Tag: 200-300

Alayrac, Carole; Witulski, Bernhard published an article in 2021. The article was titled 《Rhodium-catalyzed crossed [2+2+2] cycloaddition with ynamides: key-strategy for the concise total synthesis of 3-oxygenated carbazole alkaloids》, and you may find the article in Heterocycles.Safety of 4-Chloro-2-iodoaniline The information in the text is summarized as follows:

Total syntheses of a set of naturally occurring 3-oxygenated carbazole alkaloids – 6-chlorohyellazole, carazostatin, carbazomycins A and B – are described. The key-strategy underlines a highly chemo- and regioselective rhodium-catalyzed [2+2+2] cyclotrimerization between appropriately tailored yne-ynamides and 1-methoxypropyne that is stirred by the interplay of stereoelectronic and steric effects allowing the introduction of four ring substituents of the natural carbazoles within a single step and making the overall syntheses short and efficient. In the experiment, the researchers used many compounds, for example, 4-Chloro-2-iodoaniline(cas: 63069-48-7Safety of 4-Chloro-2-iodoaniline)

4-Chloro-2-iodoaniline(cas: 63069-48-7) belongs to anime. The methylamines occur in small amounts in some plants. Many polyfunctional amines (i.e., those having other functional groups in the molecule) occur as alkaloids in plants—for example, mescaline, 2-(3,4,5-trimethoxyphenyl)ethylamine; the cyclic amines nicotine, atropine, morphine, and cocaine; and the quaternary salt choline, N-(2-hydroxyethyl)trimethylammonium chloride, which is present in nerve synapses and in plant and animal cells.Safety of 4-Chloro-2-iodoaniline

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Wang, Miao; Saad, Ali; Li, Xiaoguang; Peng, Tao; Zhang, Qi-Tao; Kumar, Mohan; Zhao, Wei published an article in 2021. The article was titled 《Solid-state synthesis of single-phase nickel monophosphosulfide for the oxygen evolution reaction》, and you may find the article in Dalton Transactions.Electric Literature of C4H4INO2 The information in the text is summarized as follows:

High-performance and cost-effective nonprecious-metal catalysts are essential for the next-generation oxygen evolution reaction (OER). However, the electrocatalysis of the OER during water splitting is often carried out by using noble metal catalysts, such as RuO2 or IrO2 with high-cost and limited stability. Herein, we reported a successful synthesis of a ternary nickel monophosphosulfide (NiPS) compound via a simple solid-state route and further investigated its electrocatalytic performances for water oxidation It is found that the NiPS electrocatalyst exhibits good OER performance in 1.0 M KOH solution, i.e., achieving a c.d. of 20 mA cm-2 at an overpotential of 400 mV and a Tafel slope of 126 mV dec-1, comparable to com. benchmark RuO2. The ternary NiPS electrocatalyst for the OER is superior to its binary counterparts, i.e., Ni2P and NiS. D. functional theory (DFT) calculations combined with ex situ XPS were performed to obtain further insights into the intrinsic catalytic mechanism of NiPS, and their results clearly revealed that the instability of the Ni=O intermediate during the OH* → O* process and the easy oxidation of the (PS)3- anion favoring the formation of hydroxyl-based species (i.e., Ni(OH)2/NiOOH) on the surface of the catalyst, which plays a crucial role in facilitating the OER activity. Furthermore, we creatively extended this method to the fabrication of heteroatom substituted catalysts and a new quaternary CoNiP2S2 compound was successfully synthesized for the first time in the same way. The structural properties and electrocatalytic performance towards the OER for CoNiP2S2 (e.g., 20 mA cm-2 at 376 mV) are also systematically investigated in this work.1-Iodopyrrolidine-2,5-dione(cas: 516-12-1Electric Literature of C4H4INO2) was used in this study.

1-Iodopyrrolidine-2,5-dione(cas: 516-12-1) is used in the preparation of vinyl sulfones from olefins and benzenesulfinic acid. It acts as a source for I+ and involved in Hunsdiecker reactions for the conversion of cinnamic acids, and propiolic acids to the corresponding alfa-halostyrenes and 1-halo-1-alkynes respectively. Electric Literature of C4H4INO2

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Hu, Xiao-Qiang; Liu, Zi-Kui; Hou, Ye-Xing; Xu, Ji-Hang; Gao, Yang published an article in 2021. The article was titled 《Merging C-H Activation and Strain-Release in Ruthenium-Catalyzed Isoindolinone Synthesis》, and you may find the article in Organic Letters.Reference of 4-Iodobenzoic acid The information in the text is summarized as follows:

The merger of strain-release of 1,2-oxazetidines I (R = 4-Me, 2,4,5-(OMe)3, 4-Br, etc.) with carboxylic acids 2-R1-3-R2-4-R3-5-R4C6HC(O)OH [R1 = H, Me, Bn, I, etc.; R2 = H, Ph, Br, Me, etc.; R1R2 = -(CH2)4-; R3 = H, Me, t-Bu, Br, etc.; R2R3 = -CH=CH-CH=CH-; R4 = H, OMe] directed C-H activation in catalytic synthesis of isoindolinones II was reported for the first time. This reaction opens a new and sustainable avenue to prepare a range of structurally diverse isoindolinone skeletons II from readily available benzoic acids. The success of late-stage functionalization of some bioactive acids II, and concise synthesis of biol. important skeletons demonstrated its great synthetic potential in drug discovery. Mechanistic studies indicated a plausible C-H activation/β-carbon elimination/intramol. cyclization cascade pathway. In the experimental materials used by the author, we found 4-Iodobenzoic acid(cas: 619-58-9Reference of 4-Iodobenzoic acid)

4-Iodobenzoic acid(cas: 619-58-9) belongs to organic iodides.Reference of 4-Iodobenzoic acid The carbon-iodine bond is weaker than other carbon-halogen bonds due to the poor electronegative nature of the iodine atom. In general, organic iodides are light-sensitive and turn yellow during storage, owing to the formation of iodine.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Zhu, Daoyong; Xu, Wenqiang; Pu, Maoping; Wu, Yun-Dong; Chi, Yonggui Robin; Zhou, Jianrong Steve published an article in 2021. The article was titled 《Asymmetric Domino Heck Arylation and Alkylation of Nonconjugated Dienes: Double C-F···Sodium Attractive Noncovalent Interaction》, and you may find the article in Organic Letters.HPLC of Formula: 15164-44-0 The information in the text is summarized as follows:

Palladium catalyzed domino Heck arylation and alkylation of nonconjugated cyclodienes to produce trans isomers of disubstituted cyclohexenes in exceptionally high enantiomeric ratios, reaching 100:1 to 200:1 in many cases. Importantly, the interactions of the two CF bonds of Josiphos and the sodium ion of malonates facilitated stereoselective allylic attack through DFT calculations and experiments This is a new type of attractive noncovalent interactions found in organometallic catalysis. In the experiment, the researchers used 4-Iodobenzaldehyde(cas: 15164-44-0HPLC of Formula: 15164-44-0)

4-Iodobenzaldehyde(cas: 15164-44-0) is used in synthesis of 4-[2-(trimethylsilyl)ethynyl]benzaldehyde, 5,15-dimesityl-10-(3-[2-(trimethylsilyl)ethynyi]phenyl}-20-(4-iodophenyl)porphyrin, and 5,15-dimesityl-10-[3,5-bis{2-[4-(N,N’-difluoroboryl-1,9-dimethyidipyrrin-5-yl)-phenyl]ethynyl}phenyl]-20-(4-iodophenyl)porphyrin.HPLC of Formula: 15164-44-0

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Qiu, Ji-Ying; Yuan, Ding; Yu, Jing-Jing; Zhang, Yi; Li, Wen-Hao; Tang, Zeng-Xiang; He, Ping; Ren, Zhi-Lin published an article in 2021. The article was titled 《A Facile Synthesis of Indole Derivatives by a Palladium-Catalyzed Process Initiated from Ugi Adducts and their Antifungal Activities》, and you may find the article in ChemistrySelect.SDS of cas: 63069-48-7 The information in the text is summarized as follows:

In this work, an efficient synthesis of indole derivatives through palladium-catalyzed double isocyanide insertion reactions has been developed. The reaction intermediates could be readily obtained by Ugi reactions. The transformation features broad functional-group compatibility, com. available starting materials, and moderate to good reaction yields. Furthermore, the bioactivities of the synthesized compounds were evaluated in mycelial growth tests against Penicilium digitatum and Colletotrichun gloeosporioides, and showed potential antifungal activities. The results came from multiple reactions, including the reaction of 4-Chloro-2-iodoaniline(cas: 63069-48-7SDS of cas: 63069-48-7)

4-Chloro-2-iodoaniline(cas: 63069-48-7) belongs to anime. Examples of direct uses of amines and their salts are as corrosion inhibitors in boilers and in lubricating oils (morpholine), as antioxidants for rubber and roofing asphalt (diarylamines), as stabilizers for cellulose nitrate explosives (diphenylamine), as protectants against damage from gamma radiation (diarylamines), as developers in photography (aromatic diamines), as flotation agents in mining, as anticling and waterproofing agents for textiles, as fabric softeners, in paper coating, and for solubilizing herbicides.SDS of cas: 63069-48-7

