Tag: 200-300

《Radionuclide molecular imaging of EpCAM expression in triple-negative breast cancer using the scaffold protein DARPin Ec1》 was published in Molecules in 2020. These research results belong to Vorobyeva, Anzhelika; Bezverkhniaia, Ekaterina; Konovalova, Elena; Schulga, Alexey; Garousi, Javad; Vorontsova, Olga; Abouzayed, Ayman; Orlova, Anna; Deyev, Sergey; Tolmachev, Vladimir. Formula: C7H5IO2 The article mentions the following:

Efficient treatment of disseminated triple-neg. breast cancer (TNBC) remains an unmet clin. need. The epithelial cell adhesion mol. (EpCAM) is often overexpressed on the surface of TNBC cells, which makes EpCAM a potential therapeutic target. Radionuclide mol. imaging of EpCAM expression might permit selection of patients for EpCAM-targeting therapies. In this study, we evaluated a scaffold protein, designed ankyrin repeat protein (DARPin) Ec1, for imaging of EpCAM in TNBC. DARPin Ec1 was labeled with a non-residualizing [125I]I-para-iodobenzoate (PIB) label and a residualizing [99mTc]Tc(CO)3 label. Both imaging probes retained high binding specificity and affinity to EpCAM-expressing MDA-MB-468 TNBC cells after labeling. Internalization studies showed that Ec1 was retained on the surface of MDA-MB-468 cells to a high degree up to 24 h. Biodistribution in Balb/c nu/nu mice bearing MDA-MB-468 xenografts demonstrated specific uptake of both [125I]I-PIB-Ec1 and [99mTc]Tc(CO)3-Ec1 in TNBC tumors. [125I]I-PIB-Ec1 had appreciably lower uptake in normal organs compared with [99mTc]Tc(CO)3-Ec1, which resulted in significantly (p < 0.05) higher tumor-to-organ ratios. The biodistribution data were confirmed by micro-Single-Photon Emission Computed Tomog./Computed Tomog. (microSPECT/CT) imaging. In conclusion, an indirectly radioiodinated Ec1 is the preferable probe for imaging of EpCAM in TNBC. In the experiment, the researchers used many compounds, for example, 2-Iodobenzoic acid(cas: 88-67-5Formula: C7H5IO2)

2-Iodobenzoic acid(cas: 88-67-5) belongs to organic iodides. Alkyl iodides react at a faster rate than alkyl fluorides due to the weak C-I bond.Formula: C7H5IO2Iodo alkanes participate in a variety of organic synthesis reactions, which include the Simmons–Smith reaction (cyclopropanation using iodomethane), Williamson ether synthesis, Wittig reaction, Grignard reaction, alkyl coupling reactions, and Wurtz reaction.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

《Visible-Light-Induced, Base-Promoted Transition-Metal-Free Dehalogenation of Aryl Fluorides, Chlorides, Bromides, and Iodides》 was published in Organic Letters in 2020. These research results belong to Ding, Ting-Hui; Qu, Jian-Ping; Kang, Yan-Biao. Related Products of 90-14-2 The article mentions the following:

A simple and efficient visible-light-induced transition-metal-free hydrogenation of aryl halides to afford aromatic compounds The combined visible light and base system was used to initiate the desired radical-mediated hydrogenation. A variety of aryl fluorides, chlorides, bromides and iodides could be reduced to the corresponding (hetero)arenes with excellent yields under mild conditions. Various functional groups and other heterocyclic compounds were tolerated.1-Iodonaphthalene(cas: 90-14-2Related Products of 90-14-2) was used in this study.

