Tag: 200-300

In 2018,Organic Letters included an article by Trost, Barry M.; Zhang, Lei; Lam, Tom M.. Recommanded Product: 624-73-7. The article was titled 《Synthesis of the Aminocyclitol Core of Jogyamycin via an Enantioselective Pd-Catalyzed Trimethylenemethane (TMM) Cycloaddition》. The information in the text is summarized as follows:

The use of β-nitroenamines as a new class of acceptors in the enantioselective Pd-catalyzed trimethylenemethane cycloaddition afforded differentiated 1,2-dinitrogen bearing cyclopentanes with three contiguous stereocenters. The utility of these acceptors was demonstrated with the efficient construction of the core of jogyamycin and aminocyclopentitols. Further elaboration of the cycloadducts provided a concise synthetic approach toward joygamycin. In the experiment, the researchers used 1,2-Diiodoethane(cas: 624-73-7Recommanded Product: 624-73-7)

1,2-Diiodoethane(cas: 624-73-7) is one of organic iodides. The carbon-iodine bond is weaker than other carbon-halogen bonds due to the poor electronegative nature of the iodine atom. In general, organic iodides are light-sensitive and turn yellow during storage, owing to the formation of iodine. Organic iodides can be alkyl, alkenyl, or alkynyl, and all of them are very reactive toward with many kinds of nucleophiles.Recommanded Product: 624-73-7

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

In 2017,Lee, Minjae; Lee, Yong-Hoon; Park, Jong Hyeok; Choi, U. Hyeok published 《Bis-imidazolium iodide organic ionic plastic crystals and their applications to solid state dye-sensitized solar cells》.Organic Electronics published the findings.Safety of 1,2-Diiodoethane The information in the text is summarized as follows:

Novel dicationic bis-imidazolium iodide salts have been discovered as new organic ionic plastic crystalline materials. Most of them show multiple solid-solid phase transitions below their melting temperatures Their phase transition temperatures are dependent on the imidazolium cation structure. According to Timmermans’ definition of plastic crystals, bis-imidazolium iodide salts with either n-heptyl or n-octyl side arms can be classified as “”true plastic crystals”” because of their low ΔSf values (<20 J mol-1 K-1). The bis-imidazolium iodide salts are stable up to 260°C under thermal gravimetric anal. The ionic conductivities, investigated using dielec. relaxation spectroscopy, follow the Arrhenius temperature dependence with discontinuities and changes in slopes at the observed solid-solid phase transition temperature Dye-sensitized solar cells (DSSCs) fabricated by a whole solid-state electrolyte consisting of n-hexyl side-armed bis-imidazolium iodide (BII-6) show a 4.93% power conversion efficiency (η): a remarkable result for the solid-state electrolyte system compared to that obtained using an liquid electrolyte with 1-butyl-3-methylimidazolium iodide (η = 8.00%) as a reference composition1,2-Diiodoethane(cas: 624-73-7Safety of 1,2-Diiodoethane) was used in this study.

1,2-Diiodoethane(cas: 624-73-7) is one of organic iodides. Organic iodides are used in veterinary products (Organic Iodide Powder) as a nutritional source of iodine. In the chemical industry, alkyl iodides serve as excellent alkylating agents and, specifically, methyl iodide is used as a methylating agent in the synthesis of various pharmaceutical drugs. Oceanic alkyl iodides are believed to be the principal source of atmospheric iodine.Safety of 1,2-Diiodoethane

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

In 2016,Zhang, Wei; Tan, Yue Hua; Finch, James A. published 《Synthesis and characterization of alkyl, propoxy, ethoxy-based frothers》.Minerals Engineering published the findings.Safety of 1,2-Diiodoethane The information in the text is summarized as follows:

In this paper the authors describe the synthesis and characterization of a homologous series of linear polyglycol-based frothers comprising alkyl, propoxy (propylene oxide, PO), and ethoxy (ethylene oxide, EO) groups. The identities were confirmed by proton NMR spectroscopy and total organic carbon anal. Characterization used three parameters, bubble size, gas holdup and water overflow rate, measured in a bubble column. The results indicate that increasing number of PO groups led to significant decrease in bubble size, and increase in gas holdup and water overflow rate. Increasing the alkyl chain length, gave similar but less pronounced trends; the least effect was increasing the number of EO groups. Changing the relative position of the PO and EO group had a significant effect on all three parameters. To account for the effect of PO/EO position, a mechanism based on effect of structure on mol. packing at the air/water interface is proposed. In addition to this study using 1,2-Diiodoethane, there are many other studies that have used 1,2-Diiodoethane(cas: 624-73-7Safety of 1,2-Diiodoethane) was used in this study.

