Tag: 200-300

(4+3) Annulation of Donor-Acceptor Cyclopropanes and Azadienes: Highly Stereoselective Synthesis of Azepanones was written by Nicolai, Stefano;Waser, Jerome. And the article was included in Angewandte Chemie, International Edition in 2022.Recommanded Product: 3-Iodo-4-methoxybenzaldehyde This article mentions the following:

Herein, the Lewis acid catalyzed (4+3) annulative addition of aryl and amino donor-acceptor cyclopropanes with 2-aza-1,3-dienes were reported. Densely substituted azepane derivatives were obtained in good to excellent yields and with high diastereoselectivity. The reaction occurred under mild conditions with ytterbium triflate as the catalyst. The use of copper triflate with a trisoxazoline (Tox) ligand led to an enantioselective transformation. The obtained cycloadducts were convenient substrates for a series of further modifications, showing the synthetic utility of these compounds In the experiment, the researchers used many compounds, for example, 3-Iodo-4-methoxybenzaldehyde (cas: 2314-37-6Recommanded Product: 3-Iodo-4-methoxybenzaldehyde).

3-Iodo-4-methoxybenzaldehyde (cas: 2314-37-6) belongs to iodide derivatives. Organic iodides can be alkyl, alkenyl, or alkynyl, and all of them are very reactive toward with many kinds of nucleophiles. A typical method for synthesis of aromatic iodides is diazotization of primary aromatic amines followed by treatment of potassium iodide. Aliphatic alcohols are converted to alkyl iodides by treating with hydrogen iodide.Recommanded Product: 3-Iodo-4-methoxybenzaldehyde

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

[Pd]-Catalyzed Intermolecular Coupling and Acid Mediated Intramolecular Cyclodehydration: One-Pot Synthesis of Indenes was written by Niharika, Pedireddi;Satyanarayana, Gedu. And the article was included in European Journal of Organic Chemistry in 2018.Recommanded Product: 5460-32-2 This article mentions the following:

An efficient one-pot synthesis of indenes from simple starting materials is presented. This process involves a dual C-C bond formation through an intermol. Heck coupling reaction followed by acid-mediated intramol. cyclodehydration. The strategy is amenable to various substituted aromatics to give indenes. In addition, the regioselective synthesis of benzyl styrenes in a single column purification technique through in-situ reduction of Heck products (ketones) followed by acid mediated dehydration of crude reaction mixture is presented. In the experiment, the researchers used many compounds, for example, 4-Iodo-1,2-dimethoxybenzene (cas: 5460-32-2Recommanded Product: 5460-32-2).

4-Iodo-1,2-dimethoxybenzene (cas: 5460-32-2) belongs to iodide derivatives. Organic iodides are widely used in organic synthesis. Halogenation of aromatic hydrocarbons is a very important reaction via an electrophilic aromatic substitution. A typical method for synthesis of aromatic iodides is diazotization of primary aromatic amines followed by treatment of potassium iodide. Aliphatic alcohols are converted to alkyl iodides by treating with hydrogen iodide.Recommanded Product: 5460-32-2

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

A simple access to N-(un)substituted isoquinolin-1(2H)-ones: Unusual formation of regioisomeric isoquinolin-1(4H)-ones was written by Chary, R. Gangadhara;Dhananjaya, G.;Prasad, K. Vara;Vaishaly, S.;Ganesh, Y. S. S.;Dulla, Balakrishna;Kumar, K. Shiva;Pal, Manojit. And the article was included in Chemical Communications (Cambridge, United Kingdom) in 2014.HPLC of Formula: 123278-03-5 This article mentions the following:

A ligand/additive/Pd-free Cu-mediated coupling/cyclization strategy from 2-iodobenzamides and terminal alkynes afforded a practical, one-pot, and general approach towards the synthesis of N-(un)substituted isoquinolin-1(2H)-ones. Both the catalyst and the solvent used are recyclable. The use of the Cu reagent in excess led to the unusual formation of regioisomeric and uncommon isoquinolin-1(4H)-ones. In the experiment, the researchers used many compounds, for example, 3-Chloro-2-iodobenzoic acid (cas: 123278-03-5HPLC of Formula: 123278-03-5).

3-Chloro-2-iodobenzoic acid (cas: 123278-03-5) belongs to iodide derivatives. Organic iodides are widely used in organic synthesis. Halogenation of aromatic hydrocarbons is a very important reaction via an electrophilic aromatic substitution. The C–I bond is the weakest of the carbon–halogen bonds. These bond strengths correlate with the electronegativity of the halogen, decreasing in the order F > Cl > Br > I.HPLC of Formula: 123278-03-5

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

The synthesis of natural acetylenic compounds from Eutypa lata (pers:F.) Tul was written by Defranq, Eric;Zesiger, Thierry;Tabacchi, Raffaele. And the article was included in Helvetica Chimica Acta in 1993.HPLC of Formula: 2314-37-6 This article mentions the following:

The synthesis of a series of novel acetylenic compounds I (R = CO₂H, CHO, CH₂OH; R¹ = OH, OMe), isolated recently from the fungus Eutypa lata, is described. The crucial step is the coupling reaction between a protected aryl halide and a cuprous acetylide. A more efficient method using Pd(PPh₃)₂Cl₂ as catalyst was also carried out with success. In the experiment, the researchers used many compounds, for example, 3-Iodo-4-methoxybenzaldehyde (cas: 2314-37-6HPLC of Formula: 2314-37-6).

