Tag: 200-300

In 2019,Chem included an article by Liu, Wei; Zhao, Liang-Liang; Melaimi, Mohand; Cao, Lei; Xu, Xingyu; Bouffard, Jean; Bertrand, Guy; Yan, Xiaoyu. Related Products of 15164-44-0. The article was titled 《Mesoionic Carbene (MIC)-Catalyzed H/D Exchange at Formyl Groups》. The information in the text is summarized as follows:

Investigation of the reaction of aldehydes with 1,2,3-triazolylidenes has revealed the reversible formation of Breslow intermediates and the inhibition of the condensation steps in methanol solvent. 1,2,3-Triazolylidenes catalyzed the H/D exchange of aryl, alkenyl and alkyl aldehydes in high yields and deuterium incorporation levels using deuterated methanol as an affordable D source. The unique properties of these mesoionic carbenes (MICs) enabled a streamlined preparation of deuterated synthetic intermediates and pharmacophores that are highly valuable as mechanistic and metabolic probes. In addition to this study using 4-Iodobenzaldehyde, there are many other studies that have used 4-Iodobenzaldehyde(cas: 15164-44-0Related Products of 15164-44-0) was used in this study.

4-Iodobenzaldehyde(cas: 15164-44-0) is used in synthesis of 4-[2-(trimethylsilyl)ethynyl]benzaldehyde, 5,15-dimesityl-10-(3-[2-(trimethylsilyl)ethynyi]phenyl}-20-(4-iodophenyl)porphyrin, and 5,15-dimesityl-10-[3,5-bis{2-[4-(N,N’-difluoroboryl-1,9-dimethyidipyrrin-5-yl)-phenyl]ethynyl}phenyl]-20-(4-iodophenyl)porphyrin.Related Products of 15164-44-0

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

In 2019,Green Chemistry included an article by Ge, Xin; Zhang, Shihui; Chen, Xinzhi; Liu, Xuemin; Qian, Chao. Name: 1-Iodo-4-methylbenzene. The article was titled 《A designed bi-functional sugar-based surfactant: micellar catalysis for C-X coupling reaction in water》. The information in the text is summarized as follows:

A bi-functional sugar-based surfactant ALA14 was designed as the ligand and micelle constructor and demonstrated to promote the copper-catalyzed C-X coupling reaction in water. The nature of this micelle, formed by sugar-based surfactants, was investigated with CMC, DLS, and TEM, by which encapsulation and aggregation of the substrates in micelles were verified. Addnl., it was addressed by 1H-NMR anal. that the enrichment position of the substrates is in the lipophilic alkyl chain. Finally, moderate to excellent yields of the aimed products were obtained in this work. This remarkably simple strategy expanded the scope of C-X coupling reaction in water; most notably, both water and ALA14 can be recycled and reused. In addition to this study using 1-Iodo-4-methylbenzene, there are many other studies that have used 1-Iodo-4-methylbenzene(cas: 624-31-7Name: 1-Iodo-4-methylbenzene) was used in this study.

1-Iodo-4-methylbenzene(cas: 624-31-7) undergoes Suzuki-Miyaura coupling reaction with phenylboronic acid catalyzed by (Ni,Mg)3Si2O5(OH)4 solid-solution nanotubes loaded with palladium.Name: 1-Iodo-4-methylbenzene

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

In 2019,Green Chemistry included an article by Ke, Fang; Xu, Yiwen; Zhu, Suning; Lin, Xiaoyan; Lin, Chen; Zhou, Sunying; Su, Huimin. Related Products of 88-67-5. The article was titled 《Electrochemical N-acylation synthesis of amides under aqueous conditions》. The information in the text is summarized as follows:

An electrochem. N-acylation of carboxylic acids with amines was reported for the synthesis of amides I [R1 = H, 4-CN, 2-I, etc.; R2 = H, 4-Me, 4-Cl, etc.]. The sustainable TBAB electrocatalysis proceeded with excellent chemoselectivity and positional selectivity, and with ample scope, allowing electrochem. N-acylation under mild reaction conditions at room temperature in water. Moreover, the synthetic utility of the current method was demonstrated by the synthesis of melatonin. In the experimental materials used by the author, we found 2-Iodobenzoic acid(cas: 88-67-5Related Products of 88-67-5)

