Tag: 200-300

In 2022,Wen, Ya-Ting; Kong, Xiang-Tao; Liu, Hong-Chao; Wang, Cui-Tian; Wei, Wan-Xu; Wang, Bin; Liu, Xue-Yuan; Liang, Yong-Min published an article in Organic Letters. The title of the article was 《Ni-Catalyzed Remote Radical/Cross-Electrophile Coupling Cascade for Selective C(sp3)-H Arylation》.Synthetic Route of C5H4IN The author mentioned the following in the article:

An innovative 1,5-HAT cascade strategy was advanced for the nickel-catalyzed distal arylation via cross-electrophile coupling. Through specific migration, the remote C(sp3)-H bond was regioselectively activated, and Ar-I as the available electrophile is used for the construction of the C(sp3)-C(sp2) bond. This method also has broad applicability for benzylic and aliphatic N-fluorocarboxamides with yields up to 80%. Furthermore, a series of control experiments demonstrated that this reaction was probably initiated by a radical process.4-Iodopyridine(cas: 15854-87-2Synthetic Route of C5H4IN) was used in this study.

4-Iodopyridine(cas: 15854-87-2) is used as a reagent in the synthesis of indazolylamides as glucocorticoid receptor agonists. 4-Iodopyridine is a halogenated heterocycle that is a building block for proteomics research.Synthetic Route of C5H4IN

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

In 2022,Wang, Linhua; Zheng, Xuesong; Zheng, Qinze; Li, Zhenlong; Wu, Jian; Gao, Ge published an article in Organic Letters. The title of the article was 《Thioether-Assisted Cu-Catalyzed C5-H Arylation of Imidazo[1,5-a]pyridines》.Application In Synthesis of 4-Iodopyridine The author mentioned the following in the article:

A series of ethylthio (hetero)arylimidazo[1,5-a]pyridine derivatives I (R = 4-methylphenyl, pyridin-4-yl, 1-methyl-1H-indol-5-yl, etc.; R1 = H, Cl, Br, Me, Ph, 4-methoxyphenyl, 4-trifluoromethylphenyl; R2 = H, 6-Cl, 7-Me) was prepared via Cu-catalyzed regioselective C5-H arylation of imidazo[1,5-a]pyridines I (R = H) with aryl iodides RI with the assistance of an ethylthio group at the C3 position. This directing group could be easily removed to furnish a range of 5-(hetero)arylimidazo[1,5-a]pyridine derivatives e.g., II. The reaction tolerates a variety of functionalities and is compatible with sterically hindered substrates. After reading the article, we found that the author used 4-Iodopyridine(cas: 15854-87-2Application In Synthesis of 4-Iodopyridine)

4-Iodopyridine(cas: 15854-87-2) is used as a reagent in the synthesis of indazolylamides as glucocorticoid receptor agonists. 4-Iodopyridine is a halogenated heterocycle that is a building block for proteomics research.Application In Synthesis of 4-Iodopyridine

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

In 2022,Yang, Zhenjiao; Zhang, Yongsheng; Lv, Xingxian; Yang, Yang; Jiang, Chunhao; He, Xiaoyan; Chen, Guoliang; Huang, Gang; Lu, Xiuhong published an article in Green Chemistry. The title of the article was 《Copper and neocuproine catalysed synthesis of cinnamyl ether derivatives directly from secondary and tertiary cinnamyl alcohols》.Recommanded Product: 626-02-8 The author mentioned the following in the article:

A new method for the synthesis of secondary and tertiary cinnamyl ether derivatives, e.g., (E)-1-(3-ethoxy-3-methylbut-1-en-1-yl)-4-methylbenzene employing copper sulfate pentahydrate (CuSO4.5H2O) as a catalyst and neocuproine as a ligand, was developed. Interestingly, this method enabled the efficient connection of the long alkoxy chain with secondary or tertiary cinnamyl alcs.e.g., (E)-2-methyl-4-(p-tolyl)but-3-en-2-ol. Through this method, PEG-modified secondary and tertiary cinnamyl alcs. containing natural products and small mol. drugs were realized, providing a green method to generate functional cinnamyl ether derivatives directly. In the experimental materials used by the author, we found 3-Iodophenol(cas: 626-02-8Recommanded Product: 626-02-8)

