Tag: 200-300

Application of 63069-48-7In 2021 ,《Quasi-homogeneous catalytic conversion of CO2 into quinazolinones inside a metal-organic framework microreactor》 appeared in Green Chemistry. The author of the article were Zhou, Zhenzhen; Ma, Jian-Gong; Gao, Jianbo; Cheng, Peng. The article conveys some information:

Management of CO2 has been attracting great attention in this century. Reaction of CO2 with 2-haloanilines and isocyanides is an attractive way for both converting CO2 and producing quinazolinones, which are key intermediates for the synthesis of various biol. active products. However, the heterogeneous and relatively inert nature of CO2 with 2-haloaniline and isocyanide reactants limits the types of suitable catalysts. Herein, we use metal-organic frameworks (MOFs) as a “”microreactor””, in which Pd(PPh3)2Cl2 is well-dispersed as a single-mol. catalyst, and the reactants react in the mol. level through a “”quasi-homogeneous”” way to convert CO2 into quinazolinones under mild conditions with both promising yields over homogeneous catalysts and good recyclability as a heterogeneous reaction. The MOF-assisted single-mol. catalysis strategy should contribute to CO2 conversion, production of quinazolinone-type bioactive intermediates, and the epochal development of “”homo-and-heterogeneous”” catalysis. In addition to this study using 4-Chloro-2-iodoaniline, there are many other studies that have used 4-Chloro-2-iodoaniline(cas: 63069-48-7Application of 63069-48-7) was used in this study.

4-Chloro-2-iodoaniline(cas: 63069-48-7) belongs to anime. Amines have a free lone pair with which they can coordinate to metal centers. Amine–metal bonds are weaker because amines are incapable of backbonding, but they are still important for sensing applications.While stronger than hydrogen bonds, amine–metal bonds are still weaker than both covalent and ionic bonds.Application of 63069-48-7

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Related Products of 15164-44-0In 2022 ,《Apoptotic mechanism in human brain microvascular endothelial cells triggered by 4′-iodo-α-pyrrolidinononanophenone: Contribution of decrease in antioxidant properties》 appeared in Toxicology Letters. The author of the article were Sakai, Yuji; Taguchi, Maki; Morikawa, Yoshifumi; Miyazono, Hidetoshi; Suenami, Koichi; Ochiai, Yuto; Yanase, Emiko; Takayama, Tomohiro; Ikari, Akira; Matsunaga, Toshiyuki. The article conveys some information:

In this study, four α-pyrrolidinononanophenone (α-PNP) derivatives [4′-halogenated derivatives and α-pyrrolidinodecanophenone (α-PDP)] were synthesized, and then performed the structure-cytotoxicity relationship analyses. The results showed the rank order for the cytotoxic effects, α-PNP < α-PDP < 4'-fluoro-α-PNP < 4'-chloro-α-PNP < 4'-bromo-α-PNP < 4'-iodo-α-PNP (I-α-PNP), and suggest that cytotoxicities of 4'-halogenated derivatives were more intensive than that of elongation of the hydrocarbon chain (α-PDP). The apoptotic mechanism of I-α-PNP was also surveyed in brain microvascular endothelial (HBME) cells that are utilized as the in-vitro model of the blood-brain barrier. HBME cell treatment with I-α-PNP facilitated the apoptotic events (caspase-3 activation, externalization of phosphatidylserine, and DNA fragmentation), which were almost completely abolished by pretreating with antioxidants. In addition, the immunofluorescent staining revealed the enhanced production of hydroxyl radical in mitochondria by the I-α-PNP treatment, inferring that the I-α-PNP treatment triggers the apoptotic mechanism dependent on the enhanced ROS production in mitochondria. The treatment with I-α-PNP increased the production of cytotoxic aldehyde 4-hydroxy-2-nonenal and decreased the amount of reduced glutathione. Addnl., the treatment decreased the 26S proteasome-based proteolytic activities and aggresome formation. These results suggest that decrease in the antioxidant properties is also ascribable to HBME cell apoptosis elicited by I-α-PNP. In the part of experimental materials, we found many familiar compounds, such as 4-Iodobenzaldehyde(cas: 15164-44-0Related Products of 15164-44-0)

4-Iodobenzaldehyde(cas: 15164-44-0) is used in synthesis of 4-[2-(trimethylsilyl)ethynyl]benzaldehyde, 5,15-dimesityl-10-(3-[2-(trimethylsilyl)ethynyi]phenyl}-20-(4-iodophenyl)porphyrin, and 5,15-dimesityl-10-[3,5-bis{2-[4-(N,N’-difluoroboryl-1,9-dimethyidipyrrin-5-yl)-phenyl]ethynyl}phenyl]-20-(4-iodophenyl)porphyrin.Related Products of 15164-44-0