3-Iodo-4-methoxybenzaldehyde (cas: 2314-37-6) belongs to iodide derivatives. Organic iodides can be alkyl, alkenyl, or alkynyl, and all of them are very reactive toward with many kinds of nucleophiles. Iodo alkanes participate in a variety of organic synthesis reactions, which include the Simmons–Smith reaction (cyclopropanation using iodomethane), Williamson ether synthesis, Wittig reaction, Grignard reaction, alkyl coupling reactions, and Wurtz reaction.HPLC of Formula: 2314-37-6

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Synthesis of reversible PAD4 inhibitors via copper-catalyzed C-H arylation of benzimidazole was written by Guo, Zhengwei;Shi, Lai;Wang, Bo;He, Gang;Wang, Yanming;Chen, Gong. And the article was included in Science China: Chemistry in 2019.Safety of 2-Iodo-1H-pyrrolo[2,3-b]pyridine This article mentions the following:

A Cu-catalyzed C-H arylation reaction of N-heteroarene I [R = H; R¹ = H₃CO] has been applied to the synthesis of complex non-covalent PAD4 inhibitors I [R = 1-benzyl-1H-indol-2-yl, naphthalen-2-yl, pyrazin-2-yl, etc.; R¹ = (3S,4R)-3-amino-4-hydroxypiperidin-1-yl] bearing a bi-heteroaryl pharmacophore. This strategy access various analogs of C₂-aryl substituted benzimidazoles I [R¹ = OH, H₃CO] from a common benzimidazole core I [R = H; R¹ = H₃CO] and easily accessible aryl iodides RI. Preliminary SAR studies revealed that the indole motif of GSK-484 is critical to its activity. Replacing the N-cyclopropylmethyl group to N-benzyl group on the indole ring of GSK-484 resulted in more than 5-fold increase in cell killing efficacy against 4T1 cell line. In the experiment, the researchers used many compounds, for example, 2-Iodo-1H-pyrrolo[2,3-b]pyridine (cas: 1227270-32-7Safety of 2-Iodo-1H-pyrrolo[2,3-b]pyridine).

2-Iodo-1H-pyrrolo[2,3-b]pyridine (cas: 1227270-32-7) belongs to iodide derivatives. Typical reactions of alkyl iodides include nucleophilic substitution, elimination, reduction, and the formation of organometallics. Iodo alkanes participate in a variety of organic synthesis reactions, which include the Simmons–Smith reaction (cyclopropanation using iodomethane), Williamson ether synthesis, Wittig reaction, Grignard reaction, alkyl coupling reactions, and Wurtz reaction.Safety of 2-Iodo-1H-pyrrolo[2,3-b]pyridine

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Utilizing an Encapsulated Solution of Reagents to Achieve the Four-Component Synthesis of (Benzo)Thiophene Derivatives was written by Shen, Chaoren;Spannenberg, Anke;Auer, Matthias;Wu, Xiao-Feng. And the article was included in Advanced Synthesis & Catalysis in 2017.SDS of cas: 5460-32-2 This article mentions the following:

Herein, a facile method for encapsulating smelly liquid chems. and its application in a modular palladium-catalyzed carbonylative synthesis of multi-substituted thiophenes from terminal alkynes and aryl iodides as well as a palladium-catalyzed carbonylative synthesis of benzothiophene derivatives from aryl iodides and arylboronic acids is demonstrated. Here, the capsule plays a pivotal role in solving the issues on reaction condition incompatibilities and selectivity of multicomponent reactions as well as avoiding deactivation of the catalyst by releasing the reagents when the reaction temperature is raised. It greatly facilitates the development of highly-efficient multicomponent reactions and demonstrates a modular pathway to obtain functionalized mols. In the experiment, the researchers used many compounds, for example, 4-Iodo-1,2-dimethoxybenzene (cas: 5460-32-2SDS of cas: 5460-32-2).

4-Iodo-1,2-dimethoxybenzene (cas: 5460-32-2) belongs to iodide derivatives. Organic iodides can be alkyl, alkenyl, or alkynyl, and all of them are very reactive toward with many kinds of nucleophiles. Alkyl iodides react at a faster rate than alkyl fluorides due to the weak C-I bond.SDS of cas: 5460-32-2

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Pd-catalyzed dehydrogenative annulation approach for the efficient synthesis of phenanthridinones was written by Li, Xinyao;Pan, Jun;Song, Song;Jiao, Ning. And the article was included in Chemical Science in 2016.SDS of cas: 36748-88-6 This article mentions the following:

A novel Pd-catalyzed intermol. dehydrogenative annulation of aryl iodides and aryl carbamic chlorides for the efficient synthesis of phenanthridinone derivatives was developed. Simple aryl iodides and carbamic chlorides readily made from various anilines, a broad substrate scope with hetero/polycycles, as well as high-value products, made this direct dehydrogenative annulation approach very practical and attractive. In the experiment, the researchers used many compounds, for example, 3-Iodobenzo[b]thiophene (cas: 36748-88-6SDS of cas: 36748-88-6).