3-Iodophenol(cas: 626-02-8) belongs to organic iodides. Organic iodides are used in veterinary products (Organic Iodide Powder) as a nutritional source of iodine. In the chemical industry, alkyl iodides serve as excellent alkylating agents and, specifically, methyl iodide is used as a methylating agent in the synthesis of various pharmaceutical drugs.Recommanded Product: 626-02-8

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

In 2022,Xiao, Yong-Mei; Lv, Wen-Wen; Yuan, Jin-Wei; Yang, Liang-Ru; Mao, Pu; Mai, Wen-Peng published an article in ChemistrySelect. The title of the article was 《Nickel-Catalyzed Thiocarbonylation of Aryl Iodides with Dialkyl Disulfides for the Synthesis of Thioesters》.Recommanded Product: 625-99-0 The author mentioned the following in the article:

A nickel-catalyzed molybdenum-promoted carbonylative synthesis of thioesters between aryl iodides and dialkyl disulfides has been developed. This method provides a novel and practical route to aryl thioesters under CO-gas-free conditions. Using Mo(CO)6 as a solid CO source, many thioesters were obtained in moderate yields without expensive metals such as palladium. In the part of experimental materials, we found many familiar compounds, such as 1-Chloro-3-iodobenzene(cas: 625-99-0Recommanded Product: 625-99-0)

1-Chloro-3-iodobenzene(cas: 625-99-0) belongs to organic iodides. Alkyl iodides react at a faster rate than alkyl fluorides due to the weak C-I bond.Iodo alkanes participate in a variety of organic synthesis reactions, which include the Simmons–Smith reaction (cyclopropanation using iodomethane), Williamson ether synthesis, Wittig reaction, Grignard reaction, alkyl coupling reactions, and Wurtz reaction.Recommanded Product: 625-99-0

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Sasmal, Sheuli; Prakash, Gaurav; Dutta, Uttam; Laskar, Ranjini; Lahiri, Goutam Kumar; Maiti, Debabrata published an article in 2022. The article was titled 《Directing group assisted rhodium catalyzed meta-C-H alkynylation of arenes》, and you may find the article in Chemical Science.HPLC of Formula: 88-67-5 The information in the text is summarized as follows:

Site-selective C-H alkynylation of arenes to produce aryl alkynes is a highly desirable transformation due to the prevalence of aryl alkynes in various natural products, drug mols. and in materials. To ensure site-selective C-H functionalization, directing group (DG) assisted C-H activation has been evolved as a useful synthetic tool. In contrast to DG-assisted ortho-C-H activation, distal meta-C-H activation is highly challenging and has attracted significant attention in recent years. However, developments are majorly focused on Pd-based catalytic systems. In order to diversify the scope of distal meta-C-H functionalization, herein the first Rh(I) catalyzed meta-C-H alkynylation protocol through the inverse Sonogashira coupling reaction is disclosed. The protocol is compatible with various substrate classes which include phenylacetic acids, hydrocinnamic acids, 2-Ph benzoic acids, 2-Ph phenols, benzyl sulfonates and ether-based scaffolds. The post-synthetic modification of meta-alkynylated arenes is also demonstrated through DG-removal as well as functional group interconversion. In the experimental materials used by the author, we found 2-Iodobenzoic acid(cas: 88-67-5HPLC of Formula: 88-67-5)

2-Iodobenzoic acid(cas: 88-67-5) belongs to organic iodides. Organic iodides are used in veterinary products (Organic Iodide Powder) as a nutritional source of iodine.HPLC of Formula: 88-67-5 In the chemical industry, alkyl iodides serve as excellent alkylating agents and, specifically, methyl iodide is used as a methylating agent in the synthesis of various pharmaceutical drugs.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

