Tag: 200-300

Nickel-Catalyzed Cross-Coupling of Potassium Aryl- and Heteroaryltrifluoroborates with Unactivated Alkyl Halides was written by Molander, Gary A.;Argintaru, O. Andreea;Aron, Ioana;Dreher, Spencer D.. And the article was included in Organic Letters in 2010.Formula: C4H8ClI This article mentions the following:

A method for the cross-coupling of alkyl electrophiles with various potassium aryl- and heteroaryltrifluoroborates has been developed. Nearly stoichiometric amounts of organoboron species could be employed to cross-couple a large variety of challenging heteroaryl nucleophiles. Several functional groups were tolerated on both the electrophilic and the nucleophilic partners. Chemoselective reactivity of C(sp³)-Br bonds in the presence of C(sp²)-Br bonds was achieved. In the experiment, the researchers used many compounds, for example, 1-Chloro-4-iodobutane (cas: 10297-05-9Formula: C4H8ClI).

1-Chloro-4-iodobutane (cas: 10297-05-9) belongs to iodide derivatives. Generally organic iodides can be divided into two classes of alkyl iodides and aryl iodides. Typical reactions of alkyl iodides include nucleophilic substitution, elimination, reduction, and the formation of organometallics. Organoiodine lubricants can be used with titanium, stainless steels, and other metals which tend to seize up with conventional lubricants: organoiodine lubricants can be used in turbines and spacecraft, and as a cutting oil in machining.Formula: C4H8ClI

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Late-stage functionalization of peptides and cyclopeptides using organozinc reagents was written by Leroux, Marcel;Vorherr, Thomas;Lewis, Ian;Schaefer, Michael;Koch, Guido;Karaghiosoff, Konstantin;Knochel, Paul. And the article was included in Angewandte Chemie, International Edition in 2019.Synthetic Route of C4H8ClI This article mentions the following:

We report a new late-stage functionalization of small peptides and cyclopeptides relying on the Negishi cross-coupling of readily prepared iodotyrosine- or iodophenylalanine-containing peptides with aryl-, heteroaryl-, and alkylzinc pivalates or halides. In silico and in vitro determinations of membrane permeability parameters of the modified cyclopeptides showed that in most cases, the solubility was improved by the introduction of polar pyridyl units while the cell-membrane permeability was maintained. In the experiment, the researchers used many compounds, for example, 1-Chloro-4-iodobutane (cas: 10297-05-9Synthetic Route of C4H8ClI).

1-Chloro-4-iodobutane (cas: 10297-05-9) belongs to iodide derivatives. Organic iodides can be alkyl, alkenyl, or alkynyl, and all of them are very reactive toward with many kinds of nucleophiles. Organoiodine lubricants can be used with titanium, stainless steels, and other metals which tend to seize up with conventional lubricants: organoiodine lubricants can be used in turbines and spacecraft, and as a cutting oil in machining.Synthetic Route of C4H8ClI

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Synthesis of 8-(3″-formyl-6″-methoxyphenyl)-5,7,4′-trimethoxyflavone was written by Khan, Hamid A.;Ahmad, Faizan;Rahman, W.. And the article was included in Indian Journal of Chemistry in 1978.Formula: C8H7IO2 This article mentions the following:

The iodoflavone I and 3,4-I(MeO)C₆H₃CHO were coupled by heating at 230-5° for 45 min in the presence of activated Cu to give 34% (formylphenyl)flavone II and a trace of biflavone III. III was the main product when DMF was the solvent for the coupling reaction. In the experiment, the researchers used many compounds, for example, 3-Iodo-4-methoxybenzaldehyde (cas: 2314-37-6Formula: C8H7IO2).

