Tag: 200-300

Dutta, Shubham; Shandilya, Shashank; Yang, Shengwen; Gogoi, Manash Protim; Gandon, Vincent; Sahoo, Akhila K. published an article in 2022. The article was titled 《Cationic-palladium catalyzed regio- and stereoselective syn-1,2-dicarbofunctionalization of unsymmetrical internal alkynes》, and you may find the article in Nature Communications.Safety of 4-Iodobenzoic acid The information in the text is summarized as follows:

The discovery of a regio- and stereoselective syn-1,2-dicarbofunctionalization of unsym. internal alkynes was reported. A cationic Pd-catalyzed three-component coupling of aryl diazonium salts, aryl boronic acids (or olefins) and yne-acetates enables access to all-carbon substituted unsym. olefins. The transformation features broad scope with labile functional group tolerance, building broad chem. space of structural diversity (94 mols.). The value of this synthetic method was demonstrated by the direct transformation of natural products and drug candidates containing yne-acetates, to enable highly substituted structurally complex allyl acetate analogs of biol. important compounds Synthetic versatility of the carboxylate bearing highly substituted olefins was also presented. The reaction outcome was attributed to the in situ formation of stabilized cationic aryl-Pd species, which regulated regioselective aryl-palladation of unsym. yne-acetates. Control experiments reveal the synergy between the carboxylate protecting group and the cationic Pd-intermediate in the regioselectivity and reaction productivity; d. functional theory (DFT) studies rationalize the selectivity of the reaction. In the part of experimental materials, we found many familiar compounds, such as 4-Iodobenzoic acid(cas: 619-58-9Safety of 4-Iodobenzoic acid)

4-Iodobenzoic acid(cas: 619-58-9) belongs to organic iodides. The carbon-iodine bond is weaker than other carbon-halogen bonds due to the poor electronegative nature of the iodine atom. Safety of 4-Iodobenzoic acid Alkyl iodides react at a faster rate than alkyl fluorides due to the weak C-I bond.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Feng, Jianling; Wang, Qiang; Duan, Ruomeng; Li, Huadeng; Zheng, Ke; Wang, Xiaoxia; Xie, Guanqun published an article in 2022. The article was titled 《A facile electrosynthesis of N-acyl benzotriazoles from aldehydes and benzotriazole》, and you may find the article in Tetrahedron Letters.Category: iodides-buliding-blocks The information in the text is summarized as follows:

An electrochem. synthesis of N-acylbenzotriazoles I [R = Ph, 4-ClC6H4, 2-naphthyl, etc.] had been developed under mild conditions with good to excellent yields using aldehydes and benzotriazole as starting materials. In addition, a one-pot reaction of aldehyde, benzotriazole and phenol had been achieved affording phenolic esters II [R1 = Ph, 4-MeC6H4, 4-BrC6H4, etc.] in moderate yields under the combination of electricity-on/off conditions, where N-acyl benzotriazole acted as the benign acylating reagent. It was noteworthy the research provided environmental friendly syntheses in that no superstoichiometric hazardous chem. oxidants were required, corrosive/toxic reagents had been avoided and waste production had significantly been reduced. The key of the electrochem. synthesis involved the oxidation of benzotriazole-aldehyde adduct by phthalimido-N-oxy (PINO), which was generated by N-hydroxyphthalimide (NHPI) as a redox mediator. The experimental part of the paper was very detailed, including the reaction process of 4-Iodobenzaldehyde(cas: 15164-44-0Category: iodides-buliding-blocks)

4-Iodobenzaldehyde(cas: 15164-44-0) is used in synthesis of 4-[2-(trimethylsilyl)ethynyl]benzaldehyde, 5,15-dimesityl-10-(3-[2-(trimethylsilyl)ethynyi]phenyl}-20-(4-iodophenyl)porphyrin, and 5,15-dimesityl-10-[3,5-bis{2-[4-(N,N’-difluoroboryl-1,9-dimethyidipyrrin-5-yl)-phenyl]ethynyl}phenyl]-20-(4-iodophenyl)porphyrin.Category: iodides-buliding-blocks

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Song, Yuting; Tao, Jiayu; Wang, Yi; Cai, Zhengchun; Fang, Xianying; Wang, Shifa; Xu, Haijun published an article in 2021. The article was titled 《A novel dual-responsive fluorescent probe for the detection of copper(II) and nickel(II) based on BODIPY derivatives》, and you may find the article in Inorganica Chimica Acta.Related Products of 516-12-1 The information in the text is summarized as follows:

A novel dual-responsive fluorescence probe 6 was constructed by introducing a dipicolyamine moiety on the BODIPY-based skeleton via Sonogashira coupling reaction and confirmed by 1H NMR, 13C NMR, elemental anal. and high-resolution mass spectroscopy (HRMS). The present probe 6 exhibited high selectivity and sensitivity toward Cu2+ and Ni2+ detection over other competitive metal ions by fluorescence quenching phenomena, resp. In addition, the detection limits (DLs) for Cu2+ and Ni2+ were calculated to be as low as both 0.1 μM resp., which were lower than the maximum allowable level of the World Health Organization (WHO) limit for the drinking water. The stoichiometric ratio of the probe 6 toward the Cu2+ or Ni2+ ions was determined to be 1:1 according to the result of the Job′s plot and HRMS anal. These results indicated that probe 6 can be used as a selective ′′turn-off′′ fluorescent sensor for the detection of Cu2+ and Ni2+. In the experiment, the researchers used 1-Iodopyrrolidine-2,5-dione(cas: 516-12-1Related Products of 516-12-1)

1-Iodopyrrolidine-2,5-dione(cas: 516-12-1) is used in the preparation of vinyl sulfones from olefins and benzenesulfinic acid. It acts as a source for I+ and involved in Hunsdiecker reactions for the conversion of cinnamic acids, and propiolic acids to the corresponding alfa-halostyrenes and 1-halo-1-alkynes respectively. Related Products of 516-12-1

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Zu, Bing; Ke, Jie; Guo, Yonghong; He, Chuan published their research in Chinese Journal of Chemistry in 2021. The article was titled 《Synthesis Of Diverse Aryliodine(III) Reagents By Anodic Oxidation》.Reference of 2-Iodobenzoic acid The article contains the following contents:

An anodic oxidation enabled synthesis of hypervalent iodine(III) reagents from aryl iodides is demonstrated. Under mild electrochem. conditions, a range of aryliodine(III) reagents, including iodosylarenes, e.g., PhI(OAc)2, (difunctional-iodo)arenes, e.g., PhI(OH){OP(O)Ph2}, diaryliodonium salts, e.g., I, and benziodoxoles, e.g., II, were efficiently synthesized and derivatized in good to excellent yields with high selectivity. As only electrons serve as the oxidation reagents, this method offers a more straightforward and sustainable manner that avoids the use of expensive or hazardous chem. oxidants. In the experiment, the researchers used 2-Iodobenzoic acid(cas: 88-67-5Reference of 2-Iodobenzoic acid)

2-Iodobenzoic acid(cas: 88-67-5) belongs to organic iodides. The carbon-iodine bond is weaker than other carbon-halogen bonds due to the poor electronegative nature of the iodine atom. Reference of 2-Iodobenzoic acid Alkyl iodides react at a faster rate than alkyl fluorides due to the weak C-I bond.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

《Efficient Nondoped Pure Blue Organic Light-Emitting Diodes Based on an Anthracene and 9,9-Diphenyl-9,10-dihydroacridine Derivative》 was written by He, Xin; Ren, Shenghong; Liu, Hui; Zhao, Shiyuan; Liu, Futong; Du, Chunya; Min, Jiarui; Zhang, Haiquan; Lu, Ping. Related Products of 589-87-7 And the article was included in Chemistry – An Asian Journal in 2020. The article conveys some information:

Organic light-emitting diodes (OLEDs) have been greatly developed in recent years owing to their abundant advantages for full-color displays and general-purpose lightings. Blue emitters not only provide one of the primary colors of the RGB (red, green and blue) display system to reduce the power consumption of OLEDs, but are able to generate light of all colors, including blue, green, red, and white by energy transfer processes in devices. However, it remains a challenge to achieve high-performance blue electroluminescence, especially for nondoped devices. In this paper, we report a blue light emitting mol., DPAC-AnPCN, which consists of 9,9-diphenyl-9,10-dihydroacridine and p-benzonitrile substituted anthracene moieties. The asym. decoration on anthracene with different groups on its 9 and 10 positions combines the merits of the resp. constructing units and endows DPAC-AnPCN with pure blue emission, high solid-state efficiency, good thermal stability and appropriate HOMO and LUMO energy levels. Furthermore, DPAC-AnPCN can be applied in a nondoped device to effectively reduce the fabrication complexity and cost. The nondoped device exhibits pure blue electroluminescence (EL) locating at 464 nm with CIE coordinates of (0.15, 0.15). Moreover, it maintains high efficiency at relatively high luminescence. The maximum external quantum efficiency (EQE) reaches 6.04% and still remains 5.31% at the luminance of 1000 cd m-2 showing a very small efficiency roll-off. In addition to this study using 1-Bromo-4-iodobenzene, there are many other studies that have used 1-Bromo-4-iodobenzene(cas: 589-87-7Related Products of 589-87-7) was used in this study.