2-Iodobenzoic acid(cas: 88-67-5) belongs to organic iodides. Alkyl iodides react at a faster rate than alkyl fluorides due to the weak C-I bond.Related Products of 88-67-5Iodo alkanes participate in a variety of organic synthesis reactions, which include the Simmons–Smith reaction (cyclopropanation using iodomethane), Williamson ether synthesis, Wittig reaction, Grignard reaction, alkyl coupling reactions, and Wurtz reaction.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Category: iodides-buliding-blocksIn 2020 ,《A pyranoxanthone as a potent antimitotic and sensitizer of cancer cells to low doses of paclitaxel》 appeared in Molecules. The author of the article were Franca, Fabio; Silva, Patricia M. A.; Soares, Jose X.; Henriques, Ana C.; Loureiro, Daniela R. P.; Azevedo, Carlos M. G.; Afonso, Carlos M. M.; Bousbaa, Hassan. The article conveys some information:

Microtubule-targeting agents (MTAs) remain a gold standard for the treatment of several cancer types. By interfering with microtubules dynamic, MTAs induce a mitotic arrest followed by cell death. This antimitotic activity of MTAs is dependent on the spindle assembly checkpoint (SAC), which monitors the integrity of the mitotic spindle and proper chromosome attachments to microtubules in order to ensure accurate chromosome segregation and timely anaphase onset. However, the cytotoxic activity of MTAs is restrained by drug resistance and/or toxicities, and had motivated the search for new compounds and/or alternative therapeutic strategies. Here, we describe the synthesis and mechanism of action of the xanthone derivative pyranoxanthone 2 that exhibits a potent anti-growth activity against cancer cells. We found that cancer cells treated with the pyranoxanthone 2 exhibited persistent defects in chromosome congression during mitosis that were not corrected over time, which induced a prolonged SAC-dependent mitotic arrest followed by massive apoptosis. Importantly, pyranoxanthone 2 was able to potentiate apoptosis of cancer cells treated with nanomolar concentrations of paclitaxel. Our data identified the potential of the pyranoxanthone 2 as a new potent antimitotic with promising antitumor potential, either alone or in combination regimens.2-Iodobenzoic acid(cas: 88-67-5Category: iodides-buliding-blocks) was used in this study.

2-Iodobenzoic acid(cas: 88-67-5) belongs to organic iodides. Organic iodides are used in veterinary products (Organic Iodide Powder) as a nutritional source of iodine.Category: iodides-buliding-blocks In the chemical industry, alkyl iodides serve as excellent alkylating agents and, specifically, methyl iodide is used as a methylating agent in the synthesis of various pharmaceutical drugs.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

COA of Formula: C2H4I2In 2019 ,《A Practical Synthesis of Ammonia from Nitrogen Gas, Samarium Diiodide and Water Catalyzed by a Molybdenum-PCP Pincer Complex》 appeared in Synthesis. The author of the article were Ashida, Yuya; Kondo, Shoichi; Arashiba, Kazuya; Kikuchi, Takamasa; Nakajima, Kazunari; Kakimoto, Seizo; Nishibayashi, Yoshiaki. The article conveys some information:

A practical method for ammonia synthesis is described. The reaction of atm. pressure of nitrogen gas with samarium diiodide as a reducing reagent and water as a proton source in the presence of a catalytic amount of a molybdenum trichloride complex bearing a PCP [1,3-bis(di- tert-butylphosphinomethyl)benzimidazol-2-ylidene]-type pincer ligand occurs under ambient conditions to afford ammonium sulfate after treatment with sulfuric acid. After reading the article, we found that the author used 1,2-Diiodoethane(cas: 624-73-7COA of Formula: C2H4I2)

1,2-Diiodoethane(cas: 624-73-7) is one of organic iodides. The carbon-iodine bond is weaker than other carbon-halogen bonds due to the poor electronegative nature of the iodine atom. In general, organic iodides are light-sensitive and turn yellow during storage, owing to the formation of iodine. Organic iodides can be alkyl, alkenyl, or alkynyl, and all of them are very reactive toward with many kinds of nucleophiles.COA of Formula: C2H4I2

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

In 2022,Bae, Jinsu; Kim, Yeo-Ok; Han, Xuehao; Yoon, Myung-Ha; Kim, Woong-Mo; Kim, Yong-Chul published an article in Molecules. The title of the article was 《Synthesis and Structure-Activity Relationship Studies of Benzimidazole-4,7-dione-Based P2X3 Receptor Antagonists as Novel Anti-Nociceptive Agents》.Application In Synthesis of 4-Chloro-2-iodoaniline The author mentioned the following in the article:

P2X3 receptors (P2X3R) are ATP-gated ion channels predominantly expressed in C- and Aδ-fiber primary afferent neurons and have been introduced as a novel therapeutic target for neurol. disorders, including neuropathic pain and chronic cough. Because of its localized distribution, antagonism of P2X3R has been thoroughly considered, and the avoidance of issues related to CNS side effects has been proven in clin. trials. In this article, benzimidazole-4,7-dione-based derivatives were introduced as a new chem. entity for the development of P2X3R antagonists. Starting from the discovery of a hit compound from the screening of 8364 random library compounds in the Korea Chem. Bank, which had an IC50 value of 1030 nM, studies of structure-activity and structure-property relationships enabled further optimization toward improving the antagonistic activities as well as the drug′s physicochem. properties, including metabolic stability. As for the results, the final optimized compound 14h was developed with an IC50 value of 375 nM at P2X3R with more than 23-fold selectivity vs. P2X2/3R, along with properties of metabolic stability and improved solubility In neuropathic pain animal models evoked by either nerve ligation or chemotherapeutics in male Sprague-Dawley rats, compound 14h showed anti-nociceptive effects through an increase in the mech. withdrawal threshold as measured by von Frey filament following i.v. administration. After reading the article, we found that the author used 4-Chloro-2-iodoaniline(cas: 63069-48-7Application In Synthesis of 4-Chloro-2-iodoaniline)

4-Chloro-2-iodoaniline(cas: 63069-48-7) belongs to anime. Examples of direct uses of amines and their salts are as corrosion inhibitors in boilers and in lubricating oils (morpholine), as antioxidants for rubber and roofing asphalt (diarylamines), as stabilizers for cellulose nitrate explosives (diphenylamine), as protectants against damage from gamma radiation (diarylamines), as developers in photography (aromatic diamines), as flotation agents in mining, as anticling and waterproofing agents for textiles, as fabric softeners, in paper coating, and for solubilizing herbicides.Application In Synthesis of 4-Chloro-2-iodoaniline

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Shan, Zi-Wei; Chen, Xiao-Yan; Zhang, Hao; Liu, Hai-Yang; Yuan, Gao-Qing published an article in 2022. The article was titled 《Copper Porphyrin Catalyzed C(sp3)-H Activation via Cross-Dehydrogenative Coupling: Facile Transformation of Aldehydes to Esters》, and you may find the article in Synlett.Recommanded Product: 15164-44-0 The information in the text is summarized as follows:

Copper porphyrin catalyzed alkane C-H bond functionalization with aldehydes via cross-dehydrogenative coupling (CDC) using DTBP oxidant has been firstly described in nonsolvents or nonadditives system. Different aryl/heteroaryl carboxylic esters were obtained in good to excellent yields depending on the aldehyde derivatives This CDC reaction catalyzed by copper porphyrin has the advantages of shorter reaction time, lower reaction temperature, and catalyst loading as well as the aerobic reaction atm. In the part of experimental materials, we found many familiar compounds, such as 4-Iodobenzaldehyde(cas: 15164-44-0Recommanded Product: 15164-44-0)

4-Iodobenzaldehyde(cas: 15164-44-0) is used in synthesis of 4-[2-(trimethylsilyl)ethynyl]benzaldehyde, 5,15-dimesityl-10-(3-[2-(trimethylsilyl)ethynyi]phenyl}-20-(4-iodophenyl)porphyrin, and 5,15-dimesityl-10-[3,5-bis{2-[4-(N,N’-difluoroboryl-1,9-dimethyidipyrrin-5-yl)-phenyl]ethynyl}phenyl]-20-(4-iodophenyl)porphyrin.Recommanded Product: 15164-44-0

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

《3-(4-Iodophenyl)-2,3-dihydro-1H-benzo[f]chromen-1-one》 was written by Dean, Raven; Miller, Chelsea N.; Zingales, Sarah K.; Padgett, Clifford W.. Formula: C7H5IO And the article was included in IUCrData in 2020. The article conveys some information:

In the title compound, C19H13IO2, the dihedral angle between the naphthyl ring system and the pendant iodophenyl ring is 72.48 (11)°. In the crystal, C-H···π interactions and I···O [3.293 (2) Å] halogen bonds are observed, which combine to generate a herringbone packing motif. In the experiment, the researchers used many compounds, for example, 4-Iodobenzaldehyde(cas: 15164-44-0Formula: C7H5IO)