3-Iodo-4-methoxybenzaldehyde (cas: 2314-37-6) belongs to iodide derivatives. Organic iodides can be alkyl, alkenyl, or alkynyl, and all of them are very reactive toward with many kinds of nucleophiles. In the chemical industry, alkyl iodides serve as excellent alkylating agents and, specifically, methyl iodide is used as a methylating agent in the synthesis of various pharmaceutical drugs.Formula: C8H7IO2

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Imidazopyridine-Based Fatty Acid Synthase Inhibitors That Show Anti-HCV Activity and in Vivo Target Modulation was written by Oslob, Johan D.;Johnson, Russell J.;Cai, Haiying;Feng, Shirley Q.;Hu, Lily;Kosaka, Yuko;Lai, Julie;Sivaraja, Mohanram;Tep, Samnang;Yang, Hanbiao;Zaharia, Cristiana A.;Evanchik, Marc J.;McDowell, Robert S.. And the article was included in ACS Medicinal Chemistry Letters in 2013.Formula: C8H7IO2 This article mentions the following:

Potent imidazopyridine-based inhibitors of fatty acid synthase (FASN) are described. The compounds are shown to have antiviral (HCV replicon) activities that track with their biochem. activities. The most potent analog (compound 19) also inhibits rat FASN and inhibits de novo palmitate synthesis in vitro (cell-based) as well as in vivo. In the experiment, the researchers used many compounds, for example, 3-Iodo-2-methylbenzoic acid (cas: 133232-56-1Formula: C8H7IO2).

3-Iodo-2-methylbenzoic acid (cas: 133232-56-1) belongs to iodide derivatives. Iodide-containing intermediates are common in organic synthesis, because of the easy formation and cleavage of the C–I bond. The C–I bond is the weakest of the carbon–halogen bonds. These bond strengths correlate with the electronegativity of the halogen, decreasing in the order F > Cl > Br > I. This periodic order also follows the atomic radius of halogens and the length of the carbon-halogen bond.Formula: C8H7IO2

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Empowering Transition-Metal-Free Cascade Protocol for the Green Synthesis of Biaryls and Alkynes was written by Walia, Preet Kamal;Kumar, Manoj;Bhalla, Vandana. And the article was included in ACS Omega in 2018.Application of 5460-32-2 This article mentions the following:

The work being presented in this manuscript demonstrates the simple and efficient ‘transition-metal-free’ and ‘light-mediated’ synthetic protocol for the synthesis of aryl iodides/biaryls/alkynes from aryl bromides. Under UV irradiation and in basic aqueous media, aryl bromides undergo transformation into aryl iodides which efficiently couple via a cascade reaction with a wide range of terminal alkynes/unactivated arenes to generate target mols. under green conditions. In the experiment, the researchers used many compounds, for example, 4-Iodo-1,2-dimethoxybenzene (cas: 5460-32-2Application of 5460-32-2).

4-Iodo-1,2-dimethoxybenzene (cas: 5460-32-2) belongs to iodide derivatives. Typical reactions of alkyl iodides include nucleophilic substitution, elimination, reduction, and the formation of organometallics. Organoiodine lubricants can be used with titanium, stainless steels, and other metals which tend to seize up with conventional lubricants: organoiodine lubricants can be used in turbines and spacecraft, and as a cutting oil in machining.Application of 5460-32-2

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

The First Regioselective Hydroformylation of Acetylenic Thiophenes Catalyzed by a Zwitterionic Rhodium Complex and Triphenyl Phosphite was written by Van den Hoven, Bernard G.;Alper, Howard. And the article was included in Journal of Organic Chemistry in 1999.Related Products of 36748-88-6 This article mentions the following:

The hydroformylation of acetylenic thiophenes is readily accomplished by using the zwitterionic rhodium catalyst (η⁶-C₆H₅BPh₃)^–Rh⁺(1,5-COD) and tri-Ph phosphite in the presence of CO and H₂. This catalytic system affords, as the major product, the α,β-unsaturated aldehyde with the aldehyde and thiophene attached to the same olefin carbon atom. Assistance of sulfur from the heterocycle provides excellent regioselectivity and yields when the acetylenic unit is a propargyl ether or ester, phenylacetylene, or an enyne. In the experiment, the researchers used many compounds, for example, 3-Iodobenzo[b]thiophene (cas: 36748-88-6Related Products of 36748-88-6).