3-Iodobenzo[b]thiophene (cas: 36748-88-6) belongs to iodide derivatives. Organic iodides can be alkyl, alkenyl, or alkynyl, and all of them are very reactive toward with many kinds of nucleophiles. Polyiodoorganic compounds are sometimes employed as X-ray contrast agents, in fluoroscopy, a type of medical imaging. This application exploits the X-ray absorbing ability of the heavy iodine nucleus.SDS of cas: 36748-88-6

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Electron transfer mechanism for periodic acid oxidation of aromatic substrates was written by Bhatt, M. V.;Hosur, B. M.. And the article was included in Indian Journal of Chemistry in 1986.Quality Control of 3-Iodo-4-methoxybenzaldehyde This article mentions the following:

Oxidation of phenolic ethers, e.g. I (R = Me, R¹ = H) with 1 equiv of H₅IO₆ gave the iodinated product I (R = Me, R¹ = iodo). Use of 2 equiv of oxidant gave I (R = CHO, R¹ = iodo) in which the side chain was oxidized. Oxidation of binaphthyl II with either H₅IO₆ or ceric ammonium nitrate in MeOH gave the same cyclized product III. ESR signals were found for the H₅IO₆ oxidation of 11 aromatic substrates. The ESR data and addnl. chem. evidence suggest a radical cation mechanism for the oxidation In the experiment, the researchers used many compounds, for example, 3-Iodo-4-methoxybenzaldehyde (cas: 2314-37-6Quality Control of 3-Iodo-4-methoxybenzaldehyde).

3-Iodo-4-methoxybenzaldehyde (cas: 2314-37-6) belongs to iodide derivatives. Typical reactions of alkyl iodides include nucleophilic substitution, elimination, reduction, and the formation of organometallics. Iodo alkanes participate in a variety of organic synthesis reactions, which include the Simmons–Smith reaction (cyclopropanation using iodomethane), Williamson ether synthesis, Wittig reaction, Grignard reaction, alkyl coupling reactions, and Wurtz reaction.Quality Control of 3-Iodo-4-methoxybenzaldehyde

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Development of a Palladium-Catalyzed Carbonylative Coupling Strategy to 1,4-Diketones was written by Yin, Hongfei;Nielsen, Dennis U.;Johansen, Mette K.;Lindhardt, Anders T.;Skrydstrup, Troels. And the article was included in ACS Catalysis in 2016.COA of Formula: C8H9IO2 This article mentions the following:

We report on a three-component palladium-catalyzed coupling strategy for accessing a wide range of 1,4-diketones, which represent important precursors to heterocycles. Our method relies on a carbonylative Heck reaction employing substituted allylic alcs., aryl iodides, and carbon monoxide. The reaction conditions are mild and do not require high CO pressure, and a wide functional group tolerance is revealed, providing the desired 1,4-diketones in moderate to good yields. Furthermore, the methodol. is adaptable to the selective installment of ¹³C-carbon isotopes at either one or both of the carbonyl positions. In the experiment, the researchers used many compounds, for example, 4-Iodo-1,2-dimethoxybenzene (cas: 5460-32-2COA of Formula: C8H9IO2).

4-Iodo-1,2-dimethoxybenzene (cas: 5460-32-2) belongs to iodide derivatives. Organoiodine compounds occur widely in organic chemistry, but are relatively rare in nature. Alkyl iodides react at a faster rate than alkyl fluorides due to the weak C-I bond.COA of Formula: C8H9IO2

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Development of a one-pot sequential Sonogashira coupling for the synthesis of benzofurans was written by Csekei, Marton;Novak, Zoltan;Kotschy, Andras. And the article was included in Tetrahedron in 2008.Name: 4-Bromo-2-iodophenol This article mentions the following:

An efficient one-pot protocol was developed for the construction of the benzofuran system from aryl halides and protected iodophenols using carbinol-based acetylene sources. The sequence includes alternating palladium-catalyzed Sonogashira couplings and deprotection steps concluded by a ring closure. The developed one-pot procedure was compared with the stepwise approach and its efficiency was also demonstrated by the total synthesis of vignafuran, a benzofuran natural product. In the experiment, the researchers used many compounds, for example, 4-Bromo-2-iodophenol (cas: 207115-22-8Name: 4-Bromo-2-iodophenol).

4-Bromo-2-iodophenol (cas: 207115-22-8) belongs to iodide derivatives. Organic iodides can be alkyl, alkenyl, or alkynyl, and all of them are very reactive toward with many kinds of nucleophiles. The C–I bond is the weakest of the carbon–halogen bonds. These bond strengths correlate with the electronegativity of the halogen, decreasing in the order F > Cl > Br > I.Name: 4-Bromo-2-iodophenol

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com