1-Iodonaphthalene(cas: 90-14-2) is one of organic iodides. Organic iodides are used in veterinary products (Organic Iodide Powder) as a nutritional source of iodine. In the chemical industry, alkyl iodides serve as excellent alkylating agents and, specifically, methyl iodide is used as a methylating agent in the synthesis of various pharmaceutical drugs. Oceanic alkyl iodides are believed to be the principal source of atmospheric iodine.Related Products of 90-14-2

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

The author of 《Photoinduced Transition-Metal-Free Cross-Coupling of Aryl Halides with H-Phosphonates》 were Zeng, Huiying; Dou, Qian; Li, Chao-Jun. And the article was published in Organic Letters in 2019. Formula: C7H7I The author mentioned the following in the article:

Preparation of arylphosphonates and phosphine oxides ArP(O)X2 (Ar = substituted Ph, naphthyl, biphenyl; X = OMe, OEt, OiPr, aryl) by photoinduced transition-metal- and photosensitizer-free cross-coupling of aryl halides (including Ar-Cl, Ar-Br, and Ar-I) with H-phosphonates (including dialkyl phosphonates and diarylphosphine oxides) is reported. Various functional groups were tolerated, including ester, methoxy, dimethoxy, alkyl, Ph, trifluoromethyl, and heterocyclic compounds This simple and green strategy provides a practical pathway to synthesize arylphosphine oxides. The results came from multiple reactions, including the reaction of 1-Iodo-4-methylbenzene(cas: 624-31-7Formula: C7H7I)

1-Iodo-4-methylbenzene(cas: 624-31-7) is used in wide range of medicals industrial applications as well as in pharmaceutical intermediates, polarizing films for Liquid Crystal Display (LCD) chemicals.Formula: C7H7I

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

The author of 《Trideuteromethylation Enabled by a Sulfoxonium Metathesis Reaction》 were Shen, Zuyuan; Zhang, Shilei; Geng, Huihui; Wang, Jiarui; Zhang, Xinyu; Zhou, Anqi; Yao, Cheng; Chen, Xiaobei; Wang, Wei. And the article was published in Organic Letters in 2019. Product Details of 1774-47-6 The author mentioned the following in the article:

A conceptually novel sulfoxonium metathesis reaction between TMSOI and cost-effective DMSO-d6 is developed for the efficient generation of a new trideuteromethylation reagent TDMSOI. The new reagent TDMSOI is produced highly efficiently by simply heating a mixture of TMSOI and DMSO-d6 and directly used for subsequent trideuteromethylation in a “”one-pot”” operation. The preparative power of the new versatile reagent and the “”one-pot”” protocol is demonstrated by its use to install the -CD3 moiety into broad functionalities including phenols, thiophenols, acidic amines, and enolizable methylene units in high yield and at a useful level of deuteration (>87% D). In the part of experimental materials, we found many familiar compounds, such as Trimethylsulfoxonium iodide(cas: 1774-47-6Product Details of 1774-47-6)

Trimethylsulfoxonium iodide(cas: 1774-47-6) reacts with sodium hydride to prepare dimethyloxosulfonium methylide, which is used as a methylene-transfer reagent in synthetic chemistry. It is used to prepare ylide, which reacts with carbonyl compounds to get epoxides. Further, it reacts with alfa,beta-unsaturated esters to get cyclopropyl esters.Product Details of 1774-47-6

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

The author of 《Synthesis of α-heterosubstituted ketones through sulfur mediated difunctionalization of internal alkynes》 were Zhang, Zhong; Luo, Yuzheng; Du, Hongguang; Xu, Jiaxi; Li, Pingfan. And the article was published in Chemical Science in 2019. Computed Properties of C6H4ClI The author mentioned the following in the article:

Synthesis of α-heterosubstituted ketones was achieved through sulfur mediated difunctionalization of internal alkynes in one-pot. The reaction design involved Ph substituted internal alkyne attacking triflic anhydride activated di-Ph sulfoxide to give a sulfonium vinyl triflate intermediate hydrolysis to give an α-sulfonium ketone and then substitution with various nucleophiles. This method provided a unified route to accessed α-amino ketones, α-acyloxy ketones, α-thio ketones, α-halo ketones, α-hydroxy ketones and related heterocyclic structures in a rapid fashion. The results came from multiple reactions, including the reaction of 1-Chloro-3-iodobenzene(cas: 625-99-0Computed Properties of C6H4ClI)