3-Iodobenzo[b]thiophene (cas: 36748-88-6) belongs to iodide derivatives. Organic iodides can be alkyl, alkenyl, or alkynyl, and all of them are very reactive toward with many kinds of nucleophiles. The C–I bond is the weakest of the carbon–halogen bonds. These bond strengths correlate with the electronegativity of the halogen, decreasing in the order F > Cl > Br > I.Related Products of 36748-88-6

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

A Versatile Chemoenzymatic Synthesis for the Discovery of Potent Cryptophycin Analogs was written by Schmidt, Jennifer J.;Khatri, Yogan;Brody, Scott I.;Zhu, Catherine;Pietraszkiewicz, Halina;Valeriote, Frederick A.;Sherman, David H.. And the article was included in ACS Chemical Biology in 2020.Formula: C4H5IN2 This article mentions the following:

The cryptophycins are a family of macrocyclic depsipeptide natural products that display exceptionally potent antiproliferative activity against drug-resistant cancers. Unique challenges facing the synthesis and derivatization of this complex group of mols. motivated us to investigate a chemoenzymic synthesis designed to access new analogs for biol. evaluation. The cryptophycin thioesterase (CrpTE) and the cryptophycin epoxidase (CrpE) are a versatile set of enzymes that catalyze macrocyclization and epoxidation of over 20 natural cryptophycin metabolites. Thus, we envisioned a drug development strategy involving their use as standalone biocatalysts for production of unnatural derivatives Herein, we developed a scalable synthesis of 12 new unit A-B-C-D linear chain elongation intermediates containing heterocyclic aromatic groups as alternatives to the native unit A benzyl group. N-Acetyl cysteamine activated forms of each intermediate were assessed for conversion to macrocyclic products using wild type CrpTE, which demonstrated the exceptional flexibility of this enzyme. Semipreparative scale reactions were conducted for isolation and structural characterization of new cryptophycins. Each was then evaluated as a substrate for CrpE P 450 and its ability to generate the epoxidized products from these substrates that possess altered electronics at the unit A styrenyl double bond position. Finally, biol. evaluation of the new cryptophycins revealed a des-β-epoxy analog with low picomolar potency, previously limited to cryptophycins bearing epoxide functionality. In the experiment, the researchers used many compounds, for example, 5-Iodo-1-methyl-1H-pyrazole (cas: 34091-51-5Formula: C4H5IN2).

5-Iodo-1-methyl-1H-pyrazole (cas: 34091-51-5) belongs to iodide derivatives. Organoiodine compounds occur widely in organic chemistry, but are relatively rare in nature. A typical method for synthesis of aromatic iodides is diazotization of primary aromatic amines followed by treatment of potassium iodide. Aliphatic alcohols are converted to alkyl iodides by treating with hydrogen iodide.Formula: C4H5IN2

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Transformation of photophysical properties from solution to solid state in alkoxy-cyano-diphenylacetylene molecules was written by Karunakaran, Venugopal;Prabhu, Deepak D.;Das, Suresh;Varughese, Sunil. And the article was included in Physical Chemistry Chemical Physics in 2015.Recommanded Product: 4-Iodo-1,2-dimethoxybenzene This article mentions the following:

Detailed photophys. properties of cyano and mono (MA)/bis alkoxy (DA) substituted diphenylacetylene moieties with different alkyl chain lengths (Me (1), octyl (8) and dodecyl (12)) were investigated in solution and the solid state in an effort to determine the effect of self-aggregation on these properties. The solvated mols. showed a minimal bathochromic shift with an increase of solvent polarity in their absorption spectra, whereas a significant shift was observed in the emission spectra. This could be attributed to the relatively low change in dipole moment between ground and Franck-Condon excited states and luminescence arising from the intramol. charge transfer state with a dipole moment significantly higher than that of the ground state. In solid state the emission quantum yields of these materials were significantly higher than in solution For DA1, polymorphic materials with distinct photophys. properties were obtained. The DA1 materials obtained by fast precipitation (DA1) showed broad fluorescence with peaks at 398, 467 and 535 nm upon excitation at different wavelengths. Detailed anal. of absorption, emission and excitation spectra and lifetime experiments indicated that these peaks could be attributed to the monomer, J- and H-type aggregates resp. Whereas the crystals obtained by slow crystallization (DA1C) showed only one emission peak at around 396 nm attributed to the monomer. This is supported by the single crystal X-ray structure which consists of a monomer mol. having minimal interaction with nearest neighbor mols. In the experiment, the researchers used many compounds, for example, 4-Iodo-1,2-dimethoxybenzene (cas: 5460-32-2Recommanded Product: 4-Iodo-1,2-dimethoxybenzene).

