Tag: 200-300

In 2019,Organic Letters included an article by Chen, Pu; Nan, Jiang; Hu, Yan; Ma, Qiong; Ma, Yangmin. Category: iodides-buliding-blocks. The article was titled 《RuII-Catalyzed/NH2-Assisted Selective Alkenyl C-H [5 + 1] Annulation of Alkenylanilines with Sulfoxonium Ylides to Quinolines》. The information in the text is summarized as follows:

A novel ruthenium-catalyzed [5 + 1] annulation of 2-alkenylanilines with sulfoxonium ylides was developed for the rapid assembly of highly functionalized quinolines. This new catalytic process employs challenging but synthetically ideal free amino functionality to achieve alkenyl C-H activation with sulfoxonium ylides as one-carbon coupling partners. Various 2-acylquinolines could be obtained with good yields and excellent functional group tolerance. Moreover, the potential synthetic application of this methodol. was exemplified by several chem. transformations. After reading the article, we found that the author used Trimethylsulfoxonium iodide(cas: 1774-47-6Category: iodides-buliding-blocks)

Trimethylsulfoxonium iodide(cas: 1774-47-6) is a sulfoxonium salt. It is used to generate dimethyloxosulfonium methylide by reaction with sodium hydride. The latter compound is used as a methylene-transfer reagent, and is used to prepare epoxides.Category: iodides-buliding-blocks

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

《Trifluoromethylation of Benzoic Acids: An Access to Aryl Trifluoromethyl Ketones》 was written by Liu, Xue; Liu, Long; Huang, Tianzeng; Zhang, Jingjing; Tang, Zhi; Li, Chunya; Chen, Tieqiao. Electric Literature of C7H5IO2This research focused ontrifluoromethyl ketone preparation green chem; benzoic acid trifluoromethyltrimethylsilane trifluoromethylation nucleophilic substitution. The article conveys some information:

The trifluoromethylation of benzoic acids with TMSCF3 was achieved through nucleophilic substitution with the use of anhydrides as an in situ activating reagent. Under the reaction conditions, a wide range of carboxylic acids including the bioactive ones worked well, thus providing a facile and efficient method for preparing aryl trifluoromethyl ketones from the readily available starting materials. In the part of experimental materials, we found many familiar compounds, such as 4-Iodobenzoic acid(cas: 619-58-9Electric Literature of C7H5IO2)

4-Iodobenzoic acid(cas: 619-58-9) belongs to organic iodides. Organic iodides are used in veterinary products (Organic Iodide Powder) as a nutritional source of iodine.Electric Literature of C7H5IO2 In the chemical industry, alkyl iodides serve as excellent alkylating agents and, specifically, methyl iodide is used as a methylating agent in the synthesis of various pharmaceutical drugs.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Synthetic Route of C6H5ClINIn 2022 ,《Recyclable Palladium-Catalyzed Carbonylative Coupling of 2-Iodoanilines, Trimethyl Orthoformate, and Amines: A Practical Synthesis of Quinazolin-4(3H)-ones》 appeared in Synthesis. The author of the article were Li, Jianying; Zhou, Zebiao; Xie, Gang; Cai, Mingzhong. The article conveys some information:

An efficient heterogeneous palladium-catalyzed carbonylative annulation of 2-iodoanilines, tri-Me orthoformate, and amines has been developed. The reaction proceeds smoothly in toluene at 110°C using N,N-diisopropylethylamine (DiPEA) as base and 2 mol% of MCM-41-anchored bidentate phosphine palladium complex [MCM-41-2P-Pd(OAc)2] as catalyst under 10 bar of carbon monoxide and provides a general and practical method for the construction of a wide variety of quinazolin-4(3H)-ones in good to excellent yields from com. easily available starting materials. This heterogenized palladium catalyst can be easily recovered via a simple centrifugation process and reused more than nine times with almost consistent catalytic efficiency. The experimental process involved the reaction of 4-Chloro-2-iodoaniline(cas: 63069-48-7Synthetic Route of C6H5ClIN)