4-Iodobenzaldehyde(cas: 15164-44-0) is used in synthesis of 4-[2-(trimethylsilyl)ethynyl]benzaldehyde, 5,15-dimesityl-10-(3-[2-(trimethylsilyl)ethynyi]phenyl}-20-(4-iodophenyl)porphyrin, and 5,15-dimesityl-10-[3,5-bis{2-[4-(N,N’-difluoroboryl-1,9-dimethyidipyrrin-5-yl)-phenyl]ethynyl}phenyl]-20-(4-iodophenyl)porphyrin.Formula: C7H5IO

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

《Cesium Cation Complexation by a Flavin Receptor via Self-Assembly and Deprotonation》 was published in ACS Omega in 2020. These research results belong to Oka, Yoshimi. Application of 619-58-9 The article mentions the following:

This study focuses on the self-assembly of a new flavin compound and its scaffolding function for a Cs+ ion. 7,8-Dimethyl-10-[4′-(methoxycarbonyl)phenyl]-isoalloxazine (FlH-MB) displays self-assembly in a DMSO solution and has strong dependence on the solvent. In the DMSO solution, both the resulting scaffold and the deprotonation of FlH-MB were demonstrated to induce complex formation with a Cs+ ion, which was investigated by UV-vis, 1H NMR, and fluorescence titrations This complex formation involves both Coulombic and cation-π interactions through the Fl- site in an Fl–MB dimer.4-Iodobenzoic acid(cas: 619-58-9Application of 619-58-9) was used in this study.

4-Iodobenzoic acid(cas: 619-58-9) belongs to organic iodides. Organic iodides are used in veterinary products (Organic Iodide Powder) as a nutritional source of iodine. In the chemical industry, alkyl iodides serve as excellent alkylating agents and, specifically, methyl iodide is used as a methylating agent in the synthesis of various pharmaceutical drugs.Application of 619-58-9

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

The author of 《Two-dimensional Janus heterostructures for superior Z-scheme photocatalytic water splitting》 were Li, Zhuwei; Hou, Jungang; Zhang, Bo; Cao, Shuyan; Wu, Yunzhen; Gao, Zhanming; Nie, Xiaowa; Sun, Licheng. And the article was published in Nano Energy in 2019. Application In Synthesis of 1-Iodopyrrolidine-2,5-dione The author mentioned the following in the article:

Developing robust water splitting photocatalyst remains a pivot challenge for solar-to-fuel conversion. Herein, two-dimensional (2D) Janus bilayer heterostructures are reported by sulfur-vacancy-confined-in ZnIn2S4 (Vs-ZnIn2S4) and WO3 nanosheets as an all-solid-state Z-scheme prototype. First-principle calculations and exptl. observations clearly confirm the spontaneous formation of this redox-mediator-free Z-scheme van der Waals heterostructure at at. level, not only facilitating the space separation of photoexcited carriers with high charge d., enhancing charge dynamics and optimizing charge lifetime, but also accumulating electrons in conduction band of Vs-ZnIn2S4 and holes in valence band of WO3 by internal elec. field through W-S bonds. After integrated by NiS quantum dots, novel 2D/2D NiS/Vs-ZnIn2S4/WO3 heterostructures with high stability exhibited an outstanding visible-light hydrogen evolution rate of 11.09 mmol g-1 h-1 and an apparent quantum efficiency about 72% at 420 nm, the highest value so far reported among the family of ZnIn2S4 photocatalysts. This work not only presents novel Janus heterostructures but also paves the at.-level structural and interfacial design and the construction of 2D Janus bilayer Z-scheme heterojunctions for solar energy conversion applications. The results came from multiple reactions, including the reaction of 1-Iodopyrrolidine-2,5-dione(cas: 516-12-1Application In Synthesis of 1-Iodopyrrolidine-2,5-dione)

1-Iodopyrrolidine-2,5-dione(cas: 516-12-1) is used in the preparation of vinyl sulfones from olefins and benzenesulfinic acid. It acts as a source for I+ and involved in Hunsdiecker reactions for the conversion of cinnamic acids, and propiolic acids to the corresponding alfa-halostyrenes and 1-halo-1-alkynes respectively. Application In Synthesis of 1-Iodopyrrolidine-2,5-dione

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com