1,2-Diiodoethane(cas: 624-73-7) is one of organic iodides. Organic iodides are used in veterinary products (Organic Iodide Powder) as a nutritional source of iodine. In the chemical industry, alkyl iodides serve as excellent alkylating agents and, specifically, methyl iodide is used as a methylating agent in the synthesis of various pharmaceutical drugs. Oceanic alkyl iodides are believed to be the principal source of atmospheric iodine.Safety of 1,2-Diiodoethane

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Safety of 2-Amino-5-iodopyrimidin-4(1H)-oneOn March 1, 2011, Inouye, Masahiko; Doi, Yasuhiro; Azuchi, Junichi; Shirato, Wataru; Chiba, Junya; Abe, Hajime published an article in Heterocycles. The article was 《Hexamethyldisilazane-promoted Sonogashira reaction of poly-functionalized N-containing heterocycles》. The article mentions the following:

1,1,1,3,3,3-Hexamethyldisilazane (HMDS) was found to be an efficient solvent for Sonogashira reaction. For the synthesis of C-nucleosides, e.g. I, , Sonogashira reaction of ethynyldeoxyriboside with halogenated pyrimidine or pyridine derivatives could be improved by the use of an HMDS-DMF mixed solvent. In situ protection of hydroxy and amino groups by the solvent system may play an important role for the improvement.2-Amino-5-iodopyrimidin-4(1H)-one(cas: 3993-79-1Safety of 2-Amino-5-iodopyrimidin-4(1H)-one) was used in this study.

2-Amino-5-iodopyrimidin-4(1H)-one(cas: 3993-79-1) belongs to anime. Amines characteristically form salts with acids; a hydrogen ion, H+, adds to the nitrogen. With the strong mineral acids (e.g., H2SO4, HNO3, and HCl), the reaction is vigorous. Salt formation is instantly reversed by strong bases such as NaOH. Neutral electrophiles (compounds attracted to regions of negative charge) also react with amines; alkyl halides (R′X) and analogous alkylating agents are important examples of electrophilic reagents.Safety of 2-Amino-5-iodopyrimidin-4(1H)-one

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

《Photomediated reductive coupling of nitroarenes with aldehydes for amide synthesis》 was published in Chemical Science in 2022. These research results belong to Li, Qingyao; Dai, Peng; Tang, Haidi; Zhang, Muliang; Wu, Jie. HPLC of Formula: 23779-17-1 The article mentions the following:

In view of the widespread significance of amide functional groups in organic synthesis and pharmaceutical studies, an efficient and practical synthetic protocol that avoids the use of stoichiometric activating reagents or metallic reductants is highly desirable. A straight-forward pathway to access amides from abundant chem. feedstock would offer a strategic advantage in the synthesis of complex amides. Authors herein disclose a direct reductive amidation reaction using readily available aldehydes and nitroarenes enabled by photo-mediated hydrogen atom transfer catalysis. It avoids the use of metallic reductants and production of toxic chem. waste. While aldehydes represent a classic class of electrophilic synthons, the corresponding nucleophilic acyl radicals could be directly accessed by photo hydrogen atom transfer catalysis, enabling polarity inversion. Authors method provides an orthogonal strategy to conventional amide couplings, tolerating nucleophilic substituents such as free alcs. and sensitive functional groups to amines such as carbonyl or formyl groups. The synthetic utilization of this reductive amidation is demonstrated by the late-stage modification of complex biol. active mols. and direct access of drug mols. leflunomide and lidocaine.N-(4-Iodophenyl)cyclopropanecarboxamide(cas: 23779-17-1HPLC of Formula: 23779-17-1) was used in this study.

