Tag: 200-300

TosMIC and its derivatives as versatile sulfonylating agents for the synthesis of p-toluenesulfonylarenes from aryl halides and arylboronic acids was written by Ravi Kumar, G.;Ramesh, B.;Banik, Swarnayu;Subba Reddy, B. V.. And the article was included in Tetrahedron in 2020.HPLC of Formula: 5460-32-2 This article mentions the following:

An efficient copper(II) catalyzed sulfonyation of aryl halides had been achieved using TosMIC (p-toluenesulfonylmethyl isocyanide) as a sulfonylating agent. This newly developed sulfonylation approach provided an easy access for the synthesis of diaryl sulfones I [Ar = Ph, 4-MeOC₆H₄, 2-pyridyl, etc.] from aryl bromides, iodides and boronic acids with TosMIC under neutral conditions. This method was useful for the sulfonylation of aryl boronic acids under similar conditions. This was the first report on the sulfonylation of aryl bromides, iodides and boronic acids using TosMIC. In the experiment, the researchers used many compounds, for example, 4-Iodo-1,2-dimethoxybenzene (cas: 5460-32-2HPLC of Formula: 5460-32-2).

4-Iodo-1,2-dimethoxybenzene (cas: 5460-32-2) belongs to iodide derivatives. Organic iodides can be alkyl, alkenyl, or alkynyl, and all of them are very reactive toward with many kinds of nucleophiles. Polyiodoorganic compounds are sometimes employed as X-ray contrast agents, in fluoroscopy, a type of medical imaging. This application exploits the X-ray absorbing ability of the heavy iodine nucleus.HPLC of Formula: 5460-32-2

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Palladium Nanoparticle-Catalyzed Stereoselective Domino Synthesis of All-Carbon Tetrasubstituted Olefin Containing Oxindoles via Carbopalladation/C-H Activation was written by Parveen, Naziya;Sekar, Govindasamy. And the article was included in Journal of Organic Chemistry in 2020.SDS of cas: 5460-32-2 This article mentions the following:

The binaphthyl stabilized palladium nanoparticles (Pd-BNP) catalyzed single-step, stereoselective domino synthesis of sym. and unsym. all-carbon tetrasubstituted olefin containing oxindoles from readily accessible anilides has been developed. The Pd-BNP catalyst showed a wide range of functional group tolerance that enabled building a library of heteroaromatics This reusable Pd catalyst reflected its utility in the synthesis of biol. important AMP-activated protein kinase deprived of any metal Pd contamination. The nanocatalyst was easily recovered and reused five times without any appreciable loss in particle size or catalytic activity. In the experiment, the researchers used many compounds, for example, 4-Iodo-1,2-dimethoxybenzene (cas: 5460-32-2SDS of cas: 5460-32-2).

4-Iodo-1,2-dimethoxybenzene (cas: 5460-32-2) belongs to iodide derivatives. Organoiodine compounds occur widely in organic chemistry, but are relatively rare in nature. Polyiodoorganic compounds are sometimes employed as X-ray contrast agents, in fluoroscopy, a type of medical imaging. This application exploits the X-ray absorbing ability of the heavy iodine nucleus.SDS of cas: 5460-32-2

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Encapsulation of polyoxotungstate into dendrimers by ionic bonding and their use as oxidation catalyst was written by Jahier, Claire;Plault, Lauriane;Nlate, Sylvain. And the article was included in Israel Journal of Chemistry in 2009.Related Products of 10297-05-9 This article mentions the following:

A family of 36-armed dendrimers containing six internal amino groups was synthesized and used to incorporate polyoxometalates (POMs) into their structures by ionic bonding. Allyl-terminated dendrimer 17 (with oxidizable end groups) and methylphenyl-terminated dendrimer 18 (with non-oxidizable end groups) were used for these studies. It was found that the electrostatic incorporation of the tri-anionic POM [PO₄{WO(O₂)₂}₄]^3- into the methylphenyl-terminated dendrimer 18, in an acidic medium, leads to the dendritic POM hybrid 19, bearing two POM units in its structure. In contrast, attempts to encapsulate POMs into allyl-terminated dendrimer 17 gave unsatisfactory results. Indeed, the epoxidation kinetics of the 36-olefinic terminated dendrimer 17 was too slow, and the expected 36-epoxy-dendritic POM framework 20 was not obtained. Lengthening the reaction up to six hours led to the decomposition of POM species. The solubility in organic solvents of the dendritic POM hybrid 19, combined with its NMR and IR data, indicate that POM units are clearly connected to the dendritic structure. The catalytic performance of this hybrid material in the oxidation of cyclooctene shows that the properties of POM are retained. The POM-encapsulated dendrimer 19 was found to be an effective catalyst in the oxidation of cyclooctene. In the experiment, the researchers used many compounds, for example, 1-Chloro-4-iodobutane (cas: 10297-05-9Related Products of 10297-05-9).

