Tag: 200-300

On February 4, 2021, Schenkel, Laurie B.; Vasbinder, Melissa Marie; Kuntz, Kevin Wayne; Perl, Nicholas Robert; Downing, Jennifer published a patent.Product Details of 1096481-48-9 The title of the patent was Preparation of pyrazolopyrimidine carboxamides and related heterobicyclic amides as inhibitors of CD38 useful in the treatment of cancer. And the patent contained the following:

The invention relates to preparation of pyrazolopyrimidine carboxamides and related heterobicyclic amides(I) which are inhibitors of CD38 and are useful in the treatment of cancer. Compounds I wherein V is N or CRv; Rv is H, halo, or C1-4 alkyl; W is N or CRw; Rw is H, halo, or C1-4 alkyl;; Ring A is a 5-membered heteroaryl group having 1, 2 or 3 ring-forming heteroatoms selected from N, O, and S; L is a C1-4 alkylene linker; n is 0 or 1; Q is H, C1-10 alkyl, C2-10 alkenyl, C2-10 alkynyl, etc.; etc…, are claimed. The example compound II was prepared via 3-steps synthesis using imidazole as starting material (procedure given). Compounds I were evaluated for their biol. activity (data given). Compounds I can be useful in treatment of cancers. The experimental process involved the reaction of Methyl 2-amino-5-iodo-3-methylbenzoate(cas: 1096481-48-9).Product Details of 1096481-48-9

The Article related to pyrazolopyrimidine carboxamide preparation cd38 inhibitor antitumor cancer, heterobicyclic amide preparation cd38 inhibitor antitumor cancer, Heterocyclic Compounds (More Than One Hetero Atom): Pyrimidines and Quinazolines and other aspects.Product Details of 1096481-48-9

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

On February 1, 2016, Beaudegnies, Renaud; Quaranta, Laura; Murphy Kessabi, Fiona; Lamberth, Clemens; Knauf-Beiter, Gertrud; Fraser, Torquil published an article.Category: iodides-buliding-blocks The title of the article was Synthesis and anti-oomycete activity of novel quinazolin- and benzothiazol-6-yloxyacetamides: Potent aza-analogs and five-ring analogs of quinoline fungicides. And the article contained the following:

Synthesis and anti-oomycete activity of quinazolines, e.g., I and benzothiazol-6-yloxyacetamide II was described. The synthesized compounds showed excellent in vivo activity against the three economically most important oomycete pathogens Phytophthora infestans, Plasmopara viticola and Pythium ultimum. These were polar analogs of known quinolin-6-yloxyacetamides, which were not active against the soil-borne damping-off disease caused by Pythium ultimum. The Bogert quinazoline synthesis, proved to be highly useful for the concise construction of required quinazolin-6-ol building blocks. The experimental process involved the reaction of Methyl 2-amino-5-iodo-3-methylbenzoate(cas: 1096481-48-9).Category: iodides-buliding-blocks

The Article related to preparation quinazoline benzothiazolyloxyacetamide anti oomycete sar, benzothiazole, crop protection, fungicide, heterocycle, quinazoline, Heterocyclic Compounds (More Than One Hetero Atom): Pyrimidines and Quinazolines and other aspects.Category: iodides-buliding-blocks

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

On January 8, 2009, Annis, Gary David published a patent.Formula: C9H10INO2 The title of the patent was Process for preparing 2-amino-5-cyanobenzoic acid derivatives using nickel-catalyzed cyanation reaction. And the patent contained the following:

