Tag: 200-300

《Synthesis of 18F-Labeled Aryl Fluorosulfates via Nucleophilic Radiofluorination》 was written by Kwon, Young-Do; Jeon, Min Ho; Park, Nam Kyu; Seo, Jeong Kon; Son, Jeongmin; Ryu, Young Hoon; Hong, Sung You; Chun, Joong-Hyun. Related Products of 626-02-8 And the article was included in Organic Letters in 2020. The article conveys some information:

Sulfuryl fluoride gas is a key reagent for SO2F transfer. However, conventional SO2F transfer reactions have limited 18F-radiochem. translation, due to the inaccessibility of gaseous [18F]SO2F2. Herein, we report the first SO2F2-free synthesis of aryl [18F]fluorosulfates from both phenolic and isolated aryl imidazylate precursors with cyclotron-produced 18F-. The radiochem. yields ranged from moderate to good with excellent functional group tolerance. The reliability of our approach was validated by the automated radiosynthesis of 4-acetamidophenyl [18F]fluorosulfate. In the experimental materials used by the author, we found 3-Iodophenol(cas: 626-02-8Related Products of 626-02-8)

3-Iodophenol(cas: 626-02-8) belongs to organic iodides. Organic iodides are used in veterinary products (Organic Iodide Powder) as a nutritional source of iodine. In the chemical industry, alkyl iodides serve as excellent alkylating agents and, specifically, methyl iodide is used as a methylating agent in the synthesis of various pharmaceutical drugs.Related Products of 626-02-8

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

《Electrochemical intramolecular C-H/N-H functionalization for the synthesis of isoxazolidine-fused isoquinolin-1(2H)-ones》 was written by Zhang, Lin-Bao; Geng, Rui-Sen; Wang, Zi-Chen; Ren, Guang-Yi; Wen, Li-Rong; Li, Ming. SDS of cas: 589-87-7 And the article was included in Green Chemistry in 2020. The article conveys some information:

A general and practical protocol for the construction of isoxazolidine-fused isoquinolin-1(2H)-ones I (R = H, Me; R1 = H, Cl, F, SMe, etc.; R2 = H, Me, OMe; R3 = H, F, Cl, Br, Me; R4 = C6H5, 4-FC6H4, CCC6H5, etc.; R1R2 = -OCH2O-; R2R3 = CH=CHCH=CH; n = 1, 2) has been described by electrochem.-oxidation-induced intramol. annulation via amidyl radicals. In an undivided cell, isoquinolinones I could be easily generated from various available amides R5CONHO(CH2)nCCR4 (R5 = 4-Cl, 2H-1,3-benzodioxol-5-yl, naphthalen-1-yl, etc.) bearing CONHOR groups under metal-free, additive-free and external oxidant-free conditions. Moreover, this transformation proceeded smoothly by using cheap 95% ethanol as the green solvent and could be extended to the gram scale.1-Bromo-4-iodobenzene(cas: 589-87-7SDS of cas: 589-87-7) was used in this study.

1-Bromo-4-iodobenzene(cas: 589-87-7) is mainly used as the OLED pharmaceutical intermediate, as reagent for in situ desilylation and coupling of silylated alkynes, as substrate in copper-free Sonogashira coupling in aqueous acetone..SDS of cas: 589-87-7 It is also used in synthesis of β,β,dibromostyrenes, as starting reagent in the total syntheses of ent-conduramine A and ent-7-deoxypancratistatin (alkaloids)

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

《Nickel-Catalyzed Reductive Aryl Thiocarbonylation of Alkene via Thioester Group Transfer Strategy》 was written by Feng, Yunxia; Yang, Shimin; Zhao, Shen; Zhang, Dao-Peng; Li, Xinjin; Liu, Hui; Dong, Yunhui; Sun, Feng-Gang. Synthetic Route of C6H5ClIN And the article was included in Organic Letters in 2020. The article conveys some information:

Herein reported is a nickel-catalyzed reductive aryl thiocarbonylation of alkene via thioester group transfer strategy by using simple and readily available thioesters. In contrast to traditional activation of weaker C(acyl)-S bond, the C(acyl)-C bond of thioester was selectively cleaved to enable this reaction under mild conditions. Furthermore, this approach features operational simplicity and broad substrate scope, providing a complementary and practical route for thioester synthesis without requiring toxic thiol or CO gas. The experimental part of the paper was very detailed, including the reaction process of 4-Chloro-2-iodoaniline(cas: 63069-48-7Synthetic Route of C6H5ClIN)

4-Chloro-2-iodoaniline(cas: 63069-48-7) belongs to anime. Amines can be classified according to the nature and number of substituents on nitrogen. Aliphatic amines contain only H and alkyl substituents. Aromatic amines have the nitrogen atom connected to an aromatic ring.Important amines include amino acids, biogenic amines, trimethylamine, and aniline. Inorganic derivatives of ammonia are also called amines, such as monochloramine (NClH2).Synthetic Route of C6H5ClIN

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

《Preparation, Characterization and First Application of Graphene Oxide-Metformin-Nickel for the Suzuki Cross-Coupling Reaction》 was published in ChemistrySelect in 2020. These research results belong to Raoufi, Farveh; Monajjemi, Majid; Aghaei, Hossein; Zare, Karim; Ghaedi, Mehrorang. Category: iodides-buliding-blocks The article mentions the following:

In this project, in the first step, the graphene oxide-metformin nickel catalyst I has been prepared and then the Ni(II) was reduced to Ni(0) by hydrazine hydrate and Ni(0) nanoparticle coordinated to metformin-GO was achieved. After full characterization of catalyst structure by different analyses like Fourier-transform IR spectroscopy (FT-IR), transmission electron microscopy (TEM), SEM (SEM), energy dispersive X-Ray anal. (EDX), X-Ray diffraction anal. (XRD), thermal gravimetric anal. (TGA), and coupled plasma/at. emission spectroscopy (ICP), as well as confirmation of the successful synthesis of catalyst, the activity of catalyst has been examined in the Suzuki-Miyaura cross-coupling reaction. In addition to this study using 3-Iodophenol, there are many other studies that have used 3-Iodophenol(cas: 626-02-8Category: iodides-buliding-blocks) was used in this study.

3-Iodophenol(cas: 626-02-8) belongs to organic iodides. Organic iodides are used in veterinary products (Organic Iodide Powder) as a nutritional source of iodine.Category: iodides-buliding-blocks In the chemical industry, alkyl iodides serve as excellent alkylating agents and, specifically, methyl iodide is used as a methylating agent in the synthesis of various pharmaceutical drugs.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

《Regioselective Cross-Electrophile Coupling of Epoxides and (Hetero)aryl Iodides via Ni/Ti/Photoredox Catalysis》 was published in ACS Catalysis in 2020. These research results belong to Parasram, Marvin; Shields, Benjamin J.; Ahmad, Omar; Knauber, Thomas; Doyle, Abigail G.. Electric Literature of C7H7I The article mentions the following:

A cross-electrophile coupling reaction of epoxides and (hetero)aryl iodides that operates via the merger of three catalytic cycles involving a Ni-, Ti-, and organic photoredox catalyst has been developed. Three distinct classes of epoxides, styrene oxides, cyclic epoxides, and terminal aliphatic epoxides, underwent coupling in moderate to good yield and high regioselectivity with the use of three different nitrogen-based ligands for Ni under otherwise identical reaction conditions. The mild reaction conditions accommodate a broad scope of abundant and complex coupling partners. Mechanistic studies suggest that when styrene oxides are employed radical intermediates are involved via Ti-radical ring opening of the epoxide. Conversely, for terminal aliphatic epoxides, involvement of an iodohydrin intermediate enables the formation of the unexpected linear product. After reading the article, we found that the author used 1-Iodo-4-methylbenzene(cas: 624-31-7Electric Literature of C7H7I)