1-Chloro-3-iodobenzene(cas: 625-99-0) belongs to organic iodides. Organic iodides are used in veterinary products (Organic Iodide Powder) as a nutritional source of iodine.Computed Properties of C6H4ClI In the chemical industry, alkyl iodides serve as excellent alkylating agents and, specifically, methyl iodide is used as a methylating agent in the synthesis of various pharmaceutical drugs.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

The author of 《Rhodium-Catalyzed Reaction of Sulfoxonium Ylides and Anthranils toward Indoloindolones via a (4 + 1) Annulation》 were Wu, Xiaopeng; Xiao, Yan; Sun, Song; Yu, Jin-Tao; Cheng, Jiang. And the article was published in Organic Letters in 2019. SDS of cas: 1774-47-6 The author mentioned the following in the article:

A rhodium-catalyzed annulation between aroyl sulfoxonium ylides and anthranils has been developed to synthesize 10H-indolo[1,2-a]indol-10-one derivatives This reaction started with an unprecedented (4 + 1) annulation toward N-(2-formylphenyl) indolones, proceeding with the sequential ortho-amination of the C-H bond in aroyl sulfoxonium ylides by anthranils and the insertion of N-H to carbene. Finally, the Aldol condensation constructed the second indole ring. This procedure features the formation of two C-N bonds and one C=C bond in one pot. The results came from multiple reactions, including the reaction of Trimethylsulfoxonium iodide(cas: 1774-47-6SDS of cas: 1774-47-6)

Trimethylsulfoxonium iodide(cas: 1774-47-6) is a sulfoxonium salt. It is used to generate dimethyloxosulfonium methylide by reaction with sodium hydride. The latter compound is used as a methylene-transfer reagent, and is used to prepare epoxides.SDS of cas: 1774-47-6

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

In 2019,Organic Letters included an article by Jana, Sripati; Koenigs, Rene M.. Reference of 1-Chloro-3-iodobenzene. The article was titled 《Rhodium-Catalyzed Carbene Transfer Reactions for Sigmatropic Rearrangement Reactions of Selenium Ylides》. The information in the text is summarized as follows:

The rearrangement of selenium ylides is even today almost unexplored, although it would provide access to important organoselenium compounds with broad downstream applications. In this report, the first systematic study of sigmatropic rearrangement reactions of selenium ylides using a simple rhodium catalyst with catalyst loadings as low as 0.01 mol % is described. Selenium oxide pyrolysis of the rearrangement products gives access to important 1,1-disubstituted butadienes. In the experiment, the researchers used 1-Chloro-3-iodobenzene(cas: 625-99-0Reference of 1-Chloro-3-iodobenzene)

1-Chloro-3-iodobenzene(cas: 625-99-0) belongs to organic iodides. The carbon-iodine bond is weaker than other carbon-halogen bonds due to the poor electronegative nature of the iodine atom. In general, organic iodides are light-sensitive and turn yellow during storage, owing to the formation of iodine.Reference of 1-Chloro-3-iodobenzene

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

In 2019,Chemical Science included an article by Huy, Peter H.; Mbouhom, Christelle. Computed Properties of C7H5IO2. The article was titled 《Formamide catalyzed activation of carboxylic acids – versatile and cost-efficient amidation and esterification》. The information in the text is summarized as follows:

A novel, broadly applicable method for amide C-N and ester C-O bond formation is presented based on formylpyrrolidine (FPyr) as a Lewis base catalyst. Herein, trichlorotriazine (TCT), which was the most cost-efficient reagent for OH-group activation, was employed in amounts of ≤40 mol% with respect to the starting material (100 mol%). The new approach is distinguished by excellent cost-efficiency, waste-balance (E-factor down to 3) and scalability (up to >80 g). Moreover, high levels of functional group compatibility, which includes acid-labile acetals 3-R(CH2)2OC6H4C(O)R1 (R = 1,3-dioxan-2-yl; R1 = NHCH2CCH, OCH2CCH) and silyl ethers 3-(CH3)3CSi(CH3)2OC6H4C(O)R2 [R2 = OH, (CH3)3CSi(CH3)2O, C6H5CH2N(CH3)], are demonstrated and even peptide C-N bonds can be formed. In comparison to reported amidation procedures using TCT, yields are considerably improved (for instance from 26 to 91%) and esterification is facilitated for the first time in synthetically useful yields. These significant enhancements are rationalized by activation by means of acid chlorides R3C(O)Cl (R3 = Ph, m-tolyl, o-tolyl, benzyl) instead of less electrophilic acid anhydride intermediates. In the experimental materials used by the author, we found 2-Iodobenzoic acid(cas: 88-67-5Computed Properties of C7H5IO2)