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Miyamoto, Kazunori; Okada, Tomohide; Toyama, Takashi; Imamura, Shinji; Uchiyama, Masanobu published an article in 2021. The article was titled 《Facile preparation of 1-hydroxy-1,2-benziodoxol-3(1H)-one 1-oxide (IBX) and Dess-Martin reagent using sodium hypochlorite under carbon dioxide》, and you may find the article in Heterocycles.Related Products of 88-67-5 The information in the text is summarized as follows:

A safe, convenient, and inexpensive method for preparation of the widely used oxidizing agent 1-hydroxy-1,2-benziodoxol-3(1H)-one 1-oxide (IBX) has been developed, by treatment of 2-iodobenzoic acid with aqueous sodium hypochlorite under CO2 at room temperature As the only byproduct is NaCl, this reaction can be utilized for one-pot synthesis of 1,1,1-triacetoxy-1,2-benziodoxol-3(1H)-one (Dess-Martin reagent) in excellent yield. In the experiment, the researchers used 2-Iodobenzoic acid(cas: 88-67-5Related Products of 88-67-5)

2-Iodobenzoic acid(cas: 88-67-5) belongs to organic iodides.Related Products of 88-67-5 The carbon-iodine bond is weaker than other carbon-halogen bonds due to the poor electronegative nature of the iodine atom. In general, organic iodides are light-sensitive and turn yellow during storage, owing to the formation of iodine.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Van Den Hauwe, Robin; Elsocht, Mathias; Hollanders, Charlie; Ballet, Steven published their research in Synlett in 2021. The article was titled 《Efficient synthesis of polysubstituted 1,5-benzodiazepinone dipeptide mimetics via an Ugi-4CR-Ullmann condensation sequence》.Category: iodides-buliding-blocks The article contains the following contents:

An efficient three-step synthesis towards 3-amino-1,4-benzodiazepin-2-one derivatives is presented. The versatile Ugi-4-component reaction (Ugi-4CR) and Boc deprotection is followed by a ligand-free Ullmann condensation. This protocol allows the rapid construction of a diverse array of substituted 1,5-benzodiazepinones. Since Ugi-based products are typically limited by their ‘inert’ C-terminal amides, the use of a convertible (‘cleavable’) isocyanide was envisaged and resulted in building blocks that can be made SPPS compatible. To demonstrate the potential of this novel synthetic route, the design and preparation of novel phenylurea-1,5-benzodiazepin-4(5 H)-one dipeptide mimetics with potential CCK2-antagonist properties is reported. In the experiment, the researchers used many compounds, for example, 4-Chloro-2-iodoaniline(cas: 63069-48-7Category: iodides-buliding-blocks)

4-Chloro-2-iodoaniline(cas: 63069-48-7) belongs to anime. Amines characteristically form salts with acids; a hydrogen ion, H+, adds to the nitrogen. With the strong mineral acids (e.g., H2SO4, HNO3, and HCl), the reaction is vigorous. Salt formation is instantly reversed by strong bases such as NaOH. Neutral electrophiles (compounds attracted to regions of negative charge) also react with amines; alkyl halides (R′X) and analogous alkylating agents are important examples of electrophilic reagents.Category: iodides-buliding-blocks

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Ye, Shaofeng; Guo, Runda; Wang, Yaxiong; Duan, Yalei; Wang, Lei published their research in Dyes and Pigments in 2021. The article was titled 《Exploiting novel electron-deficient moiety 2,5-diazarcarbazole to functionally construct DPA-containing electron transporting materials for highly efficient sky-blue fluorescent OLEDs》.Related Products of 589-87-7 The article contains the following contents:

A span-new electron-deficient moiety 2,5-diazarcarbazole (25NCz) with high T1 = 2.77 eV was firstly designed and synthesized, which had enormous potential to construct organic electronic materials in photoelec. field. Herein, 25NCz as large rigid-type periphery functionalized group, was introduced to develop novel electron transporting materials (ETMs) by grafting large rigid-type π-conjugated core anthracene. Two novel ETMs p-S25NCzDPA and p-D25NCzDPA were designed and developed. Due to the dual characteristics of rigidity and electron-accepting of the 25NCz, as expected, these two ETMs possessed good thermal stability and high electron mobility. When triplet-triplet fusion (TTF) sky-blue fluorescent OLEDs based on these two novel ETMs were manufactured, they exhibited superior performances. In particular, the maximum external quantum efficiency (EQE) reached 7.45% and the EQE kept 7.45% at the luminance of 50,000 cd m-2 for p-S25NCzDPA based device. This work rationally demonstrated that the significance of newly developed electron-deficient moiety 25NCz in designing ETMs for high-performance OLEDs. In addition to this study using 1-Bromo-4-iodobenzene, there are many other studies that have used 1-Bromo-4-iodobenzene(cas: 589-87-7Related Products of 589-87-7) was used in this study.