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

In 2022,Kang, Kang; Li, Lei; Zhang, Meiyu; Miao, Xiaohe; Lei, Lecheng; Xiao, Chengliang published an article in Inorganic Chemistry. The title of the article was 《Two-Fold Interlocking Cationic Metal-Organic Framework Material with Exchangeable Chloride for Perrhenate/Pertechnetate Sorption》.Product Details of 15854-87-2 The author mentioned the following in the article:

Albeit reported substantial sorbents for elimination of TcO4-, the issue of secondary contamination caused by released counterions (such as NO3-) from the cationic metal-organic framework (MOF) has not come into the sufficient limelight for researchers. Herein, our efforts are dedicated to settle the matter through synthesis of NiCl2 based on the cationic MOF (ZJU-X4). Less harmful chlorides are used as exchangeable anions for replacing hazardous anions. Notably, ZJU-X4 exhibited fast sorption kinetics, high sorption capacity of 395 mg/g, decent selectivity, and excellent reusability in four recycles. The results of ion chromatog. revealed that the released chloride ion was equal to sorption of target ions, and pair distribution functions were employed to analyze the changes in ZJU-X4 after sorption of ReO4-, clearly elucidating the anion-exchange mechanism. Furthermore, in the dynamic sorption experiments, ReO4- could be facilely and effectively removed and recovered, showing the value of practical applications. This work indicated that cationic MOF-based metal chloride salts would be a better choice for anionic sorbents. In the part of experimental materials, we found many familiar compounds, such as 4-Iodopyridine(cas: 15854-87-2Product Details of 15854-87-2)

4-Iodopyridine(cas: 15854-87-2) is used as a reagent in the synthesis of indazolylamides as glucocorticoid receptor agonists. 4-Iodopyridine is a halogenated heterocycle that is a building block for proteomics research.Product Details of 15854-87-2

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

In 2022,Yu, Shilin; Ward, Jas S. published an article in Dalton Transactions. The title of the article was 《Ligand exchange among iodine(I) complexes》.Application In Synthesis of 4-Iodopyridine The author mentioned the following in the article:

A detailed investigation of ligand exchange between iodine(I) ions in [N···I···N]+ halogen-bonded complexes is presented. Ligand exchange reactions were conducted to successfully confirm whether iodine(I) complex formation, via the classical [N···Ag···N]+ to [N···I···N]+ cation exchange reaction from their analogous Ag+ complexes, could be determined solely by using 1H NMR spectroscopy. In instances where the formation of the iodine(I) complex was unclear or in low yield by the traditional cation exchange reaction, a ligand exchange reaction was used to form the desired iodine(I) complexes in a quant. manner. Mixing two homoleptic [N···I···N]+ iodine(I) complexes in 1:1 ratio was found to undergo a statistical ligand exchange, with 1H NMR studies showing that the preferred formation of the relative heteroleptic [N1···I···N2]+ complexes increases with greater differences in the Lewis basicities of two XB acceptors of the complexes involved. The experimental part of the paper was very detailed, including the reaction process of 4-Iodopyridine(cas: 15854-87-2Application In Synthesis of 4-Iodopyridine)

4-Iodopyridine(cas: 15854-87-2) is used as a reagent in the synthesis of indazolylamides as glucocorticoid receptor agonists. 4-Iodopyridine is a halogenated heterocycle that is a building block for proteomics research.Application In Synthesis of 4-Iodopyridine

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

In 2022,Rakshit, Amitava; Dhara, Hirendra Nath; Sahoo, Ashish Kumar; Alam, Tipu; Patel, Bhisma K. published an article in Organic Letters. The title of the article was 《Pd(II)-Catalyzed Synthesis of Furo[2,3-b]pyridines from β-Ketodinitriles and Alkynes via Cyclization and N-H/C Annulation》.Application of 625-99-0 The author mentioned the following in the article:

A Pd(II)-catalyzed synthesis of furopyridines, e.g., I has been developed from β-ketodinitriles, e.g., 2-(1-oxo-1,2,3,4-tetrahydronaphthalen-2-yl)propanedinitrile and alkynes, e.g., diphenylacetylene via an unusual N-H/C annulation. The participation of both the nitrile groups and the concurrent construction of furan and pyridine rings through the formation of C-C, C=C, C-O, C-N, and C=N bonds are the important features. The synthetic applicability is further demonstrated through a series of postsynthetic alterations. The results came from multiple reactions, including the reaction of 1-Chloro-3-iodobenzene(cas: 625-99-0Application of 625-99-0)