1-Iodo-4-methylbenzene(cas: 624-31-7) undergoes Suzuki-Miyaura coupling reaction with phenylboronic acid catalyzed by (Ni,Mg)3Si2O5(OH)4 solid-solution nanotubes loaded with palladium.Electric Literature of C7H7I

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

The author of 《Palladium-Catalyzed Oxidative Allylation of Sulfoxonium Ylides: Regioselective Synthesis of Conjugated Dienones》 were Li, Chunsheng; Li, Meng; Zhong, Wentao; Jin, Yangbin; Li, Jianxiao; Wu, Wanqing; Jiang, Huanfeng. And the article was published in Organic Letters in 2019. Quality Control of Trimethylsulfoxonium iodide The author mentioned the following in the article:

The first examples of palladium-catalyzed allylic C-H oxidative allylation of sulfoxonium ylides to afford the corresponding conjugated dienones with moderate to good yields have been established. The features of this novel conversion include mild reaction conditions, wide substrate scope, and excellent regioselectivity. In the experiment, the researchers used many compounds, for example, Trimethylsulfoxonium iodide(cas: 1774-47-6Quality Control of Trimethylsulfoxonium iodide)

Trimethylsulfoxonium iodide(cas: 1774-47-6) is a sulfoxonium salt. It is used to generate dimethyloxosulfonium methylide by reaction with sodium hydride. The latter compound is used as a methylene-transfer reagent, and is used to prepare epoxides.Quality Control of Trimethylsulfoxonium iodide

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

The author of 《Ni/Photoredox-Dual-Catalyzed Functionalization of 1-Thiosugars》 were Zhu, Mingxiang; Dagousset, Guillaume; Alami, Mouad; Magnier, Emmanuel; Messaoudi, Samir. And the article was published in Organic Letters in 2019. Category: iodides-buliding-blocks The author mentioned the following in the article:

A general protocol for functionalization of glycosyl thiols has been reported. This protocol is based on a single-electron Ni/photoredox dual-catalyzed cross coupling between 1-thiosugars and a broad range of aryl bromides and iodides as well as alkenyl and alkynyl halides. This base-free method gives access to a series of functionalized thioglycosides in moderate to excellent yields with a perfect control of the anomeric configuration. Moreover, it has been shown that this methodol. may be transposed successfully to the continuous-flow photoredox chem.1-Chloro-3-iodobenzene(cas: 625-99-0Category: iodides-buliding-blocks) was used in this study.

1-Chloro-3-iodobenzene(cas: 625-99-0) belongs to organic iodides. Alkyl iodides react at a faster rate than alkyl fluorides due to the weak C-I bond.Iodo alkanes participate in a variety of organic synthesis reactions, which include the Simmons–Smith reaction (cyclopropanation using iodomethane), Williamson ether synthesis, Wittig reaction, Grignard reaction, alkyl coupling reactions, and Wurtz reaction.Category: iodides-buliding-blocks

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

The author of 《Iridium-Catalyzed B-H Bond Insertion Reactions Using Sulfoxonium Ylides as Carbene Precursors toward α-Boryl Carbonyls》 were Li, Jianglian; He, Hua; Huang, Mengyi; Chen, Yuncan; Luo, Yi; Yan, Kaichuan; Wang, Qiantao; Wu, Yong. And the article was published in Organic Letters in 2019. Synthetic Route of C3H9IOS The author mentioned the following in the article:

An Ir-catalyzed B-H bond insertion reaction between borane adducts and sulfoxonium ylides to afford α-boryl carbonyls was developed. The starting materials are safe and readily available. Analogs of sulfoxonium ylides, such as sulfonium salts and sulfonium ylides could also be amenable to the reaction. The experimental part of the paper was very detailed, including the reaction process of Trimethylsulfoxonium iodide(cas: 1774-47-6Synthetic Route of C3H9IOS)