1-Bromo-4-iodobenzene(cas: 589-87-7) is mainly used as the OLED pharmaceutical intermediate, as reagent for in situ desilylation and coupling of silylated alkynes, as substrate in copper-free Sonogashira coupling in aqueous acetone..Related Products of 589-87-7 It is also used in synthesis of β,β,dibromostyrenes, as starting reagent in the total syntheses of ent-conduramine A and ent-7-deoxypancratistatin (alkaloids)

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

《Nickel-Catalyzed trans-Carboamination across Internal Alkynes to Access Multifunctionalized Indoles》 was written by Tambe, Shrikant D.; Iqbal, Naeem; Cho, Eun Jin. Synthetic Route of C6H5ClIN And the article was included in Organic Letters in 2020. The article conveys some information:

A Ni-catalyzed reaction was developed for the synthesis of multifunctionalized indoles. The reaction proceeded through oxidative cyclization of the Ni(0)/bidentate P-N complex with an enyne system, 2-alkynyl anilinoacrylate, to provide a nickelacycle intermediate. The trans-carboamination around the internal alkyne was achieved by syn/anti-rotation of the Ni-carbenoid intermediate formed by C-N bond cleavage of the nickelacycle, and 3-alkenylated indoles were formed by C-N bond-forming reductive elimination. Notably, the synthesized indoles could be successfully transformed to functionalized carbazoles. The results came from multiple reactions, including the reaction of 4-Chloro-2-iodoaniline(cas: 63069-48-7Synthetic Route of C6H5ClIN)

4-Chloro-2-iodoaniline(cas: 63069-48-7) belongs to anime. Milder oxidation, using reagents such as NaOCl, can remove four hydrogen atoms from primary amines of the type RCH2NH2 to form nitriles (R―C≡N), and oxidation with reagents such as MnO2 can remove two hydrogen atoms from secondary amines (R2CH―NHR′) to form imines (R2C=NR′). Tertiary amines can be oxidized to enamines (R2C=CHNR2) by a variety of reagents.Synthetic Route of C6H5ClIN

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

《Discovery of Diphenoxy Derivatives with Flexible Linkers as Ligands for β-Amyloid Plaques》 was published in Molecular Pharmaceutics in 2020. These research results belong to Jia, Jianhua; Zhang, Longfei; Song, Jia; Dai, Jiapei; Cui, Mengchao. Category: iodides-buliding-blocks The article mentions the following:

The highly rigid and planar scaffolds with π-conjugated systems have been widely considered to be indispensable for β-amyloid (Aβ) binding ligands. In this study, a library of diphenoxy compounds with different types of more flexible linkers as Aβ ligands were synthesized and evaluated. Most of them displayed good affinity (Ki < 100 nM) for Aβ1-42 aggregates, and some ligands even showed values of Ki less than 10 nM. Structure-activity relationship anal. revealed that modification on the linkers or substituents tolerated great flexibility, which challenged the long-held belief that rigid and planar structures are exclusively favored for Aβ binding. Three ligands were labeled by iodine-125, and they exhibited good properties in vitro and in vivo, which further supported that this flexible scaffold was potential and promising for the development of Aβ imaging agents.3-Iodophenol(cas: 626-02-8Category: iodides-buliding-blocks) was used in this study.

3-Iodophenol(cas: 626-02-8) belongs to organic iodides. Organic iodides are used in veterinary products (Organic Iodide Powder) as a nutritional source of iodine.Category: iodides-buliding-blocks In the chemical industry, alkyl iodides serve as excellent alkylating agents and, specifically, methyl iodide is used as a methylating agent in the synthesis of various pharmaceutical drugs.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

《A multiphase nickel iron sulfide hybrid electrode for highly active oxygen evolution》 was published in Science China Materials in 2020. These research results belong to Li, Pengsong; Zhao, Xiuping; Duan, Xinxuan; Li, Yaping; Kuang, Yun; Sun, Xiaoming. Product Details of 516-12-1 The article mentions the following:

Development of highly active electrocatalysts for oxygen evolution reaction (OER) is one of the critical issues for water splitting, and most reported catalysts operate at overpotentials above 190 mV. Here we present a multiphase nickel iron sulfide (MPS) hybrid electrode with a hierarchical structure of iron doped NiS and Ni3S2, possessing a benchmark OER activity in alk. media with a potential as low as 1.33 V (vs. reversible hydrogen electrode) to drive an OER c.d. of 10 mA cm-2. The Fe doped NiS, combined with highly conductive disulfide phase on porous Ni foam, is believed to be responsible for the ultrahigh activity. Further more, d. functional theory simulation reveals that partially oxidized sulfur sites in Fe doped NiS could dramatically lower the energy barrier for the rate determining elementary reaction, thus contributing to the active oxygen evolution.1-Iodopyrrolidine-2,5-dione(cas: 516-12-1Product Details of 516-12-1) was used in this study.