In 2022,Zhang, Lin-Bao; Xie, Zuowei published an article in Organic Letters. The title of the article was 《Iridium-Catalyzed Selective B(4)-H Acylmethylation of o-Carboranes with Sulfoxonium Ylides》.Quality Control of Trimethylsulfoxonium iodide The author mentioned the following in the article:

A highly efficient Ir-catalyzed regioselective cage B(4)-H acylmethylation of o-carboranyl acids using sulfoxonium ylides as alkylating regents was developed, giving a large class of B(4)-acylmethylated o-carboranes in good to excellent yields with a broad substrate scope under redox neutral condition. The -COOH moiety serves as the traceless directing group and controls both the regioselectivity and monoselectivity. The experimental process involved the reaction of Trimethylsulfoxonium iodide(cas: 1774-47-6Quality Control of Trimethylsulfoxonium iodide)

Trimethylsulfoxonium iodide(cas: 1774-47-6) reacts with sodium hydride to prepare dimethyloxosulfonium methylide, which is used as a methylene-transfer reagent in synthetic chemistry. It is used to prepare ylide, which reacts with carbonyl compounds to get epoxides.Quality Control of Trimethylsulfoxonium iodide

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

In 2022,Dong, Weizhe; Yen-Pon, Expedite; Li, Longbo; Bhattacharjee, Ayan; Jolit, Anais; Molander, Gary A. published an article in Nature Chemistry. The title of the article was 《Exploiting the sp2 character of bicyclo[1.1.1]pentyl radicals in the transition-metal-free multi-component difunctionalization of [1.1.1]propellane》.Product Details of 15854-87-2 The author mentioned the following in the article:

Strained bicyclic substructures are increasingly relevant in medicinal chem. discovery research because of their role as bioisosteres. Over the last decade, the successful use of bicyclo[1.1.1]pentane (BCP) as a para-disubstituted benzene replacement has made it a highly valuable pharmacophore. However, various challenges, including limited and lengthy access to useful BCP building blocks, are hampering early discovery research. Here authors report a single-step transition-metal-free multi-component approach to synthetically versatile BCP boronates. Radicals derived from commonly available carboxylic acids and organo halides perform additions onto [1.1.1]propellane to afford BCP radicals, which then engage in polarity-matched borylation. A wide array of alkyl-, aryl- and alkenyl-functionalized BCP boronates were easily prepared Late-stage functionalization performed on natural products and approved drugs proceeded with good efficiency to generate the corresponding BCP conjugates. Various photoredox transformations forging C-C and C-N bonds were demonstrated by taking advantage of BCP trifluoroborate salts derived from the BCP boronates. The experimental process involved the reaction of 4-Iodopyridine(cas: 15854-87-2Product Details of 15854-87-2)

4-Iodopyridine(cas: 15854-87-2) belongs to pyridine. Pyridine’s structure is isoelectronic with that of benzene, but its properties are quite different. Pyridine is completely miscible with water, whereas benzene is only slightly soluble. Like all hydrocarbons, benzene is neutral (in the acid–base sense), but because of its nitrogen atom, pyridine is a weak base.Product Details of 15854-87-2

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

In 2022,Leifert, Dirk; Weidlich, Frauke; Adler, Florin; Daniliuc, Constantin G.; Alasmary, Fatmah A.; Studer, Armido published an article in Organic Letters. The title of the article was 《2,3-Difunctionalized Indoles via Radical Acylation or Trifluoromethylation of ortho-Alkynylphenyl Isonitriles》.SDS of cas: 63069-48-7 The author mentioned the following in the article:

A radical cascade to 2,3-disubstituted indoles proceeding via acylation or trifluoromethylation of ortho-alkynylphenyl isonitriles was presented. In these cascades, two C-C bonds and one C-O bond was formed using an inexpensive oxidant and a catalytic copper or iron salt. The starting isonitriles were easily accessible, and com. available aldehydes and fluoromethylation reagents served as reaction partners. Functional group tolerance was high, as documented by the successful preparation of a series of 2,3-disubstituted indoles.4-Chloro-2-iodoaniline(cas: 63069-48-7SDS of cas: 63069-48-7) was used in this study.