N-(4-Iodophenyl)cyclopropanecarboxamide(cas: 23779-17-1) belongs to anime. The reaction of alkyl halides, R―X, where X is a halogen, or analogous reagents with ammonia (or amines) is useful with certain compounds. Not all alkyl halides are effective reagents; the reaction is sluggish with secondary alkyl groups and fails with tertiary ones. Its usefulness is largely confined to primary alkyl halides (those having two hydrogen atoms on the reacting site).HPLC of Formula: 23779-17-1

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

《Controllable access to trifluoromethyl-containing indoles and indolines: palladium-catalyzed regioselective functionalization of unactivated alkenes with trifluoroacetimidoyl chlorides》 was written by Yang, Hefei; Wang, Le-Cheng; Zhang, Yu; Zheng, Dongling; Chen, Zhengkai; Wu, Xiao-Feng. Electric Literature of C6H5ClINThis research focused ontrifluoromethyl containing indole regioselective preparation; regioselective preparation trifluoromethyl containing indoline; alkene trifluoroacetimidoyl chloride cyclization palladium catalyst. The article conveys some information:

A palladium-catalyzed substrate-controlled regioselective functionalization of unactivated alkenes with trifluoroacetimidoyl chlorides had been developed, which provided a direct but controllable access to a variety of structurally diverse trifluoromethyl-containing indoles I [R = CF2H, CF3, C2F5, C3F7; R1 = H, 5-Et, 6-F, etc.; R2 = H, Me, Ph; R3 = H, Me, cyclopropyl; Q = 8-quinolininyl] and trifluoromethyl-containing indolines II [R4 = H, 6-Br, 5-MeO, etc.; R5 = H, Me, Et, i-Pr, Bn, (CH2)2C6H5; R6 = CF2H, CF3, C2F5, CF2Cl, CF2Br]. In more detail, with respect to γ,δ-alkenes, 1,1-geminal difunctionalization of unactivated alkenes with trifluoroacetimidoyl chloride enables the [4 + 1] annulation to produce indoles; as for β,γ-alkenes, a [3 + 2] heteroannulation with the hydrolysis product of trifluoroacetimidoyl chloride through 1,2-vicinal difunctionalization of alkenes occurs to deliver indoline products. The structure of alkene substrates differentiates the regioselectivity of the reaction. In the experiment, the researchers used many compounds, for example, 4-Chloro-2-iodoaniline(cas: 63069-48-7Electric Literature of C6H5ClIN)

4-Chloro-2-iodoaniline(cas: 63069-48-7) belongs to anime.Typically the presence of an amine functional group is deduced by a combination of techniques, including mass spectrometry as well as NMR and IR spectroscopies. 1H NMR signals for amines disappear upon treatment of the sample with D2O. In their infrared spectrum primary amines exhibit two N-H bands, whereas secondary amines exhibit only one.Electric Literature of C6H5ClIN

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Reference of Trimethylsulfoxonium iodideIn 2019 ,《Synthesis of Furoxans and Isoxazoles via Divergent [2 + 1 + 1 + 1] Annulations of Sulfoxonium Ylides and tBuONO》 was published in Organic Letters. The article was written by Tang, Zhonghe; Zhou, Yao; Song, Qiuling. The article contains the following contents:

A simple method for the divergent assembly of furoxans and isoxazoles in which the [2 + 1 + 1 + 1] annulation reaction of sulfoxonium ylides is reported. When the reaction was performed using t-BuONO as the nitrogen source without metal catalyst, the desired furoxans were obtained in decent yields with wide substrate scope. Isoxazoles bearing three carbonyl groups were achieved when the reaction was conducted using Cu(TFA)2 as catalyst. In addition to this study using Trimethylsulfoxonium iodide, there are many other studies that have used Trimethylsulfoxonium iodide(cas: 1774-47-6Reference of Trimethylsulfoxonium iodide) was used in this study.

Trimethylsulfoxonium iodide(cas: 1774-47-6) reacts with sodium hydride to prepare dimethyloxosulfonium methylide, which is used as a methylene-transfer reagent in synthetic chemistry. It is used to prepare ylide, which reacts with carbonyl compounds to get epoxides. Further, it reacts with alfa,beta-unsaturated esters to get cyclopropyl esters.Reference of Trimethylsulfoxonium iodide

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Safety of 1-IodonaphthaleneIn 2020 ,《Cu2O Nanocrystals-Catalyzed Photoredox Sonogashira Coupling of Terminal Alkynes and Arylhalides Enhanced by CO2》 appeared in ChemSusChem. The author of the article were Shanmugam, Munusamy; Sagadevan, Arunachalam; Charpe, Vaibhav Pramod; Pampana, V. Kishore Kumar; Hwang, Kuo Chu. The article conveys some information:

The first visible-light-activated Sonogashira C-C coupling reaction at room temperature catalyzed by single-metal heterogeneous Cu2O truncated nanocubes (Cu2O TNCs) was developed. A wide variety of aryl halides and terminal alkynes worked well in this recyclable heterogeneous photochem. process and formed the corresponding Sonogashira C-C coupling products in good yields. Mechanistic control studies indicated that CO2 enhances the formation of light-absorbing heterogeneous surface-bound CuI-phenylacetylide (λmax=472 nm), which further underwent single-electron transfer with aryl iodides/bromides to enable Sonogashira Csp2-Csp bond formation. In contrast to literature-reported bimetallic TiO2-containing nanoparticles as photocatalyst, this work avoided the need of cocatalysis by TiO2. Single-metal CuI in Cu2O TNCs was solely responsible for the observed Csp2-Csp coupling reactions under CO2 atmosphere. In the part of experimental materials, we found many familiar compounds, such as 1-Iodonaphthalene(cas: 90-14-2Safety of 1-Iodonaphthalene)

1-Iodonaphthalene(cas: 90-14-2) is one of organic iodides. The carbon-iodine bond is weaker than other carbon-halogen bonds due to the poor electronegative nature of the iodine atom. In general, organic iodides are light-sensitive and turn yellow during storage, owing to the formation of iodine. Organic iodides can be alkyl, alkenyl, or alkynyl, and all of them are very reactive toward with many kinds of nucleophiles.Safety of 1-Iodonaphthalene

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Computed Properties of C6H5ClINIn 2022 ,《Cyclization of o-Alkynylisocyanobenzenes with 1,3-Dicarbonyl Compounds》 appeared in Synlett. The author of the article were La-ongthong, Kannika; Sawekteeratana, Natthapat; Klaysuk, Jasarin; Soorukram, Darunee; Leowanawat, Pawaret; Reutrakul, Vichai; Krobthong, Sucheewin; Wongtrakoongate, Patompon; Kuhakarn, Chutima. The article conveys some information:

A facile and convenient reaction of o-alkynylisocyanobenzenes with various active-methylene compounds, including 1,3-diesters, 1,3-diketones,β-keto esters, and β-keto amides, under Bronsted basic conditions, had been developed. Di-Et malonate reacted smoothly with a collection of o-alkynylisocyanobenzenes to provide the corresponding 2-quinolin-2-yl malonates in excellent yields. Acetylacetone gave a mixture of quinolin-4-yl and quinolin-2-yl derivatives Acetoacetate esters and acetoacetyl amide derivative initially gave 2-quinolin-2-yl adducts that underwent partial deacetylation under the reaction conditions. The results came from multiple reactions, including the reaction of 4-Chloro-2-iodoaniline(cas: 63069-48-7Computed Properties of C6H5ClIN)

4-Chloro-2-iodoaniline(cas: 63069-48-7) belongs to anime. Reaction with nitrous acid (HNO2), which functions as an acylating agent that is a source of the nitrosyl group (―NO), converts aliphatic primary amines to nitrogen and mixtures of alkenes and alcohols corresponding to the alkyl group in a complex process. This reaction has been used for analytical determination of primary amino groups in a procedure known as the Van Slyke method.Computed Properties of C6H5ClIN

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

In 2022,Ye, Hai-Bing; Zhou, Xu-Yu; Li, Lei; He, Xiang-Kui; Xuan, Jun published an article in Organic Letters. The title of the article was 《Photochemical Synthesis of Succinic Ester-Containing Phenanthridines from Diazo Compounds as 1,4-Dicarbonyl Precursors》.Related Products of 63069-48-7 The author mentioned the following in the article:

Authors disclosed herein a straightforward photochem. method for the construction of phenanthridines containing a synthetically useful succinate unit. The reaction occurred under visible-light irradiation with cheap eosin Y Na as photoredox catalyst and a diazo compound as the succinate precursor. Under the optimal reaction conditions, a wide range of phenanthridines were obtained in moderate to good yields. Note that the succinate units in the final heterocycles could be easily transformed into many valuable structures, such as γ-butyrolactone, dihydrofuran-2(3H)-one, and THF. Mechanistic experiments were performed to support the proposed mechanism. After reading the article, we found that the author used 4-Chloro-2-iodoaniline(cas: 63069-48-7Related Products of 63069-48-7)

4-Chloro-2-iodoaniline(cas: 63069-48-7) belongs to anime. Left-handed and right-handed forms (mirror-image configurations, known as optical isomers or enantiomers) are possible when all the substituents on the central nitrogen atom are different (i.e., the nitrogen is chiral). With amines, there is extremely rapid inversion in which the two configurations are interconverted.Related Products of 63069-48-7

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com