1-Chloro-4-iodobutane (cas: 10297-05-9) belongs to iodide derivatives. Organic iodides are widely used in organic synthesis. Halogenation of aromatic hydrocarbons is a very important reaction via an electrophilic aromatic substitution. A typical method for synthesis of aromatic iodides is diazotization of primary aromatic amines followed by treatment of potassium iodide. Aliphatic alcohols are converted to alkyl iodides by treating with hydrogen iodide.Related Products of 10297-05-9

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Deoxygenative Arylation of Carboxylic Acids by Aryl Migration was written by Ruzi, Rehanguli;Ma, Junyang;Yuan, Xiang-Ai;Wang, Wenliang;Wang, Shanshan;Zhang, Muliang;Dai, Jie;Xie, Jin;Zhu, Chengjian. And the article was included in Chemistry – A European Journal in 2019.Application of 20776-54-9 This article mentions the following:

An unprecedented deoxygenative arylation of aromatic carboxylic acids was achieved, allowing the construction of an enhanced library of unsym. diaryl ketones. The synergistic photoredox catalysis and phosphoranyl radical chem. allows for precise cleavage of a stronger C-O bond and formation of a weaker C-C bond by 1,5-aryl migration under mild reaction conditions. This new protocol was independent of substrate redox-potential, electronic, and substituent effects. It afforded a general and promising access to 60 examples of synthetically versatile o-amino and o-hydroxy diaryl ketones under redox-neutral conditions. Furthermore, it also brings one concise route to the total synthesis of quinolone alkaloid, (±)-yaequinolone A2, and a viridicatin derivative in satisfying yields. In the experiment, the researchers used many compounds, for example, 2-Amino-4-iodobenzoic acid (cas: 20776-54-9Application of 20776-54-9).

2-Amino-4-iodobenzoic acid (cas: 20776-54-9) belongs to iodide derivatives. Typical reactions of alkyl iodides include nucleophilic substitution, elimination, reduction, and the formation of organometallics. The C–I bond is the weakest of the carbon–halogen bonds. These bond strengths correlate with the electronegativity of the halogen, decreasing in the order F > Cl > Br > I. This periodic order also follows the atomic radius of halogens and the length of the carbon-halogen bond.Application of 20776-54-9

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Synthesis of diaryl ethers from tyrosine derivatives was written by Crimmin, Michael J.;Brown, Allan G.. And the article was included in Tetrahedron Letters in 1990.Related Products of 2314-37-6 This article mentions the following:

Diaryl ethers of tyrosine, maintaining optical activity, have been formed through the reaction of a tyrosine derivative with an aryl iodonium salt. Thus, iodonium salt I was treated with tyrosine derivative II in refluxing DMF to give 59% ether III. In the experiment, the researchers used many compounds, for example, 3-Iodo-4-methoxybenzaldehyde (cas: 2314-37-6Related Products of 2314-37-6).

3-Iodo-4-methoxybenzaldehyde (cas: 2314-37-6) belongs to iodide derivatives. Organoiodine compounds occur widely in organic chemistry, but are relatively rare in nature. The C–I bond is the weakest of the carbon–halogen bonds. These bond strengths correlate with the electronegativity of the halogen, decreasing in the order F > Cl > Br > I. This periodic order also follows the atomic radius of halogens and the length of the carbon-halogen bond.Related Products of 2314-37-6

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

TCDA: Practical Synthesis and Application in the Trifluoromethylation of Arenes and Heteroarenes was written by Wang, Jian;Zhang, Xiaomin;Wan, Zehong;Ren, Feng. And the article was included in Organic Process Research & Development in 2016.Formula: C8H9IO2 This article mentions the following:

A practical synthesis of the reagent trimethylsilyl chlorodifluoroacetate (TCDA) is reported on a 50 g scale. The trifluoromethylation with TCDA was optimized, and the reaction shows very broad scope with respect to electron-deficient, -neutral, -rich aryl/heteroaryl iodides, as well as excellent functional group tolerability, such as ester, amide, aldehyde, hydroxyl, and carboxylic acid. The reagent was also applied to the late-stage trifluoromethylation of three medicinally relevant compounds Addnl., the building block trifluoromethylpyridine and one drug related mol. Boc-Fluoxetin were synthesized in 10 g scale by this method, demonstrating its practical applications in process chem. In the experiment, the researchers used many compounds, for example, 4-Iodo-1,2-dimethoxybenzene (cas: 5460-32-2Formula: C8H9IO2).

4-Iodo-1,2-dimethoxybenzene (cas: 5460-32-2) belongs to iodide derivatives. Organic iodides are widely used in organic synthesis. Halogenation of aromatic hydrocarbons is a very important reaction via an electrophilic aromatic substitution. The C–I bond is the weakest of the carbon–halogen bonds. These bond strengths correlate with the electronegativity of the halogen, decreasing in the order F > Cl > Br > I. This periodic order also follows the atomic radius of halogens and the length of the carbon-halogen bond.Formula: C8H9IO2

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Nickel-Catalyzed Asymmetric Hydrogenation of Cyclic Alkenyl Sulfones, Benzo[b]thiophene 1,1-Dioxides, with Mechanistic Studies was written by Liu, Gongyi;Tian, Kui;Li, Chenzong;You, Cai;Tan, Xuefeng;Zhang, Heng;Zhang, Xumu;Dong, Xiu-Qin. And the article was included in Organic Letters in 2021.Application In Synthesis of 4-Iodo-1,2-dimethoxybenzene This article mentions the following:

A highly efficient catalytic system based on the cheap transition metal nickel for the asym. hydrogenation of challenging cyclic alkenyl sulfones, 3-substituted benzo[b]thiophene 1,1-dioxides, was first successfully developed. A series of hydrogenation products, chiral 2,3-dihydrobenzo[b]thiophene 1,1-dioxides I [R = H, OMe; R¹ = Et, Ph, 2-MeC₆H₄, etc.] was obtained in high yields (95-99%) with excellent enantioselectivities (90-99% ee). According to the results of nonlinear effect studies, deuterium-labeling experiments, and DFT calculation investigations, a reasonable catalytic mechanism for this nickel-catalyzed asym. hydrogenation was provided, which displayed that the two added hydrogen atoms of the hydrogenation products could be from H₂ through the insertion of Ni-H and subsequent hydrogenolysis. In the experiment, the researchers used many compounds, for example, 4-Iodo-1,2-dimethoxybenzene (cas: 5460-32-2Application In Synthesis of 4-Iodo-1,2-dimethoxybenzene).

4-Iodo-1,2-dimethoxybenzene (cas: 5460-32-2) belongs to iodide derivatives. Organoiodine compounds occur widely in organic chemistry, but are relatively rare in nature. Iodo alkanes participate in a variety of organic synthesis reactions, which include the Simmons–Smith reaction (cyclopropanation using iodomethane), Williamson ether synthesis, Wittig reaction, Grignard reaction, alkyl coupling reactions, and Wurtz reaction.Application In Synthesis of 4-Iodo-1,2-dimethoxybenzene

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Azine and Diazine Functionalization Using 2,2,6,6-Tetramethylpiperidino-Based Lithium-Metal Combinations: Application to the Synthesis of 5,9-Disubstituted Pyrido[3′,2′:4,5]pyrrolo[1,2-c]pyrimidines was written by Marquise, Nada;Nguyen, Tan Tai;Chevallier, Floris;Picot, Laurent;Thiery, Valerie;Lozach, Olivier;Bach, Stephane;Ruchaud, Sandrine;Mongin, Florence. And the article was included in Synlett in 2015.COA of Formula: C4H2ClIN2 This article mentions the following:

The synthesis of triaryl methanols was investigated by reacting different 4-metalated 2-substituted pyrimidines with diaryl ketones, the latter being generated by deprotocupration-aroylation of azine and diazine substrates. Cyclization of the triaryl methanols thus obtained afforded pyrido[3′,2′:4,5]pyrrolo[1,2-c]pyrimidines, which were evaluated for kinase inhibition and antiproliferative activities in melanoma cells. In the experiment, the researchers used many compounds, for example, 2-Chloro-4-iodopyrimidine (cas: 395082-55-0COA of Formula: C4H2ClIN2).