1-Iodopyrrolidine-2,5-dione(cas: 516-12-1) is used in the preparation of vinyl sulfones from olefins and benzenesulfinic acid. It acts as a source for I+ and involved in Hunsdiecker reactions for the conversion of cinnamic acids, and propiolic acids to the corresponding alfa-halostyrenes and 1-halo-1-alkynes respectively. Product Details of 516-12-1

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

The author of 《Efficient deep blue OLEDs with extremely low efficiency roll-off at high brightness based on phenanthroimidazole derivatives》 were Chen, Xiang; Zhao, Jue-Wen; Zheng, Xu-Hui; Zhu, Jie-Ji; Yang, Guo-Xi; Tang, Shan-Shun; Tong, Qing-Xiao; Tao, Si-Lu. And the article was published in Chinese Chemical Letters in 2019. Name: 1-Bromo-3-iodobenzene The author mentioned the following in the article:

Phosphorescent and thermally activated delayed fluorescence (TADF) emitters can break through the spin statistics rules and achieve great success in external quantum efficiency (>5%). Maintaining high efficiency at high brightness is a tremendous challenge for applications of organic light emitting diodes. Two phenanthroimidazole derivatives PPI-An-CN and PPI-An-TP are reported, and extremely low efficiency roll-off with ∼99% of the maximum external quantum efficiency (EQEmax) maintained even at a high luminance of 1000 cd/cm2 based nondoped devices were achieved. When doping the 2 materials in CBP (4,4′-bis(N-carbazolyl)-1,1′-biphenyl), the doped devices still exhibited excellent stability at high brightness with CIEy ≈ 0.07 and low turn-on voltage of only 2.8 V. The state-of-the-art low efficiency roll-off makes the new materials attractive for potential applications. It is the 1st time that the Fragment Contribution Anal. method was used to analyze the excited state properties of the mols. in the field of OLEDs, which helps one understand the mechanism more intuitively and deeply.1-Bromo-3-iodobenzene(cas: 591-18-4Name: 1-Bromo-3-iodobenzene) was used in this study.

1-Bromo-3-iodobenzene(cas: 591-18-4) has been used in the preparation of 1-(3′-bromophenyl)-3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,10-heptadecafluorodec-1-ene and 1-(3′-bromophenyl)-3,3,4,4,5,5,6,6,7,7,8,8,8-tridecafluorooct-1-ene.Name: 1-Bromo-3-iodobenzene

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

The author of 《Oxidative organocatalysed enantioselective coupling of indoles with aldehydes that forms quaternary carbon stereocentres》 were Rezayee, Nomaan M.; Lauridsen, Vibeke H.; Naesborg, Line; Nguyen, Thanh V. Q.; Tobiesen, Henriette N.; Joergensen, Karl Anker. And the article was published in Chemical Science in 2019. Recommanded Product: Trimethylsulfoxonium iodide The author mentioned the following in the article:

The first organocatalyzed, metal-free cross-nucleophile coupling of indoles with α-branched aldehydes forming acyclic stereoselective quaternary carbon centers was presented. Applying an amino acid-derived catalyst with suitable organic oxidants afforded the desired enantioenriched indole functionalized products with moderate to excellent yield and enantioselectivity. Two metal-free oxidative protocols employing either DDQ or a sequential approach that uses two organocatalysts to facilitate the use of O2 as the terminal oxidant were disclosed. These methods were compatible with various indoles ranging from electron-rich to -deficient substituents at the C-2,-5,-6 and -7-positions reacting with a series of different α-branched aldehydes. In addition to this study using Trimethylsulfoxonium iodide, there are many other studies that have used Trimethylsulfoxonium iodide(cas: 1774-47-6Recommanded Product: Trimethylsulfoxonium iodide) was used in this study.

Trimethylsulfoxonium iodide(cas: 1774-47-6) is a sulfoxonium salt. It is used to generate dimethyloxosulfonium methylide by reaction with sodium hydride. The latter compound is used as a methylene-transfer reagent, and is used to prepare epoxides.Recommanded Product: Trimethylsulfoxonium iodide

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com