1-Bromo-4-iodobenzene(cas: 589-87-7) has been employed as reagent for in situ desilylation and coupling of silylated alkynes, as starting reagent in the total syntheses of ent-conduramine A and ent-7-deoxypancratistatin (alkaloids), as substrate in copper-free Sonogashira coupling in aqueous acetone in synthesis of β,β,dibromostyrenesRelated Products of 589-87-7

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Tber, Zahira; Loubidi, Mohammed; Jouha, Jabrane; Hdoufane, Ismail; Erdogan, Mumin Alper; Saso, Luciano; Armagan, Guliz; Berteina-Raboin, Sabine published their research in Pharmaceuticals in 2021. The article was titled 《Pyrido[2′,1′:2,3]imidazo[4,5-c]isoquinolin-5-amines as potential cytotoxic agents against human neuroblastoma》.Application In Synthesis of 4-Iodopyridine The article contains the following contents:

We report herein the evaluation of various pyrido[2′,1′:2,3]imidazo[4,5-c]isoquinolin-5-amines as potential cytotoxic agents. These mols. were obtained by developing the multicomponent Groebke-Blackburn-Bienayme reaction to yield various pyrido[2′,1′:2,3]imidazo[4,5-c]quinolines which are isosteres of ellipticine whose biol. activities are well established. To evaluate the anticancer potential of these pyrido[2′,1′:2,3]imidazo[4,5-c]isoquinolin-5-amine derivatives in the human neuroblastoma cell line, the cytotoxicity was examined using the WST-1 assay after 72 h drug exposure. A clonogenic assay was used to assess the ability of treated cells to proliferate and form colonies. Protein expressions (Bax, bcl-2, cleaved caspase-3, cleaved PARP-1) were analyzed using Western blotting. The colony number decrease in cells was 50.54%, 37.88% and 27.12% following exposure to compounds 2d, 2g and 4b resp. at 10 ΜM. We also show that treating the neuroblastoma cell line with these compounds resulted in a significant alteration in caspase-3 and PARP-1 cleavage. The experimental part of the paper was very detailed, including the reaction process of 4-Iodopyridine(cas: 15854-87-2Application In Synthesis of 4-Iodopyridine)

4-Iodopyridine(cas: 15854-87-2) belongs to pyridine. Pyridine is very deactivated towards electrophilic substitution with respect to benzene. For this reason classical formylation, using methods such as the Gattermann or Vilsmeier reactions, are not generally successful. Application In Synthesis of 4-Iodopyridine

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Ming, Xiao-Xia; Wu, Shuai; Tian, Ze-Yu; Song, Jia-Wei; Zhang, Cheng-Pan published their research in Organic Letters in 2021. The article was titled 《Pd/Cu-Catalyzed Vinylation of Terminal Alkynes with (2-Bromoethyl)diphenylsulfonium Triflate》.Safety of 1,2-Diiodoethane The article contains the following contents:

The potential of (2-bromoethyl)diphenylsulfonium triflate to be a powerful vinylation reagent was determined by the Sonogashira cross-coupling reactions with terminal alkynes RCCH (R = Ph, thiophen-3-yl, 4,4-dimethyl-3,4-dihydro-2H-1-benzothiopyran-6-yl, etc.). The vinylation proceeded smoothly at 25°C under Pd/Cu catalysis to afford a variety of 1- and 2-unsubstituted 1,3-enynes RCCCH=CH2 in moderate to excellent yields. This protocol represents the first application of (2-haloethyl)diphenylsulfonium triflates X(CH2)2S+(C6H5)2.-OTf (X = Br, F, OTs) and 5-(2-bromoethyl)-5H-thianthren-5-ium triflate as a CH=CH2 transfer source in organic synthesis. In the experimental materials used by the author, we found 1,2-Diiodoethane(cas: 624-73-7Safety of 1,2-Diiodoethane)

1,2-Diiodoethane(cas: 624-73-7) is one of organic iodides. Organic iodides are used in veterinary products (Organic Iodide Powder) as a nutritional source of iodine. In the chemical industry, alkyl iodides serve as excellent alkylating agents and, specifically, methyl iodide is used as a methylating agent in the synthesis of various pharmaceutical drugs. Oceanic alkyl iodides are believed to be the principal source of atmospheric iodine.Safety of 1,2-Diiodoethane

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com