4-Chloro-2-iodoaniline(cas: 63069-48-7) belongs to anime. Amine, any member of a family of nitrogen-containing organic compounds that is derived, either in principle or in practice, from ammonia (NH3). Naturally occurring amines include the alkaloids, which are present in certain plants; the catecholamine neurotransmitters (i.e., dopamine, epinephrine, and norepinephrine); and a local chemical mediator, histamine, that occurs in most animal tissues.SDS of cas: 63069-48-7

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Tang, Jiaying; Ren, Linlin; Li, Jianwei; Wang, Yonggong; Hu, Dongyan; Tong, Xiaogang; Xia, Chengfeng published an article in 2022. The article was titled 《Photochemical Synthesis of Indolocarbazoles through Tandem Indolization/Dimerization/Mannich Cyclization from Allenes》, and you may find the article in Organic Letters.Category: iodides-buliding-blocks The information in the text is summarized as follows:

Disclosed herein was the photochem. synthesis of the indolocarbazole ring system from N-allenyl-2-iodoanilines. The tandem protocol included visible-light-mediated 5-exo-trig radical cyclization and subsequent radical dimerization, followed by acid-promoted deprotection and intramol. Mannich cyclization. This strategy showed exceptional functional group tolerance and was successfully applied in the concise synthesis of natural products tjipanazoles B and D. In the experiment, the researchers used many compounds, for example, 4-Chloro-2-iodoaniline(cas: 63069-48-7Category: iodides-buliding-blocks)

4-Chloro-2-iodoaniline(cas: 63069-48-7) belongs to anime. Halogenation, in which one or more hydrogen atoms of an amine is replaced by a halogen atom, occurs with chlorine, bromine, and iodine, as well as with some other reagents, notably hypochlorous acid (HClO). With primary amines the reaction proceeds in two stages, producing N-chloro- and N,N-dichloro-amines, RNHCl and RNCl2, respectively. With tertiary amines, an alkyl group may be displaced by a halogen.Category: iodides-buliding-blocks

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Song, Xuan-Di; Guo, Meng-Meng; Xu, Shuang; Shen, Chuanji; Zhou, Xiaocong; Chu, Xue-Qiang; Ma, Mengtao; Shen, Zhi-Liang published an article in 2021. The article was titled 《Nickel-Catalyzed Diastereoselective Reductive Cross-Coupling of Disubstituted Cycloalkyl Iodides with Aryl Iodides》, and you may find the article in Organic Letters.Recommanded Product: 15164-44-0 The information in the text is summarized as follows:

A nickel-catalyzed direct reductive cross-coupling of disubstituted cycloalkyl iodides with aryl iodides was developed. The one-pot reaction, which is simple to operate, was capable of proceeding efficiently in a stereocontrolled manner to afford a variety of cross-coupled products with high diastereoselectivity and wide functional group tolerance. In the experiment, the researchers used many compounds, for example, 4-Iodobenzaldehyde(cas: 15164-44-0Recommanded Product: 15164-44-0)

4-Iodobenzaldehyde(cas: 15164-44-0) is used in synthesis of 4-[2-(trimethylsilyl)ethynyl]benzaldehyde, 5,15-dimesityl-10-(3-[2-(trimethylsilyl)ethynyi]phenyl}-20-(4-iodophenyl)porphyrin, and 5,15-dimesityl-10-[3,5-bis{2-[4-(N,N’-difluoroboryl-1,9-dimethyidipyrrin-5-yl)-phenyl]ethynyl}phenyl]-20-(4-iodophenyl)porphyrin.Recommanded Product: 15164-44-0

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com