Trimethylsulfoxonium iodide(cas: 1774-47-6) is a sulfoxonium salt. It is used to generate dimethyloxosulfonium methylide by reaction with sodium hydride. The latter compound is used as a methylene-transfer reagent, and is used to prepare epoxides.Synthetic Route of C3H9IOS

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

The author of 《Accelerating Effect of DMAP on CuI Catalyzed Buchwald-Hartwig C-N Coupling: Mechanistic Insight to the Reaction Pathway》 were Roy, Subhasish; Dutta, Mintu Maan; Sarma, Manas Jyoti; Phukan, Prodeep. And the article was published in ChemistrySelect in 2019. Quality Control of 1-Bromo-4-iodobenzene The author mentioned the following in the article:

An efficient methodol. was developed for C-N cross-coupling reaction between aryl halides and amines using a catalytic system comprised of CuI and N,N-dimethylaminopyridine (DMAP). Coupling reactions were carried out in DMSO at 120°C in the presence of 5 mol% CuI, 20 mol% DMAP and 2.5 equiv of KOH. Addition of DMAP was found to be beneficial in significantly accelerating the reaction rate. Both aryl iodides and aryl bromides were successfully coupled with different primary and secondary amines to furnish the desired cross-coupling product in high yield. A copper complex [Cu(DMAP)4I]I, made by combining CuI and DMAP, was found to produce superior results for the Buchwlad-Hartwig cross-coupling reaction. The use of 2 mol% of the copper complex was sufficient to produce high yields of product. In the part of experimental materials, we found many familiar compounds, such as 1-Bromo-4-iodobenzene(cas: 589-87-7Quality Control of 1-Bromo-4-iodobenzene)

1-Bromo-4-iodobenzene(cas: 589-87-7) has been employed as reagent for in situ desilylation and coupling of silylated alkynes, as starting reagent in the total syntheses of ent-conduramine A and ent-7-deoxypancratistatin (alkaloids), as substrate in copper-free Sonogashira coupling in aqueous acetone in synthesis of β,β,dibromostyrenesQuality Control of 1-Bromo-4-iodobenzene

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

In 2019,Green Chemistry included an article by Lang, Xian-Dong; You, Fei; He, Xing; Yu, Yi-Chen; He, Liang-Nian. Quality Control of 1-Bromo-4-iodobenzene. The article was titled 《Rhodium(I)-catalyzed Pauson-Khand-type reaction using formic acid as a CO surrogate: an alternative approach for indirect CO2 utilization》. The information in the text is summarized as follows:

Formic acid was found to be an ideal CO surrogate for the rhodium(I)-catalyzed Pauson-Khand-type (PK-type) reaction of various substituted 1,6-enynes to afford bicyclic cyclopentenones I [R = Ph, 2-MeOC6H4, 4-BrC6H4, etc.] and II [R1 = Ph, 4-FC6H4 2-ClC6H4, etc.] in moderate to good yields. High TON value up to 263 and good results in the gram-scale experiment were also obtained. In addition, heterocyclic mols. of pharmaceutical importance were also furnished via inter- or intra-mol. hetero-PK-type reactions, further broadening the application of current strategy. Formic acid was utilized as a bridging mol. for the conversion of CO2 to CO, since formic acid was manufactured via catalytic hydrogenation of CO2 and released CO in the presence of acetic anhydride readily. Therefore, this methodol. represented a green and indirect approach for chem. valorization of CO2 in the preparation of value-added compounds In addition to this study using 1-Bromo-4-iodobenzene, there are many other studies that have used 1-Bromo-4-iodobenzene(cas: 589-87-7Quality Control of 1-Bromo-4-iodobenzene) was used in this study.

1-Bromo-4-iodobenzene(cas: 589-87-7) has been employed as reagent for in situ desilylation and coupling of silylated alkynes, as starting reagent in the total syntheses of ent-conduramine A and ent-7-deoxypancratistatin (alkaloids), as substrate in copper-free Sonogashira coupling in aqueous acetone in synthesis of β,β,dibromostyrenesQuality Control of 1-Bromo-4-iodobenzene

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com