Tag: 200-300

The author of 《One-Pot Synthesis of Spiro-2H-pyrroles from N-Propargylic β-Enaminones》 were Karadeniz, Eda; Zora, Metin. And the article was published in Synlett in 2019. Computed Properties of C6H4BrI The author mentioned the following in the article:

A simple and general one-pot method for the synthesis of spiro-2H-pyrroles has been developed. Initially, cyclohexane-embedded β-enaminones with internal alkyne functionality were synthesized by conjugate addition of 1-ethynylcyclohexylamine to α,β-alkynic ketones, followed by palladium-catalyzed coupling of the resulting N-propargylic β-enaminones with aryl iodides. When subjected to basic conditions, the cyclohexane-embedded β-enaminones with internal alkyne functionality underwent tandem nucleophilic cyclization and benzylic C-H oxidation to furnish 3,4-diaryloyl-1-azaspiro[4.5]deca-1,3-diene derivatives I (R1 = Ph; R2 = Ph, 4-ClC6H4; R3 = Ph, 4-MeC6H4, 4-FC6H4, 3-BrC6H4, 4-O2NC6H4) in good yields. In the part of experimental materials, we found many familiar compounds, such as 1-Bromo-3-iodobenzene(cas: 591-18-4Computed Properties of C6H4BrI)

1-Bromo-3-iodobenzene(cas: 591-18-4) has been used in the preparation of 1-(3′-bromophenyl)-3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,10-heptadecafluorodec-1-ene and 1-(3′-bromophenyl)-3,3,4,4,5,5,6,6,7,7,8,8,8-tridecafluorooct-1-ene.Computed Properties of C6H4BrI

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

In 2019,Synlett included an article by Lee, Melissa; Adams, Ashley; Cox, Philip B.; Sanford, Melanie S.. Related Products of 15854-87-2. The article was titled 《Access to 3D Alicyclic Amine-Containing Fragments through Transannular C-H Arylation》. The information in the text is summarized as follows:

In this Letter, authors adapt a recently reported Pd-catalyzed transannular C(sp3)-H arylation of alicyclic amines for applications in fragment-based drug discovery (FBDD). Authors apply this method to the synthesis of a series of 6-arylated 3-azabicyclo[3.1.0]hexanes I (Ar = Ph, 4-ClC6H4, 4-OMeC6H4, 4-Py, 2-Py, etc.) that are rule-of-three compliant fragments. Several modifications were made to the Pd-catalyzed C-H arylation method to enhance its utility in fragment synthesis. These include the use of microwave heating to shorten reaction times to under 1 h and the development of new approaches for directing group cleavage. Finally, authors demonstrate that this fragment library falls within desirable physicochem. space for FBDD applications. After reading the article, we found that the author used 4-Iodopyridine(cas: 15854-87-2Related Products of 15854-87-2)

4-Iodopyridine(cas: 15854-87-2) belongs to pyridine. In industry and in the lab, pyridine is used as a reaction solvent, particularly when its basicity is useful, and as a starting material for synthesizing some herbicides, fungicides, and antiseptics.Related Products of 15854-87-2

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

In 2019,ACS Catalysis included an article by Lin, Hua; Pan, Xiaohong; Barsamian, Adam L.; Kamenecka, Theodore M.; Bannister, Thomas D.. HPLC of Formula: 624-31-7. The article was titled 《Native Directed Site-Selective δ-C(sp3)-H and δ-C(sp2)-H Arylation of Primary Amines》. The information in the text is summarized as follows:

A Pd(II)-catalyzed, selective δ-C(sp3)-H and δ-C(sp2)-H arylation method for free primary aliphatic amines using NH2 as a native directing group has been developed. A variety of free primary amines with adjacent quaternary centers and/or with alpha esters react with a diverse range of aryl and heteroaryl iodides to provide δ-aryl and δ-heteroaryl amines. In the experiment, the researchers used 1-Iodo-4-methylbenzene(cas: 624-31-7HPLC of Formula: 624-31-7)