Disclosed is a method for preparing a compound of formula I (X = CN; R1 = NHR3, OR4; R2 = Me, Cl; R3 = H, C1-4 alkyl, cyclopropyl, cyclopropylcyclopropyl, cyclopropylmethyl, methylcyclopropyl; R4 = H, C1-4 alkyl) by reacting a compound of formula I (X = Br, Cl, I; R1 = NHR3, OR4; R2 = Me, Cl; R3 = H, C1-4 alkyl, cyclopropyl, cyclopropylcyclopropyl, cyclopropylmethyl, methylcyclopropyl; R4 = H, C1-4 alkyl) with at least one alkali metal cyanide in the presence of a nickel catalyst. Also disclosed is a method for preparing the nickel catalyst, by reacting 1-chloronaphthalene with dichlorobis(triphenylphosphine)nickel.. Furthermore, a method for removing nickel impurities from a mixture thereof with compounds of formula I (X = CN) comprising contacting the mixture with oxygen in the presence of an aqueous cyanide solution is disclosed. In addition, a method for preparing a compound of formula II (R2 = Me, Cl; R3 = H, C1-4 alkyl, cyclopropyl, cyclopropylcyclopropyl, cyclopropylmethyl, methylcyclopropyl; Z = CR8, N; R5 = Cl, Br, CF3, OCF2, OCH2CF3; R6 = F, Cl, Br; R7 = H, F, Cl; R8 = H, F, Cl, Br) using a compound of formula I, is disclosed. Example compound III was prepared by nickel-catalyzed cyanation of 2-amino-5-bromo-N,3-dimethylbenzamide; the resulting 2-amino-5-cyano-N,3-dimethylbenzamide underwent amidation with 3-bromo-1-(3-chloro-2-pyridinyl)-1H-pyrazole-5-carboxylic acid to give compound III. The experimental process involved the reaction of Methyl 2-amino-5-iodo-3-methylbenzoate(cas: 1096481-48-9).Formula: C9H10INO2

The Article related to halobenzoic acid derivative cyanation nickel, cyanobenzoic acid derivative preparation pyrazolecarboxylic acid amidation, cyanophenyl pyrazolecarboxamide preparation, nickel cyanation catalyst and other aspects.Formula: C9H10INO2

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

In 2022,Zhu, Yu-Rong; Lin, Jin-Hong; Xiao, Ji-Chang published an article in Synlett. The title of the article was 《Triphenylphosphine/1,2-Diiodoethane-Promoted Formylation of Indoles with N,N -Dimethylformamide》.HPLC of Formula: 624-73-7 The author mentioned the following in the article:

A Ph3P/ICH2CH2I-promoted formylation of indoles with DMF under mild conditions was described. A Vilsmeier-type intermediate was readily formed from DMF promoted by the Ph3P/ICH2CH2I system. A one-step formylation process was applied to various electron-rich indoles, but a hydrolysis needs to be carried out as a second step in the case of electron-deficient indoles. Convenient operations make this protocol attractive. In the part of experimental materials, we found many familiar compounds, such as 1,2-Diiodoethane(cas: 624-73-7HPLC of Formula: 624-73-7)

1,2-Diiodoethane(cas: 624-73-7) is one of organic iodides. Alkyl iodides react at a faster rate than alkyl fluorides due to the weak C-I bond. Iodo alkanes participate in a variety of organic synthesis reactions, which include the Simmons–Smith reaction (cyclopropanation using iodomethane), Williamson ether synthesis, Wittig reaction, Grignard reaction, alkyl coupling reactions, and Wurtz reaction.HPLC of Formula: 624-73-7

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

In 2022,Chen, Jialuo; Duan, Lili; Liu, Kunming; Liu, Jin-Biao published an article in Molbank. The title of the article was 《A Convenient Synthesis towards 2-Bromo-2-(methoxy(phenyl)methyl)malononitrile and 2-Iodo-2-(methoxy(phenyl)methyl)malononitrile》.Name: 1-Iodopyrrolidine-2,5-dione The author mentioned the following in the article:

The synthesis of two novel vicinal haloethers bearing a malonontrile group, 2-bromo-2-(methoxy(phenyl)methyl)malononitrile and 2-iodo-2-(methoxy(phenyl)methyl)malononitrile was reported. The structures of the synthesized compounds were confirmed by 1H, 13C-NMR spectroscopy. The final products indicated that methanol not only acts as solvent but also participates in and dominates the reaction result. The experimental process involved the reaction of 1-Iodopyrrolidine-2,5-dione(cas: 516-12-1Name: 1-Iodopyrrolidine-2,5-dione)

1-Iodopyrrolidine-2,5-dione(cas: 516-12-1) is used in the preparation of vinyl sulfones from olefins and benzenesulfinic acid. It acts as a source for I+ and involved in Hunsdiecker reactions for the conversion of cinnamic acids, and propiolic acids to the corresponding alfa-halostyrenes and 1-halo-1-alkynes respectively. Name: 1-Iodopyrrolidine-2,5-dione