1-Chloro-3-iodobenzene(cas: 625-99-0) belongs to organic iodides. The carbon-iodine bond is weaker than other carbon-halogen bonds due to the poor electronegative nature of the iodine atom. Organic iodides can be alkyl, alkenyl, or alkynyl, and all of them are very reactive toward with many kinds of nucleophiles.Application of 625-99-0

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

In 2022,Wang, Chang-Sheng; Tan, Ploypailin Siew Ling; Ding, Wei; Ito, Shingo; Yoshikai, Naohiko published an article in Organic Letters. The title of the article was 《Regio- and Stereoselective Synthesis of Enol Carboxylate, Phosphate, and Sulfonate Esters via Iodo(III)functionalization of Alkynes》.Recommanded Product: 88-67-5 The author mentioned the following in the article:

Synthesis of β-Iodo(III)enol carboxylates, I (R1 = Et, Me, Bu, t-Bu; R2 = Et, Ph, thiophen-2-yl, etc.; R3 = 4-oxopentanoyl, benzoyl, 2,2-dimethylpropyl, etc.) phosphates, I (R3 = diethoxyphosphoroso, diphenoxyphosphoroso, dimethoxyphosphoroso, diphenylphosphoroso) and tosylates I (R3 = Ts) can be efficiently performed through regio- and stereoselective iodo(III)functionalization of alkynes R1CCR2. The combination of 1,2-benziodoxole, 1-chloro-1,3-dihydro-3,3-bis(trifluoromethyl)- and silver salt has proven to generate a versatile cationic iodine(III) electrophile to activate alkynes and engage various carboxylic acids R4COOH (R4 = Me, Ph, 2-phenylethenyl, etc.), tri-Et phosphate and p-toluenesulfonic acid as nucleophiles. The β-iodo(III)enol esters serve as starting materials for the synthesis of multisubstituted alkenes I through sequential cross-coupling of the C-I(III) and C-O bonds. In the experimental materials used by the author, we found 2-Iodobenzoic acid(cas: 88-67-5Recommanded Product: 88-67-5)

2-Iodobenzoic acid(cas: 88-67-5) belongs to organic iodides. The carbon-iodine bond is weaker than other carbon-halogen bonds due to the poor electronegative nature of the iodine atom. In general, organic iodides are light-sensitive and turn yellow during storage, owing to the formation of iodine.Recommanded Product: 88-67-5

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

In 2022,He, Yuli; Ma, Jiawei; Song, Huayue; Zhang, Yao; Liang, Yong; Wang, You; Zhu, Shaolin published an article in Nature Communications. The title of the article was 《Regio- and enantioselective remote hydroarylation using a ligand-relay strategy》.Synthetic Route of C7H5IO The author mentioned the following in the article:

The design of a single complicated chiral ligand to well-promote each step of an asym. cascade reaction is sometimes a formidable challenge in transition metal catalysis. In this work, a highly regio- and enantioselective Ni-catalyzed migratory hydroarylation relay process has been achieved with the combination of two simple ligands, one which accomplishes chain-walking and the other causing asym. arylation. This formal asym. C(sp3)-H arylation provides direct access to a wide range of structurally diverse chiral 1,1-diarylalkanes, a structural unit found in a number of bioactive mols. The value of this strategy was further demonstrated by the Ni-catalyzed migratory asym. 1,3-arylboration. In the experiment, the researchers used 4-Iodobenzaldehyde(cas: 15164-44-0Synthetic Route of C7H5IO)

4-Iodobenzaldehyde(cas: 15164-44-0) is used in synthesis of 4-[2-(trimethylsilyl)ethynyl]benzaldehyde, 5,15-dimesityl-10-(3-[2-(trimethylsilyl)ethynyi]phenyl}-20-(4-iodophenyl)porphyrin, and 5,15-dimesityl-10-[3,5-bis{2-[4-(N,N’-difluoroboryl-1,9-dimethyidipyrrin-5-yl)-phenyl]ethynyl}phenyl]-20-(4-iodophenyl)porphyrin.Synthetic Route of C7H5IO

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Marchese, Austin D.; Adrianov, Timur; Kollen, Martin F.; Mirabi, Bijan; Lautens, Mark published an article in 2021. The article was titled 《Synthesis of Carbocyclic Compounds via a Nickel-Catalyzed Carboiodination Reaction》, and you may find the article in ACS Catalysis.Computed Properties of C7H5IO2 The information in the text is summarized as follows:

A scalable nickel-catalyzed carboiodination reaction generating 6-membered carbocycles I [R1 = H, 7-Me, 5-F, etc.; R2 = Me, n-Pr, Bn; R3 = CO2Me, CO2Et, CO2t-Bu, CO2Ph; R4 = CO2Me, CO2Et, CO2t-Bu, CO2Ph] was reported. NiI2 and P(OEt)3 as the ligand and reducing agent, provided decorated iodomethyl-tetrahydronaphthalenes I in up to 94% yield. The impact of varying electronic and steric parameters on the reaction were reported and a nonlinear Hammett plot was obtained, supporting a change in rate-determining step from oxidative addition to reductive elimination. Exptl. and DFT studies suggested the malonate group might stabilize a nickel oxidative-addition complex. A variety of heteroatom-containing nucleophiles and medicinally relevant heterocycles were easily incorporated into the products via simple SN2 chem. In addition to this study using 2-Iodobenzoic acid, there are many other studies that have used 2-Iodobenzoic acid(cas: 88-67-5Computed Properties of C7H5IO2) was used in this study.

2-Iodobenzoic acid(cas: 88-67-5) belongs to organic iodides. The carbon-iodine bond is weaker than other carbon-halogen bonds due to the poor electronegative nature of the iodine atom. Computed Properties of C7H5IO2 Organic iodides can be alkyl, alkenyl, or alkynyl, and all of them are very reactive toward with many kinds of nucleophiles.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Zhang, Tianze; Yu, Min; Huang, Hanmin published an article in 2021. The article was titled 《Fe-catalyzed Fukuyama-type indole synthesis triggered by hydrogen atom transfer》, and you may find the article in Chemical Science.Formula: C6H5ClIN The information in the text is summarized as follows:

An efficient Fe-catalyzed intramol. isonitrile-olefin coupling reaction delivering 3-substituted indoles, in which isonitrile was firstly applied as the hydrogen atom acceptor in the radical generation step by MHAT were reported. The protocol features low catalyst loading, mild reaction conditions and excellent functional group tolerance. After reading the article, we found that the author used 4-Chloro-2-iodoaniline(cas: 63069-48-7Formula: C6H5ClIN)

4-Chloro-2-iodoaniline(cas: 63069-48-7) belongs to anime. Amine, any member of a family of nitrogen-containing organic compounds that is derived, either in principle or in practice, from ammonia (NH3). Naturally occurring amines include the alkaloids, which are present in certain plants; the catecholamine neurotransmitters (i.e., dopamine, epinephrine, and norepinephrine); and a local chemical mediator, histamine, that occurs in most animal tissues.Formula: C6H5ClIN

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Zhang, Sikun; Liu, Xu; Li, Guoping; Yu, Shi; Yan, Ni; He, Gang published their research in Dyes and Pigments in 2021. The article was titled 《Novel dithienoazaborine viologen derivatives with two different π-conjugated extensions for electrochromic application》.HPLC of Formula: 15854-87-2 The article contains the following contents:

Two kinds of dithienoazaborine viologen derivatives (3a and 3b) with different π-conjugated extensions were synthesized via late-stage functionalization of dithienoazaborine precursor (BNDT). In sharp contrast to 3a (conjugation I), 3b (conjugation II) showed red-shifted absorption (∼468 nm), narrower optical bandgap (2.65 eV), and aggregation-induced emission (AIE) property. Meanwhile, 3b-based electrochromic device (ECD) showed longer switching times (21.6 s for coloration and 34.9 s for bleaching), higher color contrast ratios (21.3%), higher coloration efficiency (13.29 cm2/C), as well as better stability compared with 3a-based ECD. In addition, an electronic information (E-information) tag and a flexible ECD were assembled using 3b, further manifesting its potential applications in display areas. The research not only expands the structural types of viologen derivatives but also compares the effects of different conjugation on the properties of viologen derivatives for the first time, which may provide a feasible way to design new electrochromic materials. In the experimental materials used by the author, we found 4-Iodopyridine(cas: 15854-87-2HPLC of Formula: 15854-87-2)

4-Iodopyridine(cas: 15854-87-2) belongs to pyridine. Pyridine is very deactivated towards electrophilic substitution with respect to benzene. For this reason classical formylation, using methods such as the Gattermann or Vilsmeier reactions, are not generally successful. HPLC of Formula: 15854-87-2

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com