1-Iodo-4-methylbenzene(cas: 624-31-7) undergoes Suzuki-Miyaura coupling reaction with phenylboronic acid catalyzed by (Ni,Mg)3Si2O5(OH)4 solid-solution nanotubes loaded with palladium.HPLC of Formula: 624-31-7

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

In 2018,Klein, Eugen; Heymann, Leonard; Hungria, Ana B.; Lesyuk, Rostyslav; Klinke, Christian published 《Colloidal lead iodide nanorings》.Nanoscale published the findings.Application of 624-73-7 The information in the text is summarized as follows:

Colloidal chem. of nanomaterials experienced a tremendous development in the last decades. In the course of the journey 0D nanoparticles, 1D nanowires, and 2D nanosheets have been synthesized. They have in common to possess a simple topol. We present a colloidal synthesis strategy for lead iodide nanorings, with a non-trivial topol. First, two-dimensional structures were synthesized in nonanoic acid as the sole solvent. Subsequently, they underwent an etching process in the presence of trioctylphosphine, which determines the size of the hole in the ring structure. We propose a mechanism for the formation of lead iodide nanosheets which also explains the etching of the two-dimensional structures starting from the inside, leading to nanorings. In addition, we demonstrate a possible application of the as-prepared nanorings in photodetectors. These devices are characterized by a fast response, high gain values, and a linear relation between photocurrent and incident light power intensity over a large range. The synthesis approach allows for inexpensive large-scale production of nanorings with tunable properties. In the part of experimental materials, we found many familiar compounds, such as 1,2-Diiodoethane(cas: 624-73-7Application of 624-73-7)

1,2-Diiodoethane(cas: 624-73-7) is one of organic iodides. Alkyl iodides react at a faster rate than alkyl fluorides due to the weak C-I bond. Iodo alkanes participate in a variety of organic synthesis reactions, which include the Simmons–Smith reaction (cyclopropanation using iodomethane), Williamson ether synthesis, Wittig reaction, Grignard reaction, alkyl coupling reactions, and Wurtz reaction.Application of 624-73-7

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

In 2022,Adachi, Yohei; Kondo, Keisuke; Yin, Xiaodong; Jakle, Frieder; Ohshita, Joji published an article in Polymer. The title of the article was 《m-Phenylene linked macrocycle composed of electron-rich dithienogermole and electron-deficient tricoordinate boron units》.Electric Literature of C6H4BrI The author mentioned the following in the article:

Incorporation of non-conventional elements into π-conjugated systems is a powerful tool to control the electronic structures. In this work, electron-deficient tricoordinate boron units were combined with electron-rich dithienogermole units to provide an element-hybrid conjugated macrocycle with m-phenylene linkers. In contrast to the absorption spectra which were unaffected by solvent polarity, the element-hybrid macrocycle exhibited clear solvatochromism in the fluorescence spectra originating from the charge transfer (CT) transition between the dithienogermole and tricoordinate boron units. The addition of fluoride to the solution of the macrocycle resulted in the stoichiometric formation of tetracoordinate borate species. Interestingly, the fluorescence was intensified by the addition of fluoride, and the mechanism was confirmed by fluorescence spectroscopy and TD-DFT calculations In addition to this study using 1-Bromo-3-iodobenzene, there are many other studies that have used 1-Bromo-3-iodobenzene(cas: 591-18-4Electric Literature of C6H4BrI) was used in this study.

1-Bromo-3-iodobenzene(cas: 591-18-4) has been used in the preparation of 1-(3′-bromophenyl)-3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,10-heptadecafluorodec-1-ene and 1-(3′-bromophenyl)-3,3,4,4,5,5,6,6,7,7,8,8,8-tridecafluorooct-1-ene.Electric Literature of C6H4BrI

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

In 2022,He, Hua-Feng; Wang, Yuwan; Zou, Chun; Tu, Zheng; Xu, Yongquan; Yin, Junfeng published an article in ACS Omega. The title of the article was 《Ag2O-mediated Tandem Reaction between Terminal Alkyne and o-Iodibenzoic Acid: Construction of 3-Ethylideneisobenzofuran-1(3H)-ones》.Application In Synthesis of 2-Iodobenzoic acid The author mentioned the following in the article:

Taking aryl propargyl ether and o-iodibenzoic acid as substrates, a series of aryl cyclolactones bearing an exocyclized C=C bond were constructed with moderate to good yields. Diverse substituent groups could be tolerant in the reaction, which indicated excellent compatibility of the reaction. In this tandem reaction, Ag2O was employed as the media and Et3N was screened as the base to facilitate the reaction. A concise mechanism was proposed on the basis of the expansion of the substrates and theor. anal. Sonogashira type coupling coupled with intramol. nucleophilic addition in one pot to construct the product, 3-ethylideneisobenzofuran-1(3H)-one.2-Iodobenzoic acid(cas: 88-67-5Application In Synthesis of 2-Iodobenzoic acid) was used in this study.

2-Iodobenzoic acid(cas: 88-67-5) belongs to organic iodides. Generally organic iodides can be divided into two classes of alkyl iodides and aryl iodides. Typical reactions of alkyl iodides include nucleophilic substitution, elimination, reduction, and the formation of organometallics.Application In Synthesis of 2-Iodobenzoic acid

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

In 2022,Tang, Baoxin; Hua, Ruimao published an article in Molecules. The title of the article was 《Cu(I)/Pd(II)-Catalyzed Intramolecular Hydroamidation and C-H Dehydrogenative Coupling of ortho-Alkynyl-N-arylbenzamides for Access to Isoindolo[2,1-a]Indol-6-Ones》.Quality Control of 2-Iodobenzoic acid The author mentioned the following in the article:

An efficient, atom-economic and one-pot synthesis of isoindolo[2,1-a]indol-6-ones I [R = H, 9-F, 9-MeO; R1 = H, 2-Me, 2-i-Pr, 2-MeO, 2-CF3, 2-CN; Ar = Ph, 2-MeC6H4, 4-MeOC6H4, etc.] via CuI/Pd(OAc)2-catalyzed intramol. hydroamidation of alkynyl group, and C-H dehydrogenative coupling of ortho-alkynyl-N-arylbenzamides had been developed. This transformation occurs with the use of oxygen as the oxidant, and water was the only byproduct. The reaction showed a high tolerance to a variety of functional groups, and affords isoindolo[2,1-a]indol-6-ones I in good to high yields. The experimental part of the paper was very detailed, including the reaction process of 2-Iodobenzoic acid(cas: 88-67-5Quality Control of 2-Iodobenzoic acid)

2-Iodobenzoic acid(cas: 88-67-5) belongs to organic iodides. The carbon-iodine bond is weaker than other carbon-halogen bonds due to the poor electronegative nature of the iodine atom. Alkyl iodides react at a faster rate than alkyl fluorides due to the weak C-I bond.Quality Control of 2-Iodobenzoic acid

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Dalal, Arup; Babu, Srinivasarao Arulananda published their research in Synthesis in 2021. The article was titled 《Pd(II)-Catalyzed Directing-Group-Aided C-H Arylation and Alkylation of Pyrene Core: Synthesis of C1,C2- and C1,C10-Disubstituted Pyrene Motifs》.Related Products of 625-99-0 The article contains the following contents:

The application of the Pd(II)-catalyzed, directing-group-aided C-H arylation/alkylation tactics to functionalize the pyrene core, especially, the relatively inaccessible C2 I (R = H; R1 = quinolin-8-yl, 2-(methylsulfanyl)phenyl) and K-region C10 II (R2 = H) positions of the pyrene core and augmentation of the library of pyrene derivatives with C1,C2- I (R = Ph, 2,3-dihydro-1,4-benzodioxin-6-yl, thiophen-2-yl, etc.) and C1,C10-disubstituted pyrene II (R2 = 3,4-dimethylphenyl, 5-bromopyridin-2-yl, Ph, etc.) motifs was reported. The Pd(II)-catalyzed β-C-H arylation/alkylation of the C2-position of pyrene-1-carboxamide I possessing an 8-aminoquinoline directing group yielded various C1,C2-disubstituted pyrenes I. Similarly, the Pd(II)-catalyzed selective γ-C-H arylation/alkylation of the C10-position of N-(pyren-1-yl)picolinamide, possessing a picolinamide directing group, yielded various C1,C10-disubstituted pyrenes II. Examples of C(9)-H arylation of pyrene-1-carboxamide I (R1 = tert-butyl) and the removal of the directing group after the C-H arylation/alkylation reactions were also shown. The structures of representative pyrene derivatives were confirmed by the X-ray structure anal. Given the importance of the pyrene derivatives in various fields of chem. sciences, this report is a contribution towards augmentation of the library of pyrene derivatives with C1,C2- I and C1,C10-disubstituted pyrene amide motifs II. The experimental part of the paper was very detailed, including the reaction process of 1-Chloro-3-iodobenzene(cas: 625-99-0Related Products of 625-99-0)

1-Chloro-3-iodobenzene(cas: 625-99-0) belongs to organic iodides. Alkyl iodides react at a faster rate than alkyl fluorides due to the weak C-I bond.Iodo alkanes participate in a variety of organic synthesis reactions, which include the Simmons–Smith reaction (cyclopropanation using iodomethane), Williamson ether synthesis, Wittig reaction, Grignard reaction, alkyl coupling reactions, and Wurtz reaction.Related Products of 625-99-0

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

《Gold(I)-catalyzed domino reaction for furopyrans synthesis》 was written by Ruch, Marie; Brach, Nicolas; Galea, Romeric; Wagner, Patrick; Blond, Gaelle. Recommanded Product: 1-Bromo-3-iodobenzene And the article was included in Molecules in 2020. The article conveys some information:

Herein an efficient synthesis of furopyran derivatives through a gold(I)-catalyzed domino reaction were reported. The cascade reaction started with two regioselective cyclizations, a 5-endo-dig and a 8-endo-dig, followed with a Grob-type ragmentation and a hetero Diels-Alder. The obtained furopyran derivatives contain fused and spiro-heterocycles. During this one-pot process, four bonds and four controlled stereogenic centers including a quaternary center were formed.1-Bromo-3-iodobenzene(cas: 591-18-4Recommanded Product: 1-Bromo-3-iodobenzene) was used in this study.

1-Bromo-3-iodobenzene(cas: 591-18-4) has been used in the preparation of 1-(3′-bromophenyl)-3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,10-heptadecafluorodec-1-ene and 1-(3′-bromophenyl)-3,3,4,4,5,5,6,6,7,7,8,8,8-tridecafluorooct-1-ene.Recommanded Product: 1-Bromo-3-iodobenzene

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

《Alkyl Tosylates as Alkylating Reagents in the Catellani Reaction》 was published in Synthesis in 2020. These research results belong to Gao, Qianwen; Liu, Ze-Shui; Hua, Yu; Zhou, Siwei; Cheng, Hong-Gang; Zhou, Qianghui. Recommanded Product: 1-Iodonaphthalene The article mentions the following:

A cooperative catalytic system involving a Pd/XPhos complex and inexpensive 5-norbornene-2-carbonitrile that enabled the use of alkyl tosylates as alkylating reagents in the Catellani reaction was developed. This mild, scalable protocol was compatible with a range of readily available functionalized aryl iodides and alkyl tosylates, as well as terminating olefins (45 examples, up to 97% yield). The experimental part of the paper was very detailed, including the reaction process of 1-Iodonaphthalene(cas: 90-14-2Recommanded Product: 1-Iodonaphthalene)

1-Iodonaphthalene(cas: 90-14-2) is one of organic iodides. Organic iodides are used in veterinary products (Organic Iodide Powder) as a nutritional source of iodine. In the chemical industry, alkyl iodides serve as excellent alkylating agents and, specifically, methyl iodide is used as a methylating agent in the synthesis of various pharmaceutical drugs. Oceanic alkyl iodides are believed to be the principal source of atmospheric iodine.Recommanded Product: 1-Iodonaphthalene

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com