2-Iodobenzoic acid(cas: 88-67-5) belongs to organic iodides. Generally organic iodides can be divided into two classes of alkyl iodides and aryl iodides. Typical reactions of alkyl iodides include nucleophilic substitution, elimination, reduction, and the formation of organometallics.Computed Properties of C7H5IO2Halogenation of aromatic hydrocarbons is a very important reaction via an electrophilic aromatic substitution.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

In 2019,Organic Letters included an article by Li, Guoqing; Yan, Qiuli; Gan, Ziyu; Li, Qin; Dou, Xiaomeng; DaoshanYang. Application of 15164-44-0. The article was titled 《Photocatalyst-Free Visible-Light-Promoted C(sp2)-S Coupling: A Strategy for the Preparation of S-Aryl Dithiocarbamates》. The information in the text is summarized as follows:

We have successfully developed a green and efficient multicomponent reaction protocol to synthesize S-aryl dithiocarbamates under visible light. Most appealingly, the reaction can proceed smoothly without adding any transition-metal catalysts, ligands, or photocatalysts while minimizing chem. wastes and metal residues in the end products. The advantages of this method meet the requirements of sustainable and green synthetic chem., and it provides a straightforward way to create valuable S-aryl dithiocarbamates. In the experiment, the researchers used many compounds, for example, 4-Iodobenzaldehyde(cas: 15164-44-0Application of 15164-44-0)

4-Iodobenzaldehyde(cas: 15164-44-0) is used in synthesis of 4-[2-(trimethylsilyl)ethynyl]benzaldehyde, 5,15-dimesityl-10-(3-[2-(trimethylsilyl)ethynyi]phenyl}-20-(4-iodophenyl)porphyrin, and 5,15-dimesityl-10-[3,5-bis{2-[4-(N,N’-difluoroboryl-1,9-dimethyidipyrrin-5-yl)-phenyl]ethynyl}phenyl]-20-(4-iodophenyl)porphyrin.Application of 15164-44-0

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Product Details of 697300-79-1On May 6, 2022 ,《Access to Thienopyridine and Thienoquinoline Derivatives via Site-Selective C-H Bond Functionalization and Annulation》 appeared in Organic Letters. The author of the article were He, Runfa; Liu, Yang; Feng, Yingqi; Chen, Lu; Huang, Yubing; Xie, Feng; Li, Yibiao. The article conveys some information:

To develop of an effective synthetic methodol. for biol. relevant thienopyridines, a concise and efficient protocol is described for the synthesis of a series of substituted thienopyridine and thienoquinoline derivatives with high selectivity using EtOCS2K as the sulfur source. The reaction proceeds via metal-free, site-selective C-H bond thiolation and cyclization of the alkynylpyridine and alkynylquinoline substrates. The results came from multiple reactions, including the reaction of 2-Fluoro-5-iodopyrimidine(cas: 697300-79-1Product Details of 697300-79-1)

2-Fluoro-5-iodopyrimidine(cas: 697300-79-1) is one of organic iodides. The carbon-iodine bond is weaker than other carbon-halogen bonds due to the poor electronegative nature of the iodine atom. In general, organic iodides are light-sensitive and turn yellow during storage, owing to the formation of iodine. Organic iodides can be alkyl, alkenyl, or alkynyl, and all of them are very reactive toward with many kinds of nucleophiles.Product Details of 697300-79-1

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com