2-Chloro-4-iodopyrimidine (cas: 395082-55-0) belongs to iodide derivatives. Organic iodides are widely used in organic synthesis. Halogenation of aromatic hydrocarbons is a very important reaction via an electrophilic aromatic substitution. A typical method for synthesis of aromatic iodides is diazotization of primary aromatic amines followed by treatment of potassium iodide. Aliphatic alcohols are converted to alkyl iodides by treating with hydrogen iodide.COA of Formula: C4H2ClIN2

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Synthesis and nematicidal activities of 1,2,3-benzotriazin-4-one containing 4,5-dihydrothiazole-2-thiol derivatives against Meloidogyne incognita was written by Chen, Xiulei;Zhou, Zhen;Li, Zhong;Xu, Xiaoyong. And the article was included in Phosphorus, Sulfur and Silicon and the Related Elements in 2020.Product Details of 20776-54-9 This article mentions the following:

A series of novel 1,2,3-benzotriazin-4-one derivatives containing 4,5-dihydrothiazole-2-thiol I (R = H, 5-OMe, 7-F, 8-NO₂, etc.) was synthesized. The bioassay results showed that compounds I (R = 7-OMe, 6-NO₂, 7-Cl (A)) exhibited good control efficacy against the cucumber root-knot nematode disease caused by Meloidogyne incognita at the concentration of 10.0 mg L^-1 in vivo. Compound (A) showed excellent nematicidal activity with inhibition 68.3% at a concentration of 1.0 mg L^-1. It suggested that the structure of 1,2,3-benzotriazin-4-one containing 4,5-dihydro-thiazole-2-thiol could be optimized further. In the experiment, the researchers used many compounds, for example, 2-Amino-4-iodobenzoic acid (cas: 20776-54-9Product Details of 20776-54-9).

2-Amino-4-iodobenzoic acid (cas: 20776-54-9) belongs to iodide derivatives. Organoiodine compounds occur widely in organic chemistry, but are relatively rare in nature. The C–I bond is the weakest of the carbon–halogen bonds. These bond strengths correlate with the electronegativity of the halogen, decreasing in the order F > Cl > Br > I. This periodic order also follows the atomic radius of halogens and the length of the carbon-halogen bond.Product Details of 20776-54-9

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Application of organolithium compounds in organic synthesis. Part 19. Synthetic strategies based on aromatic metalation. A concise regiospecific synthesis of 3-halogenated picolinic and isonicotinic acids was written by Epsztajn, J.;Plotka, M. W.;Grabowska, A.. And the article was included in Synthetic Communications in 1997.Electric Literature of C6H4INO2 This article mentions the following:

The synthesis of the halogenated picolin- and isonicotinanilides I (R = Cl, Br, iodo, X = N, Y = CH; X = CH, Y = N) (II) via metalation (n-BuLi) of the anilides I (R = H) and then the reaction of the generated bis-lithiated anilides with halogenating agents (CCl₃-CCl₃, CH₂Br-CH₂Br, I₂) followed by subsequent acidic hydrolysis of II, as a way of regiospecific transformation of picolinic and isonicotinic acids into their C³-halogenated derivatives, is described. In the experiment, the researchers used many compounds, for example, 3-Iodopicolinic acid (cas: 73841-32-4Electric Literature of C6H4INO2).

3-Iodopicolinic acid (cas: 73841-32-4) belongs to iodide derivatives. Generally organic iodides can be divided into two classes of alkyl iodides and aryl iodides. Typical reactions of alkyl iodides include nucleophilic substitution, elimination, reduction, and the formation of organometallics. Polyiodoorganic compounds are sometimes employed as X-ray contrast agents, in fluoroscopy, a type of medical imaging. This application exploits the X-ray absorbing ability of the heavy iodine nucleus.Electric Literature of C6H4INO2

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com