4-Chloro-2-iodoaniline(cas: 63069-48-7) belongs to anime. Acylation is one of the most important reactions of primary and secondary amines; a hydrogen atom is replaced by an acyl group (a group derived from an acid, such as RCOOH or RSO3H, by removal of ―OH, such as RC(=O)―, RS(O)2―, and so on). Reagents may be acid chlorides (RCOC1, RSO2C1), anhydrides ((RCO)2O), or even esters (RCOOR′); the products are amides of the corresponding acids.Synthetic Route of C6H5ClIN

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

In 2022,Li, Zhijun; Zhang, Mingyang; Zhang, Lili; Dong, Xiuli; Leng, Leipeng; Horton, J. Hugh; Wang, Jun published an article in Nano Research. The title of the article was 《Engineering the atomic interface of porous ceria nanorod with single palladium atoms for hydrodehalogenation reaction》.Name: 3-Iodophenol The author mentioned the following in the article:

Tuning the electronic properties of single atom catalysts (SACs) between the central metal and the neighboring surface atoms has emerged as an efficient strategy to boost catalytic efficiency and metal utilization. Here we describe a simple and efficient approach to create atomically dispersed palladium atoms supported over defect-contg porous ceria nanorod contg palladium up to 0.26 weight The existence of singly dispersed palladium atoms is confirmed by spherical aberration correction electron microscopy and extended X-ray absorption fine structure measurements. This catalyst shows excellent efficiency in hydrodehalogenation reactions at low H2 pressure under mild conditions, along with satisfactory recyclability and scalability. D. functional theory (DFT) calculations reveal that the high activity stems from the spatial isolation of palladium atoms and the modified electronic structure of palladium confined in defect-containing ceria nanorod. This work may lay the foundation for the facile creation of single atom catalysts within the synthetic community and shed light on the possibility for scale-up prodn graphic not available see fulltext. The results came from multiple reactions, including the reaction of 3-Iodophenol(cas: 626-02-8Name: 3-Iodophenol)

3-Iodophenol(cas: 626-02-8) belongs to organic iodides. Generally organic iodides can be divided into two classes of alkyl iodides and aryl iodides. Typical reactions of alkyl iodides include nucleophilic substitution, elimination, reduction, and the formation of organometallics.Name: 3-IodophenolHalogenation of aromatic hydrocarbons is a very important reaction via an electrophilic aromatic substitution.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

In 2022,Das, Ashis; Buzzetti, Luca; Purins, Mikus; Waser, Jerome published an article in ACS Catalysis. The title of the article was 《Palladium-Catalyzed trans-Hydroalkoxylation: Counterintuitive Use of an Aryl Iodide Additive to Promote C-H Bond Formation》.Application In Synthesis of 1-Chloro-3-iodobenzene The author mentioned the following in the article:

Authors report an enantioselective palladium-catalyzed trans-hydroalkoxylation of propargylic amines with a trifluoroacetaldehyde-derived tether to build chiral oxazolidines. Diastereoselective hydrogenation using a heterogeneous palladium catalyst then gave access to protected benzylic amino alcs. in 45-87% yields and 84-94% ee values. Hydroalkoxylation of the alkynes required a catalytic amount of aryl iodide, highlighting the counterintuitive key role played by a putative Pd(II)/ArI oxidative addition complex to promote oxypalladation/protodemetalation. In the experiment, the researchers used many compounds, for example, 1-Chloro-3-iodobenzene(cas: 625-99-0Application In Synthesis of 1-Chloro-3-iodobenzene)

1-Chloro-3-iodobenzene(cas: 625-99-0) belongs to organic iodides. Generally organic iodides can be divided into two classes of alkyl iodides and aryl iodides. Typical reactions of alkyl iodides include nucleophilic substitution, elimination, reduction, and the formation of organometallics.Application In Synthesis of 1-Chloro-3-iodobenzeneHalogenation of aromatic hydrocarbons is a very important reaction via an electrophilic aromatic substitution.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

In 2022,Smolkin, Boris; Levi, Noam; Chen, Ravit published an article in ACS Omega. The title of the article was 《Efficient Decontamination of HD by an Electrophilic Iodine/Carboxylate Composite as an Active Sorbent》.HPLC of Formula: 516-12-1 The author mentioned the following in the article:

The development of new and efficient decontamination methods has become more relevant in recent years, especially with regard to solid-based decontamination and detoxification systems. The majority of powders used today are dealing with the phys. adsorption of chem. warfare agents (CWAs) and their removal from sites without actively destroying them. In this work, we have designed and developed an active solid composite matrix combining organic carboxylate salts and N-iodosuccinimide (NIS) for HD decontamination via oxidation All the reactions and mechanistic studies for the sorption and degradation of CWAs were conducted using direct polarization and cross polarization solid-state magic-angle spinning NMR techniques. Performance toward the sorption and detoxification of HD was tested, exhibiting oxidation within minutes in a mild and selective manner to the nontoxic sulfoxide derivative followed by visible formation of iodine. The results indicate that carboxylate moieties in the matrix are important for stabilizing the pos. charged sulfonium ion intermediate and for supplying oxygen for hydrolysis in a water-deficient environment. The NaOBz/NIS composite was shown to be the most efficient in sorbing and converting the water-insoluble agent HD to its nontoxic, water-soluble sulfoxide, which could then be removed from the site with mere water, resulting in less environmental damage and quick remediation. In the experiment, the researchers used many compounds, for example, 1-Iodopyrrolidine-2,5-dione(cas: 516-12-1HPLC of Formula: 516-12-1)

1-Iodopyrrolidine-2,5-dione(cas: 516-12-1) is used in the preparation of vinyl sulfones from olefins and benzenesulfinic acid. It acts as a source for I+ and involved in Hunsdiecker reactions for the conversion of cinnamic acids, and propiolic acids to the corresponding alfa-halostyrenes and 1-halo-1-alkynes respectively. HPLC of Formula: 516-12-1

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Hong, Chao; Yu, Shuling; Liu, Zhanxiang; Zhang, Yuhong published an article in 2021. The article was titled 《Rhodium(III)-catalyzed annulation of enamides with sulfoxonium ylides toward isoquinolines》, and you may find the article in RSC Advances.Synthetic Route of C3H9IOS The information in the text is summarized as follows:

An efficient rhodium(III)-catalyzed C-H activation followed by intermol. annulation between enamides and sulfoxonium ylides had been developed. The transformation proceeded smoothly with a broad range of substrates, affording a series of isoquinoline derivatives I [R = Ph, 4-BrC6H4, 2-furyl, etc.; R1 = H, 6-F, 8-MeO, etc; R2 = H, Me, Ph] in moderate to good yields under additive-free conditions. In addition to this study using Trimethylsulfoxonium iodide, there are many other studies that have used Trimethylsulfoxonium iodide(cas: 1774-47-6Synthetic Route of C3H9IOS) was used in this study.

Trimethylsulfoxonium iodide(cas: 1774-47-6) reacts with sodium hydride to prepare dimethyloxosulfonium methylide, which is used as a methylene-transfer reagent in synthetic chemistry. It is used to prepare ylide, which reacts with carbonyl compounds to get epoxides.Synthetic Route of C3H9IOS

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Wen, Si; Tian, Qingyu; Chen, Yanhui; Zhang, Yuqing; Cheng, Guolin published their research in Organic Letters in 2021. The article was titled 《Annulation of CF3-Imidoyl Sulfoxonium Ylides with 1,3-Dicarbonyl Compounds: Access to 1,2,3-Trisubstituted 5-Trifluoromethylpyrroles》.Category: iodides-buliding-blocks The article contains the following contents:

A lithium-bromide-promoted nucleophilic substitution/annulation cascade reaction between CF3-imidoyl sulfoxonium ylides and 1,3-dicarbonyl compounds was established and the corresponding 1,2,3-trisubstituted 5-trifluoromethylpyrroles was obtained in 27-78% yield. This reaction features a broad substrate scope and generated DMSO and H2O as byproducts. After reading the article, we found that the author used Trimethylsulfoxonium iodide(cas: 1774-47-6Category: iodides-buliding-blocks)