4-Iodo-1,2-dimethoxybenzene (cas: 5460-32-2) belongs to iodide derivatives. Generally organic iodides can be divided into two classes of alkyl iodides and aryl iodides. Typical reactions of alkyl iodides include nucleophilic substitution, elimination, reduction, and the formation of organometallics. Iodo alkanes participate in a variety of organic synthesis reactions, which include the Simmons–Smith reaction (cyclopropanation using iodomethane), Williamson ether synthesis, Wittig reaction, Grignard reaction, alkyl coupling reactions, and Wurtz reaction.Recommanded Product: 4-Iodo-1,2-dimethoxybenzene

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Synthesis of 1,8-, 1,6- and 3,6-dichloro-9H-thioxanthen-9-ones was written by Okabayashi, Ichizo;Fujiwara, Hidetoshi;Tanaka, Chika. And the article was included in Journal of Heterocyclic Chemistry in 1991.Product Details of 13420-63-8 This article mentions the following:

Cyclization of chlorinated (phenylthio)benzoic acid I gave a mixture of 1,8-(II) and 1,6-dichloro-9H-thioxanthen-9-ones (III). The mixture was converted to 1,8-diamino- and 1-amino-6-chloro-9H-thioxanthen-9-ones from which II and III were sep. prepared 3,6-Dichloro-9H-thioxanthen-9-one was similarly prepared In the experiment, the researchers used many compounds, for example, 2-Chloro-6-iodobenzoic acid (cas: 13420-63-8Product Details of 13420-63-8).

2-Chloro-6-iodobenzoic acid (cas: 13420-63-8) belongs to iodide derivatives. Organic iodides are widely used in organic synthesis. Halogenation of aromatic hydrocarbons is a very important reaction via an electrophilic aromatic substitution. A typical method for synthesis of aromatic iodides is diazotization of primary aromatic amines followed by treatment of potassium iodide. Aliphatic alcohols are converted to alkyl iodides by treating with hydrogen iodide.Product Details of 13420-63-8

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Synthesis of δ,δ-Diaryl-α-cyanoacrylamides and δ,δ-Diarylallylidiene Malononitriles by Pd(OAc)₂ Catalyzed Mizoroki-Heck Reaction was written by Sengupta, Ayon;Sarkar, Piyali;Maity, Suvendu;Basu, Soumyadip;Ghosh, Prasanta;Rudra, Sonali;Mukhopadhyay, Chhanda. And the article was included in ChemistrySelect in 2021.Category: iodides-buliding-blocks This article mentions the following:

An expeditious route for the stereoselective catalytic monohydration of nitrile and ‘CN’ directed regio-stereoselctive δ-arylation of various arylallylidene malononitriles affording δ, δ-Diaryl-α-cyanoacrylamides in hydrolysis condition and δ, δ-Diarylallylidene malononitriles in anhydrous condition by Pd(OAc)₂ catalyzed Mizoriki-Heck reaction was described. This provides an instantaneous formation of a library of compounds in a very short time period and simple operational process. The structure elucidation of the diastereomers was done by HMBC, HSQC, 2-D NMR experiments and X-ray single crystallog. anal. A probable reaction mechanism directed by nitriles and involvement of syn and anti π-allylic Pd-complexes was proposed that is in consonance with the exptl. findings and product distributions. In the experiment, the researchers used many compounds, for example, 4-Iodo-1,2-dimethoxybenzene (cas: 5460-32-2Category: iodides-buliding-blocks).

4-Iodo-1,2-dimethoxybenzene (cas: 5460-32-2) belongs to iodide derivatives. Iodide-containing intermediates are common in organic synthesis, because of the easy formation and cleavage of the C–I bond. A typical method for synthesis of aromatic iodides is diazotization of primary aromatic amines followed by treatment of potassium iodide. Aliphatic alcohols are converted to alkyl iodides by treating with hydrogen iodide.Category: iodides-buliding-blocks

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com