Tag: 200-300

Application of 624-73-7In 2020 ,《Dehydroxylative Fluorination of Tertiary Alcohols》 was published in Organic Letters. The article was written by Zhang, Wei; Gu, Yu-Cheng; Lin, Jin-Hong; Xiao, Ji-Chang. The article contains the following contents:

A large number of fluorination methods have been developed, but the construction of a tertiary C-F bond remains challenging. Herein, we describe an efficient dehydroxylative fluorination of tertiary alcs. with Selectfluor via the activation of a hydroxyl group by a Ph2PCH2CH2PPh2/ICH2CH2I system. Although the reagents appear to be not compatible (Selectfluor with the phosphine and I- generated in situ), the reactions occur rapidly to give the desired products in moderate to high yields. This work may present a new discovery in fluorination of alcs. since the reported methods are mainly limited to primary and secondary alcs. The experimental part of the paper was very detailed, including the reaction process of 1,2-Diiodoethane(cas: 624-73-7Application of 624-73-7)

1,2-Diiodoethane(cas: 624-73-7) is one of organic iodides. The carbon-iodine bond is weaker than other carbon-halogen bonds due to the poor electronegative nature of the iodine atom. In general, organic iodides are light-sensitive and turn yellow during storage, owing to the formation of iodine. Organic iodides can be alkyl, alkenyl, or alkynyl, and all of them are very reactive toward with many kinds of nucleophiles.Application of 624-73-7

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Electric Literature of C6H5IOIn 2021 ,《SuFExable polymers with helical structures derived from thionyl tetrafluoride》 was published in Nature Chemistry. The article was written by Li, Suhua; Li, Gencheng; Gao, Bing; Pujari, Sidharam P.; Chen, Xiaoyan; Kim, Hyunseok; Zhou, Feng; Klivansky, Liana M.; Liu, Yi; Driss, Hafedh; Liang, Dong-Dong; Lu, Jianmei; Wu, Peng; Han, Zuilhof; Moses, John; Sharpless, K. Barry. The article contains the following contents:

Sulfur(VI) fluoride exchange (SuFEx) is a category of click chem. that enables covalent linking of modular units through sulfur(VI) connective hubs. The efficiency of SuFEx and the stability of the resulting bonds have led to polymer chem. applications. Now, we report the SuFEx click chem. synthesis of several structurally diverse SOF4-derived copolymers based on the polymerization of bis(iminosulfur oxydifluorides) and bis(aryl silyl ethers). This polymer class presents two key characteristics. First, the [-N=S(=O)F-O-] polymer backbone linkages are themselves SuFExable and undergo precise SuFEx-based post-modification with phenols or amines to yield branched functional polymers. Second, studies of individual polymer chains of several of these new materials indicate helical polymer structures. The robust nature of SuFEx click chem. offers the potential for post-polymerization modification, enabling the synthesis of materials with control over composition and conformation. After reading the article, we found that the author used 3-Iodophenol(cas: 626-02-8Electric Literature of C6H5IO)

3-Iodophenol(cas: 626-02-8) belongs to organic iodides. Organic iodides are used in veterinary products (Organic Iodide Powder) as a nutritional source of iodine.Electric Literature of C6H5IO In the chemical industry, alkyl iodides serve as excellent alkylating agents and, specifically, methyl iodide is used as a methylating agent in the synthesis of various pharmaceutical drugs.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Computed Properties of C7H5IO2In 2019 ,《Influence of strong electron donating nature of phenothiazine on A3B- type porphyrin based dye sensitized solar cells》 appeared in Solar Energy. The author of the article were Duvva, Naresh; Prasanthkumar, Seelam; Giribabu, Lingamallu. The article conveys some information:

Structural modifications of porphyrin sensitizers have shown significant impact on incident photon to current generation while applied into dye sensitized solar cells. Nevertheless, various positional alterations of donor/acceptors attached porphyrin dyes reported until now in which A3B based sensitizers received much attention in DSSCs. Herein, we reported A3B type hexyl-phenothiazine appended porphyrins (G10 and G11) utilized as sensitizer with liquid redox electrolyte results the efficiency of 5.4% which is highest performance amongst A3B type sensitizers reported. Optical and electrochem. properties of G10 and G11 suggested that photoinduced intramol. electron transfer mechanism occurred from donor hexyl-phenothiazine to acceptor acetic acid via porphyrin macrocycle. D. functional theory calculations revealed that lowest occupied MO of dyes close to the conduction band of TiO2 facilitates efficient electron injection from dye to nanoparticles. Incident photon to electron conversion efficiency (IPCE) spectra and J-V curve of dyes depict broad band from 350 to 750 nm in the range of >50-55% as a result power conversion efficiency (η) of 5.11-5.40%. Therefore, design of diverse mol. structures pave the way for improved efficiency and durability of photovoltaic devices. After reading the article, we found that the author used 4-Iodobenzoic acid(cas: 619-58-9Computed Properties of C7H5IO2)