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

The author of 《Teaching an Old Poly(arylene ether) New Tricks: Efficient Blue Thermally Activated Delayed Fluorescence》 were Liu, Xinrui; Rao, Jiancheng; Li, Xuefei; Wang, Shumeng; Ding, Junqiao; Wang, Lixiang. And the article was published in iScience in 2019. Category: iodides-buliding-blocks The author mentioned the following in the article:

Polymer light-emitting diodes are attractive for optoelectronic applications owing to their brightness and ease of processing. However, often metals have to be inserted to increase the luminescence efficiency, and producing blue emitters is a challenge. Here we present a strategy to make blue thermally activated delayed fluorescence (TADF) polymers by directly embedding a small mol. blue TADF emitter into a poly(aryl ether) (PAE) backbone. Thanks to the oxygen-induced negligible electronic communication between neighboring TADF fragments, its corresponding blue delayed fluorescence can be inherited by the developed polymers. These polymers are free from metal catalyst contamination and show improved thermal stability. Through device optimization, a current efficiency of 29.7 cd/A (21.2 lm/W, 13.2%) is realized together with Commission Internationale de L′Eclairage coordinates of (0.18, 0.32). The value is competitive with blue phosphorescent polymers, highlighting the importance of the PAE backbone in achieving high-performance blue delayed fluorescence at a macromol. level. The experimental process involved the reaction of 1-Bromo-4-iodobenzene(cas: 589-87-7Category: iodides-buliding-blocks)

1-Bromo-4-iodobenzene(cas: 589-87-7) is mainly used as the OLED pharmaceutical intermediate, as reagent for in situ desilylation and coupling of silylated alkynes, as substrate in copper-free Sonogashira coupling in aqueous acetone..Category: iodides-buliding-blocks It is also used in synthesis of β,β,dibromostyrenes, as starting reagent in the total syntheses of ent-conduramine A and ent-7-deoxypancratistatin (alkaloids)

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

The author of 《A Practical, Large-Scale Synthesis of p-(Difluoroiodo)toluene (p-TolIF2)》 were Tao, Jason; Murphy, Graham K.. And the article was published in Synthesis in 2019. Application In Synthesis of 1-Iodo-4-methylbenzene The author mentioned the following in the article:

A detailed three-step synthesis of p-(difluoroiodo)toluene, carried out on a 50 mmol scale, that consistently provided high-quality product that was suitable for long-term storage was described. The reactions employed inexpensive, readily available starting materials and reagents, and used the commodity chem. 48% aqueous HF as the source of fluorine atoms. The results came from multiple reactions, including the reaction of 1-Iodo-4-methylbenzene(cas: 624-31-7Application In Synthesis of 1-Iodo-4-methylbenzene)

1-Iodo-4-methylbenzene(cas: 624-31-7) is used in wide range of medicals industrial applications as well as in pharmaceutical intermediates, polarizing films for Liquid Crystal Display (LCD) chemicals.Application In Synthesis of 1-Iodo-4-methylbenzene

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

《Alkaline Soil Degradation and Crop Safety of 5-Substituted Chlorsulfuron Derivatives》 was published in Molecules in 2022. These research results belong to Wu, Lei; Hua, Xue-Wen; Li, Yong-Hong; Wang, Zhong-Wen; Zhou, Sha; Li, Zheng-Ming. Name: 1-Chloro-4-iodo-2-nitrobenzene The article mentions the following:

Sulfonylurea herbicides can lead to serious weed resistance due to their long degradation times and large-scale applications. This is especially true for chlorsulfuron, a widely used acetolactate synthase inhibitor used around the world. Its persistence in soil often affects the growth of crop seedlings in the following crop rotation, and leads to serious environmental pollution all over the world. Our research goal is to obtain chlorsulfuron-derived herbicides with high herbicidal activities, fast degradation times, as well as good crop safety. On account of the slow natural degradation of chlorsulfuron in alk. soil, based on the previously reported results in acidic soil, the degradation behaviors of 5-substituted chlorsulfuron analogs (L101-L107) were investigated in a soil with pH 8.39. The exptl. data indicated that 5-substituted chlorsulfuron compounds could accelerate degradation rates in alk. soil, and thus, highlighted the potential for rational controllable degradation in soil. The degradation rates of these chlorsulfuron derivatives were accelerated by 1.84-77.22-fold, compared to chlorsulfuron, and exhibited excellent crop safety in wheat and corn (through pre-emergence treatment). In combination with bioassay activities, acidic and alk. soil degradation, and crop safety, it was concluded that compounds L104 and L107, with Et or Me groups, are potential green sulfonylurea herbicides for pre-emergence treatment on wheat and corn. This paper provides a reference for the further design of new sulfonylurea herbicides with high herbicidal activity, fast, controllable degradation rates, and high crop safety. After reading the article, we found that the author used 1-Chloro-4-iodo-2-nitrobenzene(cas: 41252-95-3Name: 1-Chloro-4-iodo-2-nitrobenzene)

1-Chloro-4-iodo-2-nitrobenzene(cas: 41252-95-3) belongs to organic iodides. The carbon-iodine bond is weaker than other carbon-halogen bonds due to the poor electronegative nature of the iodine atom. In general, organic iodides are light-sensitive and turn yellow during storage, owing to the formation of iodine.Name: 1-Chloro-4-iodo-2-nitrobenzene

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Name: Trimethylsulfoxonium iodideIn 2021 ,《Ni-Catalyzed Intramolecular Reductive 1,2-Dicarbofunctionalization of Alkene: Facile Access to Podophyllum Lignans Core》 was published in Synlett. The article was written by Xiao, Jian; Wang, Ya-Wen; Qiu, Zhong-Ping; Peng, Yu. The article contains the following contents:

The facile access to the tetracyclic skeleton of podophyllotoxin (5R,5aS,6R,8aR)/(5R,5aS,6S,8aS)-I, a medicinally important lignan natural product, was efficiently achieved via a unique intramol. alkylarylation of the tethered alkene II in dihalide under mild conditions using reductive nickel catalysis. In the experiment, the researchers used Trimethylsulfoxonium iodide(cas: 1774-47-6Name: Trimethylsulfoxonium iodide)

Trimethylsulfoxonium iodide(cas: 1774-47-6) reacts with sodium hydride to prepare dimethyloxosulfonium methylide, which is used as a methylene-transfer reagent in synthetic chemistry. It is used to prepare ylide, which reacts with carbonyl compounds to get epoxides. Further, it reacts with alfa,beta-unsaturated esters to get cyclopropyl esters.Name: Trimethylsulfoxonium iodide

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

In 2022,Wang, Wei; Yao, Ken; Wu, Fan published an article in Synlett. The title of the article was 《Nickel-Catalyzed Reductive Cross-Coupling of Benzylic Sulfonium Salts with Aryl Iodides》.Related Products of 15164-44-0 The author mentioned the following in the article:

A nickel-catalyzed cross-electrophile coupling of benzylic sulfonium salts R1CH(S+(CH3)2)R2·O-S(O)CF3 [R1 = Ph, naphthalen-2-yl, benzo[d][1,3]dioxol-5-yl, etc.; R2 = H, Me, Et] with aryl iodides R3I [R3 = 4-carboxymethylphenyl, 9H-fluoren-2-yl, 4-formylphenyl, etc.] has been developed, providing direct access to diarylalkanes R1CH(R2)R3 from readily available and stable coupling partners. Preliminary mechanistic studies suggest that the C-S bond cleavage proceeds through a single-electron transfer process to generate a benzylic radical. After reading the article, we found that the author used 4-Iodobenzaldehyde(cas: 15164-44-0Related Products of 15164-44-0)

4-Iodobenzaldehyde(cas: 15164-44-0) is used in synthesis of 4-[2-(trimethylsilyl)ethynyl]benzaldehyde, 5,15-dimesityl-10-(3-[2-(trimethylsilyl)ethynyi]phenyl}-20-(4-iodophenyl)porphyrin, and 5,15-dimesityl-10-[3,5-bis{2-[4-(N,N’-difluoroboryl-1,9-dimethyidipyrrin-5-yl)-phenyl]ethynyl}phenyl]-20-(4-iodophenyl)porphyrin.Related Products of 15164-44-0

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com