ylides is reported. Importantly, this protocol not only represents the first example of successful asym. epoxidation via carbonyl ylides, but also constitutes the first reaction of vinyl cations with carbonyl compounds This method leads to the divergent, practical and atom-economical synthesis of a range of chiral oxiranes and dihydrofurans in moderate to excellent yields with generally excellent enantioselectivities and diastereoselectivities via remote-stereocontrol strategy. In the experiment, the researchers used many compounds, for example, 4-Iodo-1,2-dimethoxybenzene (cas: 5460-32-2Synthetic Route of C8H9IO2).

4-Iodo-1,2-dimethoxybenzene (cas: 5460-32-2) belongs to iodide derivatives. Generally organic iodides can be divided into two classes of alkyl iodides and aryl iodides. Typical reactions of alkyl iodides include nucleophilic substitution, elimination, reduction, and the formation of organometallics. The C–I bond is the weakest of the carbon–halogen bonds. These bond strengths correlate with the electronegativity of the halogen, decreasing in the order F > Cl > Br > I. This periodic order also follows the atomic radius of halogens and the length of the carbon-halogen bond.Synthetic Route of C8H9IO2

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Structure-Kinetic Profiling of Haloperidol Analogues at the Human Dopamine D₂ Receptor was written by Fyfe, Tim J.;Kellam, Barrie;Sykes, David A.;Capuano, Ben;Scammells, Peter J.;Lane, J. Robert;Charlton, Steven J.;Mistry, Shailesh N.. And the article was included in Journal of Medicinal Chemistry in 2019.Application In Synthesis of 1,2-Difluoro-3-iodobenzene This article mentions the following:

Haloperidol is a typical antipsychotic drug (APD) associated with an increased risk of extrapyramidal side-effects (EPS) and hyperprolactinemia relative to atypical APDs such as clozapine. Both drugs are dopamine D₂ receptor (D₂R) antagonists, with contrasting kinetic profiles. Haloperidol displays fast association/slow dissociation at the D₂R whereas clozapine exhibits relatively slow association/fast dissociation Recently, the authors have provided evidence that slow dissociation from the D₂R predicts hyperprolactinemia, whereas fast association predicts EPS. Unfortunately, clozapine can cause severe side-effects independent of its D₂R action. The results suggest an optimal kinetic profile for D₂R antagonist APDs that avoids EPS. To begin exploring this hypothesis, the authors conducted a structure-kinetic relationship study of haloperidol and reveal that subtle structural modifications dramatically change binding kinetic rate constants, affording compounds with a clozapine-like kinetic profile. Thus, optimization of these kinetic parameters may allow development of novel APDs based on the haloperidol scaffold with improved side-effect profiles. In the experiment, the researchers used many compounds, for example, 1,2-Difluoro-3-iodobenzene (cas: 64248-57-3Application In Synthesis of 1,2-Difluoro-3-iodobenzene).

1,2-Difluoro-3-iodobenzene (cas: 64248-57-3) belongs to iodide derivatives. Iodide-containing intermediates are common in organic synthesis, because of the easy formation and cleavage of the C–I bond. Polyiodoorganic compounds are sometimes employed as X-ray contrast agents, in fluoroscopy, a type of medical imaging. This application exploits the X-ray absorbing ability of the heavy iodine nucleus.Application In Synthesis of 1,2-Difluoro-3-iodobenzene

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Rapid aerobic iodination of arenes mediated by hypervalent iodine in fluorinated solvents was written by Iskra, Jernej;Murphree, S. Shaun. And the article was included in Tetrahedron Letters in 2017.Computed Properties of C8H9IO2 This article mentions the following:

Arenes such as 1,3,5-trimethoxybenzene, 4-tert-butylanisole, 1,2,4,5-tetramethylbenzene, etc. were rapidly converted to their corresponding iodides RI (R = 2-nitro-5-methylphenyl, 2-methyl-4-t-butylphenyl, 2,4,6-trimethylphenyl, etc.) by aerobic oxidative iodination at room temperature on treatment with iodine and catalytic quantities of nitrous acid in a fluorinated solvent. Dichloroiodic acid is proposed as the actual iodination reagent. In the experiment, the researchers used many compounds, for example, 4-Iodo-1,2-dimethoxybenzene (cas: 5460-32-2Computed Properties of C8H9IO2).

4-Iodo-1,2-dimethoxybenzene (cas: 5460-32-2) belongs to iodide derivatives. Organoiodine compounds occur widely in organic chemistry, but are relatively rare in nature. Organoiodine lubricants can be used with titanium, stainless steels, and other metals which tend to seize up with conventional lubricants: organoiodine lubricants can be used in turbines and spacecraft, and as a cutting oil in machining.Computed Properties of C8H9IO2

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com