4-Iodobenzoic acid(cas: 619-58-9) belongs to organic iodides. The carbon-iodine bond is weaker than other carbon-halogen bonds due to the poor electronegative nature of the iodine atom. Computed Properties of C7H5IO2 Alkyl iodides react at a faster rate than alkyl fluorides due to the weak C-I bond.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

In 2022,Hosseini, S. Sina; Abdi, Aida; Nikbakht, Ali; Bijanzadeh, Hamid Reza; Rominger, Frank; Werz, Daniel B.; Balalaie, Saeed published an article in Synlett. The title of the article was 《Hydrothiolation of Donor-Acceptor Cyclopropanes through Er(OTf)3-Promoted Three-Component Ring-Opening Reaction》.COA of Formula: C3H9IOS The author mentioned the following in the article:

A novel ring-opening reaction of donor-acceptor cyclopropanes (DACs) I (R = Ph, 2-phenylethenyl, furan-2-yl, etc.) through a one-pot three-component nucleophilic addition of amines R1R2NH [R1 = R2 = CH2CH=CH2, CH2CH3; R1R2 = -(CH2)5-, -(CH2)2O(CH2)2-, -(CH2)2N(CH3)(CH2)2-], CS2, and DACs has been described. New γ-dithiocarbamate dialkyl malonate skeletons R1R2C(S)SCH(R)CH2CH((C(O)OR1)2) were obtained in up to 97% yield. After reading the article, we found that the author used Trimethylsulfoxonium iodide(cas: 1774-47-6COA of Formula: C3H9IOS)

Trimethylsulfoxonium iodide(cas: 1774-47-6) reacts with sodium hydride to prepare dimethyloxosulfonium methylide, which is used as a methylene-transfer reagent in synthetic chemistry. It is used to prepare ylide, which reacts with carbonyl compounds to get epoxides. Further, it reacts with alfa,beta-unsaturated esters to get cyclopropyl esters.COA of Formula: C3H9IOS

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

In 2022,He, Dandan; Zhong, Wentao; Zhou, Miaomiao; Wang, Bowen; Li, Meng; Jiang, Huanfeng; Wu, Wanqing published an article in Organic Letters. The title of the article was 《Palladium-Catalyzed Regio- and Stereoselective Coupling of Alkynylsulfones with Alkenes: Access to Dichlorinated Vinyl Sulfones》.COA of Formula: C6H4ClI The author mentioned the following in the article:

A palladium-catalyzed coupling reaction of alkynylsulfones with alkenes/ester was described, which provided an efficient and practical entry to various functionalized dichlorinated vinyl sulfones I [R1 = H, 4-Me, 3-F, etc.; R2 = Me, Ph, 4-ClC6H4, etc.]. This method featured excellent regio- and stereoselectivities, good functional group compatibility, as well as mild reaction conditions. After reading the article, we found that the author used 1-Chloro-3-iodobenzene(cas: 625-99-0COA of Formula: C6H4ClI)

1-Chloro-3-iodobenzene(cas: 625-99-0) belongs to organic iodides. Alkyl iodides react at a faster rate than alkyl fluorides due to the weak C-I bond.Iodo alkanes participate in a variety of organic synthesis reactions, which include the Simmons–Smith reaction (cyclopropanation using iodomethane), Williamson ether synthesis, Wittig reaction, Grignard reaction, alkyl coupling reactions, and Wurtz reaction.COA of Formula: C6H4ClI

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

In 2022,Chen, Yuli; Yang, Shuai; Zhang, Taojun; Xu, Mengdie; Zhao, Jing; Zeng, Minfeng; Sun, Kailang; Feng, Ruokun; Yang, Zhen; Zhang, Peng; Wang, Baoyi; Cao, Xingzhong published an article in Polymer Testing. The title of the article was 《Positron annihilation study of chitosan and its derived carbon/pillared montmorillonite clay stabilized Pd species nanocomposites》.Recommanded Product: 1-Chloro-3-iodobenzene The author mentioned the following in the article:

To establish the structure-properties relations of an organic polymer-inorganic hybrid nanocomposite, insightful investigation of the mols. packing and interfacial interactions is essential. Positron annihilation lifetime spectroscopy (PALS) has been proven as one of the most suitable technique to characterize the free volume structure (mol. packing) of polymer matrixes. However, most of the attentions were paid limitedly in organic polymer-based hybrid systems rather than inorganic-based hybrid systems. Classic spherical model was the most frequently used model in free volume holes size calculation of polymer matrix. In the present study, mol. level micro-defects within inorganic-based hybrid systems encaging polymers and carbon species, i.e. novel biol. macromols. of chitosan and its derived carbon/Al pillared montmorillonite clay (CS/PILC and CS-derived C/PILC) stabilized palladium species hybrid nanocomposites, have been investigated by PALS. Besides the classic spherical model, cuboidal and cylindrical models were used to evaluate the mols. packing behavior within the interlayer space of PILC matrixes encaging of polymers of CS or CS-derived carbons. The layered porous structure of the nanocomposites was also characterized with other methods, such as X-ray diffraction, N2 adsorption/desorption, and high-resolution transmission electron microscopy, etc. The correlations of the microstructure and catalytic properties applied in Sonogashira coupling reactions of the nanocomposites were discussed. In the experiment, the researchers used 1-Chloro-3-iodobenzene(cas: 625-99-0Recommanded Product: 1-Chloro-3-iodobenzene)

1-Chloro-3-iodobenzene(cas: 625-99-0) belongs to organic iodides. Generally organic iodides can be divided into two classes of alkyl iodides and aryl iodides. Typical reactions of alkyl iodides include nucleophilic substitution, elimination, reduction, and the formation of organometallics.Recommanded Product: 1-Chloro-3-iodobenzeneHalogenation of aromatic hydrocarbons is a very important reaction via an electrophilic aromatic substitution.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

In 2022,Sun, Deli; Tao, Xianghua; Ma, Guobin; Wang, Jifen; Chen, Yunrong published an article in Chemical Science. The title of the article was 《Asymmetric synthesis of aryl/vinyl alkyl carbinol esters via Ni-catalyzed reductive arylation/vinylation of 1-chloro-1-alkanol esters》.Name: 1-Chloro-3-iodobenzene The author mentioned the following in the article:

An asym. Ni-catalyzed cross-electrophile coupling approach to prepare enantioenriched aryl/vinyl alkyl carbinol esters RC(O)OC(R1)R2 [R = 4-methylphenyl, iso-Pr, naphthalen-2-yl, etc.; R1 = 4-(methoxycarbonyl)phenyl, 2H-1,3-benzodioxol-5-yl, cyclopent-1-en-1-yl, etc; R2 = Et, 2-phenylethyl, 4-methoxy-4-oxobutyl, etc.] through arylation/vinylation of easily accessible racemic 1-chloro-1-alkanol esters RC(O)OC(Cl)R2 with aryl/vinyl electrophiles R1X (X = Br, I, OTf) was reported. The method features a broad substrate scope as demonstrated by more than 60 examples including the challenging chiral allylic esters. It tolerates a wide array of functional groups including alkenyl, carbonyl and free hydroxyl groups that may not survive in conventional carbonyl reduction and addition methods. The synthetic utility of the present work was showcased by facile preparation of a few key intermediates and the modification of chiral drugs and naturally occurring compounds Finally, an efficient one-pot procedure for this method was described. In the experimental materials used by the author, we found 1-Chloro-3-iodobenzene(cas: 625-99-0Name: 1-Chloro-3-iodobenzene)

1-Chloro-3-iodobenzene(cas: 625-99-0) belongs to organic iodides. Generally organic iodides can be divided into two classes of alkyl iodides and aryl iodides. Typical reactions of alkyl iodides include nucleophilic substitution, elimination, reduction, and the formation of organometallics.Name: 1-Chloro-3-iodobenzeneHalogenation of aromatic hydrocarbons is a very important reaction via an electrophilic aromatic substitution.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Zhou, Liwei; Qiao, Shujia; Zhou, Fengru; Xuchen, Xinyu; Deng, Guobo; Yang, Yuan; Liang, Yun published an article in 2021. The article was titled 《α-Oxocarboxylic Acids as Three-Carbon Insertion Units for Palladium-Catalyzed Decarboxylative Cascade Synthesis of Diverse Fused Heteropolycycles》, and you may find the article in Organic Letters.Computed Properties of C7H5IO2 The information in the text is summarized as follows:

A novel palladium-catalyzed decarboxylative cascade cyclization for the assembly of diverse fused heteropolycycles by employing α-oxocarboxylic acids as three-carbon insertion units is reported. This protocol enables the synthesis of isoquinolinedione- and indolo[2,1-a]isoquinolinone-fused benzocycloheptanones in moderate to good yields by the use of different aryl iodides, including alkene-tethered 2-iodobenzamides and 2-(2-iodophenyl)-1H-indoles. Notably, the approach achieves simultaneous construction of both six- and seven-membered rings via sequential intramol. carbopalladation, C-H activation, and decarboxylation. The results came from multiple reactions, including the reaction of 2-Iodobenzoic acid(cas: 88-67-5Computed Properties of C7H5IO2)

2-Iodobenzoic acid(cas: 88-67-5) belongs to organic iodides. Alkyl iodides react at a faster rate than alkyl fluorides due to the weak C-I bond.Computed Properties of C7H5IO2Iodo alkanes participate in a variety of organic synthesis reactions, which include the Simmons–Smith reaction (cyclopropanation using iodomethane), Williamson ether synthesis, Wittig reaction, Grignard reaction, alkyl coupling reactions, and Wurtz reaction.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Wang, Jian; Li, Lianjie; Chai, Minxue; Ding, Shumin; Li, Jing; Shang, Yongjia; Zhao, Haixia; Li, Dan; Zhu, Qiang published an article in 2021. The article was titled 《Enantioselective Construction of 1H-Isoindoles Containing Tri- and Difluoromethylated Quaternary Stereogenic Centers via Palladium-Catalyzed C-H Bond Imidoylation》, and you may find the article in ACS Catalysis.Reference of 4-Iodobenzaldehyde The information in the text is summarized as follows:

An intermol. enantioselective synthesis of 1H-isoindoles containing tri- and difluoromethylated quaternary stereogenic centers through a palladium-catalyzed desym. C-H bond imidoylation has been developed. α,α-Diaryl tri- and difluoroethylated isocyanides acted as powerful precursors of chiral 1H-isoindoles, in which the fluoroalkyl group was proven to play a crucial role in both the stereochem. and reaction efficiency. In addition, an allene insertion cascade was realized, offering rapid access to diverse C1-tethered bis-heterocyclic scaffolds with good yields and high enantioselectivities. The reactions proceeded smoothly under mild conditions with low catalyst loadings. The results came from multiple reactions, including the reaction of 4-Iodobenzaldehyde(cas: 15164-44-0Reference of 4-Iodobenzaldehyde)

4-Iodobenzaldehyde(cas: 15164-44-0) is used in synthesis of 4-[2-(trimethylsilyl)ethynyl]benzaldehyde, 5,15-dimesityl-10-(3-[2-(trimethylsilyl)ethynyi]phenyl}-20-(4-iodophenyl)porphyrin, and 5,15-dimesityl-10-[3,5-bis{2-[4-(N,N’-difluoroboryl-1,9-dimethyidipyrrin-5-yl)-phenyl]ethynyl}phenyl]-20-(4-iodophenyl)porphyrin.Reference of 4-Iodobenzaldehyde

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Wang, Lu; Xu, Ting; Rao, Qian; Zhang, Tian-Shu; Hao, Wen-Juan; Tu, Shu-Jiang; Jiang, Bo published an article in 2021. The article was titled 《Photocatalytic Biheterocyclization of 1,7-Diynes for Accessing Skeletally Diverse Tricyclic 2-Pyranones》, and you may find the article in Organic Letters.Synthetic Route of C6H5ClIN The information in the text is summarized as follows:

A new and green route to skeletally diverse oxo-heterocyclic architectures such as pyrano[3,4-c]chromen-2-ones and pyrano[3,4-c]quinolin-2-ones was reported via an unprecedented photocatalytic Kharasch-type cyclization/1,5-(SN”)-substitution/elimination/6π-electrocyclization/double nucleophilic substitution cascade starting from easily available heteroatom-linked 1,7-diynes and low-cost CBrCl3. During this reaction process, the full scission of carbon-halogen bonds of BrCCl3 was realized to directly build two new rings, including a lactone scaffold, using H2O as the oxygen source of the ester group. After reading the article, we found that the author used 4-Chloro-2-iodoaniline(cas: 63069-48-7Synthetic Route of C6H5ClIN)

4-Chloro-2-iodoaniline(cas: 63069-48-7) belongs to anime. Amines can be classified according to the nature and number of substituents on nitrogen. Aliphatic amines contain only H and alkyl substituents. Aromatic amines have the nitrogen atom connected to an aromatic ring.Important amines include amino acids, biogenic amines, trimethylamine, and aniline. Inorganic derivatives of ammonia are also called amines, such as monochloramine (NClH2).Synthetic Route of C6H5ClIN

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com