Trimethylsulfoxonium iodide(cas: 1774-47-6) reacts with sodium hydride to prepare dimethyloxosulfonium methylide, which is used as a methylene-transfer reagent in synthetic chemistry. It is used to prepare ylide, which reacts with carbonyl compounds to get epoxides. Further, it reacts with alfa,beta-unsaturated esters to get cyclopropyl esters.Category: iodides-buliding-blocks

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

You, Shengyong; Zhang, Rongli; Cai, Mingzhong published their research in Synthesis in 2021. The article was titled 《A Magnetically Recyclable Palladium-Catalyzed Formylation of Aryl Iodides with Formic Acid as CO Source: A Practical Access to Aromatic Aldehydes》.Application In Synthesis of 3-Iodophenol The article contains the following contents:

A magnetically recyclable palladium-catalyzed formylation of aryl iodides ArI (Ar = C6H5, 3-pyridyl, 2-furyl, etc.) under CO gas-free conditions has been developed by using a bidentate phosphine ligand-modified magnetic nanoparticles-anchored palladium(II) complex [2P-Fe3O4@SiO2-Pd(OAc)2] as catalyst, yielding a wide variety of aromatic aldehydes ArCHO in moderate to excellent yields. Here, formic acid was employed as both the CO source and the hydrogen donor with iodine and PPh3 as the activators. This immobilized palladium catalyst can be obtained via a simple preparative procedure and facilely recovered simply by using an external magnetic field, and reused at least 9 times without any apparent loss of catalytic activity. In the experimental materials used by the author, we found 3-Iodophenol(cas: 626-02-8Application In Synthesis of 3-Iodophenol)

3-Iodophenol(cas: 626-02-8) belongs to organic iodides. The carbon-iodine bond is weaker than other carbon-halogen bonds due to the poor electronegative nature of the iodine atom. Application In Synthesis of 3-Iodophenol Alkyl iodides react at a faster rate than alkyl fluorides due to the weak C-I bond.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

The author of 《One-step synthesis of self-supported Ni3S2/NiS composite film on Ni foam by electrodeposition for high-performance supercapacitors》 were Huang, Haifu; Deng, Xiaoli; Yan, Liqing; Wei, Geng; Zhou, Wenzheng; Liang, Xianqing; Guo, Jin. And the article was published in Nanomaterials in 2019. SDS of cas: 516-12-1 The author mentioned the following in the article:

Herein, a facile one-step electrodeposition route was presented for preparing Ni3S2/NiS composite film on Ni foam substrate (denoted as NiSx/NF). The NiSx granular film is composed of mangy interconnected ultra-thin NiSx nanoflakes with porous structures. When applied as electrodes for supercapacitors, the ultra-thin nanoflakes can provide more active sites for redox reaction, and the interconnected porous structure has an advantage for electrolyte ions to penetrate into the inner space of active materials quickly. As expected, the obtained NiSx/NF sample exhibited high gravimetric capacitance of 1649.8 F·g-1 and areal capacitance of 2.63 F·cm-1. Furthermore, a gravimetric capacitance of 1120.1 F·g-1 can be maintained at a high c.d. of 20 mA·cm-1, suggesting a good rate capability. The influence of the different molar ratios of electrodeposition electrolyte (NiNO3 and thiourea) on the morphol. and electrochem. properties of NiSx/NF sample was investigated to provide an optimum route for one-step electrodeposition of Ni3S2/NiS composite film. The outstanding performance indicated the Ni3S2/NiS composite film on Ni foam has great potential as an electrode material for supercapacitors. In the experiment, the researchers used 1-Iodopyrrolidine-2,5-dione(cas: 516-12-1SDS of cas: 516-12-1)

1-Iodopyrrolidine-2,5-dione(cas: 516-12-1) is used in the preparation of vinyl sulfones from olefins and benzenesulfinic acid. It acts as a source for I+ and involved in Hunsdiecker reactions for the conversion of cinnamic acids, and propiolic acids to the corresponding alfa-halostyrenes and 1-halo-1-alkynes respectively. SDS of cas: 516-12-1

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com